Clopidogrel does not work following cardiopulmonary resuscitation

European Journal of Clinical Pharmacology

Volumn 69, Issue 9, 2013, Pages 1727-

  Bjelland, Thor W ^a   Hjertner, Øyvind ^a,b   Klepstad, Pål ^a,b   Kaisen, Kjell ^c   Dale, Ola ^a,b   Haugen, Bjørn Olav ^a,b  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^c STAVANGER UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL;

ACUTE CORONARY SYNDROME; ANTICOAGULANT THERAPY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG TREATMENT FAILURE; HEART ARREST; HUMAN; HYPERTHERMIA; LETTER; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RESUSCITATION; STENT; STENT THROMBOSIS; THROMBOCYTE AGGREGATION INHIBITION; TREATMENT OUTCOME;

BIOLOGICAL AVAILABILITY; CARDIOPULMONARY RESUSCITATION; HUMANS; HYPOTHERMIA, INDUCED; PLATELET AGGREGATION INHIBITORS; TICLOPIDINE; TREATMENT OUTCOME;

EID: 84883033458     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-013-1522-8     Document Type: Letter

References (5)

1. Roden DM, Stein CM (2009) Clopidogrel and the concept of high-risk pharmacokinetics. Circulation 119:2127-2130
2. Souckova L, Opatrilova R, Suk P, Cundrle I Jr, Pavlik M, Zvonicek V, Hlinomaz O, Sramek V (2013) Impaired bioavailability and antiplatelet effect of high-dose clopidogrel in patients after cardiopulmonary resuscitation (CPR). Eur J Clin Pharmacol 69:309-317
3. Bjelland TW, Hjertner O, Klepstad P, Kaisen K, Dale O, Haugen BO (2010) Antiplatelet effect of clopidogrel is reduced in patients treated with therapeutic hypothermia after cardiac arrest. Resuscitation 81:1627-1631
4. Penela D, Magaldi M, Fontanals J, Martin V, Regueiro A, Ortiz JT, Bosch X, Sabate M, Heras M (2013) Hypothermia in acute coronary syndrome: brain salvage versus stent thrombosis? J Am Coll Cardiol 61:686-687
5. Ibrahim K, Christoph M, Schmeinck S et al. (2011) Clopidogrel and prasugrel non-responder in therapeutic hypothermia after cardiac arrest. Abstract presented at the ESC 2011, Paris