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Volumn 9, Issue 8, 2013, Pages 1701-1705

Progress on the research and development of inactivated EV71 whole-virus vaccines

Author keywords

Enterovirus 71; Hand footmouth diseases (HFMD); Immunogenicity; Inactivated whole virus vaccine; Protective effect; Standard

Indexed keywords

ENTEROVIRUS 71 VIRUS VACCINE; INACTIVATED VIRUS VACCINE; UNCLASSIFIED DRUG;

EID: 84882992093     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.24949     Document Type: Review
Times cited : (51)

References (56)
  • 1
    • 0016257919 scopus 로고
    • An apparently new enterovirus isolated from patients with disease of the central nervous system
    • PMID:4361245
    • Schmidt NJ, Lennette EH, Ho HH. An apparently new enterovirus isolated from patients with disease of the central nervous system. J Infect Dis 1974; 129:304-9; PMID:4361245; http://dx.doi.org/10.1093/infdis/129.3.304
    • (1974) J Infect Dis , vol.129 , pp. 304-309
    • Schmidt, N.J.1    Lennette, E.H.2    Ho, H.H.3
  • 2
    • 78049398279 scopus 로고    scopus 로고
    • Virology epidemiology patho-genesis and control of enterovirus 71
    • PMID:20961813
    • Solomon T, Lewthwaite P, Perera D, Cardosa MJ, McMinn P, Ooi MH. Virology, epidemiology, patho-genesis, and control of enterovirus 71. Lancet Infect Dis 2010; 10:778-90; PMID:20961813; http://dx.doi.org/10.1016/S1473- 3099(10)70194-8
    • (2010) Lancet Infect Dis , vol.10 , pp. 778-790
    • Solomon, T.1    Lewthwaite, P.2    Perera, D.3    Cardosa, M.J.4    McMinn, P.5    Ooi, M.H.6
  • 3
    • 78751654405 scopus 로고    scopus 로고
    • Optimized development of a candidate strain of inactivated EV71 vaccine and analysis of its immunogenicity in rhesus monkeys
    • PMID:21150270
    • Dong C, Wang J, Liu L, Zhao H, Shi H, Zhang Y, et al. Optimized development of a candidate strain of inactivated EV71 vaccine and analysis of its immunogenicity in rhesus monkeys. Hum Vaccin 2010; 6:1028-37; PMID:21150270; http://dx.doi.org/10.4161/hv.6.12.12982
    • (2010) Hum Vaccin , vol.6 , pp. 1028-1037
    • Dong, C.1    Wang, J.2    Liu, L.3    Zhao, H.4    Shi, H.5    Zhang, Y.6
  • 4
    • 84872772027 scopus 로고    scopus 로고
    • Study of the integrated immune response induced by an inactivated EV71 vaccine
    • PMID:23372725
    • Liu L, Zhang Y, Wang J, Zhao H, Jiang L, Che Y, et al. Study of the integrated immune response induced by an inactivated EV71 vaccine. PLoS One 2013; 8:e54451; PMID:23372725; http://dx.doi.org/10.1371/journal.pone.0054451
    • (2013) PLoS One , vol.8
    • Liu, L.1    Zhang, Y.2    Wang, J.3    Zhao, H.4    Jiang, L.5    Che, Y.6
  • 5
    • 80051559682 scopus 로고    scopus 로고
    • Immunoprotection elicited by an enterovirus type 71 experimental inactivated vaccine in mice and rhesus monkeys
    • PMID:21722686
    • Dong C, Liu L, Zhao H, Wang J, Liao Y, Zhang X, et al. Immunoprotection elicited by an enterovirus type 71 experimental inactivated vaccine in mice and rhesus monkeys. Vaccine 2011; 29:6269-75; PMID:21722686; http://dx.doi.org/10. 1016/j.vac-cine.2011.06.044
    • (2011) Vaccine , vol.29 , pp. 6269-6275
    • Dong, C.1    Liu, L.2    Zhao, H.3    Wang, J.4    Liao, Y.5    Zhang, X.6
  • 7
    • 79960652939 scopus 로고    scopus 로고
    • Formalin-inactivated vaccine provokes cross-protective immunity in a mouse model of human enterovirus 71 infection
    • PMID:21550375
    • Bek EJ, Hussain KM, Phuektes P, Kok CC, Gao Q, Cai F, et al. Formalin-inactivated vaccine provokes cross-protective immunity in a mouse model of human enterovirus 71 infection. Vaccine 2011; 29:4829-38; PMID:21550375; http://dx.doi.org/10.1016/j.vaccine.2011.04.070
    • (2011) Vaccine , vol.29 , pp. 4829-4838
    • Bek, E.J.1    Hussain, K.M.2    Phuektes, P.3    Kok, C.C.4    Gao, Q.5    Cai, F.6
  • 8
    • 84883039517 scopus 로고    scopus 로고
    • Immunoprotection of Inactivated EV71 Vaccine Against Enterovirus in Neonatal Rhesus Monkey
    • Zhao HL, Wang JJ, Zhang Y, et al. Immunoprotection of Inactivated EV71 Vaccine Against Enterovirus in Neonatal Rhesus Monkey. SCIENTIA SINICA Vitae 2011; 41:439-48
    • (2011) SCIENTIA SINICA Vitae , vol.41 , pp. 439-448
    • Zhao, H.L.1    Wang, J.J.2    Zhang, Y.3
  • 9
    • 33746436595 scopus 로고    scopus 로고
    • Protection of neonatal mice from lethal enterovirus 71 infection by maternal immunization with attenuated Salmonella enterica serovar Typhimurium expressing VP1 of enterovirus 71
    • PMID:16815726
    • Chiu CH, Chu C, He CC, Lin TY. Protection of neonatal mice from lethal enterovirus 71 infection by maternal immunization with attenuated Salmonella enterica serovar Typhimurium expressing VP1 of enterovirus 71. Microbes Infect 2006; 8:1671-8; PMID:16815726; http://dx.doi.org/10.1016/j. micinf.2006.01.021
    • (2006) Microbes Infect , vol.8 , pp. 1671-1678
    • Chiu, C.H.1    Chu, C.2    He, C.C.3    Lin, T.Y.4
  • 10
    • 34548162065 scopus 로고    scopus 로고
    • An attenuated strain of enterovirus 71 belonging to genotype a showed a broad spectrum of antigenicity with attenuated neurovirulence in cynomolgus monkeys
    • PMID:17567701
    • Arita M, Nagata N, Iwata N, Ami Y, Suzaki Y, Mizuta K, et al. An attenuated strain of enterovirus 71 belonging to genotype a showed a broad spectrum of antigenicity with attenuated neurovirulence in cynomolgus monkeys. J Virol 2007; 81:9386-95; PMID:17567701; http://dx.doi.org/10.1128/JVI.02856-06
    • (2007) J Virol , vol.81 , pp. 9386-9395
    • Arita, M.1    Nagata, N.2    Iwata, N.3    Ami, Y.4    Suzaki, Y.5    Mizuta, K.6
  • 11
    • 40849137446 scopus 로고    scopus 로고
    • Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge
    • PMID:18329759
    • Chung YC, Ho MS, Wu JC, Chen WJ, Huang JH, Chou ST, et al. Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge. Vaccine 2008; 26:1855-62; PMID:18329759; http://dx.doi.org/10.1016/j.vaccine.2008.01.058
    • (2008) Vaccine , vol.26 , pp. 1855-1862
    • Chung, Y.C.1    Ho, M.S.2    Wu, J.C.3    Chen, W.J.4    Huang, J.H.5    Chou, S.T.6
  • 12
    • 0035852349 scopus 로고    scopus 로고
    • Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus
    • PMID:11738755
    • Wu CN, Lin YC, Fann C, Liao NS, Shih SR, Ho MS. Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus. Vaccine 2001; 20:895-904; PMID:11738755; http://dx.doi.org/10.1016/S0264-410X(01)00385-1
    • (2001) Vaccine , vol.20 , pp. 895-904
    • Wu, C.N.1    Lin, Y.C.2    Fann, C.3    Liao, N.S.4    Shih, S.R.5    Ho, M.S.6
  • 13
    • 77957350005 scopus 로고    scopus 로고
    • Enterovirus 71 virus-like particle vaccine: Improved production conditions for enhanced yield
    • PMID:20797455
    • Chung CY, Chen CY, Lin SY, Chung YC, Chiu HY, Chi WK, et al. Enterovirus 71 virus-like particle vaccine: improved production conditions for enhanced yield. Vaccine 2010; 28:6951-7; PMID:20797455; http://dx.doi.org/10.1016/j. vaccine.2010.08.052
    • (2010) Vaccine , vol.28 , pp. 6951-6957
    • Chung, C.Y.1    Chen, C.Y.2    Lin, S.Y.3    Chung, Y.C.4    Chiu, H.Y.5    Chi, W.K.6
  • 14
    • 38349134004 scopus 로고    scopus 로고
    • DNA vaccine constructs against enterovirus 71 elicit immune response in mice
    • PMID:17445254
    • Tung WS, Bakar SA, Sekawi Z, Rosli R. DNA vaccine constructs against enterovirus 71 elicit immune response in mice. Genet Vaccines Ther 2007; 5:6; PMID:17445254; http://dx.doi.org/10.1186/1479-0556-5-6
    • (2007) Genet Vaccines Ther , vol.5 , pp. 6
    • Tung, W.S.1    Bakar, S.A.2    Sekawi, Z.3    Rosli, R.4
  • 15
    • 35148834304 scopus 로고    scopus 로고
    • Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide
    • PMID:17890123
    • Foo DG, Alonso S, Chow VT, Poh CL. Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide. Microbes Infect 2007; 9:1299-306; PMID:17890123; http://dx.doi.org/10.1016/j. micinf.2007.06.002
    • (2007) Microbes Infect , vol.9 , pp. 1299-1306
    • Foo, D.G.1    Alonso, S.2    Chow, V.T.3    Poh, C.L.4
  • 16
    • 77958165096 scopus 로고    scopus 로고
    • Combined peptides of human enterovirus 71 protect against virus infection in mice
    • PMID:20831911
    • Liu JN, Wang W, Duo JY, Hao Y, Ma CM, Li WB, et al. Combined peptides of human enterovirus 71 protect against virus infection in mice. Vaccine 2010; 28:7444-51; PMID:20831911; http://dx.doi.org/10.1016/j.vaccine.2010.08.080
    • (2010) Vaccine , vol.28 , pp. 7444-7451
    • Liu, J.N.1    Wang, W.2    Duo, J.Y.3    Hao, Y.4    Ma, C.M.5    Li, W.B.6
  • 18
    • 84859829557 scopus 로고    scopus 로고
    • Safety and immunogenicity of a novel human Enterovirus 71 (EV71) vaccine: A randomized, placebo-controlled, double-blind, Phase i clinical trial
    • PMID:22426327
    • Li YP, Liang ZL, Gao Q, Huang LR, Mao QY, Wen SQ, et al. Safety and immunogenicity of a novel human Enterovirus 71 (EV71) vaccine: a randomized, placebo-controlled, double-blind, Phase I clinical trial. Vaccine 2012; 30:3295-303; PMID:22426327; http://dx.doi.org/10.1016/j.vac-cine.2012.03.010
    • (2012) Vaccine , vol.30 , pp. 3295-3303
    • Li, Y.P.1    Liang, Z.L.2    Gao, Q.3    Huang, L.R.4    Mao, Q.Y.5    Wen, S.Q.6
  • 19
    • 82555168284 scopus 로고    scopus 로고
    • Establishing China's national standards of antigen content and neutralizing antibody responses for evaluation of enterovirus 71 (EV71) vaccines
    • PMID:22015395
    • Liang Z, Mao Q, Gao Q, Li X, Dong C, Yu X, et al. Establishing China's national standards of antigen content and neutralizing antibody responses for evaluation of enterovirus 71 (EV71) vaccines. Vaccine 2011; 29:9668-74; PMID:22015395; http://dx.doi.org/10.1016/j.vaccine.2011.10.018
    • (2011) Vaccine , vol.29 , pp. 9668-9674
    • Liang, Z.1    Mao, Q.2    Gao, Q.3    Li, X.4    Dong, C.5    Yu, X.6
  • 20
    • 79960609635 scopus 로고    scopus 로고
    • Development of a quantitative enzyme linked immunosorbent assay for monitoring the Enterovirus 71 vaccine manufacturing process
    • PMID:21704080
    • Liu CC, Chang HW, Yang G, Chiang JR, Chow YH, Sai IH, et al. Development of a quantitative enzyme linked immunosorbent assay for monitoring the Enterovirus 71 vaccine manufacturing process. J Virol Methods 2011; 176:60-8; PMID:21704080; http://dx.doi.org/10.1016/j.jviromet.2011.06.001
    • (2011) J Virol Methods , vol.176 , pp. 60-68
    • Liu, C.C.1    Chang, H.W.2    Yang, G.3    Chiang, J.R.4    Chow, Y.H.5    Sai, I.H.6
  • 21
    • 79955938192 scopus 로고    scopus 로고
    • Purification and characterization of enterovirus 71 viral particles produced from vero cells grown in a serum-free microcarrier bioreactor system
    • PMID:21603631
    • Liu CC, Guo MS, Lin FH, Hsiao KN, Chang KH, Chou AH, et al. Purification and characterization of enterovirus 71 viral particles produced from vero cells grown in a serum-free microcarrier bioreactor system. PLoS One 2011; 6:e20005; PMID:21603631; http://dx.doi.org/10.1371/journal.pone.0020005
    • (2011) PLoS One , vol.6
    • Liu, C.C.1    Guo, M.S.2    Lin, F.H.3    Hsiao, K.N.4    Chang, K.H.5    Chou, A.H.6
  • 24
    • 84863682292 scopus 로고    scopus 로고
    • Tolerability and immunogenicity of an inactivated enterovirus 71 vaccine in Chinese healthy adults and children: An open label phase 1 clinical trial
    • PMID:22634437
    • Meng FY, Li JX, Li XL, Chu K, Zhang YT, Ji H, et al. Tolerability and immunogenicity of an inactivated enterovirus 71 vaccine in Chinese healthy adults and children: an open label, phase 1 clinical trial. Hum Vaccin Immunother 2012; 8:668-74; PMID:22634437; http://dx.doi.org/10.4161/h v.19 521
    • (2012) Hum Vaccin Immunother , vol.8 , pp. 668-674
    • Meng, F.Y.1    Li, J.X.2    Li, X.L.3    Chu, K.4    Zhang, Y.T.5    Ji, H.6
  • 25
    • 85081795605 scopus 로고    scopus 로고
    • A Protected Study of Inactivated EV71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants and Children. Mar 10 2013 2013
    • A Protected Study of Inactivated EV71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants and Children. Mar 10, 2013 2013. http://www.deepdyve. com/lp/clinical-trials/a-protected-study-of-inactivated-ev71-vaccine-human- diploid-cell-k mb-679kOYq0nc/1.
  • 27
    • 84922390272 scopus 로고    scopus 로고
    • Large scale preparation of enterovirus type 71 inactivated vaccine in human diploid cells and its immunogenic study
    • Liang Y, Zhao HL, Liu LD, Liao Y, Dong CH, Na RX, et al. Large scale preparation of enterovirus type 71 inactivated vaccine in human diploid cells and its immunogenic study. Chinese Journal of Viral Diseases 2012; 2:409-14
    • (2012) Chinese Journal of Viral Diseases , vol.2 , pp. 409-414
    • Liang, Y.1    Zhao, H.L.2    Liu, L.D.3    Liao, Y.4    Dong, C.H.5    Na, R.X.6
  • 28
    • 79952534623 scopus 로고    scopus 로고
    • Neonatal rhesus monkey is a potential animal model for studying pathogenesis of EV71 infection
    • PMID:21262515
    • Liu L, Zhao H, Zhang Y, Wang J, Che Y, Dong C, et al. Neonatal rhesus monkey is a potential animal model for studying pathogenesis of EV71 infection. Virology 2011; 412:91-100; PMID:21262515; http://dx.doi.org/10.1016/j.virol. 2010.12.058
    • (2011) Virology , vol.412 , pp. 91-100
    • Liu, L.1    Zhao, H.2    Zhang, Y.3    Wang, J.4    Che, Y.5    Dong, C.6
  • 29
    • 84865285931 scopus 로고    scopus 로고
    • The effect of enterovirus 71 immunization on neuropathogenesis and protein expression profiles in the thalamus of infected rhesus neonates
    • PMID:22819834
    • Chen H, Zhang Y, Yang E, Liu L, Che Y, Wang J, et al. The effect of enterovirus 71 immunization on neuropathogenesis and protein expression profiles in the thalamus of infected rhesus neonates. Virology 2012; 432:417-26; PMID:22819834; http://dx.doi.org/10.1016/j.virol.2012.06.026
    • (2012) Virology , vol.432 , pp. 417-426
    • Chen, H.1    Zhang, Y.2    Yang, E.3    Liu, L.4    Che, Y.5    Wang, J.6
  • 30
    • 84866741759 scopus 로고    scopus 로고
    • Analysis of the Th1/Th2 reaction in the immune response induced by EV71 inactivated vaccine in neonatal rhesus monkeys
    • PMID:22585051
    • Liang Y, Zhou X, Yang E, Pu J, Che Y, Wang J, et al. Analysis of the Th1/Th2 reaction in the immune response induced by EV71 inactivated vaccine in neonatal rhesus monkeys. J Clin Immunol 2012; 32:1048-58; PMID:22585051; http://dx.doi.org/10.1007/s10875-012-9690-3
    • (2012) J Clin Immunol , vol.32 , pp. 1048-1058
    • Liang, Y.1    Zhou, X.2    Yang, E.3    Pu, J.4    Che, Y.5    Wang, J.6
  • 31
    • 84855336465 scopus 로고    scopus 로고
    • Antigenicity, animal protective effect and genetic characteristics of candidate vaccine strains of enterovirus 71
    • PMID:21984267
    • Mao Q, Li N, Yu X, Yao X, Li F, Lu F, et al. Antigenicity, animal protective effect and genetic characteristics of candidate vaccine strains of enterovirus 71. Arch Virol 2012; 157:37-41; PMID:21984267; http://d x.doi.org/10.10 07/s 0 0705-011-1136-3
    • (2012) Arch Virol , vol.157 , pp. 37-41
    • Mao, Q.1    Li, N.2    Yu, X.3    Yao, X.4    Li, F.5    Lu, F.6
  • 32
    • 84867886016 scopus 로고    scopus 로고
    • Reactogenicity and immunogenicity of an enterovirus 71 vaccine in Chinese healthy children and infants
    • PMID:22926209
    • Zhu FC, Wang JZ, Li XL, Liang ZL, Ge HM, Meng FY, et al. Reactogenicity and immunogenicity of an enterovirus 71 vaccine in Chinese healthy children and infants. Pediatr Infect Dis J 2012; 31:1158-65; PMID:22926209; http://dx.doi.org/10.1097/INF.0b013e31826eba74
    • (2012) Pediatr Infect Dis J , vol.31 , pp. 1158-1165
    • Zhu, F.C.1    Wang, J.Z.2    Li, X.L.3    Liang, Z.L.4    Ge, H.M.5    Meng, F.Y.6
  • 33
    • 84875382928 scopus 로고    scopus 로고
    • Immunogenicity and safety of an enterovirus 71 vaccine in healthy Chinese children and infants: A randomised double-blind placebo-controlled phase 2 clinical trial
    • PMID:23352749
    • Zhu FC, Liang ZL, Li XL, Ge HM, Meng FY, Mao QY, et al. Immunogenicity and safety of an enterovirus 71 vaccine in healthy Chinese children and infants: a randomised, double-blind, placebo-controlled phase 2 clinical trial. Lancet 2013; PMID:23352749
    • (2013) Lancet
    • Zhu, F.C.1    Liang, Z.L.2    Li, X.L.3    Ge, H.M.4    Meng, F.Y.5    Mao, Q.Y.6
  • 34
    • 85081798067 scopus 로고    scopus 로고
    • http://wb.yunnan.cn/html/2013/duch-eng-0312/64349.html
  • 36
    • 84855360245 scopus 로고    scopus 로고
    • Selection and characterization of vaccine strain for Enterovirus 71 vaccine development
    • PMID:22142585
    • Chang JY, Chang CP, Tsai HH, Lee CD, Lian WC, Ih-Jen-Su, et al. Selection and characterization of vaccine strain for Enterovirus 71 vaccine development. Vaccine 2012; 30:703-11; PMID:22142585; http://d x.doi.org/10.1016/j.vac cine. 2011.11.087
    • (2012) Vaccine , vol.30 , pp. 703-711
    • Chang, J.Y.1    Chang, C.P.2    Tsai, H.H.3    Lee, C.D.4    Lian, W.C.5    Ih-Jen-Su6
  • 37
    • 0037035859 scopus 로고    scopus 로고
    • Characterization of a Vero cell-adapted virulent strain of enterovirus 71 suitable for use as a vaccine candidate
    • PMID:12057603
    • Lin YC, Wu CN, Shih SR, Ho MS. Characterization of a Vero cell-adapted virulent strain of enterovirus 71 suitable for use as a vaccine candidate. Vaccine 2002; 20:2485-93; PMID:12057603; http://dx.doi.org/10.1016/S0264- 410X(02)00182-2
    • (2002) Vaccine , vol.20 , pp. 2485-2493
    • Lin, Y.C.1    Wu, C.N.2    Shih, S.R.3    Ho, M.S.4
  • 38
    • 84867388819 scopus 로고    scopus 로고
    • Immunological evaluation and comparison of different EV71 vaccine candidates
    • PMID:23008736
    • Chou AH, Liu CC, Chang JY, Lien SP, Guo MS, Tasi HP, et al. Immunological evaluation and comparison of different EV71 vaccine candidates. Clin Dev Immunol 2012; 2012:831282; PMID:23008736; http://dx.doi.org/10.1155/2012/831282
    • (2012) Clin Dev Immunol , vol.2012 , pp. 831282
    • Chou, A.H.1    Liu, C.C.2    Chang, J.Y.3    Lien, S.P.4    Guo, M.S.5    Tasi, H.P.6
  • 39
    • 84859809904 scopus 로고    scopus 로고
    • Pilot scale production of highly efficacious and stable enterovirus 71 vaccine candidates
    • PMID:22529942
    • Chou AH, Liu CC, Chang CP, Guo MS, Hsieh SY, Yang WH, et al. Pilot scale production of highly efficacious and stable enterovirus 71 vaccine candidates. PLoS One 2012; 7:e34834; PMID:22529942; http://dx.doi.org/10.1371/journal.pone. 0034834
    • (2012) PLoS One , vol.7
    • Chou, A.H.1    Liu, C.C.2    Chang, C.P.3    Guo, M.S.4    Hsieh, S.Y.5    Yang, W.H.6
  • 40
    • 4444238865 scopus 로고    scopus 로고
    • Optimization of microcarrier cell culture process for the inactivated enterovirus type 71 vaccine development
    • PMID:15364432
    • Wu SC, Liu CC, Lian WC. Optimization of microcarrier cell culture process for the inactivated enterovirus type 71 vaccine development. Vaccine 2004; 22:3858-64; PMID:15364432; http://dx.doi.org/10.1016/j.vaccine.2004.05.037
    • (2004) Vaccine , vol.22 , pp. 3858-3864
    • Wu, S.C.1    Liu, C.C.2    Lian, W.C.3
  • 41
    • 33845205522 scopus 로고    scopus 로고
    • High immuno-genic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture
    • PMID:16919374
    • Liu CC, Lian WC, Butler M, Wu SC. High immuno-genic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture. Vaccine 2007; 25:19-24; PMID:16919374; http://dx.doi.org/10.1016/j.vaccine.2006.06.083
    • (2007) Vaccine , vol.25 , pp. 19-24
    • Liu, C.C.1    Lian, W.C.2    Butler, M.3    Wu, S.C.4
  • 42
    • 84877072126 scopus 로고    scopus 로고
    • A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine
    • PMID:23541623
    • Cheng A, Fung CP, Liu CC, Lin YT, Tsai HY, Chang SC, et al. A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine. Vaccine 2013; 31:2471-6; PMID:23541623; http://dx.doi.org/10.1016/j.vac-cine.2013.03.015
    • (2013) Vaccine , vol.31 , pp. 2471-2476
    • Cheng, A.1    Fung, C.P.2    Liu, C.C.3    Lin, Y.T.4    Tsai, H.Y.5    Chang, S.C.6
  • 45
    • 0004210691 scopus 로고
    • WHO Expert Commmitte on Biological Standardiztion Thirty-sixth Report Geneva, World Health Organization: (WHO Technical Report Series, No. 745, Annex 3).
    • Requirements for continuous cell lines used for biological production. WHO Expert Commmitte on Biological Standardiztion Thirty-sixth Report Geneva, World Health Organization: (WHO Technical Report Series, No. 745, Annex 3). 1987.
    • (1987) Requirements for Continuous Cell Lines Used for Biological Production
  • 47
    • 85081801748 scopus 로고    scopus 로고
    • Safety of biological products prepared from mammalian cell culture
    • 1st ed. Basel: S Karger;
    • Safety of biological products prepared from mammalian cell culture. DNA. 1st ed. Basel: S Karger; 1998.
    • (1998) DNA
  • 49
    • 84874750285 scopus 로고    scopus 로고
    • Development of a Vero cell DNA reference standard for residual DNA measurement in China
    • PMID:23291952
    • Cao S, Dong G, Tang J, Li J, Liu J, Shi L, et al. Development of a Vero cell DNA reference standard for residual DNA measurement in China. Hum Vaccin Immunother 2013; 9; PMID:23291952; http://dx.doi.org/10.4161/hv.22699
    • (2013) Hum Vaccin Immunother , vol.9
    • Cao, S.1    Dong, G.2    Tang, J.3    Li, J.4    Liu, J.5    Shi, L.6
  • 50
    • 77956655408 scopus 로고    scopus 로고
    • Laboratory evaluation of method for determination of neutralizing antibodyagainst human enterovirus 71
    • Mao QY, He P, Yu X, Li N, Hao CS, Gao Q, et al. Laboratory Evaluation of Method for Determination of Neutralizing Antibodyagainst Human Enterovirus 71. Chin J Biologicals 2010; 8:99-102
    • (2010) Chin J Biologicals , vol.8 , pp. 99-102
    • Mao, Q.Y.1    He, P.2    Yu, X.3    Li, N.4    Hao, C.S.5    Gao, Q.6
  • 51
    • 84867011841 scopus 로고    scopus 로고
    • Comparative analysis of the immunogenicity and protective effects of inactivated EV71 vaccines in mice
    • PMID:23029378
    • Mao Q, Dong C, Li X, Gao Q, Guo Z, Yao X, et al. Comparative analysis of the immunogenicity and protective effects of inactivated EV71 vaccines in mice. PLoS One 2012; 7:e46043; PMID:23029378; http://dx.doi.org/10.1371/journal.pone. 0046043
    • (2012) PLoS One , vol.7
    • Mao, Q.1    Dong, C.2    Li, X.3    Gao, Q.4    Guo, Z.5    Yao, X.6
  • 52
    • 84878769516 scopus 로고    scopus 로고
    • Development and Evaluation of a Pseudovirus-Luciferase Assay for Rapid and Quantitative Detection of Neutralizing Antibodies against Enterovirus 71
    • Wu X, Mao QY, Yao X, Chen P, Chen XM, Shao J, et al. Development and Evaluation of a Pseudovirus-Luciferase Assay for Rapid and Quantitative Detection of Neutralizing Antibodies against Enterovirus 71. PLoS ONE 2013; 8: e64116.
    • (2013) PLoS ONE , vol.8
    • Wu, X.1    Mao, Q.Y.2    Yao, X.3    Chen, P.4    Chen, X.M.5    Shao, J.6
  • 53
    • 80053269943 scopus 로고    scopus 로고
    • The persistent circulation of enterovirus 71 in People's Republic of China: Causing emerging nationwide epidemics since 2008
    • PMID:21980521
    • Tan X, Huang X, Zhu S, Chen H, Yu Q, Wang H, et al. The persistent circulation of enterovirus 71 in People's Republic of China: causing emerging nationwide epidemics since 2008. PLoS One 2011; 6:e25662; PMID:21980521; http://dx.doi.org/10.1371/journal.pone.0025662
    • (2011) PLoS One , vol.6
    • Tan, X.1    Huang, X.2    Zhu, S.3    Chen, H.4    Yu, Q.5    Wang, H.6
  • 54
    • 77956615805 scopus 로고    scopus 로고
    • Enterovirus 71 vaccine: Close but still far
    • PMID:20400350
    • Zhang D, Lu J, Lu J. Enterovirus 71 vaccine: close but still far. Int J Infect Dis 2010; 14:e739-43; PMID:20400350; http://dx.doi.org/10.1016/j. ijid.2009.12.002
    • (2010) Int J Infect Dis , vol.14
    • Zhang, D.1    Lu, J.2    Lu, J.3
  • 55
    • 84865961485 scopus 로고    scopus 로고
    • Challenges to licensure of enterovirus 71 vaccines
    • PMID:22953003
    • Lee MS, Tseng FC, Wang JR, Chi CY, Chong P, Su IJ. Challenges to licensure of enterovirus 71 vaccines. PLoS Negl Trop Dis 2012; 6:e1737; PMID:22953003; http://dx.doi.org/10.1371/jour-nal.pntd.0001737
    • (2012) PLoS Negl Trop Dis , vol.6
    • Lee, M.S.1    Tseng, F.C.2    Wang, J.R.3    Chi, C.Y.4    Chong, P.5    Su, I.J.6
  • 56
    • 77950692185 scopus 로고    scopus 로고
    • EV71: An emerging infectious disease vaccine target in the Far East?
    • PMID:20304038
    • Xu J, Qian Y, Wang S, Serrano JM, Li W, Huang Z, et al. EV71: an emerging infectious disease vaccine target in the Far East? Vaccine 2010; 28:3516-21; PMID:20304038; http://dx.doi.org/10.1016/j.vac-cine.2010.03.003
    • (2010) Vaccine , vol.28 , pp. 3516-3521
    • Xu, J.1    Qian, Y.2    Wang, S.3    Serrano, J.M.4    Li, W.5    Huang, Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.