Purification and characterization of enterovirus 71 viral particles produced from vero cells grown in a serum-free microcarrier bioreactor system

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Liu, Chia Chyi ^a   Guo, Meng Shin ^a   Lin, Fion Hsiao Yu ^a   Hsiao, Kuang Nan ^a   Chang, Kate Hsuen Wen ^a   Chou, Ai Hsiang ^a   Wang, Yu Chao ^a   Chen, Yu Ching ^a   Yang, Chung Shi ^a   Chong, Pele Choi Sing ^a,b  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; PROTEIN VP0; PROTEIN VP1; PROTEIN VP2; PROTEIN VP3; PROTEIN VP4; SUCROSE; UNCLASSIFIED DRUG; VIRUS ANTIGEN; VIRUS PROTEIN; VIRUS VACCINE; VACCINE;

ANIMAL EXPERIMENT; ARTICLE; BIOREACTOR; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; DRUG POTENCY; DRUG PURIFICATION; DRUG SCREENING; ENTEROVIRUS 71; FEMALE; IMMUNOGENICITY; LOW DRUG DOSE; MICROCARRIER CULTURE; MOUSE; NONHUMAN; RNA ANALYSIS; SUCROSE GRADIENT; ULTRACENTRIFUGATION; VACCINE PRODUCTION; VERO CELL; VIRUS CONCENTRATION; VIRUS IDENTIFICATION; VIRUS INACTIVATION; VIRUS INFECTIVITY; VIRUS LOAD; VIRUS NEUTRALIZATION; VIRUS PARTICLE; VIRUS PURIFICATION; ANIMAL; CERCOPITHECUS; DENSITY GRADIENT CENTRIFUGATION; ENTEROVIRUS; ENTEROVIRUS INFECTION; GROWTH, DEVELOPMENT AND AGING; HAND FOOT AND MOUTH DISEASE; ISOLATION AND PURIFICATION; MICROBIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; VIRION; VIROLOGY;

HUMAN ENTEROVIRUS 71;

ANIMALS; BIOREACTORS; CENTRIFUGATION, DENSITY GRADIENT; CERCOPITHECUS AETHIOPS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENTEROVIRUS; ENTEROVIRUS A, HUMAN; ENTEROVIRUS INFECTIONS; HAND, FOOT AND MOUTH DISEASE; MICE; VACCINES; VERO CELLS; VIRION;

EID: 79955938192     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020005     Document Type: Article

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