Inhibition of GAP-43 by propentofylline in a rat model of neuropathic pain

International Journal of Clinical and Experimental Pathology

Volumn 6, Issue 8, 2013, Pages 1516-1522

  Wu, Feixiang ^a   Miao, Xuerong ^a   Chen, Jiaying ^a   Liu, Zhiqiang ^b   Tao, Yong ^a   Yu, Weifeng ^a   Sun, Yuming ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Astrocytes; Growth associated protein 43; Interleukin 1 ; Neuropathic pain

Indexed keywords

NEUROMODULIN; NEUROPROTECTIVE AGENT; PROPENTOFYLLINE; XANTHINE DERIVATIVE;

ANIMAL; ARTICLE; ASTROCYTE; DISEASE MODEL; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GROWTH-ASSOCIATED PROTEIN-43; HYPERALGESIA; INTERLEUKIN 1Β; MALE; METABOLISM; NEURALGIA; NEUROPATHIC PAIN; RAT; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ASTROCYTES; GROWTH-ASSOCIATED PROTEIN-43; INTERLEUKIN 1Β; NEUROPATHIC PAIN;

ANIMALS; ASTROCYTES; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GAP-43 PROTEIN; HYPERALGESIA; MALE; NEURALGIA; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; XANTHINES;

EID: 84882989343     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Bouhassira D, Lanteri-Minet M, Attal N, Laurent B and Touboul C. Prevalence of chronic pain with neuropathic characteristics in the general population. Pain 2008; 136: 380-387.
2. Chen MJ, Kress B, Han X, Moll K, Peng W, Ji RR, and Nedergaard M. Astrocytic CX43 hemichannels, and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. Glia 2012; 60: 1660-1670.
3. Chiang CY, Sessle BJ, and Dostrovsky JO. Role of astrocytes in pain. Neurochem Res 2012; 37: 2419-2431.
4. McMahon SB, and Malcangio M. Current challenges in glia-pain biology. Neuron 2009; 64: 46-54.
5. Sweitzer SM, Schubert P, and DeLeo JA. Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. J Pharmacol Exp Ther 2001; 297: 1210-1217.
6. Verze L, Paraninfo A, Ramieri G, Viglietti-Panzica C, and Panzica GC. Immunocytochemical evidence of plasticity in the nervous structures of the rat lower lip. Cell Tissue Res 1999; 297: 203-211.
7. Ren K, and Dubner R. Interactions between the immune, and nervous systems in pain. Nat Med 2010; 16: 1267-1276.
8. Parish CL, Finkelstein DI, Tripanichkul W, Satoskar AR, Drago J, and Horne MK. The role of interleukin-1, interleukin-6,, and glia in inducing growth of neuronal terminal arbors in mice. J Neurosci 2002; 22: 8034-8041.
9. Jaken RJ, van Gorp S, Joosten EA, Losen M, Martinez-Martinez P, De Baets M, Marcus MA, and Deumens R. Neuropathy-induced spinal GAP-43 expression is not a main player in the onset of mechanical pain hypersensitivity. J Neurotrauma 2011; 28: 2463-2473.
10. Gwak YS, Crown ED, Unabia GC, and Hulsebosch CE. Propentofylline attenuates allodynia, glial activation, and modulates GABAergic tone after spinal cord injury in the rat. Pain 2008; 138: 410-422.
11. Bennett GJ, and Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988; 33: 87-107.
12. Storkson RV, Kjorsvik A, Tjolsen A, and Hole K. Lumbar catheterization of the spinal subarachnoid space in the rat. J Neurosci Methods 1996; 65: 167-172.
13. Milligan ED, Hinde JL, Mehmert KK, Maier SF, and Watkins LR. A method for increasing the viability of the external portion of lumbar catheters placed in the spinal subarachnoid space of rats. J Neurosci Methods 1999; 90: 81-86.
14. Hargreaves K, Dubner R, Brown F, Flores C, and Joris J. A new, and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988; 32: 77-88.
15. Chaplan SR, Bach FW, Pogrel JW, Chung JM, and Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994; 53: 55-63.
16. An G, Lin TN, Liu JS, Xue JJ, He YY, and Hsu CY. Expression of c-fos, and c-jun family genes after focal cerebral ischemia. Ann Neurol 1993; 33: 457-464.
17. Milligan ED, O'Connor KA, Nguyen KT, Armstrong CB, Twining C, Gaykema RP, Holguin A, Martin D, Maier SF, and Watkins LR. Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines. J Neurosci 2001; 21: 2808-2819.
18. Znaor L, Lovric S, Hogan Q, and Sapunar D. Association of neural inflammation with hyperalgesia following spinal nerve ligation. Croat Med J 2007; 48: 35-42.
19. Wu FX, Bian JJ, Miao XR, Huang SD, Xu XW, Gong DJ, Sun YM, Lu ZJ, and Yu WF. Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain. Int J Med Sci 2010; 7: 251-259.
20. Zeilhofer HU. Loss of glycinergic, and GABAergic inhibition in chronic pain--contributions of inflammation, and microglia. Int Immunopharmacol 2008; 8: 182-187.
21. Obata H, Eisenach JC, Hussain H, Bynum T, and Vincler M. Spinal glial activation contributes to postoperative mechanical hypersensitivity in the rat. J Pain 2006; 7: 816-822.
22. Milligan ED, Twining C, Chacur M, Biedenkapp J, O'Connor K, Poole S, Tracey K, Martin D, Maier SF, and Watkins LR. Spinal glia, and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci 2003; 23: 1026-1040.
23. Watkins LR, Martin D, Ulrich P, Tracey KJ, and Maier SF. Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat. Pain 1997; 71: 225-235.
24. Yao M, Chang XY, Chu YX, Yang JP, Wang LN, Cao HQ, Liu MJ, and Xu QN. Antiallodynic effects of propentofylline Elicited by interrupting spinal glial function in a rat model of bone cancer pain. J Neurosci Res 2011; 89: 1877-1886.
25. Kuzumaki N, Narita M, Hareyama N, Niikura K, Nagumo Y, Nozaki H, Amano T, and Suzuki T. Chronic pain-induced astrocyte activation in the cingulate cortex with no change in neural or glial differentiation from neural stem cells in mice. Neurosci Lett 2007; 415: 22-27.
26. Fitzgerald M, Reynolds ML, and Benowitz LI. GAP-43 expression in the developing rat lumbar spinal cord. Neuroscience 1991; 41: 187-199.
27. Wu F, Miao X, Chen J, Sun Y, Liu Z, Tao Y, and Yu W. Down-regulation of GAP-43 by inhibition of caspases-3 in a rat model of neuropathic pain. Int J Clin Exp Pathol 2012; 5: 948-955.