Short communication: The relationship between mitochondrial dysfunction and insulin resistance in HIV-infected children receiving antiretroviral therapy

AIDS Research and Human Retroviruses

Volumn 29, Issue 9, 2013, Pages 1211-1217

  Sharma, Tanvi S ^a   Jacobson, Denise L ^b   Anderson, Lynn ^c   Gerschenson, Mariana ^c   Van Dyke, Russell B ^d   Mcfarland, Elizabeth J ^e   Miller, Tracie L ^f  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF HAWAII   (United States)

^d TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e CHILDREN S HOSPITAL COLORADO   (United States)

^f UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; CYTOCHROME C OXIDASE; GLUCOSE; INSULIN; LAMIVUDINE; MITOCHONDRIAL DNA; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; RITONAVIR; STAVUDINE; ZIDOVUDINE;

ADOLESCENT; ARTICLE; BODY MASS; CASE CONTROL STUDY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; FEMALE; GLUCOSE BLOOD LEVEL; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INSULIN RESISTANCE; LONG TERM CARE; MALE; OXIDATIVE PHOSPHORYLATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SCHOOL CHILD; T LYMPHOCYTE SUBPOPULATION; THIN LAYER CHROMATOGRAPHY; VIRUS LOAD;

ADOLESCENT; ANTI-RETROVIRAL AGENTS; BLOOD GLUCOSE; CASE-CONTROL STUDIES; CHILD; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX IV; FEMALE; HIV INFECTIONS; HUMANS; INSULIN RESISTANCE; LEUKOCYTES, MONONUCLEAR; MALE; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION;

EID: 84882987526     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2012.0354     Document Type: Article

References (26)

1. Marin B, Thiebaut R, Bucher HC, et al.: Non-AIDS-defining deaths and immunodeficiency in the era of combination antiretroviral therapy. AIDS 2009;23:1743-1753.
2. Neuhaus J, Angus B, Kowalska JD, et al.: Risk of all-cause mortality associated with nonfatal AIDS and serious non-AIDS events among adults infected with HIV. Acquir Immune Defic Syndr 2010;24:697-706.
3. Flint OP, Noor MA, Hruz PW, et al.: The role of protease inhibitors in the pathogenesis of HIV-associated lipodystrophy: Cellular mechanisms and clinical implications. Toxicol Pathol 2009;37:65-77.
4. Perez-Molina JA, Domingo P, Martinez E, et al.: The role of efavirenz compared with protease inhibitors in the body fat changes associated with highly active antiretroviral therapy. J Antimicrob Chemother 2008;62:234-245.
5. Poirier M, Divi R, Al-Harthi L, et al.: Women and Infants Transmission Study (WITS) Study Group. Long-term mitochondrial toxicity in HIV-uninfected infants born to HIVinfected mothers. JAIDS 2003;33:175-183.
6. Poirier M, Olivero O, Walker D, et al.: Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugs. Toxicol Appl Pharmacol 2004;199:151-161.
7. Shikuma CM, Day LJ, and Gerschenson M: Insulin resistance in the HIV-infected population: The potential role of mitochondrial dysfunction. Curr Drug Targets Infect Disord 2005;5:255-262.
8. McComsey GA, Libutti DE, O'Riordan M, et al.: Mitochondrial RNA and DNA alterations in HIV lipoatrophy are linked to ART therapy and not HIV infection. Antivir Ther 2008;13(5):715-722.
9. Shikuma CM, Gerschenson M, Chow D, et al.: Mitochondrial oxidative phosphorylation protein levels in peripheral blood mononuclear cells correlate with levels in subcutaneous adipose tissue within samples differing by HIV and lipoatrophy status. AIDS Res Hum Retroviruses 2008;24: 1255-1262.
10. Foster C and Lyall H: HIV and mitochondrial toxicity in children. J Antimicrob Chemother 2008;61:8-12.
11. Crain MJ, Chernoff MC, Oleske JM, et al.: Possible mitochondrial dysfunction and its association with antiretroviral therapy use in children perinatally infected with HIV. J Infect Dis 2010;202(2):291-301.
12. Saitoh A, Fenton T, Alvero C, Fletcher CV, and Spector SA: Impact of nucleoside reverse transcriptase inhibitors on mitochondria in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy. Antimicrob Agents Chemother 2007;51:4236-4242.
13. Morino K, Petersen KF, and Shulman GI: Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes 2006;55(Suppl 2): S9-S15.
14. Gerschenson M, Shiramizu B, LiButti DE, and Shikuma CM: Mitochondrial DNA levels of peripheral blood mononuclear cells and subcutaneous adipose tissue from thigh, fat and abdomen of HIV-1 seropositive and negative individuals. Antivir Ther 2005;10(Suppl 2):M83-89.
15. Lee HK, Song JH, Shin CS, et al.: Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 1998;42:161-167.
16. Miller TL, Borkowsky W, DiMeglio LA, et al. for the Pediatric HIV/AIDS Cohort Study (PHACS): Metabolic abnormalities and viral replication are associated with biomarkers of vascular dysfunction in HIV-infected children. HIV Med 2012;13(5):264-275.
17. Geffner ME, Patel K, Miller TL, et al.: Factors associated with insulin resistance among children and adolescents perinatally infected with HIV-1 in the Pediatric HIV/AIDS Cohort Study. Hormone Res Paediatr 2011;76:386-391.
18. Matthews DR, Hosker JP, Rudenski AS, et al.: Homeostasis model assessment: Insulin resistance and B cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 1985;28:412-419.
19. Kurtoǧ lu S, Hatipoǧ lu N, Mazicioǧ lu M, et al.: Insulin resistance in obese children and adolescents: HOMA-IR cutoff levels in the prepubertal and pubertal periods. J Clin Res Pediatr Endocrinol 2010;2(3):100-106.
20. Brogly SB, DiMauro S, Van Dyke RB, et al.: Transplacental nucleoside analog exposure and mitochondrial parameters in HIV-uninfected children. AIDS Res Hum Retroviruses 2011;27(7):777-783.
21. Rosner B: Fundamentals of Biostatistics, p. 252, Sect. 8.4. Duxbury Press, Pacific Grove, CA, 1995.
22. Selvin S: Statistical Analysis of Epidemiologic Data, p. 278. Oxford University Press, New York, 1996.
23. Hester EK: HIV medications: An update and review of metabolic complications. Nutr Clin Pract 2012;27:51-64.
24. Kelley DE, He J, Menshikova EV, and Ritov VB: Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002;51:2944-2950.
25. Hruz PW: Molecular mechanisms for altered glucose homeostasis in HIV infection. Am J Infect Dis 2006;2(3): 187-192.
26. Fleischman A, Johnsen S, Systrom DM, et al.: Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults. Am J Physiol Endocrinol Metab 2007;292: E1666-E1673.