Study on effect of Weinaokang and bilobalide on autophagy and neurogenesis induced by focal cerebral ischemia reperfusion

Zhongguo Zhongyao Zazhi

Volumn 38, Issue 13, 2013, Pages 2182-2186

  Zheng, Yong Qiu ^a   Liu, Jian Xun ^a   Xu, Li ^a   Yao, Ming Jiang ^a   Song, Wen Ting ^a  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

Autophagy; Bilobalide; Ischemia reperfusion; Neurogenesis; Weinaokang

Indexed keywords

BECLIN 1; BILOBALIDE; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG; WEINAOKANG;

ARTICLE; AUTOPHAGY; BRAIN ISCHEMIA; IMMUNOFLUORESCENCE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL GROWTH; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; REPERFUSION INJURY; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANIMALS; AUTOPHAGY; BRAIN ISCHEMIA; CYCLOPENTANES; DRUGS, CHINESE HERBAL; FURANS; GINKGOLIDES; MALE; NEUROGENESIS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 84882977678     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20131329     Document Type: Article

References (14)

1. Zhao J, Zhao Y, Feng G, et al. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats[J]. Brain Res, 2008, 1229: 224.
2. Sugiura S, Kitagawa K, Tanaka S, et al. Adenovirus-mediated gene transfer of heparin-binding epidermal growth factor-like growth factor enhances neurogenesis and angiogenesis after focal cerebral ischemia in rats[J]. Stroke, 2005, 36: 859.
3. Nygren J, Wieloch T, Pesic, et al. Enriched environment attenuates cell genesis in subventricular zone after focal ischemia in mice and decreases migration of newborn cells to the striatum[J]. Stroke, 2006, 37: 2824.
4. Li L Y, Zhao X L, Fei X F, et al. Bilobalide inhibits 6-OHDA-induced activation of NF-kappaB and loss of dopaminergic neurons in rat substantia nigra[J]. Acta Pharmacol Sin, 2008, 29: 539.
5. 2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia[J]. J Ethnopharmacol, 2008, 115: 441.
6. 2012, 37(19): 2943.
7. Xie J, Ding C, Ge Q, et al. Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2008, 864: 87.
8. Chandrasekaran K, Mehrabian Z, Spinnewyn B, et al. Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia[J]. Brain Res, 2001, 922: 282.
9. Chandrasekaran K, Mehrabian Z, Spinnewyn B, et al. Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death[J]. Pharmacopsychiatry, 2003, 36(Suppl 1): 89.
10. Zhao J, Zhao Y, Feng G, et al. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats[J]. Brain Res, 2008, 1229: 224.
11. Zheng Y Q, Liu J X, Li X Z, et al. RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats[J]. Acta Pharmacol Sin, 2009, 30: 919.
12. Mdzinarishvili A, Kiewert C, Kumar V, et al. Bilobalide prevents ischemia-induced edema formation in vitro and in vivo[J]. Neuroscience, 2007, 144: 217.
13. Ahlemeyer B, Junker V, Huhne R, et al. Neuroprotective effects of NV-31, a bilobalide-derived compound: evidence for an antioxidative mechanism[J]. Brain Res, 2001, 890: 338.
14. Chandrasekaran K, Mehrabian Z, Spinnewyn B, et al. Bilobalide, a component of the Ginkgo biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced excitotoxicity[J]. Cell Mol Biol, 2002, 48: 663.