-
1
-
-
27644596457
-
Predicting in vivo drug interactions from in vitro drug discovery data
-
Wienkers LC, Heath TG (2005) Predicting in vivo drug interactions from in vitro drug discovery data. Nat Rev Drug Discov 4:825-833
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 825-833
-
-
Wienkers, L.C.1
Heath, T.G.2
-
2
-
-
39049114809
-
P450-glo cyp3a4 biochemical and cell-based assays
-
Sobel M, Ma D, Cali JJ (2007) P450-Glo CYP3A4 biochemical and cell-based assays. Promega Notes 98:15-18
-
(2007)
Promega Notes
, vol.98
, pp. 15-18
-
-
Sobel, M.1
Ma, D.2
Cali, J.J.3
-
3
-
-
70449370313
-
Comprehensive characterization of cytochrome p450 isozyme selectivity across chemical libraries
-
Veith H, Southall N, Huang R, James T, Fayne D, Artemenko N, Shen M, Inglese J, Austin CP, Lloyd DG, Auld DS (2009) Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries. Nat Biotechnol 27:1050-1055
-
(2009)
Nat Biotechnol
, vol.27
, pp. 1050-1055
-
-
Veith, H.1
Southall, N.2
Huang, R.3
James, T.4
Fayne, D.5
Artemenko, N.6
Shen, M.7
Inglese, J.8
Austin, C.P.9
Lloyd, D.G.10
Auld, D.S.11
-
4
-
-
40849102689
-
Cyp2c19 inhibition: The impact of substrate probe selection on in vitro inhibition pro files
-
Foti RS, Wahlstrom JL (2008) CYP2C19 inhibition: the impact of substrate probe selection on in vitro inhibition pro files. Drug Metab Dispos 36:523-528
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 523-528
-
-
Foti, R.S.1
Wahlstrom, J.L.2
-
5
-
-
26944495704
-
High throughput p450 inhibition screens in early drug discovery
-
Zlokarnik G, Grootenhuis PD, Watson JB (2005) High throughput P450 inhibition screens in early drug discovery. Drug Discov Today 10:1443-1450
-
(2005)
Drug Discov Today
, vol.10
, pp. 1443-1450
-
-
Zlokarnik, G.1
Grootenhuis, P.D.2
Watson, J.B.3
-
6
-
-
81855183870
-
Proluciferin acetals as bioluminogenic substrates for cytochrome p450 activity and probes for cyp3a inhibition
-
Meisenheimer PL, Uyeda HT, Ma D, Sobol M, McDougall MG, Corona C, Simpson D, Klaubert DH, Cali JJ (2011) Proluciferin acetals as bioluminogenic substrates for cytochrome P450 activity and probes for CYP3A inhibition. Drug Metab Dispos 39:2403-2410
-
(2011)
Drug Metab Dispos
, vol.39
, pp. 2403-2410
-
-
Meisenheimer, P.L.1
Uyeda, H.T.2
Ma, D.3
Sobol, M.4
McDougall, M.G.5
Corona, C.6
Simpson, D.7
Klaubert, D.H.8
Cali, J.J.9
-
7
-
-
0043027104
-
In vitro drug interactions of cytochrome p450: An evaluation of fluorogenic to conventional substrates
-
Cohen LH, Remley MJ, Raunig D, Vaz AD (2003) In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates. Drug Metab Dispos 31:1005-1015
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 1005-1015
-
-
Cohen, L.H.1
Remley, M.J.2
Raunig, D.3
Vaz, A.D.4
-
8
-
-
33747828962
-
Luminogenic cytochrome p450 assays
-
Cali JJ, Ma D, Sobol M, Simpson DJ, Frackman S, Good TD, Daily WJ, Liu D (2006) Luminogenic cytochrome P450 assays. Expert Opin Drug Metab Toxicol 2:629-645
-
(2006)
Expert Opin Drug Metab Toxicol
, vol.2
, pp. 629-645
-
-
Cali, J.J.1
Ma, D.2
Sobol, M.3
Simpson, D.J.4
Frackman, S.5
Good, T.D.6
Daily, W.J.7
Liu, D.8
-
9
-
-
64349092077
-
A basis for reduced chemical library inhibition of fire fly luciferase obtained from directed evolution
-
Auld DS, Zhang YQ, Southall NT, Rai G, Landsman M, Maclure J, Langevin D, Thomas CJ, Austin CP, Inglese J (2009) A basis for reduced chemical library inhibition of fire fly luciferase obtained from directed evolution. J Med Chem 52:1450-1458
-
(2009)
J Med Chem
, vol.52
, pp. 1450-1458
-
-
Auld, D.S.1
Zhang, Y.Q.2
Southall, N.T.3
Rai, G.4
Landsman, M.5
Maclure, J.6
Langevin, D.7
Thomas, C.J.8
Austin, C.P.9
Inglese, J.10
-
10
-
-
67650792478
-
Evaluation of luciferin-isopropyl acetal as a cyp3a4 substrate for human hepatocytes: Effects of organic solvents, cytochrome p450 (p450) inhibitors, and p450 inducers
-
Li AP (2009) Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers. Drug Metab Dispos 37:1598-1603
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 1598-1603
-
-
Li, A.P.1
-
11
-
-
20544439816
-
Piezo-and solenoid valve-based liquid dispensing for miniaturized assays
-
Niles WD, Coassin PJ (2005) Piezo-and solenoid valve-based liquid dispensing for miniaturized assays. Assay Drug Dev Technol 3:189-202
-
(2005)
Assay Drug Dev Technol
, vol.3
, pp. 189-202
-
-
Niles, W.D.1
Coassin, P.J.2
-
13
-
-
47749131934
-
Heterotropic cooperativity in oxidation mediated by cytochrome p450
-
Niwa T, Murayama N, Yamazaki H (2008) Heterotropic cooperativity in oxidation mediated by cytochrome P450. Curr Drug Metab 9:453-462
-
(2008)
Curr Drug Metab
, vol.9
, pp. 453-462
-
-
Niwa, T.1
Murayama, N.2
Yamazaki, H.3
-
14
-
-
0034093628
-
Human cytochrome p-450 3a4: In vitro drug-drug interactions are substratedependent
-
Wang RW, Newton DJ, Liu N, Atkins WM, Lu AYH (2000) Human cytochrome P-450 3A4: in vitro drug-drug interactions are substratedependent. Drug Metab Dispos 28:360-366
-
(2000)
Drug Metab Dispos
, vol.28
, pp. 360-366
-
-
Wang, R.W.1
Newton, D.J.2
Liu, N.3
Atkins, W.M.4
Lu, A.Y.H.5
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