Closed-loop real-time simulation model of hemodynamics and oxygen transport in the cardiovascular system

BioMedical Engineering Online

Volumn 12, Issue 1, 2013, Pages

  Broomé, Michael ^a,b,c   Maksuti, Elira ^c   Bjällmark, Anna ^b,c   Frenckner, Björn ^a   Janerot Sjöberg, Birgitta ^a,b,c  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

Cardiovascular simulation; Computer simulation; Lumped parameter model; Oxygen transport model; Time varying elastance functions; Valve model

Indexed keywords

CARDIOVASCULAR SYSTEM; OXYGEN; PATIENT TREATMENT; PHYSIOLOGICAL MODELS; VERIFICATION;

CARDIOVASCULAR SIMULATIONS; ELASTANCE; LUMPED PARAMETER MODELING; OXYGEN TRANSPORT; VALVE MODELS;

COMPUTER SIMULATION;

ADULT; AORTA STENOSIS; AORTA VALVE REGURGITATION; ARTERIAL PRESSURE; ARTERIOSCLEROSIS; ARTERIOVENOUS SHUNT; ARTICLE; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR SYSTEM; COMPUTER SIMULATION; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DIASTOLIC HEART FAILURE; EXERCISE; HEART CYCLE; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE OXYGEN CONSUMPTION; HEART VALVE; HEART VENTRICLE PRESSURE; HEART VENTRICLE SEPTUM; HEMODYNAMICS; HUMAN; LUNG ARTERY PRESSURE; LUNG CIRCULATION; LUNG VASCULAR RESISTANCE; OXYGEN CONSUMPTION; OXYGEN SATURATION; OXYGEN TRANSPORT; PERICARDIUM; PRESSORECEPTOR REFLEX; SENSITIVITY ANALYSIS; STARLING LAW; SYSTEMIC CIRCULATION; SYSTOLIC HEART FAILURE; THORAX PRESSURE; VALSALVA MANEUVER; AORTA VALVE STENOSIS; BIOLOGICAL MODEL; HEART; HEART FAILURE; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; TIME; TRANSPORT AT THE CELLULAR LEVEL; TIME FACTOR;

OXYGEN;

ADULT; AORTIC VALVE INSUFFICIENCY; AORTIC VALVE STENOSIS; ARTERIOSCLEROSIS; BIOLOGICAL TRANSPORT; EXERCISE; HEART; HEART FAILURE; HEMODYNAMICS; HUMANS; MALE; MODELS, BIOLOGICAL; OXYGEN; TIME FACTORS; VALSALVA MANEUVER;

EID: 84882957482     PISSN: None     EISSN: 1475925X     Source Type: Journal    
DOI: 10.1186/1475-925X-12-69     Document Type: Article

References (28)

1. Okuda Y, Bryson EO, DeMaria S, Jacobson L, Quinones J, Shen B, Levine AI. The utility of simulation in medical education: what is the evidence?. Mt Sinai J Med 2009, 76(4):330-43. 10.1002/msj.20127, 19642147.
2. Hunter PJ, Pullan AJ, Smaill BH. Modeling total heart function. Annu Rev Biomed Eng 2003, 5:147-77. 10.1146/annurev.bioeng.5.040202.121537, 14527312.
3. Shim EB, Jun HM, Leem CH, Matusuoka S, Noma A. A new integrated method for analyzing heart mechanics using a cell-hemodynamics-autonomic nerve control coupled model of the cardiovascular system. Prog Biophys Mol Biol 2008, 96(1-3):44-59.
4. Paeme S, Moorhead KT, Chase JG, Lambermont B, Kolh P, D'orio V, Pierard L, Moonen M, Lancellotti P, Dauby PC, Desaive T. Mathematical multi-scale model of the cardiovascular system including mitral valve dynamics. Application to ischemic mitral insufficiency. Biomed Eng Online 2011, 10:86. 10.1186/1475-925X-10-86, 3271239, 21942971.
5. Arts T, Delhaas T, Bovendeerd P, Verbeek X, Prinzen FW. Adaptation to mechanical load determines shape and properties of heart and circulation: the CircAdapt model. Am J Physiol Heart Circ Physiol 2005, 288(4):H1943-54.
6. Chase JG, Starfinger C, Hann CE, Revie JA, Stevenson D, Shaw GM, Desaive T. Model-based prediction of the patient-specific response to adrenaline. Open Med Inform J 2010, 4:149-63. 10.2174/1874431101004010149, 3098554, 21603091.
7. Starfinger C, Chase JG, Hann CE, Shaw GM, Lambert P, Smith BW, Sloth E, Larsson A, Andreassen S, Rees S. Model-based identification of PEEP titrations during different volemic levels. Comput Methods Programs Biomed 2008, 91(2):135-44. 10.1016/j.cmpb.2008.03.005, 18466998.
8. Sun Y, Sjöberg BJ, Ask P, Loyd D, Wranne B. Mathematical model that characterizes transmitral and pulmonary venous flow velocity patterns. Am J Physiol 1995, 268(1 PT 2):H476-89.
9. Sun Y, Beshara M, Lucariello RJ, Chiaramida SA. A comprehensive model for right-left heart interaction under the influence of pericardium and baroreflex. Am J Physiol 1997, 272(3 PT 2):H1499-515.
10. Chung DC, Niranjan SC, Clark JW, Bidani A, Johnston WE, Zwischenberger JB, Traber DL. A dynamic model of ventricular interaction and pericardial influence. Am J Physiol 1997, 272(6 PT 2):H2942-62.
11. Mynard JP, Davidson MR, Penny DJ, Smolich JJ. A simple versatile model of valve dynamics for use in lumped parameter and one-dimensional cardiovascular models. International Journal for Numerical Methods in Biomedical Engineering 2011, 28(6-7):626-41.
12. Wang JJ, Parker KH. Wave propagation in a model of the arterial circulation. J Biomech 2004, 37(4):457-70. 10.1016/j.jbiomech.2003.09.007, 14996557.
13. Milnor WR. Hemodynamics 1989, Baltimore: William and Wilkins, 2.
14. Stergiopulos N, Meister JJ, Westerhof N. Determinants of stroke volume and systolic and diastolic aortic pressure. Am J Physiol 1996, 270(6 PT 2):H2050-9.
15. Maughan WL, Sunagawa K, Sagawa K. Ventricular systolic interdependence: volume elastance model in isolated canine hearts. Am J Physiol 1987, 253(6 PT 2):H1381-90.
16. Applegate RJ, Santamore WP, Klopfenstein HS, Little WC. External pressure of undisturbed left ventricle. Am J Physiol 1990, 258(4 PT 2):H1079-86.
17. Gorlin R, Gorlin SG. Hydraulic formula for calculation of the area of the stenotic mitral valve, other cardiac valves, and central circulatory shunts. Am Heart J 1951, 41(1):1-29. 10.1016/0002-8703(51)90002-6, 14799435.
18. Westerhof N, Stergiopulos N, Noble M. Snapshots of Hemodynamics. An aid for clinical research and graduate education 2005, Boston: Springer.
19. Arts T, Reesink K, Kroon W, Delhaas T. Simulation of adaptation of blood vessel geometry to flow and pressure: Implications for arterio-venous impedance. Mech Res Commun 2012, 42:15-21.
20. Murgo JP, Westerhof N, Giolma JP, Altobelli SA. Aortic input impedance in normal man: relationship to pressure wave forms. Circulation 1980, 62(1):105-16. 10.1161/01.CIR.62.1.105, 7379273.
21. Lee JJ, Tyml K, Menkis AH, Novick RJ, Mckenzie FN. Evaluation of pulsatile and nonpulsatile flow in capillaries of goat skeletal muscle using intravital microscopy. Microvasc Res 1994, 48(3):316-27. 10.1006/mvre.1994.1058, 7731396.
22. Suga H. Total mechanical energy of a ventricle model and cardiac oxygen consumption. Am J Physiol 1979, 236(3):H498-505.
23. Hufner G. Neue versuche zur bestimmung der sauerstoffcapacitat der blutyfarbstoffs. Arch Physiol 1902, 17(22):130-76.
24. Butcher JC. Chapter 23: Runge-Kutta Methods 2003, 93-104. Chichester, UK: John Wiley & Sons, Numerical methods for ordinary differential equations.
25. Lentner C. Volume 5: Heart and Circulation.8th revised and enlarged edition 1990, West Caldwell, New Jersey: CIBA-GEIGY, 5, Geigy Scientific Table.
26. Dernellis JM, Stefanadis CI, Zacharoulis AA, Toutouzas PK. Left atrial mechanical adaptation to long-standing hemodynamic loads based on pressure-volume relations. Am J Cardiol 1998, 81(9):1138-43. 10.1016/S0002-9149(98)00134-9, 9605056.
27. Harrigan PWJ, Pinsky MR. Heart-lung interactions. Part II: effects of intrathoracic pressure. Intensive Care 2001, Part II:99-106. Summer.
28. Lundbäck S. Cardiac pumping and function of the ventricular septum. Acta Physiol Scand Suppl 1986, 550:1-101.