Clustering patterns of comorbidities associated with in-hospital death in hospitalizations of us adults with venous thromboembolism

International Journal of Medical Sciences

Volumn 10, Issue 10, 2013, Pages 1352-1360

  Tsai, James ^a   Grant, Althea M ^a   Michael Soucie, J ^a   Helwig, Amy ^b   Yusuf, Hussain R ^a   Boulet, Sheree L ^c   Reyes, Nimia L ^a   Atrash, Hani K ^a  

^a NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES   (United States)

^b AGENCY FOR HEALTHCARE RESEARCH AND QUALITY   (United States)

^c NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION   (United States)

Author keywords

Clustering pattern; Comorbidity; Death; Elixhauser comorbidity index; Hospitalization; Mortality; Venous thromboembolism

Indexed keywords

ADULT; AGED; ARTICLE; BLOOD CLOTTING DISORDER; CHRONIC LUNG DISEASE; CLUSTER ANALYSIS; COMORBIDITY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; ELECTROLYTE DISTURBANCE; FEMALE; HIGH RISK PATIENT; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; KIDNEY FAILURE; LIVER DISEASE; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; MORTALITY; PERIPHERAL VASCULAR DISEASE; PULMONARY CIRCULATION DISORDER; SOLID TUMOR; UNITED STATES; VASCULAR DISEASE; VENOUS THROMBOEMBOLISM; WEIGHT REDUCTION; AGE DISTRIBUTION; MIDDLE AGED; STATISTICS AND NUMERICAL DATA; VERY ELDERLY; YOUNG ADULT;

ADULT; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; COMORBIDITY; CROSS-SECTIONAL STUDIES; FEMALE; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; UNITED STATES; VENOUS THROMBOEMBOLISM; YOUNG ADULT;

EID: 84882936421     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.6714     Document Type: Article

References (56)

1. [Internet] Office of the Surgeon General, US Department of Health & Human Services. The Surgeon General's Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism. http://www.surgeongeneral.gov/topics/deepvein/calltoaction/call-to-action-on-dvt-2008.pdf.
2. Cohen AT, Tapson VF, Bergmann JF, Goldhaber SZ, Kakkar AK, Deslandes B, et al. Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet. 2008; 371: 387-94. doi:10.1016/S0140-6736(08)60202-0
3. Tapson VF, Decousus H, Pini M, Chong BH, Froehlich JB, Monreal M, et al. Venous thromboembolism prophylaxis in acutely ill hospitalized medical patients: findings from the International Medical Prevention Registry on Venous Thromboembolism. Chest. 2007; 132: 936-45. doi:10.1378/chest.06-2993
4. Heit JA. Venous thromboembolism: disease burden, outcomes and risk factors. J Thromb Haemost. 2005; 3: 1611-7. doi:JTH1415 [pii]10.1111/j.1538-7836.2005.01415.x.
5. White RH. Identifying risk factors for venous thromboembolism. Circulation. 2012; 125: 2051-3. doi:10.1161/CIRCULATIONAHA.112.102814
6. Anderson FA, Jr., Spencer FA. Risk factors for venous thromboembolism. Circulation. 2003; 107: I9-16. doi:10.1161/01.CIR.0000078469.07362.E6
7. Goldhaber SZ. Risk factors for venous thromboembolism. J Am Coll Cardiol. 2010; 56: 1-7. doi:S0735-1097(10)01525-1 [pii]10.1016/j.jacc.2010.01.057.
8. Rosendaal FR. Venous Thrombosis: The Role of Genes, Environment, and Behavior. Hematology. 2005; 2005: 1-12. doi:10.1182/asheducation-2005.1.1
9. Spencer FA, Lessard D, Emery C, Reed G, Goldberg RJ. Venous thromboembolism in the outpatient setting. Arch Intern Med. 2007; 167: 1471-5. doi:10.1001/archinte.167.14.1471
10. CDC. Venous Thromboembolism in Adult Hospitalizations - United States, 2007-2009. Centers for Disease Control and Prevention (CDC). MMWR Morb Mortal Wkly Rep. 2012; 61: 402-4.
11. Valderas JM, Starfield B, Sibbald B, Salisbury C, Roland M. Defining comorbidity: implications for understanding health and health services. Annals of family medicine. 2009; 7: 357-63. doi:10.1370/afm.983
12. Tsai J, Grosse SD, Grant AM, Hooper WC, Atrash HK. Trends in in-hospital deaths among hospitalizations with pulmonary embolism. Arch Intern Med. 2012; 172: 960-1. doi:10.1001/archinternmed.2012.198
13. Tsai J, Grosse SD, Grant AM, Reyes NL, Hooper WC, Atrash HK. Correlates of In-Hospital Deaths among Hospitalizations with Pulmonary Embolism: Findings from the 2001-2008 National Hospital Discharge Survey. PLOS ONE. 2012; 7: e34048. doi:10.1371/journal.pone.0034048
14. Alcalay A, Wun T, Khatri V, Chew HK, Harvey D, Zhou H, et al. Venous thromboembolism in patients with colorectal cancer: incidence and effect on survival. J Clin Oncol. 2006; 24: 1112-8. doi:10.1200/JCO.2005.04.2150
15. Kelly J, Rudd A, Lewis RR, Hunt BJ. Plasma d-dimers in the diagnosis of venous thromboembolism. Arch Intern Med. 2002; 162: 747-56. doi:10-1001/pubs.Arch Intern Med.-ISSN-0003-9926-162-7-ira10030.
16. Kelly J, Hunt BJ, Rudd A, Lewis RR. Pulmonary embolism and pneumonia may be confounded after acute stroke and may co-exist. Age Ageing. 2002; 31: 235-9.
17. Smith SB, Geske JB, Morgenthaler TI. Risk Factors Associated with Delayed Diagnosis of Acute Pulmonary Embolism. The Journal of Emergency Medicine. 2012; 42: 1-6. doi:10.1016/j.jemermed.2011.06.004
18. Palareti G, Cosmi B. Bleeding with anticoagulation therapy - who is at risk, and how best to identify such patients. Thromb Haemost. 2009; 102: 268-78. doi:10.1160/TH08-11-0730
19. Gross CP, Galusha DH, Krumholz HM. The impact of venous thromboembolism on risk of death or hemorrhage in older cancer patients. J Gen Intern Med. 2007; 22: 321-6. doi:10.1007/s11606-006-0019-x
20. Lin J, Proctor MC, Varma M, Greenfield LJ, Upchurch Jr GR, Henke PK. Factors associated with recurrent venous thromboembolism in patients with malignant disease. Journal of Vascular Surgery. 2003; 37: 976-83. doi:10.1067/mva.2003.191
21. Nijkeuter M, Sohne M, Tick LW, Kamphuisen PW, Kramer MH, Laterveer L, et al. The natural course of hemodynamically stable pulmonary embolism: Clinical outcome and risk factors in a large prospective cohort study. Chest. 2007; 131: 517-23. doi:10.1378/chest.05-2799
22. [Internet] Agency for Healthcare Research and Quality (AHRQ). Introduction to the HCUP Nationwide Inpatient Sample (NIS); Healthcare Cost and Utilization Project (HCUP); 2009. http://www.hcup-us.ahrq.gov/db/nation/nis/NIS_Introduction_2009.jsp.
23. [Internet] Agency for Healthcare Research and Quality (AHRQ). Overview of the Nationwide Inpatient Sample (NIS). http://www.hcup-us.ahrq.gov/nisoverview.jsp.
24. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. Journal of chronic diseases. 1987; 40: 373-83.
25. Elixhauser A, Steiner C, Harris DR, Coffey RM. Comorbidity measures for use with administrative data. Med Care. 1998; 36: 8-27.
26. Krivak TC, Zorn KK. Venous thromboembolism in obstetrics and gynecology. Obstet Gynecol. 2007; 109: 761-77. doi:10.1097/01.AOG.0000255819.10187.70
27. James A, Jamison M, Brancazio L, Myers E. Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality. American journal of obstetrics and gynecology. 2006; 194: 1311-5.
28. [Internet] Agency for Healthcare Research and Quality (AHRQ). Procedure Classes 2012. http://www.hcup-us.ahrq.gov/toolssoftware/procedure/procedure.jsp.
29. [Internet] Agency for Healthcare Research and Quality (AHRQ). Major operating room procedure indicator. http://www.hcup-us.ahrq.gov/db/vars/orproc/nisnote.jsp.
30. [Internet] Agency for Healthcare Research and Quality (AHRQ). Comorbidity Software, Version 3.7. http://www.hcup-us.ahrq.gov/toolssoftware/comorbidity/comorbidity.jsp.
31. Southern DA, Quan H, Ghali WA. Comparison of the Elixhauser and Charlson/Deyo methods of comorbidity measurement in administrative data. Med Care. 2004; 42: 355-60.
32. Dominick KL, Dudley TK, Coffman CJ, Bosworth HB. Comparison of three comorbidity measures for predicting health service use in patients with osteoarthritis. Arthritis and rheumatism. 2005; 53: 666-72. doi:10.1002/art.21440
33. Chu YT, Ng YY, Wu SC. Comparison of different comorbidity measures for use with administrative data in predicting short- and long-term mortality. BMC health services research. 2010; 10: 140. doi:10.1186/1472-6963-10-140
34. Tsai J, Abe K, Boulet SL, Beckman MG, Hooper WC, Grant AM. Predictive accuracy of 29-comorbidity index for in-hospital deaths in US adult hospitalizations with a diagnosis of venous thromboembolism. PLOS ONE. 2013; 8(7): e70061. doi:10.1371/journal.pone.0070061
35. Rothman KJ, Greenland S, Lash T. Modern Epidemiology; Third Edition. Lippincott Williams & Wilkins. 2008.
36. Wun T, White RH. Venous thromboembolism (VTE) in patients with cancer: epidemiology and risk factors. Cancer investigation. 2009; 27 Suppl 1: 63-74. doi:10.1080/07357900802656681.
37. Kessler CM. The link between cancer and venous thromboembolism: a review. Am J Clin Oncol. 2009; 32: S3-7. doi:10.1097/COC.0b013e3181b01b17
38. He J, Ogden LG, Bazzano LA, Vupputuri S, Loria C, Whelton PK. Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic follow-up study. Arch Intern Med. 2001; 161: 996-1002.
39. Fox EA, Kahn SR. The relationship between inflammation and venous thrombosis. A systematic review of clinical studies. Thromb Haemost. 2005; 94: 362-5. doi:10.1267/THRO05020362
40. Madjid M, Willerson JT. Inflammatory markers in coronary heart disease. British Medical Bulletin. 2011; 100: 23-38. doi:10.1093/bmb/ldr043
41. Luckey AE, Parsa CJ. Fluid and electrolytes in the aged. Archives of surgery. 2003; 138: 1055-60. doi:10.1001/archsurg.138.10.1055
42. Lee JW. Fluid and electrolyte disturbances in critically ill patients. Electrolyte Blood Press. 2010; 8: 72-81. doi:10.5049/EBP.2010.8.2.72
43. Patel P, Henry LL, Ganti AK, Potti A. Clinical course of lung cancer in patients with chronic kidney disease. Lung cancer. 2004; 43: 297-300. doi:10.1016/j.lungcan.2003.08.029
44. Lugtenberg M, Burgers JS, Clancy C, Westert GP, Schneider EC. Current guidelines have limited applicability to patients with comorbid conditions: a systematic analysis of evidence-based guidelines. PLoS One. 2011; 6: e25987. doi:10.1371/journal.pone.0025987
45. Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA. 2005; 294: 716-24. doi:10.1001/jama.294.6.716
46. Tinetti ME, Bogardus ST, Jr., Agostini JV. Potential pitfalls of disease-specific guidelines for patients with multiple conditions. N Engl J Med. 2004; 351: 2870-4. doi:10.1056/NEJMsb042458
47. McLaughlin TJ, Soumerai SB, Willison DJ, Gurwitz JH, Gao X, Borbas C, et al. The effect of comorbidity on use of thrombolysis or aspirin in patients with acute myocardial infarction eligible for treatment. Journal of general internal medicine. 1997; 12: 1-6.
48. Lagu T, Weiner MG, Hollenbeak CS, Eachus S, Roberts CS, Schwartz JS, et al. The impact of concordant and discordant conditions on the quality of care for hyperlipidemia. J Gen Intern Med. 2008; 23: 1208-13. doi:10.1007/s11606-008-0647-4
49. Min LC, Wenger NS, Fung C, Chang JT, Ganz DA, Higashi T, et al. Multimorbidity is associated with better quality of care among vulnerable elders. Med Care. 2007; 45: 480-8. doi:10.1097/MLR.0b013e318030fff9
50. Ageno W, Becattini C, Brighton T, Selby R, Kamphuisen PW. Cardiovascular risk factors and venous thromboembolism: a meta-analysis. Circulation. 2008; 117: 93-102. doi:10.1161/CIRCULATIONAHA.107.709204
51. Glynn RJ, Danielson E, Fonseca FA, Genest J, Gotto AM, Jr., Kastelein JJ, et al. A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med. 2009; 360: 1851-61. doi:10.1056/NEJMoa0900241
52. van Walraven C, Austin PC, Jennings A, Quan H, Forster AJ. A modification of the Elixhauser comorbidity measures into a point system for hospital death using administrative data. Med Care. 2009; 47: 626-33. doi:10.1097/MLR.0b013e31819432e5
53. Sarrazin MS, Rosenthal GE. Finding pure and simple truths with administrative data. JAMA. 2012; 307: 1433-5. doi:10.1001/jama.2012.404
54. DHHS. Multiple Chronic Conditions: A Strategic Framework. Optimum Health and Quality of Life for Individuals with Multiple Chronic Conditions. Washington, DC: US Department of Health and Human Services (DHHS). 2010.
55. [Internet] Anderson G. Chronic Care: Making the Case for Ongoing Care. Princeton, NJ: Robert Wood Johnson Foundation. http://www.rwjf.org/files/research/50968chronic.care.chartbook.pdf.
56. Boyd CM, Fortin M. Future of Multimorbidity Research: How Should Understanding of Multimorbidity Inform Health System Design? Public Health Reviews. 2010; 32: 451-74.