Does the use of antipyretics in children who have acute infections prolong febrile illness? A systematic review and meta-analysis

Journal of Pediatrics

Volumn 163, Issue 3, 2013, Pages

  Purssell, Edward ^a   While, Alison E ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

COX; Cyclooxygenase; IL; Interleukin; Nonsteroidal anti inflammatory drug; NSAID; Randomized controlled trial; RCT

Indexed keywords

ANTIPYRETIC AGENT;

ARTICLE; CONVALESCENCE; DISEASE DURATION; DRUG EFFECT; FEVER; HUMAN; INFECTION; MALARIA; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; SYSTEMATIC REVIEW; TREATMENT OUTCOME;

EID: 84882930035     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2013.03.069     Document Type: Article

References (22)

1. J.Y. Park, M.H. Pillinger, and S.B. Abramson Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases Clin Immunol 119 2006 229 240
2. I. Morita Distinct functions of COX-1 and COX-2 Prostaglandins Other Lipid Mediat 68-69 2002 165 175
3. H. Bernheim, and M. Kluger Fever: effect of drug-induced antipyresis on survival Science 193 1976 237 239
4. M.J. Kluger, and L.K. Vaughn Fever and survival in rabbits infected with Pasteurella multocida J Physiol 282 1978 243 251
5. N.M.H. Graham, C.J. Burrell, R.M. Douglas, P. Debelle, and L. Davies Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in Rhinovirus-infected volunteers J Infect Dis 162 1990 1277 1282
6. A.A. Romanovsky, and M. Székely Fever and hypothermia: two adaptive thermoregulatory responses to systemic inflammation Med Hypotheses 50 1998 219 226
7. M. Crocetti, N. Moghbeli, and J. Serwint Fever phobia revisited: have parental misconceptions about fever changed in 20 years? Pediatrics 107 2001 1241 1246
8. M.P. Poirier, E.P. Collins, and E. McGuire Fever phobia: a survey of caregivers of children seen in a pediatric emergency department Clin Pediatr (Phila) 49 2010 530 534
9. B. Hinz, and K. Brune Paracetamol and cyclooxygenase inhibition: is there a cause for concern? Ann Rheum Dis 71 2012 20 25
10. J.K. Gierse, C.M. Koboldt, M.C. Walker, K. Seibert, and P.C. Isakson Kinetic basis for selective inhibition of cyclo-oxygenases Biochem J 339 1999 607 614
11. J. Clinch, and S. Dale Managing childhood fever and pain - the comfort loop Child Adolesc Psychiatry Ment Health 1 2007 7
12. Review Manager (RevMan) [Computer program]. Version 5.1 2011 The Nordic Cochrane Centre, The Cochrane Collaboration Copenhagen
13. A. Ahmady, and A. Samadi The adverse effects of antipyretics in measles Indian Pediatr 18 1981 49 52
14. T.F. Doran, C. De Angelis, R.A. Baumgardner, and E.D. Mellits Acetaminophen: more harm than good for chickenpox? J Pediatr 114 1989 1045 1048
15. H. Gupta, D. Shah, P. Gupta, and K. Sharma Role of paracetamol in treatment of childhood fever: a double-blind randomized placebo controlled trial Indian Pediatr 44 2007 903 911
16. C.H. Brandts, M. Ndjavé, W. Graninger, and P.G. Kremsner Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria Lancet 350 1997 704 709
17. B. Lell, M. Sovric, D. Schmid, D. Luckner, K. Herbich, and H.Y. Long Effect of antipyretic drugs in children with malaria Clin Infect Dis 32 2001 838 841
18. P.-B. Matsiegui, M. Missinou, M. Necek, E. Mavoungou, S. Issifou, and B. Lell Antipyretic effect of ibuprofen in Gabonese children with uncomplicated falciparum malaria: a randomized, double-blind, placebo-controlled trial Malar J 7 2008 91
19. M.S. Kramer, L.E. Naimark, R. Roberts-Bräuer, A. McDougall, and D.G. Leduc Risks and benefits of paracetamol antipyresis in young children with fever of presumed viral origin Lancet 337 1991 591 594
20. R. Prymula, C.-A. Siegrist, R. Chlibek, H. Zemlickova, M. Vackova, and J. Smetana Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials Lancet 374 2009 1339 1350
21. D.L. Simmons, R.M. Botting, and T. Hla Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition Pharmacol Rev 56 2004 387 437
22. J.E. Sullivan, H.C. Farrar, Section on Clinical Pharmacology and Therapeutics, and Committee on Drugs Fever and antipyretic use in children Pediatrics 127 2011 580 587