Cardiovascular toxicity of cholinesterase inhibitors

Toxicology of Organophosphate & Carbamate Compounds

Volumn , Issue , 2006, Pages 381-388

  Zoltani, Csaba K ^a   Thorne, G D ^b   Baskin, Steven I ^b  

^a U S ARMY RESEARCH LABORATORY   (United States)

^b US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882929297     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088523-7/50028-4     Document Type: Chapter

References (54)

1. c prolongation and cardiac lesions following acute organophosphate poisoning in rats. Proc. West Pharmacol. Soc. 2001, 44:185-186.
2. Alonso M.J., Arribas S., Marin J., Balfagon G., Salaices M. Presynaptic M2-muscarinic receptors on noradrenergic nerve endings and endothelium-derived M3 receptors in cat cerebral arteries. Brain Res. 1991, 567:76-82.
3. Antzelevitch C., Shimizu W. Cellular mechanisms underlying the long QT syndrome. Curr. Opin. Cardiol. 2002, 17:43-51.
4. Balazs T., Ferrans V.J. Cardiac lesions induced by chemicals. Environ. Health Perspect. 1978, 26:181-191.
5. Bar-Meir A., Grubstein A., Givoni S., Tadmor B. Organophosphates- "Continuous injury to the heart". Harefuah 2002, 140:764-769.
6. Baskin S.I., Whitmer M.P. The cardiac toxicology of organophosphorous agents. Principles of Cardiac Toxicology 1991, CRC Press, Boca Raton, FL. S.I. Baskin (Ed.).
7. Baumgarten C.M., Clemo H.F. Swelling-activated chloride channels in cardiac physiology and pathophysiology. Prog. Biophys. Mol. Biol. 2003, 82:25-42.
8. Britt J.O., Martin J.L., Okerberg C.V., Dick E.J. Histopathologic changes in the brain, heart, and skeletal muscle of rhesus macaques, ten days after exposure to soman. Comp. Med. 2000, 50:133-139.
9. Cl, swell. Fundam. Clin. Pharmacol. 2003, 17:539-553.
10. Demir S.S., Clark J.W., Giles W.R. Parasympathetic modulation of sinoatrial node pacemaker activity in rabbit heart: A unifying model. Am. J. Physiol. 1999, 276:H2221-H2244.
11. + channel proteins Kir3.1 and Kir3.4 in the ventricle, atrium, and sinoatrial node of heart. J. Histochem. Cytochem. 2001, 49:1221-1234.
12. Dobrzynski H., Janvier N.C., Leach R., Findlay J.B., Boyett M.R. Effects of ACh and adenosine mediated by Kir3.1 and Kir3.4 on ferret ventricular cells. Am. J. Physiol. Heart Circ. Physiol. 2002, 283:H615-H630.
13. Egan T.M., Noble S.J. Acetylcholine and the mammalian "slow inward" current: A computer investigation. Proc. R. Soc. London B 1987, 230:315-337.
14. Filbert M.G., Moore D.H., Adler M. Relaxation of soman-induced contracture of airway smooth muscle in vitro. Drug Chem. Toxicol. 1992, 15:203-215.
15. Freeman S.E., Dawson R.M., Keeghan A.M. Modification of the effects of muscarinic agonists by reversible and irreversible anticholinesterase compounds in the guinea pig atrium. J. Mol. Cell Cardiol. 1986, 18:231-239.
16. Harvey R.D., Belevych A.E. Muscarinic regulation of cardiac ion channels. Br. J. Pharmacol. 2003, 139:1074-1084.
17. Hu C.Y., Hsu C.H., Robinson C.P. Effects of soman on calcium uptake in microsomes and mitochondria from rabbit aorta. J. Appl. Toxicol. 1991, 11:293-296.
18. Karki P., Ansari J.A., Bhandary S., Koirala S. Cardiac and electrocardiographical manifestations of acute organophosphate poisoning. Singapore Med. J. 2004, 45:385-389.
19. Kiss Z., Fazekas T. Organophosphate poisoning and complete heart block. J. R. Soc. Med. 1982, 73:138-139.
20. Kiss Z., Fazekas T. Organophosphate poisoning and complete heart block. J. R. Soc. Med. 1983, 76:85.
21. Kotev G., Paliev B. Electrocardiographic changes in dogs exposed to soman and the effect of the antidote nemicol-3. Eksp. Med. Morfol. 1968, 7:240-244.
22. Lallement G., Demoncheaux J.P., Foquin A., Baubichon D., Galonnier M., Clarencon D., Dorandeu F. Subchronic administration of pyridostigmine or huperzine to primates: Compared efficacy against soman toxicity. Drug Chem. Toxicol. 2002, 25:309-320.
23. Limaye M.R. Acute organophosphorus compound poisoning. J. Indian M. A. 1966, 47:492-498.
24. Ludomirsky A., Klein H.O., Sarelli P., Becker B., Hoffman S., Taitelman U., Barzilai J., Lang R., David D., DiSegni E., Kaplinsky E. Q-T prolongation and polymorphous ("torsades de pointes") ventricular arrhythmias associated with organophosphorus insecticide poisoning. Am. J. Cardiol. 1982, 49:1654-1658.
25. Luo C., Rudy Y. A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ. Res. 1994, 74:1071-1096.
26. Nilius B., Droogmans G. Amazing chloride channels: An overview. Acta Physiol. Scand. 2003, 177:119-147.
27. Opie L.H. The Heart Physiology, from Cell to Circulation 1998, Lippincott Williams & Wilkins, Philadelphia. 3rd ed.
28. Osterrieder W., Noma A., Trautwein W. On the kinetics of the potassium current activated by acetylcholine in the SA node of the rabbit heart. Pfluegers Arch. 1980, 386:101-109.
29. Pimentel J.M., Carrington da Costa R.B. Effects of organophosphates on the heart. Clinical and Experimental Toxicology of Organophosphates and Carbamates 1992, Butterworth-Heinemann, Oxford. B. Ballantyne, T.C. Marrs (Eds.).
30. Povoa R., Cardoso S.H., Luna F.B., Ferreira F.C., Ferreira M., Ferreira C. Organophosphate poisoning and myocardial necrosis. Arq. Bras. Cardiol. 1997, 68:377-380.
31. Preston E., Heath C. Depression of the vasomotor system in rabbits poisoned with an organophosphate anticholinesterase. Arch. Int. Pharmacodyn. Ther. 1972, 200:245-254.
32. Roth A., Zellinger I., Arad M., Atsmon J. Organophosphates and the heart. Chest 1993, 103:576-582.
33. Saadeh A.M., Farsakh N.A., Al-Ali M.K. Cardiac manifestations of acute carbamate and organophosphate poisoning. Heart 1997, 77:461-464.
34. + channels in isolated pacemaker cells of the mammalian heart. Nature 1983, 303:250-253.
35. Shibata O., Tsuda A., Makita T., Iwanaga S., Hara T., Shibata S., Sumikawa K. Contractile and phosphatidylinositol responses of rat trachea to anticholinesterase drugs. Can. J. Anaesth. 1998, 45:1190-1195.
36. +-current and action potentials in the bullfrog atrial cell. Biophys. J. 1990, 57:567-576.
37. Stephenson L.A., Kolka M.A. Acetylcholinesterase inhibitor, pyridostigmine bromide, reduces skin blood flow in humans. Am. J. Physiol. 1990, 258:R951-R957.
38. Tan H.L., Hou C.J.Y., Lauer M.R., Sung R.J. Electrophysiologic mechanisms of the long QT interval syndromes and torsades de pointes. Ann. Intern. Med. 1995, 122:701-714.
39. Thomsen R.H., Baskin S.I. Effects of AF-DX 116, a cardioselective M-2 muscarinic antagonist on the negative inotropic action of acetylcholine. FASEB J. 1988, 2:A789.
40. 1-P intermediate. Mol. Pharmacol. 1973, 9:336-349.
41. Tryphonas L., Veinot J.P., Clement J.G. Early histopathologic and ultrastructural changes in the heart of Sprague-Dawley rats following administration of soman. Toxicol. Pathol. 1996, 24:190-198.
42. Tseng G. Cell swelling increases membrane conductance of canine cardiac cells: Evidence for a volume-sensitive Cl channel. Am. J. Physiol. 1992, 262:C1056-C1068.
43. Tsuda A., Shibata O., Saito M., Hashimoto S., Iwanaga S., Makita T., Sumikawa K. A dose-response study of anticholinesterase drugs on contractile and phosphatidylinositol responses of rat trachea. Anesth. Analg. 2001, 92:100-105.
44. Tsukahara T., Hongo K., Kassell N.F., Ogawa H. Characterization of muscarinic cholinergic receptors on the endothelium and the smooth muscle of the rabbit thoracic aorta. J. Cardiovasc. Pharmacol. 1989, 13:870-878.
45. Vandenberg J.I., Bett G.C., Powell T. Contribution of a swelling-activated chloride current to changes in the cardiac action potential. Am. J. Physiol. Cell Physiol. 1997, 273:C541-C547.
46. Viskin S. Long QT syndromes and torsades de pointes. Lancet 1999, 354:1625-1633.
47. Viswanathan P.C., Rudy Y. Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. Circ. Res. 2000, 101:1192-1198.
48. Wright A.R., Rees S.A. Cardiac cell volume: Crystal clear or murky waters? A comparison with other cell types. Pharmacol. Ther. 1998, 80:89-121.
49. Yang P., Zhang B.H., Hong N. Anti-arrhythmia and vegetative nervous system effects of anisodamine. Acta Pharmacol. Sinica 1991, 12:173-176.
50. Yang Z.K., Boyett M.R., Janvier N.C., McMorn S.O., Shui Z., Karim F. Regional differences in the negative inotropic effect of acetylcholine within the canine ventricle. J. Physiol. (London) 1996, 492:789-806.
51. Ying X.Y., Zhong Y.X., Ruan J.X. Effect of anisodamine on the toxicokinetics of soman in rats. Toxicology 2003, 191:28.
52. Zoltani C.K., Baskin S.I. Simulation of acetylcholine cardiac overload caused by soman, a cholinesterase inhibitor. Proceedings of Comparative Cardiology 2000 2000, Vol. 27:243-246. IEEE Press, Piscataway, NJ. A. Murray (Ed.).
53. Zoltani C.K., Baskin S.I. Organophosphate-induced toxicity: Computer study of reentry in atrial tissue. Proceedings of Comparative Cardiology 2002 2002, Vol. 29:509-512. IEEE Press, Piscataway, NJ. A. Murray (Ed.).
54. Zoltani C.K., Baskin S.I., PlatoffG.E. ECGs and metabolic networks: An in silico exploration of cyanide-caused cardiac toxicity. Pharmacological Perspectives of Toxic Chemicals and Their Antidotes 2004, Narosa, New Delhi. S.J.S. Flora, J.A. Romano, S.I. Baskin, K. Sekhar (Eds.).