Control of antigen-binding to aluminum adjuvants and the immune response with a novel phosphonate linker

Vaccine

Volumn 31, Issue 40, 2013, Pages 4362-4367

  Lu, Fangjia ^a   Boutselis, Irene ^b   Borch, Richard F ^b   HogenEsch, Harm ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Adsorption; Aluminum adjuvant; Ligand exchange; Phosphate

Indexed keywords

ALUMINUM HYDROXIDE; ANTIGEN; DIPHTHERIA TOXOID CRM197; IMMUNOLOGICAL ADJUVANT; LYSOZYME; PHOSPHONIC ACID DERIVATIVE;

ADSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN BINDING; ANTIGEN PRESENTATION; ARTICLE; CONJUGATION; CONTROLLED STUDY; DRUG BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HYDROLYSIS; IMMUNE RESPONSE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PH; PHOSPHONYLATION; PRIORITY JOURNAL; SYNTHESIS;

3-(N-MORPHOLINO)PROPANE-SULFONIC ACID; ADSORPTION; AH; ALUMINUM ADJUVANT; ALUMINUM HYDROXIDE ADJUVANT; ALUMINUM PHOSPHATE ADJUVANT; AP; DIPHTHERIA TOXOID; DT; HEL; HEN EGG LYSOZYME; ISOELECTRIC POINT; LIGAND EXCHANGE; MOPS; N-HYDROXYSUCCINIMIDE; NHS; PBS-T; PHOSPHATE; PHOSPHATE BUFFERED SALINE WITH 0.05% TWEEN 20; PI; RECOMBINANT PROTECTIVE ANTIGEN; RPA; TETANUS TOXOID; TT;

ADJUVANTS, IMMUNOLOGIC; ADSORPTION; ALUMINUM HYDROXIDE; ANIMALS; ANTIBODIES; ANTIBODY FORMATION; BACTERIAL PROTEINS; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MURAMIDASE; ORGANOPHOSPHONATES; PROTEIN BINDING; RATS;

EID: 84882872051     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2013.07.019     Document Type: Article

References (25)

1. Lindblad E.B. Aluminium compounds for use in vaccines. Imm Cell Biol 2004 Oct, 82(5):497-505.
2. Hem S.L., HogenEsch H. Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation. Expert Rev Vaccines 2007 Oct, 6(5):685-698.
3. Iyer S., HogenEsch H., Hem S.L. Effect of the degree of phosphate substitution in aluminum hydroxide adjuvant on the adsorption of phosphorylated proteins. Pharm Dev Technol 2003, 8(1):81-86.
4. Hansen B., Belfast M., Soung G., Song L., Egan P.M., Capen R., et al. Effect of the strength of adsorption of hepatitis B surface antigen to aluminum hydroxide adjuvant on the immune response. Vaccine 2009, 27(6, Feb):888-892.
5. Hansen B., Sokolovska A., HogenEsch H., Hem S.L. Relationship between the strength of antigen adsorption to an aluminum-containing adjuvant and the immune response. Vaccine 2007, 25(36, Sep):6618-6624.
6. Glenny A.T., Buttle G.A.H., Stevens M.F. Rate of disappearance of diphtheria toxoid injected into rabbits and guinea-pigs: toxoid precipitated with alum. J Pathol Bacteriol 1931, 34:267-287.
7. Weissburg R.P., Berman P.W., Cleland J.L., Eastman D., Farina F., Frie S., et al. Characterization of the MN gp120 HIV-1 vaccine: antigen binding to alum. Pharm Res 1995 Oct, 12(10):1439-1446.
8. Shi Y., HogenEsch H., Hem S.L. Change in the degree of adsorption of proteins by aluminum-containing adjuvants following exposure to interstitial fluid: freshly prepared and aged model vaccines. Vaccine 2001 Oct 12, 20(1-2):80-85.
9. de Veer M., Kemp J., Chatelier J., Elhay M.J., Meeusen E.N. The kinetics of soluble and particulate antigen trafficking in the afferent lymph, and its modulation by aluminum-based adjuvant. Vaccine 2010 Sep 14, 28(40):6597-6602.
10. Gupta R.K., Rost B.E., Relyveld E., Siber G.R. Adjuvant properties of aluminum and calcium compounds. Pharm Biotechnol 1995, 6:229-248.
11. Noe S.M., Green M.A., HogenEsch H., Hem S.L. Mechanism of immunopotentiation by aluminum-containing adjuvants elucidated by the relationship between antigen retention at the inoculation site and the immune response. Vaccine 2010, 28(20, Apr):3588-3594.
12. Mannhalter J.W., Neychev H.O., Zlabinger G.J., Ahmad R., Eibl M.M. Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: effect on antigen uptake and antigen presentation. Clin Exp Immunol 1985, 61(1, Jul):143-151.
13. Morefield G.L., Sokolovska A., Jiang D., HogenEsch H., Robinson J.P., Hem S.L. Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro. Vaccine 2005 Feb 18, 23(13):1588-1595.
14. Berthold I., Pombo M.L., Wagner L., Arciniega J.L. Immunogenicity in mice of anthrax recombinant protective antigen in the presence of aluminum adjuvants. Vaccine 2005 Mar 14, 23(16):1993-1999.
15. Romero Mendez I.Z., Shi Y., HogenEsch H., Hem S.L. Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants. Vaccine 2007 Jan 15, 25(5):825-833.
16. Jones L.S., Peek L.J., Power J., Markham A., Yazzie B., Middaugh C.R. Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens. J Biol Chem 2005 Apr 8, 280(14):13406-13414.
17. Ljutic B., Ochs M., Messham B., Ming M., Dookie A., Harper K., et al. Formulation, stability and immunogenicity of a trivalent pneumococcal protein vaccine formulated with aluminum salt adjuvants. Vaccine 2012, 30(19, Apr):2981-2988.
18. Iyer V., Hu L., Liyanage M.R., Esfandiary R., Reinisch C., Meinke A., et al. Preformulation characterization of an aluminum salt-adjuvanted trivalent recombinant protein-based vaccine candidate against Streptococcus pneumoniae. J Pharm Sci 2012, 101(9, Sep):3078-3090.
19. Wagner L., Verma A., Meade B.D., Reiter K., Narum D.L., Brady R.A., et al. Structural and immunological analysis of anthrax recombinant protective antigen adsorbed to aluminum hydroxide adjuvant. Clin Vacc Immunol 2012, 19(9, Sep):1465-1473.
20. Regnier M., Metz B., Tilstra W., Hendriksen C., Jiskoot W., Norde W., et al. Structural perturbation of diphtheria toxoid upon adsorption to aluminium hydroxide adjuvant. Vaccine 2012 Nov 6, 30(48):6783-6788.
21. D'Souza A.J., Mar K.D., Huang J., Majumdar S., Ford B.M., Dyas B., et al. Rapid deamidation of recombinant protective antigen when adsorbed on aluminum hydroxide gel correlates with reduced potency of vaccine. J Pharm Sci 2013 Feb, 102(2):454-461.
22. Morefield G.L., Jiang D., Romero-Mendez I.Z., Geahlen R.L., Hogenesch H., Hem S.L. Effect of phosphorylation of ovalbumin on adsorption by aluminum-containing adjuvants and elution upon exposure to interstitial fluid. Vaccine 2005, 23(12, Feb):1502-1506.
23. Kamps M.P. Generation and use of anti-phosphotyrosine antibodies for immunoblotting. Meth Enzymol 1991, 201:101-110.
24. Zhang Y., Hong Y., Huang C.C., Belmont D. A novel asymmetric synthesis of tritium and carbon-14 labeled (R)-ibuprofen. J Label Comp Radiopharm 2006, 49:237-244.
25. al-Shakhshir R.H., Regnier F.E., White J.L., Hem S.L. Contribution of electrostatic and hydrophobic interactions to the adsorption of proteins by aluminium-containing adjuvants. Vaccine 1995, 13(1, Jan):41-44.