In vivo toxicology of excipients commonly employed in drug discovery in rats

Journal of Pharmacological and Toxicological Methods

Volumn 68, Issue 2, 2013, Pages 284-295

  Gopinathan, Suma ^a   O'Neill, Emily ^a   Rodriguez, Lawrence A ^a   Champ, Rose ^a   Phillips, Megan ^b   Nouraldeen, Amr ^a   Wendt, Mary ^a   Wilson, Alan G E ^a   Kramer, Jeffrey A ^c  

^a LEXICON PHARMACEUTICALS INC   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c Alcon Research   (United States)

Author keywords

Excipient; In vivo toxicology; Methods; Preclinical studies; Rat; Toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BETA CYCLODEXTRIN; BILIRUBIN; CALCIUM; CHLORIDE; CHOLESTEROL; CORN OIL; CREATININE; CREMOPHOR; DIMETHYL SULFOXIDE; EXCIPIENT; GLOBULIN; GLUCOSE; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL 400; METHYLCELLULOSE; N,N DIMETHYLFORMAMIDE; NITROGEN; OLIVE OIL; PHOSPHORUS; POLOXAMER; POLYSORBATE 80; POTASSIUM; PROPYLENE GLYCOL; SODIUM CHLORIDE; UREA;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD ANALYSIS; DRUG FORMULATION; DRUG RESEARCH; FEEDING; HEMATOLOGICAL PARAMETERS; HISTOPATHOLOGY; IN VIVO STUDY; MALE; NONHUMAN; RAT; SAFETY; TOXICITY TESTING; URINALYSIS;

ANIMALIA; RATTUS;

EXCIPIENT; IN VIVO TOXICOLOGY; METHODS; PRECLINICAL STUDIES; RAT; TOXICITY;

ADMINISTRATION, ORAL; ANIMALS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; EXCIPIENTS; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84882838930     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2013.02.009     Document Type: Article

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