Biotransformation of ent-pimaradienoic acid by cell cultures of Aspergillus niger

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 18, 2013, Pages 5870-5875

  Severiano, Marcela E ^a   Simão, Marília R ^b   Ramos, Henrique P ^a   Parreira, Renato L T ^b   Arakawa, Nilton S ^c   Said, Suraia ^a   Furtado, Niege A J C ^a   De Oliveira, Dionéia C R ^a   Gregório, Luis E ^a   Tirapelli, Carlos R ^a   Veneziani, Rodrigo C S ^b   Ambrósio, Sérgio R ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDADE DE FRANCA   (Brazil)

^c STATE UNIVERSITY OF LONDRINA   (Brazil)

Author keywords

Antispasmodic property; Aspergillus niger; Biotransformation; ent Pimaradienoic acid

Indexed keywords

1ALPHA,6BETA,14BETA TRIHYDROXY ENT PIMARA 7,15 DIEN 19 OIC ACID; 1ALPHA,6BETA,7ALPHA,11ALPHA TETRAHYDROXY ENT PIMARA 8(14),15 DIEN 19 OIC ACID; 1BETA HYDROXY ENT PIMARA 6,8(14),15 TRIEN 19 OIC ACID; 7ALPHA HYDROXY ENT PIMARA 8(14),15 DIEN 19 OIC ACID; ENT PIMARADIENOIC ACID; SPASMOLYTIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTISPASMODIC ACTIVITY; AORTA CONSTRICTION; ARTICLE; ASPERGILLUS NIGER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG ISOLATION; DRUG SCREENING; DRUG TRANSFORMATION; FUNGAL CELL CULTURE; FUNGAL STRAIN; MALE; NONHUMAN; RAT; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; STRUCTURE ACTIVITY RELATION; VASCULAR RING;

ASPERGILLUS NIGER; RATTUS NORVEGICUS;

ANTISPASMODIC PROPERTY; ASPERGILLUS NIGER; BIOTRANSFORMATION; ENT-PIMARADIENOIC ACID;

ANIMALS; AORTA; ASPERGILLUS NIGER; ASTERACEAE; BIOTRANSFORMATION; DITERPENES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MOLECULAR CONFORMATION; MUSCLE CONTRACTION; PHENYLEPHRINE; RATS; RATS, WISTAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84882831818     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.07.009     Document Type: Article

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