메뉴 건너뛰기




Volumn 31, Issue 39, 2013, Pages 4241-4246

Clinical development of Modified Vaccinia virus Ankara vaccines

Author keywords

Clinical safety; Efficacy; Immunogenicity; Poxvirus; Vaccine

Indexed keywords

APICAL MEMBRANE ANTIGEN 1; CIRCUMSPOROZOITE PROTEIN; DNA VACCINE; MALARIA VACCINE; MODIFIED VACCINIA VIRUS ANKARA VACCINE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VACCINIA VACCINE;

EID: 84882816956     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2013.03.020     Document Type: Article
Times cited : (120)

References (62)
  • 1
    • 0018967338 scopus 로고
    • The global eradication of smallpox
    • Fenner F. The global eradication of smallpox. Med J Aust 1980, 1(10):455-465.
    • (1980) Med J Aust , vol.1 , Issue.10 , pp. 455-465
    • Fenner, F.1
  • 2
    • 1642421758 scopus 로고    scopus 로고
    • Poxvirus genomes: a phylogenetic analysis
    • Gubser C., Hue S., Kellam P., Smith G.L. Poxvirus genomes: a phylogenetic analysis. J Gen Virol 2004, 85(Pt 1):105-117.
    • (2004) J Gen Virol , vol.85 , Issue.1 , pp. 105-117
    • Gubser, C.1    Hue, S.2    Kellam, P.3    Smith, G.L.4
  • 5
    • 0018246525 scopus 로고
    • The smallpox vaccination strain MVA: marker, genetic structure, experience gained with the parenteral vaccination and behavior in organisms with a debilitated defence mechanism (author's transl)
    • Erste Abteilung Originale
    • Mayr A., Stickl H., Muller H.K., Danner K., Singer H. The smallpox vaccination strain MVA: marker, genetic structure, experience gained with the parenteral vaccination and behavior in organisms with a debilitated defence mechanism (author's transl). Zentralbl Bakteriol B 1978, 167(5,6):375-390. Erste Abteilung Originale.
    • (1978) Zentralbl Bakteriol B , vol.167 , Issue.5-6 , pp. 375-390
    • Mayr, A.1    Stickl, H.2    Muller, H.K.3    Danner, K.4    Singer, H.5
  • 6
    • 36749089428 scopus 로고    scopus 로고
    • Genomic sequence of chorioallantois vaccinia virus Ankara, the ancestor of modified vaccinia virus Ankara
    • Meisinger-Henschel C., Schmidt M., Lukassen S., Linke B., Krause L., Konietzny S., et al. Genomic sequence of chorioallantois vaccinia virus Ankara, the ancestor of modified vaccinia virus Ankara. J Gen Virol 2007, 88(Pt 12):3249-3259.
    • (2007) J Gen Virol , vol.88 , Issue.12 , pp. 3249-3259
    • Meisinger-Henschel, C.1    Schmidt, M.2    Lukassen, S.3    Linke, B.4    Krause, L.5    Konietzny, S.6
  • 7
    • 0025876805 scopus 로고
    • Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence
    • Meyer H., Sutter G., Mayr A. Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence. J Gen Virol 1991, 72(Pt 5):1031-1038.
    • (1991) J Gen Virol , vol.72 , Issue.5 , pp. 1031-1038
    • Meyer, H.1    Sutter, G.2    Mayr, A.3
  • 8
    • 0031899907 scopus 로고    scopus 로고
    • Modified vaccinia virus Ankara undergoes limited replication in human cells and lacks several immunomodulatory proteins: implications for use as a human vaccine
    • Blanchard T.J., Alcami A., Andrea P., Smith G.L. Modified vaccinia virus Ankara undergoes limited replication in human cells and lacks several immunomodulatory proteins: implications for use as a human vaccine. J Gen Virol 1998, 79(Pt 5):1159-1167.
    • (1998) J Gen Virol , vol.79 , Issue.5 , pp. 1159-1167
    • Blanchard, T.J.1    Alcami, A.2    Andrea, P.3    Smith, G.L.4
  • 9
    • 0031585552 scopus 로고    scopus 로고
    • Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in a nonhuman mammalian cell line
    • Carroll M.W., Moss B. Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in a nonhuman mammalian cell line. Virology 1997, 238(2):198-211.
    • (1997) Virology , vol.238 , Issue.2 , pp. 198-211
    • Carroll, M.W.1    Moss, B.2
  • 10
    • 77956845506 scopus 로고    scopus 로고
    • Introduction of the six major genomic deletions of modified vaccinia virus Ankara (MVA) into the parental vaccinia virus is not sufficient to reproduce an MVA-like phenotype in cell culture and in mice
    • Meisinger-Henschel C., Spath M., Lukassen S., Wolferstatter M., Kachelriess H., Baur K., et al. Introduction of the six major genomic deletions of modified vaccinia virus Ankara (MVA) into the parental vaccinia virus is not sufficient to reproduce an MVA-like phenotype in cell culture and in mice. J Virol 2010, 84(19):9907-9919.
    • (2010) J Virol , vol.84 , Issue.19 , pp. 9907-9919
    • Meisinger-Henschel, C.1    Spath, M.2    Lukassen, S.3    Wolferstatter, M.4    Kachelriess, H.5    Baur, K.6
  • 12
    • 0026442276 scopus 로고
    • Nonreplicating vaccinia vector efficiently expresses recombinant genes
    • Sutter G., Moss B. Nonreplicating vaccinia vector efficiently expresses recombinant genes. Proc Natl Acad Sci USA 1992, 89(22):10847-10851.
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.22 , pp. 10847-10851
    • Sutter, G.1    Moss, B.2
  • 14
    • 9444289849 scopus 로고    scopus 로고
    • Comparison of numerous delivery systems for the induction of cytotoxic T lymphocytes by immunization
    • Allsopp C.E., Plebanski M., Gilbert S., Sinden R.E., Harris S., Frankel G., et al. Comparison of numerous delivery systems for the induction of cytotoxic T lymphocytes by immunization. Eur J Immunol 1996, 26(8):1951-1959.
    • (1996) Eur J Immunol , vol.26 , Issue.8 , pp. 1951-1959
    • Allsopp, C.E.1    Plebanski, M.2    Gilbert, S.3    Sinden, R.E.4    Harris, S.5    Frankel, G.6
  • 16
    • 14444271599 scopus 로고    scopus 로고
    • Protection from Plasmodium berghei infection by priming and boosting T cells to a single class I-restricted epitope with recombinant carriers suitable for human use
    • Plebanski M., Gilbert S.C., Schneider J., Hannan C.M., Layton G., Blanchard T., et al. Protection from Plasmodium berghei infection by priming and boosting T cells to a single class I-restricted epitope with recombinant carriers suitable for human use. Eur J Immunol 1998, 28(12):4345-4355.
    • (1998) Eur J Immunol , vol.28 , Issue.12 , pp. 4345-4355
    • Plebanski, M.1    Gilbert, S.C.2    Schneider, J.3    Hannan, C.M.4    Layton, G.5    Blanchard, T.6
  • 17
    • 0031924077 scopus 로고    scopus 로고
    • + T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara
    • + T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nat Med 1998, 4(4):397-402.
    • (1998) Nat Med , vol.4 , Issue.4 , pp. 397-402
    • Schneider, J.1    Gilbert, S.C.2    Blanchard, T.J.3    Hanke, T.4    Robson, K.J.5    Hannan, C.M.6
  • 18
    • 0033005077 scopus 로고    scopus 로고
    • Ty virus-like particles: DNA vaccines and modified vaccinia virus Ankara; comparisons and combinations
    • Gilbert S.C., Schneider J., Plebanski M., Hannan C.M., Blanchard T.J., Smith G.L., et al. Ty virus-like particles: DNA vaccines and modified vaccinia virus Ankara; comparisons and combinations. Biol Chem 1999, 380(3):299-303.
    • (1999) Biol Chem , vol.380 , Issue.3 , pp. 299-303
    • Gilbert, S.C.1    Schneider, J.2    Plebanski, M.3    Hannan, C.M.4    Blanchard, T.J.5    Smith, G.L.6
  • 20
    • 17944369697 scopus 로고    scopus 로고
    • A prime-boost immunisation regimen using DNA followed by recombinant modified vaccinia virus Ankara induces strong cellular immune responses against the Plasmodium falciparum TRAP antigen in chimpanzees
    • Schneider J., Langermans J.A., Gilbert S.C., Blanchard T.J., Twigg S., Naitza S., et al. A prime-boost immunisation regimen using DNA followed by recombinant modified vaccinia virus Ankara induces strong cellular immune responses against the Plasmodium falciparum TRAP antigen in chimpanzees. Vaccine 2001, 19(32):4595-4602.
    • (2001) Vaccine , vol.19 , Issue.32 , pp. 4595-4602
    • Schneider, J.1    Langermans, J.A.2    Gilbert, S.C.3    Blanchard, T.J.4    Twigg, S.5    Naitza, S.6
  • 22
    • 0037449091 scopus 로고    scopus 로고
    • Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers
    • Moorthy V.S., McConkey S., Roberts M., Gothard P., Arulanantham N., Degano P., et al. Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers. Vaccine 2003, 21(17,18):2004-2011.
    • (2003) Vaccine , vol.21 , Issue.17-18 , pp. 2004-2011
    • Moorthy, V.S.1    McConkey, S.2    Roberts, M.3    Gothard, P.4    Arulanantham, N.5    Degano, P.6
  • 23
    • 0038714287 scopus 로고    scopus 로고
    • Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans
    • McConkey S.J., Reece W.H., Moorthy V.S., Webster D., Dunachie S., Butcher G., et al. Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans. Nat Med 2003, 9(6):729-735.
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 729-735
    • McConkey, S.J.1    Reece, W.H.2    Moorthy, V.S.3    Webster, D.4    Dunachie, S.5    Butcher, G.6
  • 24
    • 0242364645 scopus 로고    scopus 로고
    • Safety and immunogenicity of DNA/modified vaccinia virus Ankara malaria vaccination in African adults
    • Moorthy V.S., Pinder M., Reece W.H., Watkins K., Atabani S., Hannan C., et al. Safety and immunogenicity of DNA/modified vaccinia virus Ankara malaria vaccination in African adults. J Infect Dis 2003, 188(8):1239-1244.
    • (2003) J Infect Dis , vol.188 , Issue.8 , pp. 1239-1244
    • Moorthy, V.S.1    Pinder, M.2    Reece, W.H.3    Watkins, K.4    Atabani, S.5    Hannan, C.6
  • 25
    • 15744387886 scopus 로고    scopus 로고
    • A randomised, double-blind, controlled vaccine efficacy trial of DNA/MVA ME-TRAP against malaria infection in Gambian adults
    • Moorthy V.S., Imoukhuede E.B., Milligan P., Bojang K., Keating S., Kaye P., et al. A randomised, double-blind, controlled vaccine efficacy trial of DNA/MVA ME-TRAP against malaria infection in Gambian adults. PLoS Med 2004, 1(2):e33.
    • (2004) PLoS Med , vol.1 , Issue.2
    • Moorthy, V.S.1    Imoukhuede, E.B.2    Milligan, P.3    Bojang, K.4    Keating, S.5    Kaye, P.6
  • 26
    • 10744224195 scopus 로고    scopus 로고
    • + T cell immune responses and protection elicited against Plasmodium berghei malaria by prime boost immunization regimens using a novel attenuated fowlpox virus
    • + T cell immune responses and protection elicited against Plasmodium berghei malaria by prime boost immunization regimens using a novel attenuated fowlpox virus. J Immunol 2004, 172(5):3094-3100.
    • (2004) J Immunol , vol.172 , Issue.5 , pp. 3094-3100
    • Anderson, R.J.1    Hannan, C.M.2    Gilbert, S.C.3    Laidlaw, S.M.4    Sheu, E.G.5    Korten, S.6
  • 27
    • 20144387467 scopus 로고    scopus 로고
    • Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara
    • Webster D.P., Dunachie S., Vuola J.M., Berthoud T., Keating S., Laidlaw S.M., et al. Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara. Proc Natl Acad Sci U S A 2005, 102(13):4836-4841.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.13 , pp. 4836-4841
    • Webster, D.P.1    Dunachie, S.2    Vuola, J.M.3    Berthoud, T.4    Keating, S.5    Laidlaw, S.M.6
  • 28
    • 27144489392 scopus 로고    scopus 로고
    • Durable human memory T cells quantifiable by cultured enzyme-linked immunospot assays are induced by heterologous prime boost immunization and correlate with protection against malaria
    • Keating S.M., Bejon P., Berthoud T., Vuola J.M., Todryk S., Webster D.P., et al. Durable human memory T cells quantifiable by cultured enzyme-linked immunospot assays are induced by heterologous prime boost immunization and correlate with protection against malaria. J Immunol 2005, 175(9):5675-5680.
    • (2005) J Immunol , vol.175 , Issue.9 , pp. 5675-5680
    • Keating, S.M.1    Bejon, P.2    Berthoud, T.3    Vuola, J.M.4    Todryk, S.5    Webster, D.P.6
  • 29
    • 33645768498 scopus 로고    scopus 로고
    • Safety profile of the viral vectors of attenuated fowlpox strain FP9 and modified vaccinia virus Ankara recombinant for either of 2 preerythrocytic malaria antigens: ME-TRAP or the circumsporozoite protein, in children and adults in Kenya
    • Bejon P., Peshu N., Gilbert S.C., Lowe B.S., Molyneux C.S., Forsdyke J., et al. Safety profile of the viral vectors of attenuated fowlpox strain FP9 and modified vaccinia virus Ankara recombinant for either of 2 preerythrocytic malaria antigens: ME-TRAP or the circumsporozoite protein, in children and adults in Kenya. Clin Infect Dis 2006, 42(8):1102-1110.
    • (2006) Clin Infect Dis , vol.42 , Issue.8 , pp. 1102-1110
    • Bejon, P.1    Peshu, N.2    Gilbert, S.C.3    Lowe, B.S.4    Molyneux, C.S.5    Forsdyke, J.6
  • 30
    • 33646826522 scopus 로고    scopus 로고
    • Immunogenicity of the candidate malaria vaccines FP9 and modified vaccinia virus Ankara encoding the pre-erythrocytic antigen ME-TRAP in 1-6 year old children in a malaria endemic area
    • Bejon P., Mwacharo J., Kai O.K., Todryk S., Keating S., Lang T., et al. Immunogenicity of the candidate malaria vaccines FP9 and modified vaccinia virus Ankara encoding the pre-erythrocytic antigen ME-TRAP in 1-6 year old children in a malaria endemic area. Vaccine 2006, 24(22):4709-4715.
    • (2006) Vaccine , vol.24 , Issue.22 , pp. 4709-4715
    • Bejon, P.1    Mwacharo, J.2    Kai, O.K.3    Todryk, S.4    Keating, S.5    Lang, T.6
  • 31
    • 33947310115 scopus 로고    scopus 로고
    • A phase 2b randomised trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya
    • Bejon P., Mwacharo J., Kai O., Mwangi T., Milligan P., Todryk S., et al. A phase 2b randomised trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya. PLoS Clin Trials 2006, 1(6):e29.
    • (2006) PLoS Clin Trials , vol.1 , Issue.6
    • Bejon, P.1    Mwacharo, J.2    Kai, O.3    Mwangi, T.4    Milligan, P.5    Todryk, S.6
  • 32
    • 35748960534 scopus 로고    scopus 로고
    • The induction and persistence of T cell IFN-gamma responses after vaccination or natural exposure is suppressed by Plasmodium falciparum
    • Bejon P., Mwacharo J., Kai O., Todryk S., Keating S., Lowe B., et al. The induction and persistence of T cell IFN-gamma responses after vaccination or natural exposure is suppressed by Plasmodium falciparum. J Immunol 2007, 179(6):4193-4201.
    • (2007) J Immunol , vol.179 , Issue.6 , pp. 4193-4201
    • Bejon, P.1    Mwacharo, J.2    Kai, O.3    Todryk, S.4    Keating, S.5    Lowe, B.6
  • 33
    • 0037081381 scopus 로고    scopus 로고
    • Enhanced CD8 T cell immunogenicity and protective efficacy in a mouse malaria model using a recombinant adenoviral vaccine in heterologous prime-boost immunisation regimes
    • Gilbert S.C., Schneider J., Hannan C.M., Hu J.T., Plebanski M., Sinden R., et al. Enhanced CD8 T cell immunogenicity and protective efficacy in a mouse malaria model using a recombinant adenoviral vaccine in heterologous prime-boost immunisation regimes. Vaccine 2002, 20(7,8):1039-1045.
    • (2002) Vaccine , vol.20 , Issue.7-8 , pp. 1039-1045
    • Gilbert, S.C.1    Schneider, J.2    Hannan, C.M.3    Hu, J.T.4    Plebanski, M.5    Sinden, R.6
  • 34
    • 73949160519 scopus 로고    scopus 로고
    • International epidemiology of human pre-existing adenovirus (Ad) type-5, type-6, type-26 and type-36 neutralizing antibodies: correlates of high Ad5 titers and implications for potential HIV vaccine trials
    • Mast T.C., Kierstead L., Gupta S.B., Nikas A.A., Kallas E.G., Novitsky V., et al. International epidemiology of human pre-existing adenovirus (Ad) type-5, type-6, type-26 and type-36 neutralizing antibodies: correlates of high Ad5 titers and implications for potential HIV vaccine trials. Vaccine 2010, 28(4):950-957.
    • (2010) Vaccine , vol.28 , Issue.4 , pp. 950-957
    • Mast, T.C.1    Kierstead, L.2    Gupta, S.B.3    Nikas, A.A.4    Kallas, E.G.5    Novitsky, V.6
  • 35
    • 84855372641 scopus 로고    scopus 로고
    • Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species
    • Colloca S., Barnes E., Folgori A., Ammendola V., Capone S., Cirillo A., et al. Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species. Sci Transl Med 2012, 4(115):115ra2.
    • (2012) Sci Transl Med , vol.4 , Issue.115
    • Colloca, S.1    Barnes, E.2    Folgori, A.3    Ammendola, V.4    Capone, S.5    Cirillo, A.6
  • 36
    • 84863734927 scopus 로고    scopus 로고
    • A novel chimpanzee adenovirus vector with low human seroprevalence: improved systems for vector derivation and comparative immunogenicity
    • Dicks M.D., Spencer A.J., Edwards N.J., Wadell G., Bojang K., Gilbert S.C., et al. A novel chimpanzee adenovirus vector with low human seroprevalence: improved systems for vector derivation and comparative immunogenicity. PLoS ONE 2012, 7(7):e40385.
    • (2012) PLoS ONE , vol.7 , Issue.7
    • Dicks, M.D.1    Spencer, A.J.2    Edwards, N.J.3    Wadell, G.4    Bojang, K.5    Gilbert, S.C.6
  • 37
    • 84856880087 scopus 로고    scopus 로고
    • Clinical assessment of a recombinant simian adenovirus ChAd63: a potent new vaccine vector
    • O'Hara G.A., Duncan C.J., Ewer K.J., Collins K.A., Elias S.C., Halstead F.D., et al. Clinical assessment of a recombinant simian adenovirus ChAd63: a potent new vaccine vector. J Infect Dis 2012, 205(5):772-781.
    • (2012) J Infect Dis , vol.205 , Issue.5 , pp. 772-781
    • O'Hara, G.A.1    Duncan, C.J.2    Ewer, K.J.3    Collins, K.A.4    Elias, S.C.5    Halstead, F.D.6
  • 38
    • 84860390192 scopus 로고    scopus 로고
    • Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors
    • Sheehy S.H., Duncan C.J., Elias S.C., Collins K.A., Ewer K.J., Spencer A.J., et al. Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors. Mol Ther 2011, 19(12):2269-2276.
    • (2011) Mol Ther , vol.19 , Issue.12 , pp. 2269-2276
    • Sheehy, S.H.1    Duncan, C.J.2    Elias, S.C.3    Collins, K.A.4    Ewer, K.J.5    Spencer, A.J.6
  • 39
    • 84857399087 scopus 로고    scopus 로고
    • Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors
    • Sheehy S.H., Duncan C.J., Elias S.C., Biswas S., Collins K.A., O'Hara G.A., et al. Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors. PLoS ONE 2012, 7(2):e31208.
    • (2012) PLoS ONE , vol.7 , Issue.2
    • Sheehy, S.H.1    Duncan, C.J.2    Elias, S.C.3    Biswas, S.4    Collins, K.A.5    O'Hara, G.A.6
  • 40
    • 83055188639 scopus 로고    scopus 로고
    • T-cell-inducing vaccines - what's the future
    • Gilbert S.C. T-cell-inducing vaccines - what's the future. Immunology 2012, 135(1):19-26.
    • (2012) Immunology , vol.135 , Issue.1 , pp. 19-26
    • Gilbert, S.C.1
  • 41
    • 9144267735 scopus 로고    scopus 로고
    • Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans
    • McShane H., Pathan A.A., Sander C.R., Keating S.M., Gilbert S.C., Huygen K., et al. Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans. Nat Med 2004, 10(11):1240-1244.
    • (2004) Nat Med , vol.10 , Issue.11 , pp. 1240-1244
    • McShane, H.1    Pathan, A.A.2    Sander, C.R.3    Keating, S.M.4    Gilbert, S.C.5    Huygen, K.6
  • 42
    • 65349186494 scopus 로고    scopus 로고
    • MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques
    • Verreck F.A., Vervenne R.A., Kondova I., van Kralingen K.W., Remarque E.J., Braskamp G., et al. MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques. PLoS ONE 2009, 4(4):e5264.
    • (2009) PLoS ONE , vol.4 , Issue.4
    • Verreck, F.A.1    Vervenne, R.A.2    Kondova, I.3    van Kralingen, K.W.4    Remarque, E.J.5    Braskamp, G.6
  • 43
    • 67651210877 scopus 로고    scopus 로고
    • Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis
    • Vordermeier H.M., Villarreal-Ramos B., Cockle P.J., McAulay M., Rhodes S.G., Thacker T., et al. Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis. Infect Immun 2009, 77(8):3364-3373.
    • (2009) Infect Immun , vol.77 , Issue.8 , pp. 3364-3373
    • Vordermeier, H.M.1    Villarreal-Ramos, B.2    Cockle, P.J.3    McAulay, M.4    Rhodes, S.G.5    Thacker, T.6
  • 44
    • 76749126266 scopus 로고    scopus 로고
    • MVA-85A, a novel candidate booster vaccine for the prevention of tuberculosis in children and adults
    • Nicol M.P., Grobler L.A. MVA-85A, a novel candidate booster vaccine for the prevention of tuberculosis in children and adults. Curr Opin Mol Ther 2010, 12(1):124-134.
    • (2010) Curr Opin Mol Ther , vol.12 , Issue.1 , pp. 124-134
    • Nicol, M.P.1    Grobler, L.A.2
  • 47
    • 58149204280 scopus 로고    scopus 로고
    • Lessons from IAVI-006 a phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers
    • Guimaraes-Walker A., Mackie N., McCormack S., Hanke T., Schmidt C., Gilmour J., et al. Lessons from IAVI-006 a phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers. Vaccine 2008, 26(51):6671-6677.
    • (2008) Vaccine , vol.26 , Issue.51 , pp. 6671-6677
    • Guimaraes-Walker, A.1    Mackie, N.2    McCormack, S.3    Hanke, T.4    Schmidt, C.5    Gilmour, J.6
  • 48
    • 80054003999 scopus 로고    scopus 로고
    • Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: a phase I clinical trial (RISVAC02)
    • Garcia F., Bernaldo de Quiros J.C., Gomez C.E., Perdiguero B., Najera J.L., Jimenez V., et al. Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: a phase I clinical trial (RISVAC02). Vaccine 2011, 29(46):8309-8316.
    • (2011) Vaccine , vol.29 , Issue.46 , pp. 8309-8316
    • Garcia, F.1    Bernaldo de Quiros, J.C.2    Gomez, C.E.3    Perdiguero, B.4    Najera, J.L.5    Jimenez, V.6
  • 49
    • 77957752730 scopus 로고    scopus 로고
    • Vaccination with a modified vaccinia virus Ankara (MVA)-vectored HIV-1 immunogen induces modest vector-specific T cell responses in human subjects
    • Howles S., Guimaraes-Walker A., Yang H., Hancock G., di Gleria K., Tarragona-Fiol T., et al. Vaccination with a modified vaccinia virus Ankara (MVA)-vectored HIV-1 immunogen induces modest vector-specific T cell responses in human subjects. Vaccine 2010, 28(45):7306-7312.
    • (2010) Vaccine , vol.28 , Issue.45 , pp. 7306-7312
    • Howles, S.1    Guimaraes-Walker, A.2    Yang, H.3    Hancock, G.4    di Gleria, K.5    Tarragona-Fiol, T.6
  • 50
    • 80053948074 scopus 로고    scopus 로고
    • Broad and potent immune responses to a low dose intradermal HIV-1 DNA boosted with HIV-1 recombinant MVA among healthy adults in Tanzania
    • Bakari M., Aboud S., Nilsson C., Francis J., Buma D., Moshiro C., et al. Broad and potent immune responses to a low dose intradermal HIV-1 DNA boosted with HIV-1 recombinant MVA among healthy adults in Tanzania. Vaccine 2011, 29(46):8417-8428.
    • (2011) Vaccine , vol.29 , Issue.46 , pp. 8417-8428
    • Bakari, M.1    Aboud, S.2    Nilsson, C.3    Francis, J.4    Buma, D.5    Moshiro, C.6
  • 51
    • 54949106244 scopus 로고    scopus 로고
    • Broad immunogenicity of a multigene: multiclade HIV-1 DNA vaccine boosted with heterologous HIV-1 recombinant modified vaccinia virus Ankara
    • Sandstrom E., Nilsson C., Hejdeman B., Brave A., Bratt G., Robb M., et al. Broad immunogenicity of a multigene: multiclade HIV-1 DNA vaccine boosted with heterologous HIV-1 recombinant modified vaccinia virus Ankara. J Infect Dis 2008, 198(10):1482-1490.
    • (2008) J Infect Dis , vol.198 , Issue.10 , pp. 1482-1490
    • Sandstrom, E.1    Nilsson, C.2    Hejdeman, B.3    Brave, A.4    Bratt, G.5    Robb, M.6
  • 52
    • 2442515370 scopus 로고    scopus 로고
    • Therapeutic vaccination with MVA E2 can eliminate precancerous lesions (CIN 1: CIN 2, and CIN 3) associated with infection by oncogenic human papillomavirus
    • Corona Gutierrez C.M., Tinoco A., Navarro T., Contreras M.L., Cortes R.R., Calzado P., et al. Therapeutic vaccination with MVA E2 can eliminate precancerous lesions (CIN 1: CIN 2, and CIN 3) associated with infection by oncogenic human papillomavirus. Hum Gene Ther 2004, 15(5):421-431.
    • (2004) Hum Gene Ther , vol.15 , Issue.5 , pp. 421-431
    • Corona Gutierrez, C.M.1    Tinoco, A.2    Navarro, T.3    Contreras, M.L.4    Cortes, R.R.5    Calzado, P.6
  • 53
    • 33646817087 scopus 로고    scopus 로고
    • Regression of papilloma high-grade lesions (CIN 2 and CIN 3) is stimulated by therapeutic vaccination with MVA E2 recombinant vaccine
    • Garcia-Hernandez E., Gonzalez-Sanchez J.L., Andrade-Manzano A., Contreras M.L., Padilla S., Guzman C.C., et al. Regression of papilloma high-grade lesions (CIN 2 and CIN 3) is stimulated by therapeutic vaccination with MVA E2 recombinant vaccine. Cancer Gene Ther 2006, 13(6):592-597.
    • (2006) Cancer Gene Ther , vol.13 , Issue.6 , pp. 592-597
    • Garcia-Hernandez, E.1    Gonzalez-Sanchez, J.L.2    Andrade-Manzano, A.3    Contreras, M.L.4    Padilla, S.5    Guzman, C.C.6
  • 54
    • 33846900938 scopus 로고    scopus 로고
    • MVA E2 recombinant vaccine in the treatment of human papillomavirus infection in men presenting intraurethral flat condyloma: a phase I/II study
    • Albarran Y.C.A., de la Garza A., Cruz Quiroz B.J., Vazquez Zea E., Diaz Estrada I., Mendez Fuentez E., et al. MVA E2 recombinant vaccine in the treatment of human papillomavirus infection in men presenting intraurethral flat condyloma: a phase I/II study. BioDrugs 2007, 21(1):47-59.
    • (2007) BioDrugs , vol.21 , Issue.1 , pp. 47-59
    • Albarran, Y.C.A.1    de la Garza, A.2    Cruz Quiroz, B.J.3    Vazquez Zea, E.4    Diaz Estrada, I.5    Mendez Fuentez, E.6
  • 55
    • 77952940985 scopus 로고    scopus 로고
    • HPV and therapeutic vaccines where are we in 2010?
    • Ma B., Xu Y., Hung C., Wu T. HPV and therapeutic vaccines where are we in 2010?. Curr Cancer Ther Rev 2010, 6:81-103.
    • (2010) Curr Cancer Ther Rev , vol.6 , pp. 81-103
    • Ma, B.1    Xu, Y.2    Hung, C.3    Wu, T.4
  • 56
    • 29144432729 scopus 로고    scopus 로고
    • Immunodominance of poxviral-specific CTL in a human trial of recombinant-modified vaccinia Ankara
    • Smith C.L., Mirza F., Pasquetto V., Tscharke D.C., Palmowski M.J., Dunbar P.R., et al. Immunodominance of poxviral-specific CTL in a human trial of recombinant-modified vaccinia Ankara. J Immunol 2005, 175(12):8431-8437.
    • (2005) J Immunol , vol.175 , Issue.12 , pp. 8431-8437
    • Smith, C.L.1    Mirza, F.2    Pasquetto, V.3    Tscharke, D.C.4    Palmowski, M.J.5    Dunbar, P.R.6
  • 57
    • 79751487021 scopus 로고    scopus 로고
    • Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles
    • Goepfert P.A., Elizaga M.L., Sato A., Qin L., Cardinali M., Hay C.M., et al. Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles. J Infect Dis 2011, 203(5):610-619.
    • (2011) J Infect Dis , vol.203 , Issue.5 , pp. 610-619
    • Goepfert, P.A.1    Elizaga, M.L.2    Sato, A.3    Qin, L.4    Cardinali, M.5    Hay, C.M.6
  • 59
    • 84856999917 scopus 로고    scopus 로고
    • Clinical efficacy of TroVax in the treatment of progressive castration-resistant prostate cancer. Clinical medicine insights
    • Amato R.J., Stepankiw M. Clinical efficacy of TroVax in the treatment of progressive castration-resistant prostate cancer. Clinical medicine insights. Oncology 2012, 6:67-73.
    • (2012) Oncology , vol.6 , pp. 67-73
    • Amato, R.J.1    Stepankiw, M.2
  • 60
    • 78349284842 scopus 로고    scopus 로고
    • Vaccination of metastatic renal cancer patients with MVA-5T4: a randomized, double-blind, placebo-controlled phase III study
    • Amato R.J., Hawkins R.E., Kaufman H.L., Thompson J.A., Tomczak P., Szczylik C., et al. Vaccination of metastatic renal cancer patients with MVA-5T4: a randomized, double-blind, placebo-controlled phase III study. Clin Cancer Res 2010, 16(22):5539-5547.
    • (2010) Clin Cancer Res , vol.16 , Issue.22 , pp. 5539-5547
    • Amato, R.J.1    Hawkins, R.E.2    Kaufman, H.L.3    Thompson, J.A.4    Tomczak, P.5    Szczylik, C.6
  • 61
    • 84871004671 scopus 로고    scopus 로고
    • Analysis of pre-treatment markers predictive of treatment benefit for the therapeutic cancer vaccine MVA-5T4 (TroVax)
    • Harrop R., Treasure P., de Belin J., Kelleher M., Bolton G., Naylor S., et al. Analysis of pre-treatment markers predictive of treatment benefit for the therapeutic cancer vaccine MVA-5T4 (TroVax). Cancer Immunol Immunother 2012, CII.
    • (2012) Cancer Immunol Immunother , vol.CII
    • Harrop, R.1    Treasure, P.2    de Belin, J.3    Kelleher, M.4    Bolton, G.5    Naylor, S.6
  • 62
    • 84862980937 scopus 로고    scopus 로고
    • Expression and cellular immunogenicity of a transgenic antigen driven by endogenous poxviral early promoters at their authentic loci in MVA
    • Orubu T., Alharbi N.K., Lambe T., Gilbert S.C., Cottingham M.G. Expression and cellular immunogenicity of a transgenic antigen driven by endogenous poxviral early promoters at their authentic loci in MVA. PLoS ONE 2012, 7(6):e40167.
    • (2012) PLoS ONE , vol.7 , Issue.6
    • Orubu, T.1    Alharbi, N.K.2    Lambe, T.3    Gilbert, S.C.4    Cottingham, M.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.