Generation of a hematologic malignancy-selective membranolytic peptide from the antimicrobial core (RRWQWR) of bovine lactoferricin

Experimental and Molecular Pathology

Volumn 95, Issue 2, 2013, Pages 192-198

  Hilchie, Ashley L ^a,b   Vale, Rachel ^a   Zemlak, Tyler S ^a   Hoskin, David W ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

B lymphoma; Bovine lactoferricin; Cationic antimicrobial peptide; Membranolytic; T leukemia

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; ARGINYLARGINYLARGINYLARGINYLARGINYLARGINYLARGINYLGLYCYLGLYCYLARGINYLARGINYLTRYPTOPHANYLGLUTAMINYLTRYPTOPHANYLARGININE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; LACTOFERRICIN; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; ANTINEOPLASTIC ACTIVITY; ARTICLE; B CELL LYMPHOMA; CANCER CELL CULTURE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SELECTIVITY; FLOW CYTOMETRY; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; SCANNING ELECTRON MICROSCOPY; T CELL LEUKEMIA;

B-LYMPHOMA; BOVINE LACTOFERRICIN; CATIONIC ANTIMICROBIAL PEPTIDE; MEMBRANOLYTIC; T-LEUKEMIA;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CATTLE; CELL LINE, TUMOR; CELL SURVIVAL; FLOW CYTOMETRY; HUMANS; LACTOFERRIN; LEUKEMIA; LYMPHOMA, B-CELL; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON, SCANNING; REACTIVE OXYGEN SPECIES;

EID: 84882779379     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2013.07.006     Document Type: Article

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