Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 34, 2013, Pages 13809-13814

  Liao, Shih Fen ^a,b   Liang, Chi Hui ^b   Ho, Ming Yi ^c   Hsu, Tsui Ling ^b   Tsai, Tsung I ^a,b   Hsieh, Yves S Y ^b   Tsai, Chih Ming ^b   Li, Shiou Ting ^b   Cheng, Yang Yu ^b   Tsao, Shu Ming ^d   Lin, Tung Yi ^d   Lin, Zong Yan ^c   Yang, Wen Bin ^b   Ren, Chien Tai ^b   Lin, Kuo I ^b   Khoo, Kay Hooi ^c   Lin, Chun Hung ^c   Hsu, Hsien Yeh ^b,d   Wu, Chung Yi ^b   Wong, Chi Huey ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b GENOMICS RESEARCH CENTER   (Taiwan)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Anti Globo H antibody; Antitumor activity; Mushroom polysaccharide

Indexed keywords

1,6 ALPHA GALACTAN; ANTIBODY; ANTINEOPLASTIC AGENT; CANCER VACCINE; EPITOPE; FUCOSE; FUCOSE ENRICHED REISHI POLYSACCHARIDE; GALACTAN; GANODERMA LUCIDUM EXTRACT; GLYCAN; MANNAN; MANNOSE; N ACETYLGALACTOSAMINE; POLYSACCHARIDE; TUMOR ANTIGEN; UNCLASSIFIED DRUG; XYLOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; B LYMPHOCYTE; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; GANODERMA LUCIDUM; IMMUNE RESPONSE; IMMUNIZATION; LEWIS CARCINOMA; LUNG CARCINOMA; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANTI-GLOBO H ANTIBODY; ANTITUMOR ACTIVITY; MUSHROOM POLYSACCHARIDE;

ANIMALS; ANTIBODIES, NEOPLASM; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; B-LYMPHOCYTES; CARCINOMA, LEWIS LUNG; CHEMOKINE CCL2; FUCOSE; FUNGAL POLYSACCHARIDES; IMMUNIZATION; IMMUNOGLOBULIN M; MICE; MICE, INBRED C57BL; MICROARRAY ANALYSIS; REISHI;

EID: 84882765008     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1312457110     Document Type: Article

References (48)

1. Wasser SP, Weis AL (1999) Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: A modern perspective. Crit Rev Immunol 19(1):65-96.
2. Vickers A (2000) Recent advances: Complementary medicine. BMJ 321(7262):683-686.
3. Hakomori S (2001) Tumor-associated carbohydrate antigens defining tumor malignancy: Basis for development of anti-cancer vaccines. Adv Exp Med Biol 491:369-402.
4. Dube DH, Bertozzi CR (2005) Glycans in cancer and inflammation - potential for therapeutics and diagnostics. Nat Rev Drug Discov 4(6):477-488.
5. Zhu J, Warren JD, Danishefsky SJ (2009) Synthetic carbohydrate-based anticancer vaccines: The Memorial Sloan-Kettering experience. Expert Rev Vaccines 8(10): 1399-1413.
6. Slovin SF, Keding SJ, Ragupathi G (2005) Carbohydrate vaccines as immunotherapy for cancer. Immunol Cell Biol 83(4):418-428.
7. Astronomo RD, Burton DR (2010) Carbohydrate vaccines: Developing sweet solutions to sticky situations? Nat Rev Drug Discov 9(4):308-324.
8. Gilewski T, et al. (2001) Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: A phase I trial. Proc Natl Acad Sci USA 98(6):3270-3275.
9. Huang YL, et al. (2013) Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer. Proc Natl Acad Sci USA 110(7):2517-2522.
10. Siber GR (1994) Pneumococcal disease: Prospects for a new generation of vaccines. Science 265(5177):1385-1387.
11. Lesinski GB, Westerink MA (2001) Vaccines against polysaccharide antigens. Curr Drug Targets Infect Disord 1(3):325-334.
12. Foote JB, Kearney JF (2009) Generation of B cell memory to the bacterial polysaccharide alpha-1,3 dextran. J Immunol 183(10):6359-6368.
13. Martin F, Oliver AM, Kearney JF (2001) Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity 14(5): 617-629.
14. Alugupalli KR, et al. (2004) B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 21(3):379-390.
15. Wang YY, et al. (2002) Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: Functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities. Bioorg Med Chem 10(4):1057-1062.
16. Lin KI, et al. (2006) Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor Blimp-1. J Biol Chem 281(34):24111-24123.
17. Chen WY, Yang WB, Wong CH, Shih DT (2010) Effect of Reishi polysaccharides on human stem/progenitor cells. Bioorg Med Chem 18(24):8583-8591.
18. Hua KF, et al. (2007) Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signal transduction of cytokine expression. J Cell Physiol 212(2):537-550.
19. Chen HS, et al. (2004) Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides. Bioorg Med Chem 12(21):5595-5601.
20. Hsu TL, et al. (2009) Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins. J Biol Chem 284(50):34479-34489.
21. Lai CY, et al. (2010) Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro. Vaccine 28(31):4945-4954.
22. Gao Y, et al. (2005) Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice. Immunol Invest 34(2):171-198.
23. Lu H, Kyo E, Uesaka T, Katoh O, Watanabe H (2003) A water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia suppresses azoxymethaneinduction of colon cancers in male F344 rats. Oncol Rep 10(2):375-379.
24. Wang PY, Zhu XL, Lin ZB (2012) Antitumor and immunomodulatory effects of polysaccharides from broken-spore of Ganoderma lucidum. Front Pharmacol 3:135.
25. Cao QZ, Lin ZB (2004) Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide. Acta Pharmacol Sin 25(6):833-838.
26. Mènard S, Tagliabue E, Canevari S, Fossati G, Colnaghi MI (1983) Generation of monoclonal antibodies reacting with normal and cancer cells of human breast. Cancer Res 43(3):1295-1300.
27. Bremer EG, et al. (1984) Characterization of a glycosphingolipid antigen defined by the monoclonal antibody MBr1 expressed in normal and neoplastic epithelial cells of human mammary gland. J Biol Chem 259(23):14773-14777.
28. Slovin SF, et al. (1999) Carbohydrate vaccines in cancer: Immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man. Proc Natl Acad Sci USA 96(10): 5710-5715.
29. Ye L, et al. (2008) Purification, NMR study and immunostimulating property of a fucogalactan from the fruiting bodies of Ganoderma lucidum. Planta Med 74(14): 1730-1734.
30. Alquini G, Carbonero ER, Rosado FR, Cosentino C, Iacomini M (2004) Polysaccharides from the fruit bodies of the basidiomycete Laetiporus sulphureus (Bull.: Fr.) Murr. FEMS Microbiol Lett 230(1):47-52.
31. Usui T, Hosokawa S, Mizuno T, Suzuki T, Meguro H (1981) Investigation of the heterogeneity of heterogalactan from the fruit bodies of Fomitopsis pinicola, by employing concanavalin A-Sepharose affinity chromatography. J Biochem89(4):1029-1037.
32. Hakomori S (2003) Structure, organization, and function of glycosphingolipids in membrane. Curr Opin Hematol 10(1):16-24.
33. Clausen H, Levery SB, Nudelman E, Tsuchiya S, Hakomori S (1985) Repetitive A epitope (type 3 chain A) defined by blood group A1-specific monoclonal antibody TH-1: Chemical basis of qualitative A1 and A2 distinction. Proc Natl Acad Sci USA 82(4): 1199-1203.
34. Clausen H, Holmes E, Hakomori S (1986) Novel blood group H glycolipid antigens exclusively expressed in blood group A and AB erythrocytes (type 3 chain H). II. Differential conversion of different H substrates by A1 and A2 enzymes, and type 3 chain H expression in relation to secretor status. J Biol Chem 261(3):1388-1392.
35. Cui Y, et al. (1993) Human cervical epidermal carcinoma-associated intracellular localization of glycosphingolipid with blood group A type 3 chain. Jpn J Cancer Res 84(6):664-672.
36. Kurimoto S, et al. (1995) Detection of a glycosphingolipid antigen in bladder cancer cells with monoclonal antibody MRG-1. Histochem J 27(3):247-252.
37. Fridlender ZG, et al. (2011) Monocyte chemoattractant protein-1 blockade inhibits lung cancer tumor growth by altering macrophage phenotype and activating CD8+ cells. Am J Respir Cell Mol Biol 44(2):230-237.
38. Stathopoulos GT, et al. (2008) A central role for tumor-derived monocyte chemoattractant protein-1 in malignant pleural effusion. J Natl Cancer Inst 100(20): 1464-1476.
39. Wang CC, et al. (2008) Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer. Proc Natl Acad Sci USA 105(33):11661-11666.
40. Baldus SE, et al. (1996) Characterization of the binding specificity of Anguilla anguilla agglutinin (AAA) in comparison to Ulex europaeus agglutinin I (UEA-I). Glycoconj J 13(4):585-590.
41. Mollicone R, et al. (1996) Recognition of the blood group H type 2 trisaccharide epitope by 28 monoclonal antibodies and three lectins. Glycoconj J 13(2):263-271.
42. Lombard Y, Giaimis J, Makaya-Kumba M, Fonteneau P, Poindron P (1994) A new method for studying the binding and ingestion of zymosan particles by macrophages. J Immunol Methods 174(1-2):155-165.
43. Wasser SP (2002) Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol 60(3):258-274.
44. Bilan MI, et al. (2002) Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag. Carbohydr Res 337(8):719-730.
45. Miyazaki T, Nishijima M (1981) Studies on fungal polysaccharides. XXVII. Structural examination of a water-soluble, antitumor polysaccharide of Ganoderma lucidum. Chem Pharm Bull (Tokyo) 29(12):3611-3616.
46. Ye L, et al. (2008) Structural elucidation of the polysaccharide moiety of a glycopeptide (GLPCW-II) from Ganoderma lucidum fruiting bodies. Carbohydr Res 343(4): 746-752.
47. Axelsson K, Björndal H, Svensson S, Hammarström S (1971) Polysaccharides elaborated by Fomes annosus (Fr.) Cooke. II. Neutral polysaccharides from the fruit bodies. Isolation and purification of a fucoxylomannan by precipitation with the H-agglutinin from eel-serum. Acta Chem Scand 25(10):3645-3650.
48. Gao Y, et al. (2005) Effects of water-soluble Ganoderma lucidum polysaccharides on the immune functions of patients with advanced lung cancer. J Med Food 8(2): 159-168.