Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 7, 2013, Pages 2517-2522

  Huang, Yen Lin ^a,b   Hung, Jung Tung ^a   Cheung, Sarah K C ^a   Lee, Hsin Yu ^a   Chu, Kuo Ching ^a   Li, Shiou Ting ^a   Lin, Yu Chen ^a   Ren, Chien Tai ^a   Cheng, Ting Jen R ^a   Hsu, Tsui Ling ^a   Yu, Alice L ^a   Wu, Chung Yi ^a   Wong, Chi Huey ^a  

^a ACADEMIA SINICA   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Carbohydrate vaccine; Diphtheria toxin

Indexed keywords

CANCER VACCINE; GH DT; GLOBO H; GLYCAN; SSEA4 DT; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER STEM CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGENICITY; MICROARRAY ANALYSIS; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; BACTERIAL PROTEINS; BREAST NEOPLASMS; CANCER VACCINES; FEMALE; FLOW CYTOMETRY; HEMOCYANIN; IMMUNE SERA; IMMUNOGLOBULIN G; MICE; MICROARRAY ANALYSIS; MOLECULAR STRUCTURE; NEOPLASTIC STEM CELLS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STAGE-SPECIFIC EMBRYONIC ANTIGENS; TETANUS TOXOID;

EID: 84873714203     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1222649110     Document Type: Article

References (46)

1. Meezan E, Wu HC, Black PH, Robbins PW (1969) Comparative studies on the carbohydrate-containing membrane components of normal and virus-transformed mouse fibroblasts. II. Separation of glycoproteins and glycopeptides by sephadex chromatography. Biochemistry 8(6):2518-2524.
2. Turner GA (1992) N-glycosylation of serum proteins in disease and its investigation using lectins. Clin Chim Acta 208(3):149-171.
3. Gabius HJ (2000) Biological information transfer beyond the genetic code: The sugar code. Naturwissenschaften 87(3):108-121.
4. Shriver Z, Raguram S, Sasisekharan R (2004) Glycomics: A pathway to a class of new and improved therapeutics. Nat Rev Drug Discov 3(10):863-873. (Pubitemid 39405947)
5. Pancino G, et al. (1991) Purification and characterisation of a breast-cancer-associated glycoprotein not expressed in normal breast and identified by monoclonal antibody 83D4. Br J Cancer 63(3):390-398.
6. Hakomori S, Zhang Y (1997) Glycosphingolipid antigens and cancer therapy. Chem Biol 4(2):97-104. (Pubitemid 27161748)
7. Dube DH, Bertozzi CR (2005) Glycans in cancer and inflammation - potential for therapeutics and diagnostics. Nat Rev Drug Discov 4(6):477-488. (Pubitemid 40861990)
8. Martignone S, et al. (1993) Study of the expression and function of the tumour-associated antigen CaMBr1 in small cell lung carcinomas. Eur J Cancer 29A(14):2020-2025. (Pubitemid 23324365)
9. Perrone F, et al. (1993) Prognostic significance of the CaMBr1 antigen on breast carcinoma: Relevance of the type of recognised glycoconjugate. Eur J Cancer 29A(15):2113-2117. (Pubitemid 23348127)
10. Kannagi R, et al. (1983) New globoseries glycosphingolipids in human teratocarcinoma reactive with the monoclonal antibody directed to a developmentally regulated antigen, stage-specific embryonic antigen 3. J Biol Chem 258(14):8934-8942. (Pubitemid 13026724)
11. Mènard S, Tagliabue E, Canevari S, Fossati G, Colnaghi MI (1983) Generation of monoclonal antibodies reacting with normal and cancer cells of human breast. Cancer Res 43(3):1295-1300. (Pubitemid 13160058)
12. Canevari S, Fossati G, Balsari A, Sonnino S, Colnaghi MI (1983) Immunochemical analysis of the determinant recognized by a monoclonal antibody (MBr1) which specifically binds to human mammary epithelial cells. Cancer Res 43(3):1301-1305. (Pubitemid 13160059)
13. Bremer EG, et al. (1984) Characterization of a glycosphingolipid antigen defined by the monoclonal antibody MBr1 expressed in normal and neoplastic epithelial cells of human mammary gland. J Biol Chem 259(23):14773-14777. (Pubitemid 15222206)
14. Ragupathi G, et al. (1999) A fully synthetic globo H carbohydrate vaccine induces a focused humoral response in prostate cancer patients: A proof of principle. Angew Chem Int Ed Engl 38(4):563-566. (Pubitemid 29095523)
15. Zhang S, et al. (1997) Selection of tumor antigens as targets for immune attack using immunohistochemistry: I. Focus on gangliosides. Int J Cancer 73(1):42-49.
16. Mariani-Costantini R, et al. (1984) Reactivity of a monoclonal antibody with tissues and tumors from the human breast. Immunohistochemical localization of a new antigen and clinicopathologic correlations. Am J Pathol 115(1):47-56. (Pubitemid 14171538)
17. Zhang S, et al. (1998) Expression of potential target antigens for immunotherapy on primary and metastatic prostate cancers. Clin Cancer Res 4(2):295-302. (Pubitemid 28122741)
18. Gilewski T, et al. (2001) Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: A phase I trial. Proc Natl Acad Sci USA 98(6):3270-3275. (Pubitemid 32220835)
19. Huang CY, et al. (2006) Carbohydrate microarray for profiling the antibodies interacting with Globo H tumor antigen. Proc Natl Acad Sci USA 103(1):15-20.
20. Wang CC, et al. (2008) Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer. Proc Natl Acad Sci USA 105(33):11661-11666.
21. Chang WW, et al. (2008) Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis. Proc Natl Acad Sci USA 105(33):11667-11672.
22. Ragupathi G, et al. (1997) Immunization of mice with a fully synthetic Globo H antigen results in antibodies against human cancer cells: A combined chemical immunological approach to the fashioning of an anticancer vaccine. Angew Chem Int Ed Engl 36(1-2):125-128.
23. Slovin SF, et al. (1999) Carbohydrate vaccines in cancer: Immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man. Proc Natl Acad Sci USA 96(10):5710-5715. (Pubitemid 29234683)
24. Sabbatini PJ, et al. (2007) Pilot study of a heptavalent vaccine-keyhole limpet hemocyanin conjugate plus QS21 in patients with epithelial ovarian, fallopian tube, or peritoneal cancer. Clin Cancer Res 13(14):4170-4177.
25. Wang SK, et al. (2008) Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN. Proc Natl Acad Sci USA 105(10):3690-3695.
26. Burkhart F, Zhang ZY, Wacowich-Sgarbi S, Wong CH (2001) Synthesis of the Globo H hexasaccharide using the programmable reactivity-based one-pot strategy. Angew Chem Int Ed Engl 40(7):1274-1277.
27. Gilewski T, et al. (2000) Vaccination of high-risk breast cancer patients with mucin-1 (MUC1) keyhole limpet hemocyanin conjugate plus QS-21. Clin Cancer Res 6(5):1693-1701. (Pubitemid 30305061)
28. Livingston PO, et al. (1994) Phase 1 trial of immunological adjuvant QS-21 with a GM2 ganglioside-keyhole limpet haemocyanin conjugate vaccine in patients with malignant melanoma. Vaccine 12(14):1275-1280.
29. Chapman PB, et al. (2000) Induction of antibodies against GM2 ganglioside by immunizing melanoma patients using GM2-keyhole limpet hemocyanin + QS21 vaccine: A dose-response study. Clin Cancer Res 6(3):874-879. (Pubitemid 30159343)
30. Morita M, et al. (1995) Structure-activity relationship of alpha-galactosylceramides against B16-bearing mice. J Med Chem 38(12):2176-2187.
31. Kawano T, et al. (1997) CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science 278(5343):1626-1629. (Pubitemid 27516282)
32. Kobayashi E, Motoki K, Uchida T, Fukushima H, Koezuka Y (1995) KRN7000, a novel immunomodulator, and its antitumor activities. Oncol Res 7(10-11):529-534. (Pubitemid 26077987)
33. Brossay L, et al. (1997) Mouse CD1 is mainly expressed on hemopoietic-derived cells. J Immunol 159(3):1216-1224. (Pubitemid 127484098)
34. Yamaguchi Y, et al. (1996) Enhancing effects of (2S,3S,4R)-1-O-(alpha-D- galactopyr-anosyl)-2-(N-hexacosanoylamino) -1,3,4-octadecanetriol (KRN7000) on antigen-presenting function of antigen-presenting cells and antimetastatic activity of KRN7000-pretreated antigen-presenting cells. Oncol Res 8(10-11):399-407. (Pubitemid 27173037)
35. Hong S, et al. (1999) Lipid antigen presentation in the immune system: Lessons learned from CD1d knockout mice. Immunol Rev 169:31-44. (Pubitemid 29338721)
36. Burdin N, et al. (1998) Selective ability of mouse CD1 to present glycolipids: Alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes. J Immunol 161(7):3271-3281.
37. Stetson DB, et al. (2003) Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med 198(7):1069-1076. (Pubitemid 37248622)
38. Wu D, et al. (2006) Design of natural killer T cell activators: Structure and function of a microbial glycosphingolipid bound to mouse CD1d. Proc Natl Acad Sci USA 103(11):3972-3977.
39. Wu X, Ling CC, Bundle DR (2004) A new homobifunctional p-nitro phenyl ester coupling reagent for the preparation of neoglycoproteins. Org Lett 6(24):4407-4410. (Pubitemid 39611775)
40. Wu X, Bundle DR (2005) Synthesis of glycoconjugate vaccines for Candida albicans using novel linker methodology. J Org Chem 70(18):7381-7388. (Pubitemid 41233280)
41. Fujio M, et al. (2006) Structure-based discovery of glycolipids for CD1d-mediated NKT cell activation: Tuning the adjuvant versus immunosuppression activity. J Am Chem Soc 128(28):9022-9023. (Pubitemid 44078971)
42. Miyaji EN, et al. (2001) Induction of neutralizing antibodies against diphtheria toxin by priming with recombinant Mycobacterium bovis BCG expressing CRM(197), a mutant diphtheria toxin. Infect Immun 69(2):869-874. (Pubitemid 32109551)
43. Godefroy S, et al. (2005) Effect of skin barrier disruption on immune responses to topically applied cross-reacting material, CRM(197), of diphtheria toxin. Infect Immun 73(8):4803-4809. (Pubitemid 41105636)
44. Stickings P, et al. (2008) Transcutaneous immunization with cross-reacting material CRM(197) of diphtheria toxin boosts functional antibody levels in mice primed parenterally with adsorbed diphtheria toxoid vaccine. Infect Immun 76(4):1766-1773. (Pubitemid 351562022)
45. Hwang-Verslues WW, et al. (2009) Multiple lineages of human breast cancer stem/ progenitor cells identified by profiling with stem cell markers. PLoS One 4(12):e8377.
46. Hsu CH, et al. (2010) Highly alpha-selective sialyl phosphate donors for efficient preparation of natural sialosides. Chemistry 16(6):1754-1760.