The effects of age and viral serology on γδ T-cell numbers and exercise responsiveness in humans

Cellular Immunology

Volumn 284, Issue 1-2, 2013, Pages 91-97

  Pistillo, Mira ^a   Bigley, Austin B ^a   Spielmann, Guillaume ^a   LaVoy, Emily C ^a   Morrison, Mark R ^a   Kunz, Hawley ^a   Simpson, Richard J ^a  

^a UNIVERSITY OF HOUSTON   (United States)

Author keywords

Cytomegalovirus; Epstein Barr virus; Exercise immunology; Herpes simplex virus; Immunosenescence; Parvovirus B19

Indexed keywords

ADULT; ARTICLE; BLOOD SAMPLING; CELL COUNT; CLINICAL ARTICLE; CYTOMEGALOVIRUS; EPSTEIN BARR VIRUS; EXERCISE; GAMMA DELTA T LYMPHOCYTE; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN PARVOVIRUS B19; MALE; PRIORITY JOURNAL; SEROLOGY;

CYTOMEGALOVIRUS; EPSTEIN-BARR VIRUS; EXERCISE IMMUNOLOGY; HERPES SIMPLEX VIRUS; IMMUNOSENESCENCE; PARVOVIRUS B19;

ADULT; AGE FACTORS; ANTIBODIES, VIRAL; CYTOMEGALOVIRUS; EXERCISE; FLOW CYTOMETRY; HERPESVIRUS 4, HUMAN; HUMANS; LEUKOCYTES, MONONUCLEAR; LINEAR MODELS; MALE; MIDDLE AGED; PARVOVIRUS B19, HUMAN; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SIMPLEXVIRUS; VIRUS DISEASES; YOUNG ADULT;

EID: 84882741378     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2013.07.009     Document Type: Article

References (41)

1. Girardi M. Immunosurveillance and immunoregulation by gammadelta T cells. J. Invest. Dermatol. 2006, 126:25-31.
2. Nakasone C., Yamamoto N., Nakamatsu M., Kinjo T., Miyagi K., Uezu K., Nakamura K., Higa F., Ishikawa H., O'Brien L., Ikuta K., Kaku M., Fujita J., Kawakami K. Accumulation of gamma/delta T cells in the lungs and their roles in neutrophil-mediated host defense against pneumococcal infection. Microbes Infect. 2007, 9:251-258.
3. Dhabhar F.S., McEwen B.S. Stress-induced enhancement of antigen-specific cell-mediated immunity. J. Immunol. 1996, 156:2608-2615.
4. Braza M.S., Klein B. Anti-tumour immunotherapy with Vgamma9Vdelta2 T lymphocytes: from the bench to the bedside. Br. J. Haematol. 2013, 160:123-132.
5. Carding S.R., Egan P.J. Gammadelta T cells: functional plasticity and heterogeneity. Nat. Rev. Immunol. 2002, 2:336-345.
6. Eberl M., Engel R., Aberle S., Fisch P., Jomaa H., Pircher H. Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1). J. Leukoc. Biol. 2005, 77:67-70.
7. Voehringer D., Koschella M., Pircher H. Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1). Blood 2002, 100:3698-3702.
8. Anane L.H., Edwards K.M., Burns V.E., Drayson M.T., Riddell N.E., van Zanten J.J., Wallace G.R., Mills P.J., Bosch J.A. Mobilization of gammadelta T lymphocytes in response to psychological stress, exercise, and beta-agonist infusion. Brain Behav. Immun. 2009, 23:823-829.
9. Anane L.H., Edwards K.M., Burns V.E., Zanten J.J., Drayson M.T., Bosch J.A. Phenotypic characterization of gammadelta T cells mobilized in response to acute psychological stress. Brain Behav. Immun. 2010, 24:608-614.
10. Dhabhar F.S. Enhancing versus suppressive effects of stress on immune function: implications for immunoprotection and immunopathology. Neuroimmunomodulation 2009, 16:300-317.
11. Pawelec G., Derhovanessian E. Role of CMV in immune senescence. Virus Res. 2011, 157:175-179.
12. Argentati K., Re F., Donnini A., Tucci M.G., Franceschi C., Bartozzi B., Bernardini G., Provinciali M. Numerical and functional alterations of circulating gammadelta T lymphocytes in aged people and centenarians. J. Leukoc. Biol. 2002, 72:65-71.
13. Pawelec G., Derhovanessian E., Larbi A., Strindhall J., Wikby A. Cytomegalovirus and human immunosenescence. Rev. Med. Virol. 2009, 19:47-56.
14. Bate S.L., Dollard S.C., Cannon M.J. Cytomegalovirus seroprevalence in the United States: the national health and nutrition examination surveys, 1988-2004. Clin. Infect. Dis. 2010, 50:1439-1447.
15. Appay V., Dunbar P.R., Callan M., Klenerman P., Gillespie G.M., Papagno L., Ogg G.S., King A., Lechner F., Spina C.A., Little S., Havlir D.V., Richman D.D., Gruener N., Pape G., Waters A., Easterbrook P., Salio M., Cerundolo V., McMichael A.J., Rowland-Jones S.L. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 2002, 8:379-385.
16. Stowe R.P., Peek M.K., Cutchin M.P., Goodwin J.S. Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age. J. Med. Virol. 2012, 84:1797-1802.
17. Norbeck O., Isa A., Pohlmann C., Broliden K., Kasprowicz V., Bowness P., Klenerman P., Tolfvenstam T. Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans. J. Virol. 2005, 79:12117-12121.
18. Bigley A.B., Lowder T.W., Spielmann G., Rector J.L., Pircher H., Woods J.A., Simpson R.J. NK-cells have an impaired response to acute exercise and a lower expression of the inhibitory receptors KLRG1 and CD158a in humans with latent cytomegalovirus infection. Brain Behav. Immun. 2012, 26:177-186.
19. Simpson R.J., Cosgrove C., Ingram L.A., Florida-James G.D., Whyte G.P., Pircher H., Guy K. Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise. Brain Behav. Immun. 2008, 22:544-551.
20. Turner J.E., Aldred S., Witard O.C., Drayson M.T., Moss P.M., Bosch J.A. Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise. Brain Behav. Immun. 2010, 24:1362-1370.
21. Adams G.M., Beam W.C. Exercise Physiology: Laboratory Manual 1998, McGraw-Hill, Boston.
22. Jackson A.S., Blair S.N., Mahar M.T., Wier L.T., Ross R.M., Stuteville J.E. Prediction of functional aerobic capacity without exercise testing. Med. Sci. Sports Exerc. 1990, 22:863-870.
23. Gellish R.L., Goslin B.R., Olson R.E., McDonald A., Russi G.D., Moudgil V.K. Longitudinal modeling of the relationship between age and maximal heart rate. Med. Sci. Sports Exerc. 2007, 39:822-829.
24. Astrand I. Aerobic work capacity in men and women with special reference to age. Acta Physiol. Scand. Suppl. 1960, 49:1-92.
25. Simpson R.J., Florida-James G.D., Whyte G.P., Guy K. The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (beta2 integrin) and CD53. Eur. J. Appl. Physiol. 2006, 97:109-121.
26. Marcolino I., Przybylski G.K., Koschella M., Schmidt C.A., Voehringer D., Schlesier M., Pircher H. Frequent expression of the natural killer cell receptor KLRG1 in human cord blood T cells: correlation with replicative history. Eur. J. Immunol. 2004, 34:2672-2680.
27. Simpson R.J., Lowder T.W., Spielmann G., Bigley A.B., Lavoy E.C., Kunz H. Exercise and the aging immune system. Ageing Res. Rev. 2012, 11:404-420.
28. Parker C.M., Groh V., Band H., Porcelli S.A., Morita C., Fabbi M., Glass D., Strominger J.L., Brenner M.B. Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire. J. Exp. Med. 1990, 171:1597-1612.
29. Fornara C., Lilleri D., Revello M.G., Furione M., Zavattoni M., Lenta E., Gerna G. Kinetics of effector functions and phenotype of virus-specific and gammadelta T lymphocytes in primary human cytomegalovirus infection during pregnancy. J. Clin. Immunol. 2011, 31:1054-1064.
30. Lafarge X., Merville P., Cazin M.C., Berge F., Potaux L., Moreau J.F., Dechanet-Merville J. Cytomegalovirus infection in transplant recipients resolves when circulating gammadelta T lymphocytes expand, suggesting a protective antiviral role. J. Infect. Dis. 2001, 184:533-541.
31. Dimitrov S., Lange T., Born J. Selective mobilization of cytotoxic leukocytes by epinephrine. J. Immunol. 2010, 184:503-511.
32. Bosch J.A., Berntson G.G., Cacioppo J.T., Dhabhar F.S., Marucha P.T. Acute stress evokes selective mobilization of T cells that differ in chemokine receptor expression: a potential pathway linking immunologic reactivity to cardiovascular disease. Brain Behav. Immun. 2003, 17:251-259.
33. Bosch J.A., Berntson G.G., Cacioppo J.T., Marucha P.T. Differential mobilization of functionally distinct natural killer subsets during acute psychologic stress. Psychosom. Med. 2005, 67:366-375.
34. Starkie R.L., Rolland J., Febbraio M.A. Effect of adrenergic blockade on lymphocyte cytokine production at rest and during exercise. Am. J. Physiol. Cell Physiol. 2001, 281:C1233-C1240.
35. Walsh N.P., Gleeson M., Shephard R.J., Woods J.A., Bishop N.C., Fleshner M., Green C., Pedersen B.K., Hoffman-Goetz L., Rogers C.J., Northoff H., Abbasi A., Simon P. Position statement. Part one: immune function and exercise. Exerc. Immunol. Rev. 2011, 17:6-63.
36. Walsh N.P., Gleeson M., Pyne D.B., Nieman D.C., Dhabhar F.S., Shephard R.J., Oliver S.J., Bermon S., Kajeniene A. Position statement. Part two: maintaining immune health. Exerc. Immunol. Rev. 2011, 17:64-103.
37. Ceddia M.A., Price E.A., Kohlmeier C.K., Evans J.K., Lu Q., McAuley E., Woods J.A. Differential leukocytosis and lymphocyte mitogenic response to acute maximal exercise in the young and old. Med. Sci. Sports Exerc. 1999, 31:829-836.
38. Mazzeo R.S., Rajkumar C., Rolland J., Blaher B., Jennings G., Esler M. Immune response to a single bout of exercise in young and elderly subjects. Mech. Ageing Dev. 1998, 100:121-132.
39. Poole J.G., Lawrenson L., Kim J., Brown C., Richardson R.S. Vascular and metabolic response to cycle exercise in sedentary humans: effect of age. Am. J. Physiol. Heart Circ. Physiol. 2003, 284:H1251-H1259.
40. Feldman R.D., Limbird L.E., Nadeau J., Robertson D., Wood A.J. Alterations in leukocyte beta-receptor affinity with aging. A potential explanation for altered beta-adrenergic sensitivity in the elderly. N. Engl. J. Med. 1984, 310:815-819.
41. Spielmann G., Bollard C.M., Bigley A.B., Hanley P.J., Blaney J.W., Lavoy E.C., Pircher H., Simpson R.J. The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans. Brain Behav. Immun. 2013, [Epub ahead of print]. 10.1016/j.bbi.2013.05.003.