Human Vγ9/Vδ2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1)

Journal of Leukocyte Biology

Volumn 77, Issue 1, 2005, Pages 67-70

  Eberl, Matthias ^a   Engel, Rosel ^a   Aberle, Silke ^b   Fisch, Paul ^b   Jomaa, Hassan ^a   Pircher, Hanspeter ^b  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

T lymphocytes; CD94; Killer inhibitory receptors; Memory; Senescence

Indexed keywords

4 HYDROXY 3 METHYLBUT 2 ENYL PYROPHOSPHATE; ANTIBODY; CD27 ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CCR7; KILLER CELL LECTIN LIKE RECEPTOR G1; MEMBRANE RECEPTOR; PADGEM PROTEIN; PYROPHOSPHORIC ACID DERIVATIVE; UNCLASSIFIED DRUG; 4-HYDROXY-3-METHYLBUT-2-ENYL PYROPHOSPHATE; INTERLEUKIN 2; KLRG1 PROTEIN, HUMAN; LECTIN; LYMPHOCYTE ANTIGEN RECEPTOR; PYROPHOSPHATE; TRANSACTIVATOR PROTEIN;

ADULT; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CYTOKINE PRODUCTION; CYTOLYSIS; EFFECTOR CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; METABOLITE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; UMBILICAL CORD BLOOD; BURKITT LYMPHOMA; CELL CULTURE; FETUS BLOOD; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; PATHOLOGY;

BURKITT LYMPHOMA; CELL PROLIFERATION; DIPHOSPHATES; FETAL BLOOD; HUMANS; IMMUNOLOGIC MEMORY; INTERLEUKIN-2; KILLER CELLS, NATURAL; LECTINS, C-TYPE; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 14644422190     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0204096     Document Type: Article

References (18)

1. Blaser, C., Kaufmann, M., Pircher, H. (1998) Virus-activated CD8 T cells and lymphokine-activated NK cells express the mast cell function-associated antigen, an inhibitory C-type lectin. J. Immunol. 161, 6451-6454.
2. Hanke, T., Corral, L., Vance, R. E., Raulet, D. H. (1998) 2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells. Eur. J. Immunol. 28, 4409-4417.
3. Voehringer, D., Kaufmann, M., Pircher, H. (2001) Genomic structure, alternative splicing, and physical mapping of the killer cell lectin-like receptor G1 gene (KLRG1), the mouse homologue of MAFA. Immunogenetics 52, 206-211.
4. Robbins, S. H., Nguyen, K. B., Takahashi, N., Mikayama, T., Biron, C. A., Brossay, L. (2002) Inhibitory functions of the killer cell lectin-like receptor G1 molecule during the activation of mouse NK cells. J. Immunol. 168, 2585-2589.
5. Beyersdorf, N. B., Ding, X., Karp, K., Hanke, T. (2001) Expression of inhibitory "killer cell lectin-like receptor G1" identifies unique subpopulations of effector and memory CD8 T cells. Eur. J. Immunol. 31, 3443-3452.
6. Voehringer, D., Blaser, C., Brawand, P., Raulet, D. H., Hanke, T., Pircher, H. (2001) Viral infections induce abundant numbers of senescent CD8 T cells. J. Immunol. 167, 4838-4843.
7. Butcher, S., Arney, K. L., Cook, G. P. (1998) MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells. Eur. J. Immunol. 28, 3755-3762.
8. Voehringer, D., Koschella, M., Pircher, H. (2002) Lack of proliferate capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1). Blood 100, 3698-3702.
9. Das, H., Groh, V., Kuijl, C., Sugita, M., Morita, C. T., Spies, T., Bukowski, J. F. (2001) MICA engagement by human Vγ9Vδ2 T cells enhances their antigen-dependent effector function. Immunity 15, 83-93.
10. + T lymphocytes from healthy donors and multiple sclerosis patients: involvement of phosphatidylinositol 3 kinase and calcium calmodulin-dependent kinase II. J. Immunol. 168, 6071-6077.
11. Poccia, F., Cipriani, B., Vendetti, S., Colizzi, V., Poquet, Y., Battistini, L., López-Botet, M., Fournié, J. J., Gougeon, M. L. (1997) CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive Vγ9Vδ2 T lymphocytes. J. Immunol. 159, 6009-6017.
12. Lafont, V., Liautard, J., Liautard, J. P., Favero, J. (2001) Production of TNF-α by human Vγ9Vδ2 T cells via engagement of FcγRIIIA, the low affinity type 3 receptor for the Fc portion of IgG, expressed upon TCR activation by nonpeptidic antigen. J. Immunol. 166, 7190-7199.
13. Rothenfusser, S., Buchwald, A., Kock, S., Ferrone, S., Fisch, P. (2002) Missing HLA class I expression on Daudi cells unveils cytotoxic and proliferative responses of human γδ T lymphocytes. Cell. Immunol. 215, 32-44.
14. Eberl, M., Hintz, M., Reichenberg, A., Kollas, A. K., Wiesner, J., Jomaa, H. (2003) Microbial isoprenoid biosynthesis and human γδ T cell activation. FEBS Lett. 544, 4-10.
15. Eberl, M., Engel, R., Beck, E., Jomaa, H. (2002) Differentiation of human γδ T cells towards distinct memory phenotypes. Cell. Immunol. 218, 1-6.
16. + T cell effectors in immunocompromised hosts and during active pulmonary tuberculosis. J. Immunol. 168, 1484-1489.
17. Robbins, S. H., Terrizzi, S. C., Sydora, B. C., Mikayama, T., Brossay, L. (2003) Differential regulation of killer cell lectin-like receptor G1 expression on T cells. J. Immunol. 170, 5876-5885.
18. Dieli, F., Poccia, F., Lipp, M., Sireci, G., Caccamo, N., di Sano, C., Salerno, A. (2003) Differentiation of effector/memory Vδ2 T cells and migratory routes in lymph nodes or inflammatory sites. J. Exp. Med. 198, 391-397.