Providing a diet deficient in valine but with excess leucine results in a rapid decrease in feed intake and modifies the postprandial plasma amino acid and α-keto acid concentrations in pigs

Journal of Animal Science

Volumn 90, Issue 9, 2012, Pages 3135-3142

  Gloaguen, M ^a,b,c   Le Floc'h, N ^a,b   Corrent, E ^c   Primot, Y ^c   van Milgen, J ^a,b  

^a PEGASE   (France)

^b AGROCAMPUS OUEST   (France)

^c Ajinomoto Eurolysine SAS   (France)

Author keywords

Branched chain amino acids; Feed intake; Leucine; Pig; Valine

Indexed keywords

AMINO ACID; LEUCINE; OXOACID; VALINE;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; AREA UNDER THE CURVE; ARTICLE; BLOOD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET; DOSE RESPONSE; DRUG EFFECT; EATING; FEMALE; METABOLISM; PHYSIOLOGY; POSTPRANDIAL STATE; SWINE;

AMINO ACIDS; ANIMAL FEED; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; AREA UNDER CURVE; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; FEMALE; KETO ACIDS; LEUCINE; POSTPRANDIAL PERIOD; SWINE; VALINE;

EID: 84882698423     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2011-4956     Document Type: Article

References (38)

1. AFNOR. 1993. NF V03-040, agricultural food products. Determination of crude fibre. Accessed Mar. 1, 2012. http://www.afnor.org/en.
2. AFNOR. 1997. NF V18-120, animal feeding stuffs. Determination of nitrogen content. Combustion method (DUMAS). Assoc. Française Normalisation, Paris.
3. AFNOR. 2005. NF EN ISO 13903, animal feeding stuffs. Determination of amino acids content. Accessed Mar. 1, 2012. http://www.afnor.org/en.
4. AFNOR. 2011. NF ISO 6492, animal feeding stuffs. Determination of fat content. Accessed Mar. 1, 2012. http://www.afnor.org/en.
5. Barea, R., L. Brossard, N. Le Floc'h, Y. Primot, D. Melchior, and J. van Milgen. 2009. The standardized ileal digestible valine-to-lysine requirement ratio is at least seventy percent in postweaned piglets. J. Anim. Sci. 87:935-947.
6. Block, K. P., and A. E. Harper. 1984. Valine metabolism in vivo: Effects of high dietary levels of leucine and isoleucine. Metabolism 33:559-566.
7. Bohe, J., A. Low, R. R. Wolfe, and M. J. Rennie. 2003. Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: A dose-response study. J. Physiol. 552:315-324.
8. Boirie, Y., M. Dangin, P. Gachon, M. P. Vasson, J. L. Maubois, and B. Beaufrere. 1997. Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc. Natl. Acad. Sci. U.S.A. 94:14930-14935.
9. Boisen, S. 2003. Ideal dietary amino acid profiles for pigs. Page 157 in Amino Acids in Farm Animal Nutrition. J. P. F. D'Mello, ed. CABI Publishing, Wallingford, UK.
10. Bos, C., C. C. Metges, C. Gaudichon, K. J. Petze, M. E. Pueyo, C. Morens, J. Everwand, R. Benamouzig, and D. Tome. 2003. Postprandial kinetics of dietary amino acids are the main determinant of their metabolism after soy or milk protein ingestion in humans. J. Nutr. 133:1308-1315.
11. Cusick, P. K., K. M. Koehler, B. Ferrier, and B. E. Haskell. 1978. Neurotoxicity of valine deficiency in rats. J. Nutr. 108:1200-1206.
12. Escobar, J., J. W. Frank, A. Suryawan, H. V. Nguyen, S. R. Kimball, L. S. Jefferson, and T. A. Davis. 2005. Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation. Am. J. Physiol. 288:E914-E921.
13. Gloaguen, M., N. Le Floc'h, L. Brossard, R. Barea, Y. Primot, E. Corrent, and J. van Milgen. 2011. Response of piglets to the valine content in diet in combination with the supply of other branched-chain amino acids. Animal 5:1734-1742.
14. Goto, S., K. Nagao, M. Bannai, M. Takahashi, K. Nakahara, K. Kangawa, and N. Murakami. 2010. Anorexia in rats caused by a valine-deficient diet is not ameliorated by systemic ghrelin treatment. Neuroscience 166:333-340.
15. Hao, S., J. W. Sharp, C. M. Ross-Inta, B. J. McDaniel, T. G. Anthony, R. C. Wek, D. R. Cavener, B. C. McGrath, J. B. Rudell, T. J. Koehnle, and D. W. Gietzen. 2005. Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science 307:1776-1778.
16. Harper, A. E., N. J. Benevenga, and R. M. Wohlhueter. 1970. Effects of ingestion of disproportionate amounts of amino acids. Physiol. Rev. 50:428-558.
17. Harper, A. E., R. H. Miller, and K. P. Block. 1984. Branched-chain amino acid metabolism. Annu. Rev. Nutr. 4:409-454.
18. Harper, A. E., and Q. R. Rogers. 1965. Amino acid imbalance. Proc. Nutr. Soc. 24:173-190.
19. Hegarty, J. E., P. D. Fairclough, K. J. Moriarty, M. L. Clark, M. J. Kelly, and A. M. Dawson. 1982. Comparison of plasma and intraluminal amino-acid profiles in man after meals containing a protein hydrolysate and equivalent amino-acid mixture. Gut 23:670-674.
20. Hutchison, S. N., N. S. Zarghami, P. K. Cusick, J. B. Longenecker, and B. E. Haskell. 1983. The effect of valine deficiency on neutral amino acid patterns in plasma and brain of the rat. J. Nutr. 113:2164-2170.
21. ISO. 1998. Animal feeding stuffs, animal products, and feces or urine-Determination of gross calorific value. Bomb calorimeter method. Norme international ISO 9831. Accessed Mar. 1, 2012. http://www.iso.org.
22. Koehnle, T. J., M. C. Russell, and D. W. Gietzen. 2003. Rats rapidly reject diets deficient in essential amino acids. J. Nutr. 133:2331-2335.
23. Markison, S., D. W. Gietzen, and A. C. Spector. 1999. Essential amino acid deficiency enhances long-term intake but not short-term licking of the required nutrient. J. Nutr. 129:1604-1612.
24. Matis, J. H., T. E. Wehrly, and W. C. Ellis. 1989. Some generalized stochastic compartment models for digesta flow. Biometrics 45:703-720.
25. Melchior, D., B. Seve, and N. Le Floc'h. 2004. Chronic lung inflammation affects plasma amino acid concentrations in pigs. J. Anim. Sci. 82:1091-1099.
26. Mertz, E. T., W. M. Beeson, and H. D. Jackson. 1952. Classification of essential amino acids for the weanling pig. Arch. Biochem. Biophys. 38:121-128.
27. Millward, D. J., A. Fereday, N. R. Gibson, and P. J. Pacy. 1996. Post-prandial protein metabolism. Baillieres Clin. Endocrinol. Metab. 10:533-549.
28. Noblet, J., H. Fortune, X. S. Shi, and S. Dubois. 1994. Prediction of net energy value of feeds for growing pigs. J. Anim. Sci. 72:344-354.
29. NRC. 1998. Nutrient Requirement of Swine. 10th rev. ed. Natl. Acad. Press, Washington, DC.
30. Pailla, K., F. Blonde-Cynober, C. Aussel, J. P. De Bandt, and L. Cynober. 2000. Branched-chain keto-acids and pyruvate in blood: Measurement by HPLC with fluorimetric detection and changes in older subjects. Clin. Chem. 46:848-853.
31. Pardridge, W. M. 1977. Kinetics of competitive inhibition of neutral amino acid transport across the blood-brain barrier. J. Neurochem. 28:103-108.
32. Peng, Y., J. K. Tews, and A. E. Harper. 1972. Amino acid imbalance, protein intake, and changes in rat brain and plasma amino acids. Am. J. Physiol. 222:314-321.
33. Pennings, B., Y. Boirie, J. M. G. Senden, A. P. Gijsen, H. Kuipers, and L. J. C. van Loon. 2011. Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. Am. J. Clin. Nutr. 93:997-1005.
34. Ratkowsky, D. A., R. K. Lowry, T. A. McMeekin, A. N. Stokes, and R. E. Chandler. 1983. Model for bacterial culture growth rate throughout the entire biokinetic temperature range. J. Bacteriol. 154:1222-1226.
35. Rose, W. C., and S. H. Eppstein. 1939. The dietary indispensability of valine. J. Biol. Chem. 127:677-684.
36. Sidransky, H., and T. Baba. 1960. Chemical pathology of acute amino acid deficiencies. III. Morphologic and biochemical changes in young rats fed valine- or lysine-devoid diets. J. Nutr. 70:463-483.
37. Wiltafsky, M. K., M. W. Pfaffl, and F. X. Roth. 2010. The effects of branched-chain amino acid interactions on growth performance, blood metabolites, enzyme kinetics and transcriptomics in weaned pigs. Br. J. Nutr. 103:964-976.
38. Yen, J. T., B. J. Kerr, R. A. Easter, and A. M. Parkhurst. 2004. Difference in rates of net portal absorption between crystalline and protein-bound lysine and threonine in growing pigs fed once daily. J. Anim. Sci. 82:1079-1090.