Expression of ECRG4 is associated with lower proliferative potential of esophageal cancer cells

Pathology International

Volumn 63, Issue 8, 2013, Pages 391-397

  Matsuzaki, Junichi ^a   Torigoe, Toshihiko ^a   Hirohashi, Yoshihiko ^a   Tamura, Yasuaki ^a   Asanuma, Hiroko ^a   Nakazawa, Emiri ^a   Saka, Eri ^b   Yasuda, Kazuyo ^a   Takahashi, Shuji ^a   Sato, Noriyuki ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Sapporo Immuno Diagnostic Laboratory   (Japan)

Author keywords

Esophageal cancer related gene 4; Esophageal squamous cell carcinoma; Ki 67 labeling index; Tumor suppressor

Indexed keywords

ESOPHAGEAL CANCER RELATED GENE 4; KI 67 ANTIGEN; MESSENGER RNA; MONOCLONAL ANTIBODY; PROTEIN ANTIBODY; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ESOPHAGEAL CANCER-RELATED GENE 4; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; KI-67 LABELING INDEX; TUMOR SUPPRESSOR;

AGED; ANTIBODIES, MONOCLONAL; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; ESOPHAGEAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS;

EID: 84882693100     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/pin.12079     Document Type: Article

References (14)

1. Matsuzaki J, Torogoe T, Hirohashi Y etal. ECRG4 is a novel inhibitor of Fas-induced apoptosis in human T-leukemia cells. Carcinogenesis 2012; 33: 996-1003.
2. Su T, Liu H, Lu S. Cloning and identification of cDNA fragments related to human esophageal cancer. Zhonghua Zhong Liu Za Zhi 1998; 20: 254-257 [in Chinese].
3. Yue CM, Deng DJ, Bi MX, Guo LP, Lu SH. Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma. World J Gastroenterol 2003; 9: 1174-1178.
4. Götze S, Feldhaus V, Traska T etal. ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma. BMC Cancer 2009; 9: 447.
5. Vanaja DK, Ehrich M, Van den Boom D etal. Hypermethylation of genes for diagnosis and risk stratification of prostate cancer. Cancer Invest 2009; 27: 549-560.
6. Li W, Liu X, Zhang B etal. Overexpression of candidate tumor suppressor ECRG4 inhibits glioma proliferation and invasion. J Exp Clin Cancer Res 2010; 29: 1-7.
7. Kujuro Y, Suzuki N, Kondo T. Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells. Proc Natl Acad Sci U S A 2010; 107: 8259-8264.
8. Li LW, Yu XY, Yang Y, Zhang CP, Guo LP, Lu SH. Expression of esophageal cancer related gene 4 (ECRG4), a novel tumor suppressor gene, in esophageal cancer and its inhibitory effect on the tumor growth in vitro and in vivo. Int J Cancer 2009; 125: 1505-1513.
9. Takahashi S, Sato N, Takayama S etal. Establishment of apoptosis-inducing monoclonal antibody 2D1 and 2D1-resistant variants of human T cell lines. Eur J Immunol 1993; 23: 1935-1941.
10. Inoda S, Hirohashi Y, Torigoe T etal. Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma. J Immunother 2009; 32: 474-485.
11. Asanuma H, Torigoe T, Kamiguchi K etal. Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells. Cancer Res 2005; 65: 11018-11025.
12. Mori Y, Ishiguro H, Kuwabara Y etal. Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma. Oncol Rep 2007; 18: 981-985.
13. Bashash M, Hislop TG, Shah AM, Le N, Brooks-Wilson A, Bajdik CD. The prognostic effect of ethnicity for gastric and esophageal cancer: The population-based experience in British Columbia, Canada. BMC Cancer 2011; 11: 164.
14. Bhoo-Pathy N, Hartman M, Yip CH etal. Ethnic differences in survival after breast cancer in South East Asia. PLoS One 2012; 7: e30995.