A novel protocol to accelerate dynamic combinatorial chemistry via isolation of ligand-target adducts from dynamic combinatorial libraries: A case study identifying competitive inhibitors of lysozyme

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 18, 2013, Pages 5174-5177

  Fang, Zheng ^a   He, Wei ^a   Li, Xin ^a   Li, Zhengjiang ^a   Chen, Beining ^b   Ouyang, Pingkai ^a   Guo, Kai ^a  

^a NANJING TECH UNIVERSITY   (China)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Combinatorial chemistry; Drug discovery; Enzyme inhibitors; Ligand separation

Indexed keywords

ENZYME INHIBITOR; LIGAND; LYSOZYME;

ARTICLE; BINDING AFFINITY; CASE STUDY; CHROMATOPHORE; COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; COMPETITIVE INHIBITION; DENATURATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MACROMOLECULE; MASS SPECTROMETRY; MICROCOCCUS LUTEUS; MOLECULAR WEIGHT; NONHUMAN;

COMBINATORIAL CHEMISTRY; DRUG DISCOVERY; ENZYME INHIBITORS; LIGAND SEPARATION;

ANIMALS; CHICKENS; COMBINATORIAL CHEMISTRY TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; LIGANDS; MOLECULAR STRUCTURE; MURAMIDASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84882687066     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.07.011     Document Type: Article

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