Silencing tankyrase and telomerase promotes A549 human lung adenocarcinoma cell apoptosis and inhibits proliferation

Oncology Reports

Volumn 30, Issue 4, 2013, Pages 1745-1752

  Lu, Hongda ^a,b   Lei, Zhang ^a,b   Lu, Zhongxin ^b   Lu, Qianming ^a,b   Lu, Chi ^a,b   Chen, Weiqun ^b   Wang, Chun ^a   Tang, Qiu ^a   Kong, Qingzhi ^a,b  

^a CENTRAL HOSPITAL OF WUHAN   (China)

^b Wuhan Research Institute of Machinery Technology   (China)

Author keywords

Antisense oligonucleotide; Apoptosis; Lung adenocarcinoma A549 cells; Proliferation; Tankyrase; Telomerase

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1; TANKYRASE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BAX GENE; BCL 2 GENE; CARCINOMA CELL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TELOMERE SHORTENING; UPREGULATION;

ADENOCARCINOMA; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE SILENCING; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; OLIGONUCLEOTIDES, ANTISENSE; PROTO-ONCOGENE PROTEINS C-BCL-2; TANKYRASES; TELOMERASE; TELOMERE HOMEOSTASIS; TRANSFECTION;

EID: 84882647069     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2665     Document Type: Article

References (20)

1. Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin 63: 11-30, 2013.
2. Gadgeel SM, Ramalingam SS and Kalemkerian GP: Treatment of lung cancer. Radiol Clin North Am 50: 961-974, 2012.
3. Tümpel S and Rudolph KL: The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems. Ann NY Acad Sci 1266: 28-39, 2012.
4. Gomez DE, Armando RG, Farina HG, Menna PL, Cerrudo CS, Ghiringhelli PD and Alonso DF: Telomere structure and telomerase in health and disease (Review). Int J Oncol 41: 1561-1569, 2012.
5. Shay JW and Wright WE: Role of telomeres and telomerase in cancer. Semin Cancer Biol 21: 349-353, 2011.
6. Ruden M and Puri N: Novel anticancer therapeutics targeting telomerase. Cancer Treat Rev 39: 444-456, 2013.
7. Riffell JL, Lord CJ and Ashworth A: Tankyrase-targeted therapeutics: expanding opportunities in the PARP family. Nat Rev Drug Discov 11: 923-936, 2012.
8. Cha N, Li XY, Zhao YJ, Wang EH and Wu GP: hTERT gene amplification and clinical significance in pleural effusions of patients with lung cancer. Clin Lung Cancer 13: 494-499, 2012.
9. Gigek CO, Leal MF, Silva PN, Lisboa LC, Lima EM, Calcagno DQ, Assumpção PP, Burbano RR and Smith Mde A: hTERT methylation and expression in gastric cancer. Biomarkers 14: 630-636, 2009.
10. Bantis A, Patsouris E, Gonidi M, Kavantzas N, Tsipis A, Athanassiadou AM, Aggelonidou E and Athanassiadou P: Telomerase RNA expression and DNA ploidy as prognostic markers of prostate carcinomas. Tumori 95: 744-752, 2009.
11. Chen C, Zhang Y, Wang Y, Huang D, Xi Y and Qi Y: Synergic effect of 3'-azido-3'-deoxythymidine and arsenic trioxide in suppressing hepatoma cells. Anticancer Drugs 22: 435-443, 2011.
12. Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP and Krauss S: A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res 72: 2822-2832, 2012.
13. Zhang H, Yang MH, Zhao JJ, Chen L, Yu ST, Tang XD, Fang DC and Yang SM: Inhibition of tankyrase 1 in human gastric cancer cells enhances telomere shortening by telomerase inhibitors. Oncol Rep 24: 1059-1065, 2010.
14. Zhang X, Mar V, Zhou W, Harrington L and Robinson MO: Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev 13: 2388-2399, 1999.
15. Bae J, Donigian JR and Hsueh AJ: Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis. J Biol Chem 278: 5195-5204, 2003.
16. Adams KW and Cooper GM: Rapid turnover of mcl-1 couples translation to cell survival and apoptosis. J Biol Chem 282: 6192-6200, 2007.
17. Bae J, Leo CP, Hsu SY and Hsueh AJ: MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. J Biol Chem 275: 25255-25261, 2000.
18. Buseman CM, Wright WE and Shay JW: Is telomerase a viable target in cancer? Mutat Res 730: 90-97, 2012.
19. Tian X, Chen B and Liu X: Telomere and telomerase as targets for cancer therapy. Appl Biochem Biotechnol 160: 1460-1472, 2010.
20. Seimiya H: The telomeric PARP, tankyrases, as targets for cancer therapy. Br J Cancer 94: 341-345, 2006.