Possible involvement of "phosphatidylinositol-3 kinase and endothelial nitric oxide synthase" in experimental obesity induced vascular endothelium dysfunction

Journal of Applied Pharmaceutical Science

Volumn 3, Issue 6, 2013, Pages 52-60

  Dubey, Gargee ^a   Sharma, P L ^a   Sharma, Saurabh ^a  

^a ISF COLLEGE OF PHARMACY   (India)

Author keywords

Adipocytes; ENOS; HIGH FAT PAD; OBESITY; OXIDATIVE STRESS; PI3K; Vascular endothelium dysfunction; YS 49.

Indexed keywords

EID: 84882622457     PISSN: None     EISSN: 22313354     Source Type: Journal    
DOI: 10.7324/JAPS.2013.3608     Document Type: Article

References (33)

1. Abid MR, Guo S, Minami T, Spokes KC, Ueki K, Skurk C, Walsh K, Aird WC. Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler Thromb Vasc Biol. 2004; 242: 294-300.
2. Ainsline DA, Proietto J, Fam BC, Thormburn A.W. Short-term, high-fat diet low circulating leptin concentration in rats. Am. J. Clin. Nutr. 2000; 71: 438-42.
3. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin. Chem. 1974; 20: 470-475.
4. Bernardis LL. Prediction of carcass fat, waterand lean body mass from Lee's nutritive ratio in rats with hypothalamic obesity. Experientia. 1970; 26: 789-90.
5. Yun-Choi HS, Pyo M K, Park K M, Chang K C, Lee D H. Antithrombotic effects of YS-49 and YS-51--1-naphthylmethyl analogs of higenamine. Thrombosis research. 2001; 4(104), 249-255.
6. Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie SJ, Sah R, Cheng H, Rybin O, Lembo G, Fratta L. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 2002; 110: 737-49.
7. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009; 360(15): 1509-17.
8. Desjardins F, Balligand JL. Nitric oxide-dependent endothelial function and cardiovascular disease. Acta Clin Belg. 2006; 616: 326-34.
9. De-wit NJ, Bosch-Vermeulen H, De-Groot PJ, Hooiveld GJ, Bromhaar MM, Jansen J, Muller M, Van-der-Meer R. The role of the small intestine in the development of dietary fat induced obesity and insulin resistance in C57BL/6J mice. BMC Med Genomicd. 2008; 1: 14.
10. Fulton D, Gratton JP, McCabe TJ, Fontana J, Walsh K, Franke TP, Papapetropolous A, Sessa WC. Regulation of endothelium derived nitric oxide production by the protein kinase Akt. Nature. 1999; 399 (6736): 596-601.
11. Hall JE, Crook ED, Jones DW, Wofford MR, Dubbert PM. Mechanisms of obesity-associated cardiovascular and renal disease. Am J Med Sci. 2000; 324 (3): 127-3.
12. Ignarro LJ, Byrns RE, Buga GM, Wood KS, Chaudhuri G. Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation. J Pharmacol Exp Ther. 1988; 244(1): 181-189.
13. Kang YJ, Koo EB, Lee YS, Yun-Choi HS, Chang KC. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. British Journal of Pharmacology. 1999; 128: 357-364.
14. Kim JH, Hahm D.H, Yang DC, Lee HJ, Shim I. Effect of crude saponins of Korean red ginseng on high fat diet indused obesity in the rat. J Pharmacol Sci. 2005; 97(1): 124-31.
15. Kizelsztein P, Govorko D, Komarnystsky S, Evans A, Wang Z, Cefalu WT, Raskin I. 20-Hydroxyecdysone decreases weight and hyperglycaemia in a diet induced obesity in mice model. Am J Physiol Endocrinol Metab. 2009; 296: E433-E439.
16. Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006; 125(4): 733-47.
17. Lassegue B, Clempus RE. Vascular NAD(P)H oxidases: specific features, expression and regulation. Am. J. Physiol. Regulatory integrative Comp. Physiol. 2003; 285: 277-297.
18. Li JM, Shah AM. Endothelial cell superoxide generation: regulation and relevance and relevance for Cardiovascular pathophysiology. Am. J. Physiol. Regul. Integ. Comp.physiol. 2004; 287: 1014-1030.
19. Li JM, Shah AM. Endothelial cell superoxide generation: regulation and relevance and relevance for Cardiovascular pathophysiology. Am. J. Physiol. Regul. Integ. Comp.physiol. 2004; 287: 1014-1030.
20. Liao JK, Zulueta JJ, Yu FS. Peng HB, Cote CG, Hassoun PM. Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen J. Clin Invest. 1995; 96: 2661-2666.
21. Masek J, Fabry P. High fat diet and the development of obesity in a albino rats. Experientia. 1959; 15: 444-5.
22. Milagro F I, Campión J, Martínez JA. Weight Gain Induced by High-Fat Feeding Involves Increased Liver Oxidative Stress, Obesity. 2006; 14: 1118-1123.
23. Novellie LB, Dinij YS, Galhardi CM, Ebaid GMX, Rodrigues HG, Main f, Fernandes AAH, Cicogna AC, Novellifilho JLVB. Anthropometrical parameters and markers of obesity in rats. Lab. Animals. 2007; 41: 111-119.
24. Pang J, Choi Y, Park T. Ilex paraguariensis exart ameliorate obesity induced by high fat diet: potential rale of AMPK in the visceral adipose tissue. Arch Biochem Biophys. 2008; 476(2): 178-85.
25. Singh R, Singh AP, Singh M, Krishan P. Impact of obesity on hypertension-induced cardiac remodeling: role of oxidative stress and its modulation by gemfibrozil treatment in rats, Free Radical Biology and Medicine. 2011; 50(2): 363-370.
26. Rothwell NJ, Stock MJ. Effects of feeding a palatable 'cafeteria' diet on energy balance in young and adult lean (+/?) Zucker rats. Br. J. Nurr. 1982; 41: 461.
27. Mitra S, Singh M. Possible mechanism of captopril induced endothelium-dependent relaxation in isolated rabbit aorta Mol. Cell. Biochem. 1998; 183: 63-67.
28. Saiki R, Okazaki M, Iwai S, Kumai T, Kobayashi S, Oguchi K. Effect of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemia rats fed a high fat diet and sucrose solution. J Pharmacol Sci. 2007; 105: 157-67.
29. Sastry KVH, Moudgal RP, Mohan J, Tyagi JS, Tyagi GS. Spectophotometric determination of serum nitrite and nitrate by copper-cadmium alloy. Anal. Biochem. 2002; 306: 79-82
30. Sharma S, Singh M, Sharma PL Ameliorative effect of daidzein: A caveolin-1 inhibitor in vascular endothelium dysfunction induced by ovariectomy. Indian Journal of Experimental Biology. 2012; 50: 28-34.
31. Sowers, JR. Update on the cardiometabolic syndrome. Clin Cornerston. 2011; 4(2): 17-23.
32. Sun JJ, Kim HJ, Seo HG, Lee JH, Yun-Choi HS, Chang KC. YS 49, 1-(alpha- naphtyl methyl) -6,7-dihydroxy- 1, 2, 3, 4-tetrahydroisoquinoline, regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1.Life sciences. 2008; 82: 600-607.
33. Werner M, Gabrielson DG, Eastman J. Ultramicro determination of serum triglyceride by bioluminescent assay. Clin. Chem. 1981; 27: 268-271.