Why is CA3 more vulnerable than CA1 in experimental models of controlled cortical impact-induced brain injury?

Journal of Neurotrauma

Volumn 30, Issue 17, 2013, Pages 1521-1530

  Mao, Haojie ^a   Elkin, Benjamin S ^b   Genthikatti, Vinay V ^a   Morrison III, Barclay ^b   Yang, King H ^a  

^a Wayne State University   (United States)

^b Columbia University ^*  (United States)

Author keywords

Brain injury biomechanics; Brain material; Controlled cortical impact; Finite element method; Heterogeneous hippocampus injury; Rat brain modeling

Indexed keywords

VISCOELASTIC SUBSTANCE;

ANATOMICAL CONCEPTS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BRAIN CORTEX; BRAIN INJURY; BRAIN TISSUE; CELL DEATH; CELL LOSS; COMPUTER SIMULATION; CONTROLLED CORTICAL IMPACT; CONTROLLED STUDY; EXPERIMENTAL MODEL; FINITE ELEMENT ANALYSIS; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; IMAGING SOFTWARE; NERVOUS SYSTEM INJURY; NONHUMAN; RAT;

ANIMALS; BIOMECHANICAL PHENOMENA; BRAIN INJURIES; CA1 REGION, HIPPOCAMPAL; CA3 REGION, HIPPOCAMPAL; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; RATS;

EID: 84882602942     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2012.2520     Document Type: Article

References (28)

1. Kreisman, N.R., Soliman, S., and Gozal, D. (2000). Regional differences in hypoxic depolarization and swelling in hippocampal slices. J. Neurophysiol. 83, 1031-1038
2. Anderson, K.J., Miller, K.M., Fugaccia, I., and Scheff, S.W. (2005). Regional distribution of fluoro-jade B staining in the hippocampus following traumatic brain injury. Exp. Neurol. 193, 125-130
3. Colicos, M.A., Dixon, C.E., and Dash, P.K. (1996). Delayed, selective neuronal death following experimental cortical impact injury in rats: Possible role in memory deficits. Brain Res. 739, 111-119
4. Kim, B.T., Rao, V.L., Sailor, K.A., Bowen, K.K., and Dempsey, R.J. (2001). Protective effects of glial cell line-derived neurotrophic factor on hippocampal neurons after traumatic brain injury in rats. J. Neurosurg. 95, 674-679
5. Scheff, S.W., Price, D.A., Hicks, R.R., Baldwin, S.A., Robinson, S., and Brackney, C. (2005). Synaptogenesis in the hippocampal CA1 field following traumatic brain injury. J. Neurotrauma 22, 719-732
6. Varma, M.R., Dixon, C.E., Jackson, E.K., Peters, G.W., Melick, J.A., Griffith, R.P., Vagni, V.A., Clark, R.S., Jenkins, L.W., and Kochanek, P.M. (2002). Administration of adenosine receptor agonists or antagonists after controlled cortical impact in mice: Effects on function and histopathology. Brain Res. 951, 191-201
7. Witgen, B.M., Lifshitz, J., Smith, M.L. Schwarzbach, E., Liang, S.L., Grady, M.S., and Cohen, A.S. (2005). Regional hippocampal aliteration associated with cognitive deficit following experimental brain injury: A systems, network and cellular evaluation. Neuroscience 133, 1-15
8. Grady, M.S., Charleston, J.S., Maris, D., Witgen, B.M., and Lifshitz, J. (2003). Neuronal and glial cell number in the hippocampus after experimental traumatic brain injury: Analysis by stereological estimation. J. Neurotrauma 20, 929-941
9. Geddes, D.M., and Cargill, R.S., 2nd. (2001). An in vitro model of neural trauma: Device characterization and calcium response to mechanical stretch. J. Biomech. Eng. 123, 247-255
10. LaPlaca, M.C., Cullen, D.K., McLoughlin, J.J., and Cargill, R.S., 2nd. (2005). High rate shear strain of three-dimensional neural cell cultures: A new in vitro traumatic brain injury model. J. Biomech. 38, 1093-1105
11. Morrison, B., 3rd, Meaney, D.F., and McIntosh, T.K. (1998). Mechanical characterization of an in vitro device designed to quantitatively injure living brain tissue. Ann. Biomed. Eng. 26, 381-390
12. Elkin, B.S., and Morrison, B., 3rd. (2007). Region-specific tolerance criteria for the living brain. Stapp Car Crash J. 51, 127-138
13. Morrison, B., 3rd, Cater, H.L., Benham, C.D., and Sundstrom, L.E. (2006). An in vitro model of traumatic brain injury utilising twodimensional stretch of organotypic hippocampal slice cultures. J. Neurosci. Methods 150, 192-201
14. Morrison, B., 3rd, Cater, H.L., Wang, C.C., Thomas, F.C., Hung, C.T., Ateshian, G.A., and Sundstrom, L.E. (2003). A tissue level tolerance criterion for living brain developed with an in vitro model of traumatic mechanical loading. Stapp Car Crash J. 47, 93-105
15. Cater, H.L., Sundstrom, L.E., and Morrison, B., 3rd. (2006). Temporal development of hippocampal cell death is dependent on tissue strain but not strain rate. J. Biomech. 39, 2810-2818
16. Elkin, B.S., Ilankovan, A., andMorrison, B., 3rd. (2010). Age-dependent regional mechanical properties of the rat hippocampus and cortex. J. Biomech. Eng. 132, 011010
17. Elkin, B.S., Ilankovan, A.I., and Morrison, B., 3rd. (2011). A detailed viscoelastic characterization of the P17 and adult rat brain. Neurotrauma 28, 2235-2244
18. Elkin, B.S., Azeloglu, E.U., Costa, K.D., and Morrison, B., 3rd. (2007). Mechanical heterogeneity of the rat hippocampus measured by atomic force microscope indentation. J. Neurotrauma 24, 812-822
19. Baumgartner, D., Lamy, M., Willinger, R., and Davidsson, J. (2011). A finite element model of the rat brain for injury investigation. Comput. Methods Biomech. Biomed. Eng. 14, 273-274
20. Lamy, M., Baumgartner, D., Yoganandan, N., Stemper, B.D., and Willinger, R. (2013). Experimentally validated three-dimensional finite element model of the rat for mild traumatic brain injury. Med. Biol. Eng. Comput. 51, 353-365
21. Levchakov, A., Linder-Ganz, E., Raghupathi, R., Margulies, S.S., and Gefen, A. (2006). Computational studies of strain exposures in neonate and mature rat brains during closed head impact. J. Neurotrauma 23, 1570-1580
22. Mao, H., Zhang, L., Yang, K.H., and King, A.I. (2006). Application of a finite element model of the brain to study traumatic brain injury mechanisms in the rat. Stapp Car Crash J. 50, 583-600
23. Pleasant, J.M., Carlson, S.W., Mao, H., Scheff, S., Yang, K.H., and Saatman, K.E. (2011). Rate of neurodegeneration in the mouse controlled cortical impact model is influenced by impactor tip shape: Implications for mechanistic and therapeutic studies. J. Neurotrauma 28, 2245-2262
24. Shreiber, D.I., Bain, A.C., and Meaney, D.F. (1997). In vivo thresholds for mechanical injury to the blood-brain barrier. In 41th Stapp Car Crash Conference. Lake Buena Vista, FL. SAE paper no. 973335
25. Stemper, B.D., Baumgartner, D., Yoganandan, N., Lamy, M., and Willinger, R. (2011). Tissue-level stresses within the brain during rotationally-induced MTBI: A three-dimensional finite element modle of the rat coupled with experiments J. Neurotrauma 28, A-59
26. Yeoh, S., Mathur, V., and Monson, K.L. (2011). Vascular injury and cortical deformation in a model of brain contusion. Presented at ASME 2011 Summer Bioengineering Conference. ASME, Nemacolin Woodlands Resort, Famington, PA
27. Paxinos, G., and Watson, C. (2005). The Rat Brain in Stereotaxic Coordinates. Elsevier Academic Press: Tan Diego
28. Mao, H., Jin, X., Zhang, L., Yang, K.H., Igarashi, T., Noble-Haeusslein, L.J., and King, A.I. (2010). Finite element analysis of controlled cortical impact-induced cell loss. J. Neurotrauma 27, 877-888