Dual-Specificity Phosphatase 10 Controls Brown Adipocyte Differentiation by Modulating the Phosphorylation of P38 Mitogen-Activated Protein Kinase

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Choi, Hye Ryung ^a   Kim, Won Kon ^a   Kim, Eun Young ^a   Han, Baek Soo ^a,b   Min, Jeong Ki ^a,b   Chi, Seung Wook ^a   Park, Sung Goo ^a   Bae, Kwang Hee ^a,b   Lee, Sang Chul ^a,b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BIOLOGICAL MARKER; DUAL SPECIFICITY PHOSPHATASE; MITOCHONDRIAL DNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MUTANT PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN DUSP10; PROTEIN PRDM16; RNA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; DUSP10 PROTEIN, MOUSE; IMIDAZOLE DERIVATIVE; MESSENGER RNA; PYRIDINE DERIVATIVE;

ADIPOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; DNA CONTENT; DNA DETERMINATION; DOWN REGULATION; LIPID STORAGE; MOUSE; NONHUMAN; PROADIPOCYTE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; RNA INTERFERENCE; UPREGULATION; ANIMAL; BROWN ADIPOCYTE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; GENE SILENCING; GENETICS; METABOLISM; PHOSPHORYLATION;

ADIPOCYTES, BROWN; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DUAL-SPECIFICITY PHOSPHATASES; GENE KNOCKDOWN TECHNIQUES; IMIDAZOLES; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; RNA, MESSENGER; UP-REGULATION;

EID: 84882593558     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072340     Document Type: Article

References (39)

1. Bae K-H, Kim WK, Lee SC, (2012) Involvement of protein tyrosine phosphatases in adipogenesis: New anti-obesity targets?. BMB Rep 45: 700-706.
2. Rosen ED, Spiegelman BM, (2006) Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444: 847-853.
3. Fruhbeck G, Becerril S, Sáinz N, Garrastachu P, García-Velloso MJ, (2009) BAT: a new target for human obesity?. Trends Pharmacol Sci 8: 387-396.
4. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, et al. (2009) Identification and Importance of Brown Adipose Tissue in Adult Humans. N Eng J Med 360: 1509-1517.
5. Zingaretti MC, Crosta F, Vitali A, Guerrieri M, Frontini A, et al. (2009) The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J 23: 3113-3120.
6. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, et al. (2009) Functional brown adipose tissue in healthy adults. N Eng J Med 360: 1518-1525.
7. Zhang W, Liu HT, (2002) MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 12: 9-18.
8. Ichijo H, (1999) From receptors to stress-activated MAP kinases. Oncogene 18: 6087-6097.
9. Obata T, Brown GE, Yaffe MB, (2000) MAP kinase pathways activated by stress: the p38 MAPK pathway. Crit Care Med 28: 67-77.
10. Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, et al. (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 270: 7420-7426.
11. Engelman JA, Berg AH, Lewis RY, Lin A, Lisanti MP, et al. (1999) Constitutively active mitogen-activated protein kinase kinase 6 (MKK6) or salicylate induces spontaneous 3T3-L1 adipogenesis. J Biol Chem 274: 35630-35638.
12. Engelman JA, Lisanti MP, Scherer PE, (1998) Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis. J Biol Chem 273: 32111-32120.
13. Hata K, Nishimura R, Ikeda F, Yamashita K, Matsubara T, et al. (2003) Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis. Mol Biol Cell 14: 545-555.
14. Tseng Y-H, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, et al. (2008) New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454: 1000-1004.
15. Bordicchia M, Liu D, Amri EZ, Ailhaud G, Dessì-Fulgheri P, et al. (2012) Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J Clin Invest 122: 1022-1036.
16. Mustelin T, Abraham RT, Rudd CE, Alonso A, Merlo JJ, (2002) Protein tyrosine phosphorylation in T cell signaling. Front Biosci 7: 918-969.
17. Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, et al. (2004) Protein tyrosine phosphatases in the human genome. Cell 117: 699-711.
18. Mustelin T, Taskén K, (2003) Positive and negative regulation of T-cell activation through kinases and phosphatases. Biochem J 371: 15-27.
19. Kim WK, Jung H, Kim DH, Kim EY, Chung JW, et al. (2009) Regulation of adipogenic differentiation by LAR tyrosine phosphatase in human mesenchymal stem cells and 3T3-L1 preadipocytes. J Cell Sci 122: 4160-4167.
20. Kim WK, Jung H, Kim EY, Kim DH, Cho YS, et al. (2011) RPTPμ tyrosine phosphatase promotes adipogenic differentiation via modulation of p120 catenin phosphorylation. Mol Biol Cell 22: 4883-4891.
21. Jung H, Kim WK, Kim DH, Cho YS, Kim SJ, et al. (2009) Involvement of PTP-RQ in differentiation during adipogenesis of human mesenchymal stem cells. Biochem Biophys Res Comm 383: 252-257.
22. Uehara T, Suzuki K, Yamanaka H, Kizaki T, Sakurai T, et al. (2007) SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells. Int J Mol Med 19: 895-900.
23. Glondu-Lassis M, Dromard M, Chavey C, Puech C, Fajas L, et al. (2009) Downregulation of protein tyrosine phosphatase PTP-BL repress adipogenesis. Int J Biochem Cell Biol 41: 2173-2180.
24. Choi H-R, Kim WK, Kim EY, Jung H, Kim J-H, et al. (2012) Protein tyrosine phosphatase profiling analysis of HIB-1B cells during brown adipogenesis. J Microbiol Biotechnol 22: 1029-1033.
25. Klein J, Fasshauer M, Ito M, Lowell BB, Benito M, et al. (1999) β(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes. J Biol Chem 274: 34795-34802.
26. Kim WK, Choi H-R, Park SG, Ko Y, Bae K-H, et al. (2012) Myostatin inhibits brown adipocyte differentiation via regulation of Smad3-mediated β-catenin stabilization. Int J Biochem Cell Biol 44: 327-334.
27. Tseng YH, Kriauciunas KM, Kokkotou E, Kahn CR, (2004) Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol Cell Biol 24: 1918-1929.
28. Tonoue T, Moriguchi T, Nishida E, (1999) Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. J Biol Chem 274: 19949-199456.
29. Kim EY, Kim WK, Kang HJ, Kim J-H, Chung SJ, et al. (2012) Acetylation of malate dehydrogenase 1 promotes adipogenic differentiation via activating its enzymatic activity. J Lipid Res 53: 1864-1876.
30. Jang M, Park BC, Kang S, Chi S-W, Cho S, et al. (2009) Far upstream element-binding protein-1, a novel caspase substrate, acts as a cross-talker between apoptosis and the c-myc oncogene. Oncogene 28: 1529-1536.
31. Kim WK, Cho HJ, Ryu SI, Hwang H-R, Kim D-H, et al. (2008) Comparative proteomic analysis of peripheral blood mononuclear cells from atopic dermatitis patients and healthy donors. BMB Rep 41: 597-603.
32. Seal P, Kajimura S, Yang W, Chin S, Rohas LM, et al. (2007) Transcriptional control of brown fat determination by PRDM16. Cell Metab 6: 38-54.
33. Mori H, Prestwich TC, Reid MA, Longo KA, Gerin I, et al. (2012) Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition. J Clin Invest 122: 2405-2416.
34. Choi H-R, Kim WK, Park A, Jung H, Han BS, et al. (2013) Protein tyrosine phosphatase profiling studies during brown adipogenc differentiation of mouse primary brown preadipocytes. BMB Rep in press.
35. Owens DM, Keyse SM, (2007) Differential regulation of MAP kinase signaling by dual-specificity protein phosphatases. Oncogene 26: 3203-3213.
36. Rosen ED, MacDougald OA, (2006) Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7: 885-896.
37. Vila-Bedmar R, Lorenzo M, Fernández-Veledo S, (2010) Adenosine 5′-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte differentiation. Endocrinology 151: 980-992.
38. Bermudez O, Pages G, Gimond C, (2010) The dual-specificity MAP kinase phosphatases: critical roles in development and cancer. Am J Physiol Cell Physiol 299: C189-C202.
39. Bost F, Aouadi M, Binetruy CB, (2005) The role of MAPKs in adipocyte differentiation and obesity. Biochimie 87: 51-56.