The interdependence of antibody C and V regions on specificity and affinity: Significant implications for the engineering of therapeutic antibodies

Virulence

Volumn 4, Issue 6, 2013, Pages

  Nosanchuk, Joshua D ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Antibody; Bacillus anthracis; C region; Isotope; Therapeutics; V region

Indexed keywords

IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3 ANTIBODY; POLYGLUTAMIC ACID; TUBULIN; ANTIBODY; IMMUNOGLOBULIN CONSTANT REGION; IMMUNOGLOBULIN VARIABLE REGION;

ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; BACILLUS ANTHRACIS; CRYPTOCOCCUS NEOFORMANS; EDITORIAL; HUMAN; IMMUNOGLOBULIN CONSTANT REGION; IMMUNOGLOBULIN VARIABLE REGION; NONHUMAN; ANIMAL; CHEMISTRY; DRUG THERAPY; GENETICS; IMMUNOLOGY; MOUSE; PROTEIN ENGINEERING; THERAPEUTIC USE;

BACILLUS ANTHRACIS;

ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; DRUG THERAPY; HUMANS; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN VARIABLE REGION; MICE; PROTEIN ENGINEERING;

EID: 84882585371     PISSN: 21505594     EISSN: 21505608     Source Type: Journal    
DOI: 10.4161/viru.26153     Document Type: Editorial

References (23)

1. Ehrlich P. Experimentelle Untersuchungen uber Immunitat. II. Ueber Abrin. Dtsch Med Wochenschr 1891; 17:1218-9; http://dx.doi. org/10.1055/s-0029-1206825
2. Porter RR. The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. Biochem J 1959; 73:119-26; PMID:14434282
3. Kato K, Matsunaga C, Odaka A, Yamato S, Takaha W, Shimada I, Arata Y. Carbon-13 NMR study of switch variant anti-dansyl antibodies: antigen binding and domain-domain interactions. Biochemistry 1991; 30:6604-10; PMID:2054358; http://dx.doi. org/10.1021/bi00240a033
4. Cooper LJ, Shikhman AR, Glass DD, Kangisser D, Cunningham MW, Greenspan NS. Role of heavy chain constant domains in antibody-antigen interaction. Apparent specificity differences among streptococcal IgG antibodies expressing identical variable domains. J Immunol 1993; 150:2231-42; PMID:7680687
5. Michaelsen TE, Ihle O, Beckstrøm KJ, Herstad TK, Sandin RH, Kolberg J, Aase A. Binding properties and anti-bacterial activities of V-region identical, human IgG and IgM antibodies, against group B Neisseria meningitidis. Biochem Soc Trans 2003; 31:1032-5; PMID:14505474; http://dx.doi.org/10.1042/ BST0311032
6. Torosantucci A, Chiani P, Bromuro C, De Bernardis F, Palma AS, Liu Y, Mignogna G, Maras B, Colone M, Stringaro A, et al. Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence. PLoS One 2009; 4:e5392; PMID:19399183; http://dx.doi.org/10.1371/journal. pone.0005392
7. Tudor D, Yu H, Maupetit J, Drillet AS, Bouceba T, Schwartz-Cornil I, Lopalco L, Tuffery P, Bomsel M. Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody. Proc Natl Acad Sci U S A 2012; 109:12680-5; PMID:22723360; http://dx.doi. org/10.1073/pnas.1200024109
8. Pritsch O, Magnac C, Dumas G, Bouvet JP, Alzari P, Dighiero G. Can isotype switch modulate antigen-binding affinity and influence clonal selection? Eur J Immunol 2000; 30:3387-95; PMID:11093156; http://dx.doi. org/10.1002/1521-4141(2000012)30:123387::AIDIMMU3387 3.0.CO;2-K
9. Dam TK, Torres M, Brewer CF, Casadevall A. Isothermal titration calorimetry reveals differential binding thermodynamics of variable region-identical antibodies differing in constant region for a univalent ligand. J Biol Chem 2008; 283:31366-70; PMID:18806257; http://dx.doi.org/10.1074/jbc. M806473200
10. Eryilmaz E, Janda A, Kim J, Cordero RJ, Cowburn D, Casadevall A. Global structures of IgG isotypes expressing identical variable regions. Mol Immunol 2013; 56:588-98; PMID:23911417; http://dx.doi. org/10.1016/j.molimm.2013.06.006
11. McLean GR, Torres M, Elguezabal N, Nakouzi A, Casadevall A. Isotype can affect the fine specificity of an antibody for a polysaccharide antigen. J Immunol 2002; 169:1379-86; PMID:12133962
12. Torres M, Fernández-Fuentes N, Fiser A, Casadevall A. The immunoglobulin heavy chain constant region affects kinetic and thermodynamic parameters of antibody variable region interactions with antigen. J Biol Chem 2007; 282:13917-27; PMID:17353196; http:// dx.doi.org/10.1074/jbc.M700661200
13. Torres M, Fernandez-Fuentes N, Fiser A, Casadevall A. Exchanging murine and human immunoglobulin constant chains affects the kinetics and thermodynamics of antigen binding and chimeric antibody autoreactivity. PLoS One 2007; 2:e1310; PMID:18074033; http:// dx.doi.org/10.1371/journal.pone.0001310
14. Torres M, May R, Scharff MD, Casadevall A. Variableregion-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype. J Immunol 2005; 174:2132-42; PMID:15699144
15. Janda A, Eryilmaz E, Nakouzi A, Cowburn D, Casadevall A. Variable region identical immunoglobulins differing in isotype express different paratopes. J Biol Chem 2012; 287:35409-17; PMID:22930758; http://dx.doi.org/10.1074/jbc.M112.404483
16. Correa A, Trajtenberg F, Obal G, Pritsch O, Dighiero G, Oppezzo P, Buschiazzo A. Structure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulation. Acta Crystallogr D Biol Crystallogr 2013; 69:388-97; PMID:23519414; http://dx.doi.org/10.1107/ S0907444912048664
17. Xia Y, Janda A, Eryilmaz E, Casadevall A, Putterman C. The constant region affects antigen binding of antibodies to DNA by altering secondary structure. Mol Immunol 2013; 56:28-37; PMID:23665381; http:// dx.doi.org/10.1016/j.molimm.2013.04.004
18. Xia Y, Pawar RD, Nakouzi AS, Herlitz L, Broder A, Liu K, Goilav B, Fan M, Wang L, Li QZ, et al. The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies. J Autoimmun 2012; 39:398-411; PMID:22841793; http://dx.doi.org/10.1016/j.jaut.2012.06.005
19. Hubbard MA, Thorkildson P, Kozel TR, Aucoin DP. Constant domains influence binding of mousehuman chimeric antibodies to the capsular polypeptide of Bacillus anthracis. Virulence 2013; 4: (In this issue); PMID:23863605; http://dx.doi.org/10.4161/ viru.25711
20. Hovenden M, Hubbard MA, Aucoin DP, Thorkildson P, Reed DE, Welch WH, Lyons CR, Lovchik JA, Kozel TR. IgG subclass and heavy chain domains contribute to binding and protection by mAbs to the poly g-Dglutamic acid capsular antigen of Bacillus anthracis. PLoS Pathog 2013; 9:e1003306; PMID:23637599; http://dx.doi.org/10.1371/journal.ppat.1003306
21. Kozel TR, Murphy WJ, Brandt S, Blazar BR, Lovchik JA, Thorkildson P, Percival A, Lyons CR. mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemia. Proc Natl Acad Sci U S A 2004; 101:5042-7; PMID:15051894; http://dx.doi.org/10.1073/pnas.0401351101
22. McCloskey N, Turner MW, Steffner P, Owens R, Goldblatt D. Human constant regions influence the antibody binding characteristics of mousehuman chimeric IgG subclasses. Immunology 1996; 88:169-73; PMID:8690447; http://dx.doi. org/10.1111/j.1365-2567.1996.tb00001.x
23. Beenhouwer DO, Yoo EM, Lai CW, Rocha MA, Morrison SL. Human immunoglobulin G2 (IgG2) and IgG4, but not IgG1 or IgG3, protect mice against Cryptococcus neoformans infection. Infect Immun 2007; 75:1424-35; PMID:17220317; http://dx.doi. org/10.1128/IAI.01161-06