A novel chemopreventive mechanism of selenomethionine: Enhancement of APE1 enzyme activity via a Gadd45a, PCNA and APE1 protein complex that regulates p53-mediated base excision repair

Oncology Reports

Volumn 30, Issue 4, 2013, Pages 1581-1586

  Jung, Hwa Jin ^a   Kim, Hye Lim ^b   Kim, Yeo Jin ^b   Weon, Jong Il ^c   Seo, Young Rok ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Dongguk University   (South Korea)

^c Dongguk University   (South Korea)

Author keywords

APE1 Ref 1; Base excision repair; Growth arrest and DNA damage inducible protein 45A; Proliferating cell nuclear antigen; Selenomethionine

Indexed keywords

CYCLINE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45A; PROTEIN P53; REDOX EFFECTOR FACTOR 1; SELENOMETHIONINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER PREVENTION; COLON CANCER; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; EXCISION REPAIR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION;

CELL CYCLE PROTEINS; CELL LINE, TUMOR; CHEMOPREVENTION; COLONIC NEOPLASMS; DNA DAMAGE; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ENZYME ACTIVATION; HUMANS; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; OXIDATIVE STRESS; PROLIFERATING CELL NUCLEAR ANTIGEN; RNA INTERFERENCE; RNA, SMALL INTERFERING; SELENOMETHIONINE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84882583476     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2613     Document Type: Article

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