A published pharmacogenetic algorithm was poorly predictive of tacrolimus clearance in an independent cohort of renal transplant recipients

British Journal of Clinical Pharmacology

Volumn 76, Issue 3, 2013, Pages 425-431

  Boughton, Oliver ^a   Borgulya, Gabor ^a   Cecconi, Maurizio ^a   Fredericks, Salim ^b   Moreton Clack, Michelle ^a   Macphee, Iain A M ^a  

^a ST GEORGE S HOSPITAL   (United Kingdom)

^b UNIVERSITI BRUNEI DARUSSALAM   (Brunei Darussalam)

Author keywords

Dosing algorithm; Immunosuppression; Pharmacogenetics; Renal transplant; Tacrolimus

Indexed keywords

AZATHIOPRINE; CALCIUM CHANNEL BLOCKING AGENT; CYTOCHROME P450 3A5; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; TACROLIMUS;

ADOLESCENT; ADULT; AGED; ALGORITHM; ARTICLE; DRUG BLOOD LEVEL; DRUG CLEARANCE; FEMALE; GENOTYPE; GRAFT RECIPIENT; HUMAN; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRIORITY JOURNAL; SYSTEMATIC ERROR;

DOSING ALGORITHM; IMMUNOSUPPRESSION; PHARMACOGENETICS; RENAL TRANSPLANT; TACROLIMUS;

ADOLESCENT; ADULT; AGED; ALGORITHMS; COHORT STUDIES; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENOTYPE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; PHARMACOGENETICS; PREDICTIVE VALUE OF TESTS; TACROLIMUS; YOUNG ADULT;

EID: 84882570315     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/bcp.12076     Document Type: Article

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