Design of the SHAPE-2 study: The Effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk

BMC Cancer

Volumn 13, Issue , 2013, Pages

  van Gemert, Willemijn A M ^a   Iestra, Jolein I ^a   Schuit, Albertine J ^b,c   May, Anne M ^a   Takken, Tim ^d,e   Veldhuis, Wouter B ^a   van der Palen, Job ^f,g   Wittink, Harriët ^h   Peeters, Petra H M ^a   Monninkhof, Evelyn M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f MEDISCH SPECTRUM TWENTE   (Netherlands)

^g UNIVERSITY OF TWENTE   (Netherlands)

^h UNIVERSITY OF APPLIED SCIENCES UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; ESTRADIOL; ESTRONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AGED; ARTICLE; BLOOD LEVEL; BLOOD PRESSURE MEASUREMENT; BLOOD SAMPLING; BODY COMPOSITION; BODY HEIGHT; BODY MASS; BREAST CANCER; CALORIC RESTRICTION; CANCER RISK; CONTROLLED STUDY; DIETARY INTAKE; DISEASE ASSOCIATION; ENDURANCE TRAINING; EXERCISE TEST; EXPERIMENTAL DESIGN; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OBESITY; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK FACTOR; WAIST HIP RATIO; WEIGHT REDUCTION; BREAST NEOPLASMS; CASE CONTROL STUDY; CLINICAL TRIAL; COMPARATIVE STUDY; EXERCISE; FOLLOW UP; INTERVENTION STUDY; LIFESTYLE; LOW CALORY DIET; MIDDLE AGED; PROGNOSIS;

AGED; BIOLOGICAL MARKERS; BREAST NEOPLASMS; CASE-CONTROL STUDIES; DIET, REDUCING; EXERCISE; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERVENTION STUDIES; LIFE STYLE; MIDDLE AGED; OBESITY; OVERWEIGHT; POSTMENOPAUSE; PROGNOSIS; RISK FACTORS; WEIGHT LOSS;

EID: 84882527736     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-395     Document Type: Article

References (56)

1. World Cancer Research Fund, American Institute for Cancer Research Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective 2007, Washington DC: AICR, World Cancer Research Fund, American Institute for Cancer Research.
2. Monninkhof EM, Elias SG, Vlems FA, van der Tweel I, Schuit AJ, Voskuil DW, van Leeuwen FE. Physical activity and breast cancer: a systematic review. Epidemiology 2007, 18:137-157. 10.1097/01.ede.0000251167.75581.98, 17130685.
3. Campbell KL, McTiernan A. Exercise and biomarkers for cancer prevention studies. J Nutr 2007, 137:161S-169S.
4. Hankinson SE, Eliassen AH. Endogenous estrogen, testosterone and progesterone levels in relation to breast cancer risk. J Steroid Biochem Mol Biol 2007, 106:24-30. 10.1016/j.jsbmb.2007.05.012, 2715949, 17719770.
5. Kaaks R, Rinaldi S, Key TJ, Berrino F, Peeters PH, Biessy C, Dossus L, Lukanova A, Bingham S, Khaw KT, et al. Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition. Endocr Relat Cancer 2005, 12:1071-1082. 10.1677/erc.1.01038, 16322344.
6. Key T, Appleby P, Barnes I, Reeves G. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002, 94:606-616. 10.1093/jnci/94.8.606, 11959894.
7. Tamimi RM, Byrne C, Colditz GA, Hankinson SE. Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal women. J Natl Cancer Inst 2007, 99:1178-1187. 10.1093/jnci/djm062, 17652278.
8. Nelson ME, Meredith CN, Dawson-Hughes B, Evans WJ. Hormone and bone mineral status in endurance-trained and sedentary postmenopausal women. J Clin Endocrinol Metab 1988, 66:927-933. 10.1210/jcem-66-5-927, 3360900.
9. McTiernan A, Wu L, Chen C, Chlebowski R, Mossavar-Rahmani Y, Modugno F, Perri MG, Stanczyk FZ, Van HL, Wang CY. Relation of BMI and physical activity to sex hormones in postmenopausal women. Obesity (Silver Spring) 2006, 14:1662-1677.
10. Cauley JA, Gutai JP, Kuller LH, LeDonne D, Powell JG. The epidemiology of serum sex hormones in postmenopausal women. Am J Epidemiol 1989, 129:1120-1131.
11. Chan MF, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, Welch A, Khaw KT. Usual physical activity and endogenous sex hormones in postmenopausal women: the European prospective investigation into cancer-norfolk population study. Cancer Epidemiol Biomarkers Prev 2007, 16:900-905. 10.1158/1055-9965.EPI-06-0745, 17507613.
12. Schmitz KH, Lin H, Sammel MD, Gracia CR, Nelson DB, Kapoor S, DeBlasis TL, Freeman EW. Association of physical activity with reproductive hormones: the Penn ovarian aging study. Cancer Epidemiol Biomarkers Prev 2007, 16:2042-2047. 10.1158/1055-9965.EPI-07-0061, 17905944.
13. Madigan MP, Troisi R, Potischman N, Dorgan JF, Brinton LA, Hoover RN. Serum hormone levels in relation to reproductive and lifestyle factors in postmenopausal women (United States). Cancer Causes Control 1998, 9:199-207. 10.1023/A:1008838412423, 9578297.
14. Van Gils CH, Peeters PH, Schoenmakers MC, Nijmeijer RM, Onland-Moret NC, van der Schouw YT, Monninkhof EM. Physical activity and endogenous sex hormone levels in postmenopausal women: a cross-sectional study in the prospect-EPIC cohort. Cancer Epidemiol Biomarkers Prev 2009, 18:377-383. 10.1158/1055-9965.EPI-08-0823, 19190137.
15. Bjornerem A, Straume B, Midtby M, Fonnebo V, Sundsfjord J, Svartberg J, Acharya G, Oian P, Berntsen GK. Endogenous sex hormones in relation to age, sex, lifestyle factors, and chronic diseases in a general population: the tromso study. J Clin Endocrinol Metab 2004, 89:6039-6047. 10.1210/jc.2004-0735, 15579756.
16. Verkasalo PK, Thomas HV, Appleby PN, Davey GK, Key TJ. Circulating levels of sex hormones and their relation to risk factors for breast cancer: a cross-sectional study in 1092 pre- and postmenopausal women (United Kingdom). Cancer Causes Control 2001, 12:47-59. 10.1023/A:1008929714862, 11227925.
17. Wu F, Ames R, Evans MC, France JT, Reid IR. Determinants of sex hormone-binding globulin in normal postmenopausal women. Clin Endocrinol (Oxf) 2001, 54:81-87.
18. Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 2008, 371:569-578. 10.1016/S0140-6736(08)60269-X, 18280327.
19. Bezemer ID, Rinaldi S, Dossus L, Gils CH, Peeters PH, Noord PA, Bueno-de-Mesquita HB, Johnsen SP, Overvad K, Olsen A, et al. C-peptide, IGF-I, sex-steroid hormones and adiposity: a cross-sectional study in healthy women within the European prospective investigation into cancer and nutrition (EPIC). Cancer Causes Control 2005, 16:561-572. 10.1007/s10552-004-7472-9, 15986111.
20. Kaye SA, Folsom AR, Soler JT, Prineas RJ, Potter JD. Associations of body mass and fat distribution with sex hormone concentrations in postmenopausal women. Int J Epidemiol 1991, 20:151-156. 10.1093/ije/20.1.151, 2066214.
21. Newcomb PA, Klein R, Klein BE, Haffner S, Mares-Perlman J, Cruickshanks KJ, Marcus PM. Association of dietary and life-style factors with sex hormones in postmenopausal women. Epidemiology 1995, 6:318-321. 10.1097/00001648-199505000-00022, 7619943.
22. Monninkhof EM, Velthuis MJ, Peeters PH, Twisk JW, Schuit AJ. Effect of exercise on postmenopausal sex hormone levels and role of body fat: a randomized controlled trial. J Clin Oncol 2009, 27:4492-4499. 10.1200/JCO.2008.19.7459, 19687339.
23. McTiernan A, Tworoger SS, Ulrich CM, Yasui Y, Irwin ML, Rajan KB, Sorensen B, Rudolph RE, Bowen D, Stanczyk FZ, et al. Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial. Cancer Res 2004, 64:2923-2928. 10.1158/0008-5472.CAN-03-3393, 15087413.
24. McTiernan A, Tworoger SS, Rajan KB, Yasui Y, Sorenson B, Ulrich CM, Chubak J, Stanczyk FZ, Bowen D, Irwin ML, et al. Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical trial. Cancer Epidemiol Biomarkers Prev 2004, 13:1099-1105.
25. Friedenreich CM, Woolcott CG, McTiernan A, Ballard-Barbash R, Brant RF, Stanczyk FZ, Terry T, Boyd NF, Yaffe MJ, Irwin ML, et al. Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. J Clin Oncol 2010, 28:1458-1466. 10.1200/JCO.2009.24.9557, 2849767, 20159820.
26. Campbell KL, Foster-Schubert KE, Alfano CM, Wang CC, Wang CY, Duggan CR, Mason C, Imayama I, Kong A, Xiao L, et al. Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial. J Clin Oncol 2012, 30:2314-2326. 10.1200/JCO.2011.37.9792, 3675691, 22614972.
27. Ainsworth BE, Haskell WL, Herrmann SD, Meckes N, Bassett DR, Tudor-Locke C, Greer JL, Vezina J, Whitt-Glover MC, Leon AS. Compendium of physical activities: a second update of codes and MET values. Med Sci Sports Exerc 2011, 2011(43):1575-1581.
28. Health Council of the Netherlands Guidelines for a healthy diet 2006 2006, Health Council of the Netherlands: The Hague, publication no. 2006/21E, Health Council of the Netherlands.
29. Roza AM, Shizgal HM. The Harris Benedict equation reevaluated: resting energy requirements and the body cell mass. Am J Clin Nutr 1984, 40:168-182.
30. Onland-Moret NC, Peeters PH, van der Schouw YT, Grobbee DE, Van Gils CH. Alcohol and endogenous sex steroid levels in postmenopausal women: a cross-sectional study. J Clin Endocrinol Metab 2005, 90:1414-1419.
31. Rinaldi S, Peeters PH, Bezemer ID, Dossus L, Biessy C, Sacerdote C, Berrino F, Panico S, Palli D, Tumino R, et al. Relationship of alcohol intake and sex steroid concentrations in blood in pre- and post-menopausal women: the European prospective investigation into cancer and nutrition. Cancer Causes Control 2006, 17:1033-1043. 10.1007/s10552-006-0041-7, 16933054.
32. Wayne SJ, Neuhouser ML, Ulrich CM, Koprowski C, Baumgartner KB, Baumgartner RN, McTiernan A, Bernstein L, Ballard-Barbash R. Dietary fiber is associated with serum sex hormones and insulin-related peptides in postmenopausal breast cancer survivors. Breast Cancer Res Treat 2008, 112:149-158. 10.1007/s10549-007-9834-y, 18058020.
33. Armstrong MJ, Mottershead TA, Ronksley PE, Sigal RJ, Campbell TS, Hemmelgarn BR. Motivational interviewing to improve weight loss in overweight and/or obese patients: a systematic review and meta-analysis of randomized controlled trials. Obes Rev 2011, 12:709-723.
34. Miller WR, Rollnick S. Motivational interviewing: helping people change 2012, New York: Guilford Press.
35. Shaw K, O'Rourke P, Del MC, Kenardy J. Psychological interventions for overweight or obesity. Cochrane Database Syst Rev 2005, 2:CD003818.
36. Foster-Schubert KE, Alfano CM, Duggan CR, Xiao L, Campbell KL, Kong A, Bain CE, Wang CY, Blackburn GL, McTiernan A. Effect of diet and exercise, alone or combined, on weight and body composition in overweight-to-obese postmenopausal women. Obesity (Silver Spring) 2012, 20:1628-1638.
37. Velthuis MJ, Schuit AJ, Peeters PH, Monninkhof EM. Exercise program affects body composition but not weight in postmenopausal women. Menopause 2009, 16:777-784. 10.1097/GME.0b013e318197122a, 19188848.
38. King NA, Caudwell P, Hopkins M, Byrne NM, Colley R, Hills AP, Stubbs JR, Blundell JE. Metabolic and behavioral compensatory responses to exercise interventions: barriers to weight loss. Obesity (Silver Spring) 2007, 15:1373-1383.
39. Blundell JE, Stubbs RJ, Hughes DA, Whybrow S, King NA. Cross talk between physical activity and appetite control: does physical activity stimulate appetite?. Proc Nutr Soc 2003, 62:651-661. 10.1079/PNS2003286, 14692601.
40. Byrne NM, Hills AP, Hunter GR, Weinsier RL, Schutz Y. Metabolic equivalent: one size does not fit all. J Appl Physiol 2005, 99:1112-1119. 10.1152/japplphysiol.00023.2004, 15831804.
41. Kozey S, Lyden K, Staudenmayer J, Freedson P. Errors in MET estimates of physical activities using 3.5 ml x kg(-1) x min(-1) as the baseline oxygen consumption. J Phys Act Health 2010, 7:508-516.
42. Kohrt WM, Spina RJ, Holloszy JO, Ehsani AA. Prescribing exercise intensity for older women. J Am Geriatr Soc 1998, 46:129-133.
43. Tworoger SS, Yasui Y, Chang L, Stanczyk FZ, McTiernan A. Specimen allocation in longitudinal biomarker studies: controlling subject-specific effects by design. Cancer Epidemiol Biomarkers Prev 2004, 13:1257-1260.
44. Haring R, Hannemann A, John U, Radke D, Nauck M, Wallaschofski H, Owen L, Adaway J, Keevil BG, Brabant G. Age-specific reference ranges for serum testosterone and androstenedione concentrations in women measured by liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metab 2012, 97:408-415. 10.1210/jc.2011-2134, 22162468.
45. Stichting Huisartsenlaboratorium Oost http://www.labsho.nl.
46. Dixon WT. Simple proton spectroscopic imaging. Radiology 1984, 153:189-194.
47. American Thoracic Society American College of Chest Physicians. ATS/ACCP Statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med 2003, 167:211-277. American Thoracic Society.
48. Wendel-Vos GC, Schuit AJ, Saris WH, Kromhout D. Reproducibility and relative validity of the short questionnaire to assess health-enhancing physical activity. J Clin Epidemiol 2003, 56:1163-1169. 10.1016/S0895-4356(03)00220-8, 14680666.
49. Schuit AJ, Schouten EG, Westerterp KR, Saris WH. Validity of the physical activity scale for the elderly (PASE): according to energy expenditure assessed by the doubly labeled water method. J Clin Epidemiol 1997, 50:541-546. 10.1016/S0895-4356(97)00010-3, 9180646.
50. Dutch Food Composition Database 2011, NEVO online version 2011/3.0, RIVM, Bilthoven. http://nevo-online.rivm.nl/.
51. Dansinger ML, Tatsioni A, Wong JB, Chung M, Balk EM. Meta-analysis: the effect of dietary counseling for weight loss. Ann Intern Med 2007, 147:41-50. 10.7326/0003-4819-147-1-200707030-00007, 17606960.
52. Ashford S, Edmunds J, French DP. What is the best way to change self-efficacy to promote lifestyle and recreational physical activity? a systematic review with meta-analysis. Br J Health Psychol 2010, 15:265-288. 10.1348/135910709X461752, 19586583.
53. Renjilian DA, Perri MG, Nezu AM, McKelvey WF, Shermer RL, Anton SD. Individual versus group therapy for obesity: effects of matching participants to their treatment preferences. J Consult Clin Psychol 2001, 69:717-721.
54. Orme NM, Fletcher JG, Siddiki HA, Harmsen WS, O'Byrne MM, Port JD, Tremaine WJ, Pitot HC, McFarland EG, Robinson ME, et al. Incidental findings in imaging research: evaluating incidence, benefit, and burden. Arch Intern Med 2010, 170:1525-1532. 10.1001/archinternmed.2010.317, 3721142, 20876402.
55. Pinato DJ, Stavraka C, Tanner M, Esson A, Jacobson EW, Wilkins MR, Libri V. Clinical, ethical and financial implications of incidental imaging findings: experience from a phase I trial in healthy elderly volunteers. PLoS One 2012, 7:e49814. 10.1371/journal.pone.0049814, 3500322, 23166776.
56. Wolf SM, Lawrenz FP, Nelson CA, Kahn JP, Cho MK, Clayton EW, Fletcher JG, Georgieff MK, Hammerschmidt D, Hudson K, et al. Managing incidental findings in human subjects research: analysis and recommendations. J Law Med Ethics 2008, 36:219-248. 211, 10.1111/j.1748-720X.2008.00266.x, 2575242, 18547191.