An 8-week multicenter, parallel-group, double-blind, placebo-controlled study of sertraline in elderly outpatients with major depression

American Journal of Psychiatry

Volumn 160, Issue 7, 2003, Pages 1277-1285

  Schneider, Lon S ^a   Nelson, J Craig ^a   Clary, Cathryn M ^a   Newhouse, Paul ^a   Krishnan, K Ranga Rama ^a   Shiovitz, Thomas ^a   Weihs, Karen ^a  

^a KAM 400 ^*

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; SERTRALINE; SEROTONIN UPTAKE INHIBITOR;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG CYTOTOXICITY; DRUG TOLERABILITY; DRUG WITHDRAWAL; GERIATRIC PATIENT; HAMILTON SCALE; HUMAN; MAJOR DEPRESSION; MULTICENTER STUDY; OUTPATIENT CARE; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; RATING SCALE; SAMPLE SIZE; SCORING SYSTEM; AGE; FEMALE; HOSPITALIZATION; MALE; MIDDLE AGED; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

AGE FACTORS; AGED; AGED, 80 AND OVER; DEPRESSIVE DISORDER, MAJOR; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PLACEBOS; PSYCHIATRIC STATUS RATING SCALES; SEROTONIN UPTAKE INHIBITORS; SERTRALINE; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 0041475920     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.160.7.1277     Document Type: Article

References (35)

1. Diagnosis and treatment of depression in late life: the NIH Consensus Development Conference Statement. Psychopharmacol Bull 1993; 29:87-100
2. Lebowitz BD, Pearson JL, Schneider LS, Reynolds CF III, Alexopoulos GS, Bruce ML, Conwell Y, Katz IR, Meyers BS, Morrison MF, Mossey J, Niederehe G, Parmelee P: Diagnosis and treatment of depression in late life: consensus statement update. JAMA 1997; 278:1186-1190
3. Palsson S, Skoog I: The epidemiology of affective disorders in the elderly: a review. Int Clin Psychopharmacol 1997; 12(suppl 2):S3-S13
4. Steffens DC, Skoog I, Norton MC, Hart AD, Tschanz JT, Plassman BL, Wyse BW, Welsh-Bohmer KA, Breitner JC: Prevalence of depression and its treatment in an elderly population: the Cache County study. Arch Gen Psychiatry 2000; 57:601-607
5. Katona CLE: Depression in Old Age. New York, John Wiley & Sons, 1994
6. Blazer D, Swartz M, Woodbury M, Manton KG, Hughes D, George LK: Depressive symptoms and depressive diagnoses in a community population: use of a new procedure for analysis of psychiatric classification. Arch Gen Psychiatry 1988; 45:1078-1084
7. Beekman AT, Copeland JR, Prince MJ: Review of community prevalence of depression in later life. Br J Psychiatry 1999; 174:307-311
8. Callahan CM, Hui SL, Nieanaber NA, Musick BS, Tierney VVM: Longitudinal study of depression and health services use among elderly primary care patients. J Am Geriatr Soc 1994; 42:833-838
9. Henriksson MM, Marttunen MJ, Isometsa ET, Heikkinen ME, Aro HM, Kuoppasalmi KI, Lonnqvist JK: Mental disorders in elderly suicide. Int Psychogeriatr 1995; 7:275-286
10. Katz IR: On the inseparability of mental and physical health in aged persons: lessons from depression and medical comorbidity. Am J Geriatr Psychiatry 1996; 4:1-16
11. Conwell Y, Lyness JM, Duberstein P, Cox C, Seidlitz L, DiGiorgio A. Caine ED: Completed suicide among older patients in primary care practices: a controlled study. J Am Geriatr Soc 2000; 48:23-29
12. Newhouse PA: Use of serotonin selective reuptake inhibitors in geriatric depression. J Clin Psychiatry 1996; 57:12-22
13. Nelson JC, Kennedy JS, Pollock BG, Laghrissi-Thode F, Narayan M, Nobler MS, Robin DW, Gergel I, McCafferty J, Roose S: Treatment of major depression with nortriptyline and paroxetine in patients with ischemic heart disease. Am J Psychiatry 1999; 156:1024-1028
14. Bondareff W, Alpert M, Friedhoff AJ, Richter EM, Clary CM, Batzar E: Comparison of sertraline and nortriptyline in the treatment of major depressive disorder in late life. Am J Psychiatry 2000; 157:729-736
15. Kyle CJ, Petersen HE, Overo KF: Comparison of the tolerability and efficacy of citalopram and amitriptyline in elderly depressed patients treated in general practice. Depress Anxiety 1998; 8:147-153
16. Alatamura AC, De Novellis F, Guercetti G: Fluoxetine compared with amitriptyline in major depression: a controlled clinical trial. Int J Pharmacol Res 1989; 9:391-396
17. Feighner JP, Cohn JB: Double-blind comparative trials of fluoxetine and doxepin in geriatric patients with major depressive disorder. J Clin Psychiatry 1985; 46:20-25
18. Guillibert E, Pelicier Y, Archambault JC: A double-blind, multicenter study of paroxetine vs clomipramine in depressed elderly patients. Acta Psychiatr Scand Suppl 1989; 350:132-134
19. Newhouse PA, Krishnan KR, Doraiswamy PM, Richter EM, Batzer ED, Clary CM: A double-blind comparison of sertraline and fluoxetine in depressed elderly outpatients. J Clin Psychiatry 2000; 61:559-568
20. Cohn CK, Shrivastava R, Mendels J, Cohn JB, Fabre LF, Claghorn JL, Dessain EC, Itil TM, Lautin A: Double-blind, multicenter comparison of sertraline and amitriptyline in elderly depressed patients. J Clin Psychiatry 1990; 51(suppl B):28-33
21. Weihs KL, Settle E, Batey S, Batey SR, Houser TL, Donahue RMJ, Ascher JA: Comparison of the safety and efficacy of bupropion sustained release and paroxetine in elderly depressed outpatients. J Clin Psychiatry 2000; 61:196-202
22. Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23:56-62
23. Folstein MF, Folstein SE, McHugh PR: "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198
24. Guy W (ed): ECDEU Assessment Manual for Psychopharmacology: Publication ADM 76-338. Washington, DC, US Department of Health, Education, and Welfare, 1976, pp 218-222
25. Endicott J, Nee J, Harrison W, Blumenthal R: Quality of Life Enjoyment and Satisfaction Questionnaire: a new measure. Psychopharmacol Bull 1993; 29:321-326
26. Ware JE Jr, Sherbourne CD: The MOS 36-Item Short-Form Health Survey (SF-36), I: conceptual framework and item selection. Med Care 1992; 30:473-483
27. Tollefson GD, Bosomworth JC, Heiligenstein JH, Potvin JH, Holman S (Fluoxetine Collaborative Study Group): A double-blind, placebo-controlled clinical trial of fluoxetine in geriatric patients with major depression. Int Psychogeriatr 1995; 7:89-104
28. Hinrichsen GA, Hernandez NA: Factors associated with recovery from and relapse into major depressive disorder in the elderly. Am J Psychiatry 1993; 150:1820-1825
29. Dew MA, Reynolds CF III, Houck PR, Hall M, Buysse DJ, Frank E, Kupfer DJ: Temporal profiles of the course of depression during treatment: predictors of pathways toward recovery in the elderly. Arch Gen Psychiatry 1997; 54:1016-1024
30. Blennow K, Gottfries CG: Neurochemistry of aging, in Geriatric Psychopharmacology. Edited by Nelson JC. New York, Marcel Dekker, 1998, pp 1-25
31. Alexopoulos GS: Anxiety-depression syndromes in old age. Int J Geriatr Psychiatry 1990; 5:351-353
32. Parmelee PA, Katz IR, Lawton MP: Anxiety and its association with depression among institutionalized elderly. Am J Geriatr Psychiatry 1993; 1:46-58
33. Mulsant BH, Reynolds CF, Shear MK, Sweet RA, Miller M: Comorbid anxiety disorders in late-life depression. Anxiety 1996; 2:242-247
34. Palmer BW, Jeste DV, Sheikh JI: Anxiety disorders in the elderly: DSM-IV and other barriers to diagnosis and treatment. J Affect Disord 1997; 46:183-190
35. Mulsant BH, Pollock B: Treatment-resistant depression in late life. J Geriatr Psychiatry Neurol 1998; 11:186-193