Effect of haematocrit on fibrin-based clot firmness in the FIBTEM test

Blood Transfusion

Volumn 11, Issue 3, 2013, Pages 412-418

  Solomon, Cristina ^a   Rahe Meyer, Niels ^b,c   Schöchl, Herbert ^d,e   Ranucci, Marco ^f   Görlinger, Klaus ^g  

^a Salzburger Landeskliniken SALK ^*  (Austria)

^b FRANZISKUS HOSPITAL   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d AUVA Trauma Centre   (Austria)

^e LUDWIG BOLTZMANN INSTITUTE FOR EXPERIMENTAL AND CLINICAL TRAUMATOLOGY   (Austria)

^f IRCCS POLICLINICO SAN DONATO   (Italy)

^g UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Cardiac surgery; Fibrinogen; FIBTEM; Haematocrit; Thromboelastometry

Indexed keywords

FIBRIN; FIBRINOGEN; PROTAMINE;

ADULT; AGED; ARTICLE; BLOOD CLOT; CARDIOPULMONARY BYPASS; CORRELATION COEFFICIENT; FEMALE; FIBRINOGEN BLOOD LEVEL; HEMATOCRIT; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL DEVICE; POINT OF CARE TESTING; PREOPERATIVE EVALUATION; SURGICAL PATIENT; THROMBOELASTOGRAPHY; THROMBOELASTOMETRY; BLOOD CLOTTING; BLOOD CLOTTING TEST; CLINICAL TRIAL; DEVICES; METABOLISM; PROCEDURES;

BLOOD COAGULATION; BLOOD COAGULATION TESTS; FEMALE; FIBRIN; FIBRINOGEN; HEMATOCRIT; HUMANS; MALE;

EID: 84882329168     PISSN: 17232007     EISSN: None     Source Type: Journal    
DOI: 10.2450/2012.0043-12     Document Type: Article

References (33)

1. Ogawa S, Szlam F, Chen EP, et al. A comparative evaluation of rotation thromboelastometry and standard coagulation tests in hemodilution-induced coagulation changes after cardiac surgery. Transfusion 2012; 52: 14-22.
2. Girdauskas E, Kempfert J, Kuntze T, e t a l . Thromboelastometrically guided transfusion protocol during aortic surgery with circulatory arrest: a prospective, randomized trial. J Thorac Cardiovasc Surg 2010; 140: 1117-24.
3. Rahe-Meyer N, Solomon C, Winterhalter M, et al. Thromboelastometry-guided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdominal aortic aneurysm surgery. J Thorac Cardiovasc Surg 2009; 138: 694-702.
4. Rahe-Meyer N, Pichlmaier M, Haverich A, et al. Bleeding management with fibrinogen concentrate targeting a highnormal plasma fibrinogen level: a pilot study. Br J Anaesth 2009; 102: 785-92.
5. Görlinger K, Dirkmann D, Hanke AA, et al. First-line therapy with coagulation factor concentrates combined with pointof- care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study. Anesthesiology 2011; 115: 1179-91.
6. Dorée C, Stanworth S, Brunskill SJ, et al. Where are the systematic reviews in transfusion medicine? A study of the transfusion evidence base. Transfus Med Rev 2010; 24: 286-94.
7. Reinhofer M, Brauer M, Franke U, et al. The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypass. Blood Coagul Fibrinolysis 2008; 19: 212-9.
8. Haizinger B, Gombotz H, Rehak P, et al. Activated thrombelastogram in neonates and infants with complex congenital heart disease in comparison with healthy children. Br J Anaesth 2006; 97: 545-52.
9. Lee SH, Lee SM, Kim CS, et al. Use of fibrin-based thromboelastometry for cryoprecipitate transfusion in cardiac surgery involving deep hypothermic circulatory arrest during cardiopulmonary bypass. Blood Coagul Fibrinolysis 2010; 21: 687-91.
10. Shenkman B, Livnat T, Lubetsky A, et al. The in-vitro effect of fibrinogen, factor XIII and thrombin-activatable fibrinolysis inhibitor on clot formation and susceptibility to tissue plasminogen activator-induced fibrinolysis in hemodilution model. Blood Coagul Fibrinolysis 2012; 23: 370-8.
11. Iselin BM, Willimann PF, Seifert B, et al. Isolated reduction of haematocrit does not compromise in vitro blood coagulation. Br J Anaesth 2001; 87: 246-9.
12. Spiezia L, Radu C, Marchioro P, et al. Peculiar whole blood rotation thromboelastometry (Rotem) profile in 40 sideropenic anaemia patients. Thromb Haemost 2008; 100: 1106-10.
13. Solomon C, Schöchl H, Hanke A, et al. Haemostatic therapy in coronary artery bypass graft patients with decreased platelet function: comparison of fibrinogen concentrate with allogeneic blood products. Scand J Clin Lab Invest 2012; 72: 121-8.
14. Shibata J, Hasegawa J, Siemens HJ, et al. Hemostasis and coagulation at a hematocrit level of 0.85: functional consequences of erythrocytosis. Blood 2003; 101: 4416-22.
15. Spoerke NJ, Van PY, Differding JA, et al. Red blood cells accelerate the onset of clot formation in polytrauma and hemorrhagic shock. J Trauma 2010; 69: 1054-9.
16. Schöchl H, Posch A, Hanke A, et al. High-dose fibrinogen concentrate for haemostatic therapy of a major trauma patient with recent clopidogrel and aspirin intake. Scand J Clin Lab Invest 2010; 70: 453-7.
17. Schöchl H, Nienaber U, Hofer G, et al. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care 2010; 14: R55.
18. Theusinger OM, Baulig W, Asmis LM, et al. In vitro factor XIII supplementation increases clot firmness in rotation thromboelastometry (ROTEM). Thromb Haemost 2010; 104: 385-91.
19. Gudmundsdottir BR, Francis CW, Bjornsdottir AM, et al. Critical role of factors II and X during coumarin anticoagulation and their combined measurement with a new Fiix-prothrombin time. Thromb Res 2012; 130: 674-81.
20. Solomon C, Cadamuro J, Ziegler B, et al. A comparison of fibrinogen measurement methods with fibrin clot elasticity assessed by thromboelastometry, before and after administration of fibrinogen concentrate in cardiac surgery patients. Transfusion 2011; 51: 1695-706.
21. Kalina U, Stohr HA, Bickhard H, et al. Rotational thromboelastography for monitoring of fibrinogen concentrate therapy in fibrinogen deficiency. Blood Coagul Fibrinolysis 2008; 19: 777-83. Blood Transfus 2013; 11: 412-8 DOI 10.2450/2012.0043-12.
22. Schöchl H, Maegele M, Solomon C, et al. Early and individualised goal-directed therapy for trauma-induced coagulopathy. Scand J Trauma Resusc Emerg Med 2012; 20: 15.
23. Theusinger OM, Spahn DR, Ganter MT. Transfusion in trauma: why and how should we change our current practice? Curr Opin Anaesthesiol 2009; 22: 305-12.
24. Frith D, Brohi K. The acute coagulopathy of trauma shock: clinical relevance. Surgeon 2010; 8: 159-63.
25. Jeger V, Urwyler N, Zimmermann H, Exadaktylos AK. Trauma-induced coagulopathy in severely injured patients: knowledge lost in translation? Emerg Med J 2010; 27: 551-2.
26. Kozek-Langenecker S. Management of massive operative blood loss. Minerva Anestesiol 2007; 73: 401-15.
27. Levrat A, Gros A, Rugeri L, et al. Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth 2008; 100: 792-7.
28. Plotkin AJ, Wade CE, Jenkins DH, et al. A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma 2008; 64 (Suppl. 2): S64-8.
29. Haas T, Spielmann N, Mauch J, et al. Comparison of thromboelastometry (ROTEM®) with standard plasmatic coagulation testing in paediatric surgery. Br J Anaesth 2012; 108: 36-41.
30. Erber WN. Massive blood transfusion in the elective surgical setting. Transfus Apher Sci 2002; 27: 83-92.
31. Weiss G, Lison S, Spannagl M, Heindl B. Expressiveness of global coagulation parameters in dilutional coagulopathy. Br J Anaesth 2010; 105: 429-36.
32. Fries D, Krismer A, Klingler A, et al. Effect of fibrinogen on reversal of dilutional coagulopathy: a porcine model. Br J Anaesth 2005; 95: 172-7.
33. Fenger-Eriksen C, Tonnesen E, Ingerslev J, Sorensen B. Mechanisms of hydroxyethyl starch-induced dilutional coagulopathy. J Thromb Haemost 2009; 7: 1099-105.