Successful treatment of anti-caspr2 syndrome by interleukin 6 receptor blockade through tocilizumab

JAMA Neurology

Volumn 70, Issue 8, 2013, Pages 1056-1059

  Krogias, Christos ^a   Hoepner, Robert ^a   Müller, Andre ^a   Schneider Gold, Christiane ^a   Schröder, Alexandra ^a   Gold, Ralf ^a  

^a ST JOSEF HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CASPR2 ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; METHYLPREDNISOLONE SODIUM SUCCINATE; TOCILIZUMAB; UNCLASSIFIED DRUG;

ADULT; ANTIBODY DETECTION; ANTIBODY TITER; ANTICASPR2 SYNDROME; ARTICLE; AUTOIMMUNE DISEASE; BRAIN CORTEX LESION; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; DYSARTHRIA; DYSTONIA; ELECTROMYOGRAPHY; EPILEPSY; FASCICULATION; GAIT DISORDER; GENERALIZED EPILEPSY; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PAROXYSMAL KINESIGENIC DYSKINESIA; PLASMAPHERESIS; PRIORITY JOURNAL; STARTLE REFLEX; WALKING DIFFICULTY;

EID: 84882296099     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2013.143     Document Type: Article

References (15)

1. Lancaster E, Dalmau J. Neuronal autoantigens: pathogenesis, associated disorders and antibody testing. Nat Rev Neurol. 2012;8(7):380-390.
2. Graus F, Saiz A, Dalmau J. Antibodies and neuronal autoimmune disorders of the CNS. J Neurol. 2010;257(4):509-517.
3. Zuliani L, Graus F, Giometto B, Bien C, Vincent A. Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition. J Neurol Neurosurg Psychiatry. 2012;83(6):638-645.
4. Irani SR, Pettingill P, Kleopa KA, et al. Morvan syndrome: clinical and serological observations in 29 cases. Ann Neurol. 2012;72(2):241-255.
5. Bien CG, Vincent A, Barnett MH, et al. Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis. Brain. 2012;135(pt 5):1622-1638.
6. Lancaster E, Huijbers MG, Bar V, et al. Investigations of caspr2, an autoantigen of encephalitis and neuromyotonia. Ann Neurol. 2011;69(2):303-311.
7. Irani SR, Alexander S,Waters P, et al. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain. 2010;133(9):2734-2748.
8. RosenfeldMR, Dalmau JO. Paraneoplastic disorders of the CNS and autoimmune synaptic encephalitis. Continuum (Minneap Minn). 2012;18(2):366-383.
9. Kapina V, Vargas MI, Vulliemoz S, Landis T, Picard F, Lalive PH. VGKC antibody-associated encephalitis,microbleeds and progressive brain atrophy. J Neurol. 2010;257(3):466-468.
10. Becker EB, Zuliani L, Pettingill R, et al. Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia. J Neurol Neurosurg Psychiatry. 2012;83(4):437-440.
11. Blakeley J, Jankovic J. Secondary paroxysmal dyskinesias. Mov Disord. 2002;17(4):726-734.
12. van Rootselaar AF, Schade vanWestrum S, Velis DN, Tijssen MA. The paroxysmal dyskinesias. Pract Neurol. 2009;9(2):102-109.
13. Aradillas E, Schwartzman RJ. Kinesigenic dyskinesia in a case of voltage-gated potassium channel-complex protein antibody encephalitis. Arch Neurol. 2011;68(4):529-532.
14. Irani SR,Michell AW, Lang B, et al. Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis. Ann Neurol. 2011;69(5):892-900.
15. Ayzenberg I, Kleiter I, Schröder A, et al. Interleukin 6 receptor blockade in patients with neuromyelitis optica nonresponsive to anti-CD20 therapy. JAMA Neurol. 2013;70(3):394-397.