Advances in skin cancer early detection and diagnosis

Seminars in Oncology Nursing

Volumn 29, Issue 3, 2013, Pages 170-181

  Loescher, Lois J ^a   Janda, Monika ^b   Soyer, H Peter ^c   Shea, Kimberly ^d   Curiel Lewandrowski, Clara ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d UNIVERSITY OF ARIZONA COLLEGE OF NURSING   (United States)

Author keywords

Melanoma; Non melanoma skin cancer; Skin cancer; Skin cancer early detection; Skin examination

Indexed keywords

ARTICLE; EARLY DIAGNOSIS; HUMAN; MELANOMA; METHODOLOGY; NON-MELANOMA SKIN CANCER; SKIN CANCER; SKIN CANCER EARLY DETECTION; SKIN EXAMINATION; SKIN TUMOR;

MELANOMA; NON-MELANOMA SKIN CANCER; SKIN CANCER; SKIN CANCER EARLY DETECTION; SKIN EXAMINATION;

EARLY DETECTION OF CANCER; HUMANS; SKIN NEOPLASMS;

EID: 84882252036     PISSN: 07492081     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.soncn.2013.06.003     Document Type: Article

References (111)

1. American Cancer Society. Cancer facts & figures. Atlanta, GA: American Cancer Society; 2013. Available at: (acessed April 13, 2013). http://www.cancer.org/research/cancerfactsstatistics/.
2. Bickers D.R., Lim H.W., Margolis D., et al. The burden of skin diseases: 2004. a joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology. J Am Acad Dermatol 2006, 55:490-500.
3. Rigel D.S., Friedman R.J., Kopf A.W., et al. ABCDE-an evolving concept in the early detection of melanoma. Arch Dermatol 2005, 141:1032-1034.
4. Balch C.M., Gershenwald J.E., Soong S.-J., et al. Update on the melanoma staging system: the importance of sentinel node staging and primary tumor mitotic rate. J Surg Oncol 2011, 104:379-385.
5. Screening for skin cancer: recommendation statement. Ann Intern Med 2009, 150:188-193. US Preventive Services Task Force.
6. Hamidi R., Peng D., Cockburn M. Efficacy of skin self-examination for the early detection of melanoma. Int J Dermatol 2010, 49:126-134.
7. Aitken J.F., Elwood M., Baade P.D., et al. Clinical whole-body skin examination reduces the incidence of thick melanomas. Int J Cancer 2010, 126:450-458.
8. Schneider J.S., Moore D.H., Mendelsohn M.L. Screening program reduced melanoma mortality at the Lawrence Livermore National Laboratory, 1984 to 1996. J Am Acad Dermatol 2008, 58:741-749.
9. Katalinic A., Waldmann A., Weinstock M.A., et al. Does skin cancer screening save lives?: an observational study comparing trends in melanoma mortality in regions with and without screening. Cancer 2012, 118:5395-5402.
10. Skin cancer prevention and early detection. 2013. Available at: (acessed April 13, 2013). http://www.cancer.org/cancer/cancercauses/sunanduvexposure/skincancerpreventionandearlydetection/skin-cancer-prevention-and-early-detection-skin-exams.
11. Goulart J.M., Malvehy J., Puig S., et al. Dermoscopy in skin self-examination: a useful tool for select patients. Arch Dermatol 2011, 147:53-58.
12. Helsing P., Loeb M. Small diameter melanoma: a follow-up of the Norwegian Melanoma Project. Br J Dermatol 2004, 151:1081-1083.
13. Rhodes A.R. Cutaneous melanoma and intervention strategies to reduce tumor-related mortality: what we know, what we don't know, and what we think we know that isn't so. Dermatol Ther 2006, 19:50-69.
14. Luttrell M.J., Hofmann-Wellenhof R., Fink-Puches R., et al. The AC rule for melanoma: a simpler tool for the wider community. J Am Acad Dermatol 2011, 65:1233-1234.
15. Soyer H.P., Rigel D.S., Wurm E.M.T. Actinic keratosis, basal cell carcinoma and squamous cell carcinoma. Dermatology 2012, Elsevier Saunders, Philadelphia, PA, 108.5-10. Ed3. J.L. Bolognia, J.L. Jozziro, J.V. Schaffer (Eds.).
16. Hamidi R., Cockburn M.G., Peng D.H. Prevalence and predictors of skin self-examination: prospects for melanoma prevention and early detection. Int J Dermatol 2008, 47:993-1003.
17. McPherson M., Elwood M., English D.R., et al. Presentation and detection of invasive melanoma in a high-risk population. JAm Acad Dermatol 2006, 54:783-792.
18. Francken A.B., Shaw H.M., Accortt N.A., et al. Detection of first relapse in cutaneous melanoma patients: implications for the formulation of evidence-based follow-up guidelines. Ann Surg Oncol 2007, 14:1924-1933.
19. Janda M., Neale R.E., Youl P., et al. Impact of a video-based intervention to improve the prevalence of skin self-examination in men 50 years or older: the randomized skin awareness trial. Arch Dermatol 2011, 147:799-806.
20. Pollitt R.A., Geller A.C., Brooks D.R., et al. Efficacy of skin self-examination practices for early melanoma detection. Cancer Epidemiol Biomarkers Prev 2009, 18:3018-3023.
21. Baade P.D., Youl P.H., English D.R., et al. Clinical pathways to diagnose melanoma: a population-based study. Melanoma Res 2007, 17:243-249.
22. Berwick M., Begg C.B., Fine J.A., et al. Screening for cutaneous melanoma by skin self-examination. J Natl Cancer Inst 1996, 88:17-23.
23. Youl P.H., Janda M., Aitken J.F., et al. Body-site distribution of skin cancer, pre-malignant and common benign pigmented lesions excised in general practice. Br J Dermatol 2011, 165:35-43.
24. Weinstock M.A., Martin R.A., Risica P.M., et al. Thorough skin examination for the early detection of melanoma. Am J Prev Med 1999, 17:169-175.
25. Weinstock M.A., Risica P.M., Martin R.A., et al. Melanoma early detection with thorough skin self-examination: the "Check It Out" randomized trial. Am J Prev Med 2007, 32:517-524.
26. Boone S.L., Stapleton J., Turrisi R., et al. Thoroughness of skin examination by melanoma patients: influence of age, sex and partner. Australas J Dermatol 2009, 50:176-180.
27. Chiu V., Won E., Malik M., et al. The use of mole-mapping diagrams to increase skin self-examination accuracy. J Am Acad Dermatol 2006, 55:245-250.
28. Loescher L.J., Hibler E., Hiscox H., et al. An internet-delivered video intervention for skin self-examination by patients with melanoma. Arch Dermatol 2010, 146:922-923.
29. Hay J.L., Oliveria S.A., Dusza S.W., et al. Psychosocial mediators of a nurse intervention to increase skin self-examination in patients at high risk for melanoma. Cancer Epidemiol Biomarkers Prev 2006, 15:1212-1216.
30. Robinson J.K., Ortiz S. Use of photographs illustrating ABCDE criteria in skin self-examination. Arch Dermatol 2009, 145:332-333.
31. Manne S., Lessin S. Prevalence and correlates of sun protection and skin self-examination practices among cutaneous malignant melanoma survivors. J Behav Med 2006, 29:419-434.
32. MacKie R.M., Bray C.A., Leman J.A. Effect of public education aimed at early diagnosis of malignant melanoma: cohort comparison study. BMJ 2003, 326:367.
33. Carli P., De Giorgi V., Palli D., et al. Self-detected cutaneous melanomas in Italian patients. Clin Exp Dermatol 2004, 29:593-596.
34. Carli P., Balzi D., de Giorgi V., et al. Results of surveillance programme aimed at early diagnosis of cutaneous melanoma in high risk Mediterranean subjects. Eur J Dermatol 2003, 13:482-486.
35. Carli P., De Giorgi V., Palli D., et al. Dermatologist detection and skin self-examination are associated with thinner melanomas: results from a survey of the Italian Multidisciplinary Group on Melanoma. Arch Dermatol 2003, 139:607-612.
36. Epstein D.S., Lange J.R., Gruber S.B., et al. Is physician detection associated with thinner melanomas?. JAMA 1999, 281:640-643.
37. Gordon L., Youl P.H., Elwood M., et al. Diagnosis and management costs of suspicious skin lesions from a population-based melanoma screening programme. J Med Screen 2007, 14:98-102.
38. Aitken J.F., Youl P.H., Janda M., et al. Increase in skin cancer screening during a community-based randomized intervention trial. Int J Cancer 2006, 118:1010-1016.
39. Janda M., Lowe J.B., Elwood M., et al. Do centralised skin screening clinics increase participation in melanoma screening (Australia)?. Cancer Causes Control 2006, 17:161-168.
40. McCaul K.A., Fritschi L., Baade P., et al. The incidence of second primary invasive melanoma in Queensland, 1982-2003. Cancer Causes Control 2008, 19:451-458.
41. Loescher L.J., Harris R.B., Lim K.H., et al. Thorough skin self-examination in patients with melanoma. Oncol Nurs Forum 2006, 33:633-637.
42. Mesters I., Jonkman L., Vasen H., et al. Skin self-examination of persons from families with familial atypical multiple mole melanoma (FAMMM). Patient Educ Couns 2009, 75:251-255.
43. Mujumdar U.J., Hay J.L., Monroe-Hinds Y.C., et al. Sun protection and skin self-examination in melanoma survivors. Psychooncology 2009, 18:1106-1115.
44. Blum A., Ingvar C., Avramidis M., et al. Time to diagnosis of melanoma: same trend in different continents. J Cutan Med Surg 2007, 11:137-144.
45. Federman D.G., Kravetz J.D., Kirsner R.S. Skin cancer screening by dermatologists: prevalence and barriers. J Am Acad Dermatol 2002, 46:710-714.
46. Zalaudek I., Kittler H., Marghoob A.A., et al. Time required for a complete skin examination with and without dermoscopy: a prospective, randomized multicenter study. Arch Dermatol 2008, 144:509-513.
47. Zalaudek I, Docimo G, Argenziano G. Using dermoscopic criteria and patient-related factors for the management of pigmented melanocytic nevi. Arch Dermatol 145:816-826.
48. Di Cesare A., Sera F., Gulia A., et al. The spectrum of dermatoscopic patterns in blue nevi. J Am Acad Dermatol 2012, 67:199-205.
49. Burroni M., Wollina U., Torricelli R., et al. Impact of digital dermoscopy analysis on the decision to follow up or to excise a pigmented skin lesion: a multicentre study. Skin Res Technol 2011, 17:451-460.
50. Wurm E.M., Curchin C.E., Soyer H.P. Recent advances in diagnosing cutaneous melanomas. F1000 Med Rep 2010, 2.
51. Benvenuto-Andrade C., Dusza S.W., Agero A.L., et al. Differences between polarized light dermoscopy and immersion contact dermoscopy for the evaluation of skin lesions. Arch Dermatol 2007, 143:329-338.
52. Rosendahl C., Tschandl P., Cameron A., et al. Diagnostic accuracy of dermatoscopy for melanocytic and nonmelanocytic pigmented lesions. J Am Acad Dermatol 2011, 64:1068-1073.
53. Massone C., Di Stefani A., Soyer H.P. Dermoscopy for skin cancer detection. Curr Opin Oncol 2005, 17:147-153.
54. Soyer H.P. Dermoscopy and recently developed imaging techniques. Semin Cutan Med Surg 2009, 28:141.
55. Bafounta M.L., Beauchet A., Aegerter P., et al. Is dermoscopy (epiluminescence microscopy) useful for the diagnosis of melanoma? Results of a meta-analysis using techniques adapted to the evaluation of diagnostic tests. Arch Dermatol 2001, 137:1343-1350.
56. Vestergaard M.E., Macaskill P., Holt P.E., et al. Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta-analysis of studies performed in a clinical setting. Br J Dermatol 2008, 159:669-676.
57. Hofmann-Wellenhof R., Wurm E.M., Ahlgrimm-Siess V., et al. Reflectance confocal microscopy-state-of-art and research overview. Semin Cutan Med Surg 2009, 28:172-179.
58. Ferris L.K., Harris R.J. New diagnostic aids for melanoma. Dermatol Clin 2012, 30:535-545.
59. Malvehy J., Puig S. Follow-up of melanocytic skin lesions with digital total-body photography and digital dermoscopy: a two-step method. Clin Dermatol 2002, 20:297-304.
60. Risser J., Pressley Z., Veledar E., et al. The impact of total body photography on biopsy rate in patients from a pigmented lesion clinic. J Am Acad Dermatol 2007, 57:428-434.
61. Banky J.P., Kelly J.W., English D.R., et al. Incidence of new and changed nevi and melanomas detected using baseline images and dermoscopy in patients at high risk for melanoma. Arch Dermatol 2005, 141:998-1006.
62. Hanrahan P.F., D'Este C.A., Menzies S.W., et al. A randomised trial of skin photography as an aid to screening skin lesions in older males. J Med Screen 2002, 9:128-132.
63. Drugge R.J., Nguyen C., Drugge E.D., et al. Melanoma screening with serial whole body photographic change detection using Melanoscan technology. Dermatol Online J 2009, 15:1.
64. Massone C., Wurm E.M., Hofmann-Wellenhof R., et al. Teledermatology: an update. Semin Cutan Med Surg 2008, 27:101-105.
65. Tan E., Yung A., Jameson M., et al. Successful triage of patients referred to a skin lesion clinic using teledermoscopy (IMAGE IT trial). Br J Dermatol 2010, 162:803-811.
66. Whited J.D. The status of teledermatology research 2011, American Telemedicine Association, Washington, DC.
67. Braun R.P., Vecchietti J.L., Thomas L., et al. Telemedical wound care using a new generation of mobile telephones: a feasibility study. Arch Dermatol 2005, 141:254-258.
68. Braun R.P., Rabinovitz H.S., Oliviero M., et al. Dermoscopy of pigmented skin lesions. J Am Acad Dermatol 2005, 52:109-121.
69. Massone C., Brunasso A.M., Campbell T.M., et al. Mobile teledermoscopy-melanoma diagnosis by one click?. Semin Cutan Med Surg 2009, 28:203-205.
70. Massone C., Hofmann-Wellenhof R., Ahlgrimm-Siess V., et al. Melanoma screening with cellular phones. PLoS One 2007, 2:e483.
71. Massone C., Lozzi G.P., Wurm E., et al. Cellular phones in clinical teledermatology. Arch Dermatol 2005, 141:1319-1320.
72. Ebner C., Wurm E.M., Binder B., et al. Mobile teledermatology: a feasibility study of 58 subjects using mobile phones. J Telemed Telecare 2008, 14:2-7.
73. Burg G., Hasse U., Cipolat C., et al. Teledermatology: just cool or a real tool?. Dermatology 2005, 210:169-173.
74. Fabbrocini G., De Vita V., Pastore F., et al. Teledermatology: from prevention to diagnosis of nonmelanoma and melanoma skin cancer. Int J Telemed Appl 2011, 2011:125762.
75. Massone C., Brunasso A.M., Hofmann-Wellenhof R., et al. Teledermoscopy: education, discussion forums, teleconsulting and mobile teledermoscopy. G Ital Dermatol Venereol 2010, 145:127-132.
76. Kroemer S., Fruhauf J., Campbell T.M., et al. Mobile teledermatology for skin tumour screening: diagnostic accuracy of clinical and dermoscopic image tele-evaluation using cellular phones. Br J Dermatol 2011, 164:973-979.
77. Chao J, Loescher L, Soyer HP, Curiel-Lewandrowski C. Mobile teledermoscopy and melanoma detection by primary care providers: preliminary studies from the Pan Pacific Skin Cancer Consortium. In: Joint meeting of the International Dermoscopy Society, the International Society for Digital Imaging of the Skin, and the International Confocal Working Group. Miami, FL;2013.
78. Chao J.T., Loescher L.J., Soyer H.P., et al. Barriers to mobile teledermoscopy in primary care. J Am Acad Dermatol 2012, (in press).
79. Monheit G., Cognetta A.B., Ferris L., et al. The performance of MelaFind: a prospective multicenter study. Arch Dermatol 2011, 147:188-194.
80. Wells R., Gutkowicz-Krusin D., Veledar E., et al. Comparison of diagnostic and management sensitivity to melanoma between dermatologists and MelaFind: a pilot study. Arch Dermatol 2012, 148:1083-1084.
81. Aberg P., Birgersson U., Elsner P., et al. Electrical impedance spectroscopy and the diagnostic accuracy for malignant melanoma. Exp Dermatol 2011, 20:648-652.
82. Wachsman W., Morhenn V., Palmer T., et al. Noninvasive genomic detection of melanoma. Br J Dermatol 2011, 164:797-806.
83. Chen S.C., Pennie M.L., Kolm P., et al. Diagnosing and managing cutaneous pigmented lesions: primary care physicians versus dermatologists. J Gen Intern Med 2006, 21:678-682.
84. Helfand M., Mahon S.M., Eden K.B., et al. Screening for skin cancer. Am J Prev Med 2001, 20:47-58.
85. Rampen F.H., Casparie-van Velsen J.I., van Huystee B.E., et al. False-negative findings in skin cancer and melanoma screening. J Am Acad Dermatol 1995, 33:59-63.
86. Heughan C., Kanigsberg N., Amdemichael E., et al. Canaries in the mineshaft: the dermatology workforce shortage in Eastern Ontario. J Cutan Med Surg 2008, 12:217-222.
87. Kimball A.B., Resneck J.S. The US dermatology workforce: a specialty remains in shortage. J Am Acad Dermatol 2008, 59:741-745.
88. Chow E.Y., Searles G.E. The amazing vanishing Canadian dermatologist: results from the 2006 Canadian Dermatology Association member survey. J Cutan Med Surg 2010, 14:71-79.
89. Warren L., Fuller K. Skin cancer-an Australian perspective. ABC of skin cancer 2008, 55-58. Blackwell, Malden, MA. S. Rajpar, J. Marsden (Eds.).
90. Resneck J.S., Kimball A.B. Who else is providing care in dermatology practices? Trends in the use of nonphysician clinicians. J Am Acad Dermatol 2008, 58:211-216.
91. Watson A.J., Kvedar J.C. Staying on top in dermatology: why we must act now to address the capacity challenge. Arch Dermatol 2008, 144:541-544.
92. Geller A.C., O'Riordan D.L., Oliveria S.A., et al. Overcoming obstacles to skin cancer examinations and prevention counseling for high-risk patients: results of a national survey ofprimary care physicians. J Am Board Fam Pract 2004, 17:416-423.
93. Altman J.F., Oliveria S.A., Christos P.J., et al. A survey of skin cancer screening in the primary care setting: a comparison with other cancer screenings. Arch Fam Med 2000, 9:1022-1027.
94. Oliveria S.A., Altman J.F., Christos P.J., et al. Use of nonphysician health care providers for skin cancer screening in the primary care setting. Prev Med 2002, 34:374-379.
95. Federman D.G., Concato J., Caralis P.V., et al. Screening for skin cancer in primary care settings. Arch Dermatol 1997, 133:1423-1425.
96. Kirsner R.S., Muhkerjee S., Federman D.G. Skin cancer screening in primary care: prevalence and barriers. J Am Acad Dermatol 1999, 41:564-566.
97. Christos P.J., Oliveria S.A., Masse L.C., et al. Skin cancer prevention and detection by nurses: attitudes, perceptions, and barriers. J Cancer Educ 2004, 19:50-57.
98. Loescher L.J., Harris J.M., Curiel-Lewandrowski C. A systematic review of advanced practice nurses' skin cancer assessment barriers, skin lesion recognition skills, and skin cancer training activities. J Am Acad Nurse Pract 2011, 23:667-673.
99. Doshi D.N., Firth K., Mintz M., et al. Pilot study of a skin cancer education curriculum for medical students. J Am Acad Dermatol 2007, 56:167-169.
100. Shelby S. The development of a standardized dermatology residency program for the clinical doctorate in advanced nursing practice. Dermatol Nurs 2008, 20:437-447.
101. Morrison A., O'Loughlin S., Powell F.C. Suspected skin malignancy: a comparison of diagnoses of family practitioners and dermatologists in 493 patients. Int J Dermatol 2001, 40:104-107.
102. Murchie P., Campbell N.C. Pigmented lesions, cutaneous melanoma, and future challenges for primary care. Eur J Gen Pract 2007, 13:151-154.
103. Nekhlyudov L., Latosinsky S. The interface of primary and oncology specialty care: from symptoms to diagnosis. J Natl Cancer Inst Monogr 2010, 2010:11-17.
104. Harris J.M., Salasche S.J., Harris R.B. Can Internet-based continuing medical education improve physicians' skin cancer knowledge and skills?. J Gen Intern Med 2001, 16:50-56.
105. Argenziano G., Puig S., Zalaudek I., et al. Dermoscopy improves accuracy of primary care physicians to triage lesions suggestive of skin cancer. J Clin Oncol 2006, 24:1877-1882.
106. Menzies S.W., Emery J., Staples M., et al. Impact of dermoscopy and short-term sequential digital dermoscopy imaging forthe management of pigmented lesions in primary care: a sequential intervention trial. Br J Dermatol 2009, 161:1270-1277.
107. Nestor M.S. The use of mid-level providers in dermatology: a liability risk?. Semin Cutan Med Surg 2005, 24:148-151.
108. Australian Institute of Health and Welfare. Cancer incidence projections: Australia, 2011 to 2020. Available at: (accessed). http://www.aihw.gov.au/cancer/.
109. Youl P.H., Baade P.D., Janda M., et al. Diagnosing skin cancer in primary care: how do mainstream general practitioners compare with primary care skin cancer clinic doctors?. Med J Aust 2007, 187:215-220.
110. Wolf J.A., Moreau J., Akilov O., et al. Diagnostic inaccuracy of smartphone applications for melanoma detection. JAMA Dermatol 2013, 149:422-426.
111. Janda M., Loescher L.J., Soyer H.P. Enhanced skin self-examination - a novel approach to skin cancer monitoring and follow-up. JAMA Dermatol 2013, 149:231-236.