Biochemical characterization of an S-adenosyll-methionine-dependent methyltransferase (Rv0469) of Mycobacterium tuberculosis

Biological Chemistry

Volumn 394, Issue 7, 2013, Pages 871-877

  Meena, Laxman S ^a   Chopra, Puneet ^a   Vishwakarma, Ram A ^b   Singh, Yogendra ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

Author keywords

Fatty acid; Methyltransferase; Mycobacterium tuberculosis; Oleic acid; S adenosyl l methionine; Tuberculostearic acid

Indexed keywords

CYCLOPROPANE; CYTOPLASM PROTEIN; GENOMIC DNA; HYBRID PROTEIN; LONG CHAIN FATTY ACID; METHYLTRANSFERASE; MYCOLIC ACID; OLEIC ACID; PHOSPHATIDYLCHOLINE; PROTEIN; PROTEIN UMAA; REACTIVE OXYGEN METABOLITE; S ADENOSYLMETHIONINE; SHORT CHAIN FATTY ACID; TUBERCULOSTEARIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMICAL COMPOSITION; BIOINFORMATICS; CELL FRACTIONATION; CELL LYSATE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MODIFICATION; EXPRESSION VECTOR; GENETIC SIMILARITY; LIPID MEMBRANE; MOLECULAR WEIGHT; MULTIGENE FAMILY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION;

CLONING, MOLECULAR; FATTY ACIDS, VOLATILE; METHYLTRANSFERASES; MYCOBACTERIUM TUBERCULOSIS; S-ADENOSYLMETHIONINE; STEARIC ACIDS;

EID: 84882244011     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2013-0126     Document Type: Article

References (19)

1. Akamatsu, Y. and Law, J.H. (1970). Enzymatic alkylenation of phospholipid fatty acid chains by extracts of Mycobacterium phlei. J. Biol. Chem. 245, 701-708.
2. Ballou, C.E., Vilkas, E., and Lederer, E. (1963). Structural studies on the myo-inositol phospholipids of Mycobacterium tuberculosis (var. bovis, strain BCG). J. Biol. Chem. 238, 69-76.
3. Besra, G.S., Morehouse, C.B., Rittner, C.M., Waechter, C.J., and Brennan, P.J. (1997). Biosynthesis of mycobacterial lipoarabinomannan. J. Biol. Chem. 272, 18460-18466.
4. Campbell, I.M. and Naworal, J. (1969). Composition of the saturated and monounsaturated fatty acids of Mycobacterium phlei. J. Lipid Res. 10, 593-598.
5. Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S.V., Eiglmeier, K., Gas, S., Barry, C.E., et al. (1998). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537-544.
6. Dmitriev, B.A., Ehlers, S., Rietschel, E.T., and Brennan, P.J. (2000). Molecular mechanics of the mycobacterial cell wall: from horizontal layers to vertical scaffolds. J. Med. Microbiol. 290, 251-258.
7. Glickman, M.S., Cahill, S.M., and Jacobs, W.R. Jr. (2000). The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase. J. Biol. Chem. 276, 2228-2233.
8. Goren, M.B. (1984). The mycobacteria: a sourcebook (New York: Marcel Dekker Inc.), pp. 379-415.
9. Grzegorzewicz, A.E., Kordulakova, J., Jones, V., Born, S.E., Belardinelli, J.M., Vaquie, A., Gundi, V.A., Madacki, J., Slama, N., Laval, F., et al. (2012). A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone. J. Biol. Chem. 287, 38434-38441.
10. Jackson, M., Crick, D.C., and Brennan, P.J. (2000). Phosphatidylinositol is an essential phospholipid of mycobacteria. J. Biol. Chem. 275, 30092-30099.
11. Laval, F., Haites, R., Movahedzadeh, F., Lemassu, A., Wong, C.Y., Stoker, N., Billman-Jacobe, H., and Daffe, M. (2008). Investigating the function of the putative mycolic acid methyltransferase UmaA: divergence between the Mycobacterium smegmatis and Mycobacterium tuberculosis proteins. J. Biol. Chem. 283, 1419-1427.
12. McAdam, R.A., Quan, S., Smith, D.A., Bardarov, S., Betts, J.C., Cook, F.C., Hooker, E.U., Lewis, A.P., Woollard, P., Everett, M.J., et al. (2002). Characterization of a Mycobacterium tuberculosis H 37 Rv transposon library reveals insertions in 351 ORFs and mutants with altered virulence. Microbiology 148, 2975-2986.
13. Meena, L.S., Chopra, P., Bedwal, R.S., and Singh, Y. (2008). Cloning and characterization of a GTP binding protein from M. tuberculosis H 37 Rv. Enzyme Microb. Technol. 42, 138-144.
14. Meena, L.S., Dhakate, S.R., and Sahare, P.D. (2012). Elucidation of Mg 2 + binding activity of adenylate kinase from Mycobacterium tuberculosis H 37 Rv using fluorescence studies. Biotechnol. Appl. Biochem. 59, 429-436.
15. Nigou, J., Gilleron, M., Cahuzac, B., Bounery, J.D., Herold, M., Thurnher, M., and Puzo, G. (1997). The phosphatidylmyo -inositol anchor of the lipoarabinomannans from Mycobacterium bovis bacillus Calmette-Guerin. Heterogeneity, structure, and role in the regulation of cytokine secretion. J. Biol. Chem. 272, 23094-23103.
16. Phetsuksiri, B., Jackson, M., Scherman, H., McNeil, M., Besra, G.S., Baulard, A.R., Slayden, R.A., DeBarber, A.E., Barry 3rd, C.E., Baird M.S., et al. (2003). Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis. J. Biol. Chem. 278, 53123-53130.
17. Takayama, K., Wang, C., and Besra, G.S. (2005). Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 18, 81-101.
18. Yuan, Y., Lee, R.E., Besra, G.S., Belisle, J.T., and Barry 3rd, C.E. (1995). Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 92, 6630-6634.
19. Yuan, Y., Mead, D., Schroeder, B.G., Zhu, Y., and Barry 3rd, C.E. (1998). The biosynthesis of mycolic acids in Mycobacterium tuberculosis. Enzymatic methyl(ene) transfer to acyl carrier protein bound meromycolic acid in vitro. J. Biol. Chem. 273, 21282-21290.