Interaction of alcohol and tobacco in upper aerodigestive tract and stomach cancer

Alcohol, Tobacco and Cancer

Volumn , Issue , 2006, Pages 48-62

  Salaspuro, Mikko ^a   Salaspuro, Ville ^a   Seitz, Helmut K ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Krankenhaus Salem   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882062894     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1159/000095014     Document Type: Chapter

References (71)

1. Salaspuro M: Acetaldehyde, microbes, and cancer of the digestive tract. Crit Rev Clin Lab Med 2003;40:183-208.
2. Pöschl G, Seitz HK: Alcohol and cancer. Alcohol Alcohol 2004;39:155-165.
3. Tuyns AJ, Esteve J, Raymond L, Berrino F, Benhamou E, Blanchet F, Boffetta P, Crosignani P, Del Moral A, Lehman W, Merletti F, Pequignot G, Riboli E, Sancho-Garnier H, Terracini B, Zubiri A, Zubiri L: Cancer of the larynx/hypopharynx, tobacco and alcohol: IARC international case-control study in Turin and Varese (Italy), Zaragoza and Navarra (Spain), Geneva (Switzerland) and Calvados (France). Int J Cancer 1988;41:483-491.
4. Franceschi S, Talamini R, Barra S, Baron AE, Negri E, Bidoli E, Serraino D, La Vecchia C: Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx, and esophagus in northern Italy. Cancer Res 1990;50:6502-6507.
5. Blot WJ: Alcohol and cancer. Cancer Res 1992;52(suppl):2119-2123.
6. Bagnardi V, Blangiardo M, La Vecchia C, Corrao G: A meta-analysis of alcohol drinking and can cer risk. Br J Cancer 2001;85:1700-1705.
7. IARC: Alcohol drinking. IARC monographs on the evaluation of the carcinogenic risk to humans. Lyon, International Agency for Research on Cancer, 1988, vol 44, pp 1-416.
8. Warnakulasuriya S, Sutherland G, Scully C: Tobacco, oral cancer, and treatment of dependence. Oral Oncol 2005;41:244-260.
9. Brugere J, Guenel P, Leclerc A, Rodriguez J: Differential effects of tobacco and alcohol in cancer of the larynx, pharynx, and mouth. Cancer 1986;57:391-395.
10. Tuyns AJ, Pequignot G, Jensen OM: Les cancers del'oesophage an Ille-et-Villaine en fonction de niveaux de consommation d'alcool et de tabac. Des risques qui se multiplient. Bull Cancer 1977:64:45-60.
11. Chao A, Thun MJ, Henley J, Jacobs EJ, McCullough ML, Calle EE: Cigarrette smoking, use of other tobacco products and stomach cancer mortality in US adults: the cancer prevention study II. Int J Cancer 2002;101:380-389.
12. Conzales CA, Pera G, Agudo A, Palli D, Krogh V, Vineis P, Tumino R, Panico S, Berglund G, Siman H, Nyren O, Agren A, Martinez C, Dorronsoro M, Barricarte A, Tormo MJ, Quiros JR, Allen N, Bingham S, Day N, Miller A, Nagel G, Boeing H, Overvad K, Tjonneland A, Bueno-de-Mesquita HB, Boshuizen HC, Peeters P, Numans M, Clavel-Chaplion F, Helen I, Agapitos E, Lund E, Fahey M, Saracci R, Kaaks R, Riboli E: Smoking and the risk of gastric cancer in the European prospective investigation into cancer and nutrition (EPIC). Int J Cancer 2003;107:629-634.
13. Zeka A, Gore R, Kriebel D: Effects of alcohol and tobacco on aerodigestive tract cancer risk: a meta-regression analysis. Cancer Causes Control 2003;14:897-906.
14. Choi SY, Kahyo H: Effect of cigarette smoking and alcohol consumption in the aetiology of cancer of the oral cavity, pharynx and larynx. Int J Epidemiol 1991;20:878-885.
15. Castellague X, Quintana MJ, Martinez MC, Nieto A, Sanchez MJ, Juan A, Monner A, Carrera M, Agudo A, Quer M, Munoz N, Herrero R, Franceschi S, Bosch FX: The role of type of tobacco and type of alcoholic beverage in oral carcinogenesis. Int J Cancer 2004;108:741-749.
16. Chen M-J, Chiou Y-Y, Wu D-C, Wu S-L: Lifestyle habits and gastric cancer in a hospital-based case-control study in Taiwan. Am J Gastroenterol 2000;95:3242-3249.
17. Siman JH, Forsgren A, Berglund G, Floren CH: Tobacco smoking increases the risk for gastric adenocarcinoma among Helicobacter pylori-infected individuals. Scand J Gastroenterol 2001;36: 208-213.
18. Lunet N, Barros H: Helicobacter pylori infection and gastric cancer: facing the enigmas. Int J Cancer 2003;106:953-960.
19. Crabb DW, Edenberg HJ, Bosron WF, Li TK: Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2*2 allele is dominant. J Clin Invest 1989;83:314-316.
20. Peng GS, Wang, MF, Chen CY, Luu SU, Chou HC, Li TK, Yin SJ: Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. Pharmacogenetics 1999;9:463-476.
21. Agarwal DP, Goedde HW: Pharmocogenetics of alcohol metabolism and alcoholism. Pharmacogenetics 1992;2:48-62.
22. Yokoyama A, Muramatsu T, Ohmori T, Yokoyama T, Okoyama K, Takahashi H, Hasegawa Y, Higuchi S, Maruyama K, Shirakura K, Ishii H: Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis 1998;19:1383-1387.
23. Lewis SJ, Smith GD: Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach. Cancer Epidemiol Biomarkers Prev 2005;14:1967-1971.
24. Coutelle C, Ward PJ, Fleury B, Quattrocchi P, Chambrin H, Iron A, Couzigou P, Cassaigne A: Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms. Hum Genet 1997;99:319-325.
25. Harty LC, Caporaso NE, Hayes RB, Winn DM, Bravo-Otero E, Blott WJ, Kleinmen DV, Brown LM, Armenian HK, Fraumeni JF Jr, Shields PG: Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers. J Natl Cancer Inst 1997;89:1689-1705.
26. Visapää J-P, Götte K, Benesova M, Li J, Homann N, Conradt C, Inoue H, Tisch M, Hörrmann K, Väkeväinen S, Salaspuro M, Seitz HK: Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde. Gut 2004;53:871-876.
27. Homann N, Stickel F, König IR, Jacobs A, Junghanns K, Benesova M, Schuppan D, Himsel S, Zuber-Jerger I, Hellerbrand C, Ludwig D, Caselmann WH, Seitz HK: Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers. Int J Cancer 2005;118:1998-2002.
28. Bouchardy C, Hirvonen A, Coutelle C, Ward PJ, Dayer P, Benhamou S: Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of upper aerodigestive tract. Int J Cancer 2000;87:734-740.
29. Schwartz SM, Doody DR, Fitzgibbons ED, Ricks S, Potter PL, Chen C: Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypes. Cancer Epidemiol Biomarkers Prev 2001;10:1137-1144.
30. Olshan AF, Weissler MC, Watson AM, Bell DA: Risk of head and neck cancer and the alcohol dehydrogenase 3 genotype. Carcinogenesis 2001;22:57-61.
31. Peters ES, McClean MD, Liu M, Eisen EA, Mueller N, Kelsey KT: The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use. Cancer Epidemiol Biomarkers Prev 2005;14:476-482.
32. Brennan P, Lewis S, Hahibe M, Bell DA, Bofetta P, Bouchardy C, Caporaso N, Chen C, Coutelle C, Diehl SR, Hayes RB, Olshan AF, Schwartz SM, Sturgis EM, Wei Q, Zavras AI, Benhamou S: Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGe review. Am J Epidemiol 2004;159:1-16.
33. IARC: Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide; in Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Acetaldehyde. Lyon, International Agency for Research on Cancer, 1999, vol 77, pp 319-335.
34. Woutersen RA, Appelman LM, van Garderen-Hoetmer A, Feron VJ: Inhalation toxicity of acetaldehyde in rats. III. Carcinogenicity study. Toxicology 1986;41:213-231.
35. Feron VJ, Kruysse A, Woutersen RA: Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to benzo(a)pyrene or diethylnitrosamine. Eur J Cancer Clin Oncol 1982;18:13-31.
36. Homann N, Kärkkäinen P, Koivisto T, Nosova T, Jokelainen K, Salaspuro M: Effects of acetaldehyde on cell regeneration and differentiation of the upper gastrointestinal tract mucosa. J Natl Cancer Inst 1997;89:1692-1697.
37. Fang JL, Vaca CE: Detection of DNA adducts of acetaldehyde in peripheral white blood cells of alcohol abusers. Carcinogenesis 1997;18:627-632.
38. Wang M, McIntee EJ, Cheng G, Shi Y, Villalta PW, Hecht SS: Identification of DNA adducts of acetaldehyde. Chem Res Toxicol 2000;13:1149-1157.
39. Inagaki S, Esaka Y, Goto M, Deyashiki Y, Sako M: LC-MS study on the formation of cyclic 1, N2-propane guanine adduct in the reactions of DNA with acetaldehyde in the presence of histone. Biol Pharm Bull 2004;27:273-276.
40. Theravathu JA, Jaruga P, Nath RG, Dizdaroglu M, Brooks PJ: Polyamines stimulate the formation of mutagenic 1, N2-propanodeoxyguanosine adducts from acetaldehyde. Nucleic Acids Res 2005;33:3513-3520.
41. Jones AW: Distribution of ethanol between saliva and blood in man. Clin Exp Pharmacol Physiol 1979;6:53-59.
42. Homann N, Jousimies-Somer H, Jokelainen K, Heine R, Salaspuro M: High acetaldehyde levels in saliva after ethanol consumption: methodological aspects and pathogenetic implications. Carcinogenesis 1997;18:1739-1743.
43. Väkeväinen S, Tillonen J, Agarwal DP, Svirastava N, Salaspuro M: High salivary acetaldehyde after a moderate dose of alcohol in ALDH2-deficient subjects: strong evidence for the local carcinogenic action of acetaldehyde. Alcohol Clin Exp Res 2000;24:873-877.
44. Salaspuro V, Nyfors S, Heine R, Siitonen A, Salaspuro M, Jousimies-Somer H: Ethanol oxidation and acetaldehyde production in vitro by human intestinal strains of Escherichia coli under aerobic, microaerobic, and anaerobic conditions. Scand J Gastroenterol 1999;34:967-973.
45. IARC: Monographs on the evaluation of the carcinogenic risk of chemicals to humans; in Tobacco Smoking. Lyon, International Agency for Research on Cancer, 1986, vol 38.
46. Smith CJ, Hansch C: The relative toxicity of compounds in mainstream cigarette smoke condensate. Food Chem Toxicol 2000;38:637-646.
47. Seeman JI, Dixon M, Haussman H-J: Acetaldehyde in mainstream tobacco smoke: formation and occurrence in smoke and bioavailability in the smoker. Chem Res Toxicol 2002;15:1332-1350.
48. Shaskan EG, Dolinsky ZS: Elevated endogenous breath acetaldehyde levels among abusers of alcohol and cigarettes. Prog Neuropsychopharmacol 1984;9:267-272.
49. McLaughlin SD, Scott BK, Peterson SM: The effect of cigarette smoking on breath and whole blood-associated acetaldehyde. Alcohol 1990;7:285-287.
50. Salaspuro V, Salaspuro M: Synergistic effect of alcohol drinking and smoking on in vivo acetaldehyde concentration in saliva. Int J Cancer 2004;111:480-483.
51. Homann N, Tillonen J, Meurman JH, Rintamäki H, Lindqvist C, Rautio M, Jousimies-Somer H, Salaspuro M: Increased salivary acetaldehyde levels in heavy drinkers and smokers: a microbiological approach to oral cavity cancer. Carcinogenesis 2000;22:663-668.
52. Holmstrup P, Besserman M: Clinical, therapeutic and pathogenetic aspects of chronic oral multi-focal candiasis. Oral Surg Oral Med Oral Pathol 1983;56:388-395.
53. Colman G, Beighton D, Chalk AJ, Wake S: Cigarrette smoking and the microbial flora of the mouth. Aust Dent J 1976;21:111-118.
54. Zheng TZ, Boyle P, Hu HF, Duan J, Jian PJ, Ma DQ, Shui LP, Niu SR, Scully C, MacMahon B: Dentition, oral hygiene, and risk of oral cancer: a case-control study in Beijing, People s Rebublic of China. Cancer Causes Control 1990;1:235-241.
55. Maier H, Zöller J, Herrmann A, Kreiss M, Heller WD: Dental status and oral hygiene in patients with head and neck cancer. Otolaryngol Head Neck Surg 1993;1088:655-661.
56. Homann N, Tillonen J, Rintamäki H, Salaspuro M, Lindqvist C, Meurman JH: Poor dental status increases the acetaldehyde production from ethanol in saliva: a possible link to the higher risk of oral cancer among alcohol-consumers. Oral Oncol 2001;37:153-158.
57. Tillonen J, Homann N, Rautio M, Jousimies-Somer H, Salaspuro M: Role of yeasts in the salivary acetaldehyde production from ethanol among risk groups for ethanol-associated oral cavity cancer. Alcohol Clin Exp Res 1999;23:1409-1415.
58. Väkeväinen S, Tillonen J, Salaspuro M: 4-Methylpyrazole decreases salivary acetaldehyde levels in ALDH2-deficient subjects but not in subjects with normal ALDH2. Alcohol Clin Exp Res 2001;25:829-834.
59. Huang J-Q, Subbaramiah S, Chen Y, Hunt RH: Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology 1998;114:1169-1179.
60. Eslick GD, Lim LL, Byles JE, Xia HH, Talley NJ: Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. Am J Gastroenterol 1999;94:2373-2379.
61. Xue F-B, Xu Y-Y, Pan B-R, Fan D-M: Association of H. pylori infection with gastric carcinoma: a meta analysis. World J Gastroenterol 2003;7:801-804.
62. Salmela KS, Roine RP, Koivisto T, Höök-Nikanne J, Kosunen TU, Salaspuro M: Characteristics of Helicobacter pylori alcohol dehydrogenase. Gastroenterology 1993;105:325-330.
63. Salmela KS, Roine RP, Höök-Nikanne J, Kosunen TU, Salaspuro M: Acetaldehyde and ethanol production by Helicobacter pylori. Scand J Gastroenterol 1994;29:309-312.
64. Morson BC, Sobin LH, Grundmann E, Johansen A, Nagayo T, Serck-Hanssen A: Precancerous conditions and epithelial dysplasia in the stomach. J Clin Pathol 1980;33:711-721.
65. Stockbruegger RW, Cotton PB, Menon GG, Beilby JO, Bartholomew BA, Hill MJ, Walters CL: Pernicious anaemia, intragastric bacterial overgrowth and possible consequences. Scand J Gastroenterol 1984;19:355-364.
66. Väkeväinen S, Mentula S, Nuutinen H, Salmela KS, Jousimies-Somer H, Färkkilä M, Salaspuro M: Ethanol-derived microbial production of carcinogenic acetaldehyde in achlorhydric atrophic gastritis. Scand J Gastroenterol 2002;37:648-655.
67. Jokelainen K, Heikkonen E, Roine R, Lehtonen H, Salaspuro M: Increased acetaldehyde production by mouthwashings from patients with oral cavity, laryngeal, or pharyngeal cancer. Alcohol Clin Exp Res 1996;20:1206-1210.
68. Sprince H, Parker CM, Smith GG, Gonzales LJ: Protection against acetaldehyde toxicity in the rat by l-cysteine, thiamin and l-2-methylthiazolidine-4-carboxylic acid. Agents Actions 1974;4: 125-130.
69. Salaspuro V, Hietala J, Kaihovaara P, Pihlajarinne H, Marvola M, Salaspuro M: Removal of acetaldehyde from saliva by a slow-release buccal tablet of l-cysteine. Int J Cancer 2002;97: 361-364.
70. Salaspuro V, Hietala JM, Marvola MK, Salaspuro MP: Eliminating carcinogenic acetaldehyde by cysteine from saliva during smoking. Cancer Epidemiol Biomarkers Prev 2006;15:146-149.
71. Sarkola T, Iles MR, Kohlenberg-Mueller K, Eriksson CJ: Ethanol, acetaldehyde, acetate, and lactate levels after alcohol intake in white men and women: effect of 4-methylpyrazole. Alcohol Clin Exp Res 2002;26:239-245.