Successful xenogenic islet transplantation with Ba2+-alginate encapsulation

Tissue Engineering and Regenerative Medicine

Volumn 7, Issue 5, 2010, Pages 523-530

  Park, Heon Seok ^a   Ham, Dong Sik ^a   You, Young Hye ^a   Shin, Juyoung ^a   Kim, Ji Won ^a   Jo, Jae Hyoung ^a   Kim, On You ^b   Khang, Gilson ^b   Yoon, Kun Ho ^a  

^a The Catholic University of Korea   (South Korea)

^b Chonbuk National University   (South Korea)

Author keywords

Alginate; Diabetes mellitus; Islet; Microcapsules; Xenotransplantation

Indexed keywords

ALGINATE ENCAPSULATION; ALGINATE POLYMERS; DIABETES MELLITUS; IMMUNE REJECTION; ISLET; ISLET TRANSPLANTATION; MICROCAPSULES; XENOTRANSPLANTATION;

CURING; MICROENCAPSULATION;

ALGINATE;

EID: 84881818742     PISSN: 17382696     EISSN: 22125469     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. MA Atkinson, NK Maclaren, The pathogenesis of insulindependent diabetes mellitus, New England Journal of Medicine, 331, 1428 (1994).
2. MG Patricia, SE George, Pathogenesis, prediction and trials for the prevention of insulin-dependent (type 1) diabetes mellitus, Advanced Drug Delivery Reviews, 35, 143 (1999).
3. R Stratta, Late acute rejection after pancreas transplantation, Transplantation Proceedings, 30, 646, (2000).
4. DJ Lim, HS Park, KH Yoon, et al., Optimization of Microencapsulation of the Islets, Tissue Engineering and Regenerative Medicine, 2, 280 - 286 (2005).
5. D Dufrane, RM Goebbels, A Saliez, et al., Six-month survival of microencapsulated pig islets and alginate biocompatibility in primates: proof of concept, Transplantation, 15, 1345 (2006).
6. A Omer, VF Duvivier-Kali, N Trivedi, et al., Bonner-Weir S, Weir GC, Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice, Diabetes, 52, 69 (2006).
7. C.F. Inman, M. Bailey, Validation of computer-assisted, pixelbased analysis of multiple-colour immunofluorescence histology, Journal of Immunological Methods, 302, 156 - 167 (2005).
8. S Stellan, A Arne, LE Decio, et al., Assessment of insulin secretion in vitro from microencapsulated fetal porcine isletlike cell clusters and rat, mouse, and human pancreatic islets, Transplantation, 63, 1712 (1997).
9. H Sato, T Kobayasi, M Murakami, et al., Improving function and survival of porcine islet xenografts using microencapsulation and culture preconditioning, Pancreas, 25, e42 (2002).
10. U Siebers, T Zekorn, A Horcher, et al., In vitro testing of rat and porcine islets microencapsulated in barium alginate beads, Transplantation Proceedings, 24, 950 (1992).
11. M. Cascalho, J. L. Platt, The Immunological Barrier to Xenotransplantation, Immunity, 14, 437 (2001).
12. P de Vos, AF Hamel, K Tatarkiewicz, Considerations for successful transplantation of encapsulated pancreatic islets, Diabetologia, 45, 159 (2002).
13. P De Vos, R Van Schilfgaarde, Why do microencapsulated islet grafts fail in the absence of fibrotic overgrowth?, Diabetes, 48, 1381 (1999).
14. H Cui, SA Safley, Long-term metabolic control of autoimmune diabetes in spontaneously diabetic nonobese diabetic mice by nonvascularized microencapsulated adult porcine islets, Transplantation, 88, 160 (2009).
15. WJ Zhang, C Laue, A Hyder, et al., Purity of alginate affects the viability and fibrotic overgrowth of encapsulated porcine islet xenografts, Transplantation Proceedings, 33, 3517 (2001).
16. G Orive, SK Tam, JL Pedraz, et al., Biocompatibility of alginate-poly-L-lysine microcapsules for cell therapy, Biomaterials, 27, 3691 (2006).
17. G Luca, R Calafiore, Accelerated functional maturation of isolated neonatal porcine cell clusters: in vitro and in vivo results in NOD mice, Cell Transplantation, 14, 249 (2005).