메뉴 건너뛰기




Volumn 40, Issue 9, 2013, Pages 1394-1405

Automated analysis of FDG PET as a tool for single-subject probabilistic prediction and detection of Alzheimer's disease dementia

Author keywords

Alzheimer's disease; Dementia; FDG; Mild cognitive impairment; PET; Prediction

Indexed keywords

APOLIPOPROTEIN E4; FLUORODEOXYGLUCOSE F 18;

EID: 84881670522     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-013-2458-z     Document Type: Article
Times cited : (41)

References (40)
  • 2
    • 79956142378 scopus 로고    scopus 로고
    • The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • 21514250 10.1016/j.jalz.2011.03.005
    • McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack Jr CR, Kawas CH, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011;7:263-9.
    • (2011) Alzheimers Dement , vol.7 , pp. 263-269
    • McKhann, G.M.1    Knopman, D.S.2    Chertkow, H.3    Hyman, B.T.4    Jack, Jr.C.R.5    Kawas, C.H.6
  • 3
    • 79956084514 scopus 로고    scopus 로고
    • The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • 10.1016/j.jalz.2011.03.008
    • Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer Dement. 2011;7:270-9
    • (2011) Alzheimer Dement. , vol.7 , pp. 270-279
    • Albert, M.S.1    Dekosky, S.T.2    Dickson, D.3    Dubois, B.4    Feldman, H.H.5    Fox, N.C.6
  • 4
    • 83455187954 scopus 로고    scopus 로고
    • Dementia: New criteria but no new treatments
    • 22172609 10.1016/S1474-4422(11)70272-1
    • Sperling RA, Johnson KA. Dementia: new criteria but no new treatments. Lancet Neurol. 2012;11:4-5.
    • (2012) Lancet Neurol , vol.11 , pp. 4-5
    • Sperling, R.A.1    Johnson, K.A.2
  • 5
    • 84855364400 scopus 로고    scopus 로고
    • Effectiveness and safety of 18F-FDG PET in the evaluation of dementia: A review of the recent literature
    • 22173840 10.2967/jnumed.111.096578 1:CAS:528:DC%2BC38XitFCjurw%3D
    • Bohnen NI, Djang DSW, Herholz K, Anzai Y, Minoshima S. Effectiveness and safety of 18F-FDG PET in the evaluation of dementia: a review of the recent literature. J Nucl Med. 2012;53:59-71.
    • (2012) J Nucl Med , vol.53 , pp. 59-71
    • Bohnen, N.I.1    Djang, D.S.W.2    Herholz, K.3    Anzai, Y.4    Minoshima, S.5
  • 6
    • 77954981027 scopus 로고    scopus 로고
    • Comparing predictors of conversion and decline in mild cognitive impairment
    • 20592257 10.1212/WNL.0b013e3181e8e8b8
    • Landau S, Harvey D, Madison C, Reiman E, Foster N, Aisen P, et al. Comparing predictors of conversion and decline in mild cognitive impairment. Neurology. 2010;75:230-8.
    • (2010) Neurology , vol.75 , pp. 230-238
    • Landau, S.1    Harvey, D.2    Madison, C.3    Reiman, E.4    Foster, N.5    Aisen, P.6
  • 7
    • 0029040216 scopus 로고
    • A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET
    • 7790950 1:STN:280:DyaK2MzhtFSgtQ%3D%3D
    • Minoshima S, Frey KA, Koeppe RA, Foster NL, Kuhl DE. A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J Nucl Med. 1995;36:1238-48.
    • (1995) J Nucl Med , vol.36 , pp. 1238-1248
    • Minoshima, S.1    Frey, K.A.2    Koeppe, R.A.3    Foster, N.L.4    Kuhl, D.E.5
  • 8
    • 0036743220 scopus 로고    scopus 로고
    • Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET
    • 12482085 10.1006/nimg.2002.1208 1:STN:280:DC%2BD38jhvFOhsQ%3D%3D
    • Herholz K, Salmon E, Perani D, Baron JC, Holthoff V, Frolich L, et al. Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage. 2002;17:302-16.
    • (2002) Neuroimage , vol.17 , pp. 302-316
    • Herholz, K.1    Salmon, E.2    Perani, D.3    Baron, J.C.4    Holthoff, V.5    Frolich, L.6
  • 9
    • 79958766587 scopus 로고    scopus 로고
    • Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI
    • 19660834 10.1016/j.neurobiolaging.2009.07.002
    • Landau SM, Harvey D, Madison CM, Koeppe RA, Reiman EM, Foster NL, et al. Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. Neurobiol Aging. 2011;32:1207-18.
    • (2011) Neurobiol Aging , vol.32 , pp. 1207-1218
    • Landau, S.M.1    Harvey, D.2    Madison, C.M.3    Koeppe, R.A.4    Reiman, E.M.5    Foster, N.L.6
  • 10
    • 79953041925 scopus 로고    scopus 로고
    • Characterizing Alzheimer's disease using a hypometabolic convergence index
    • 21276856 10.1016/j.neuroimage.2011.01.049 1:CAS:528:DC%2BC3MXjvVOltro%3D
    • Chen K, Ayutyanont N, Langbaum JB, Langbaum J, Fleisher AS, Reschke C, et al. Characterizing Alzheimer's disease using a hypometabolic convergence index. Neuroimage. 2011;56:52-60
    • (2011) Neuroimage , vol.56 , pp. 52-60
    • Chen, K.1    Ayutyanont, N.2    Langbaum, J.B.3    Langbaum, J.4    Fleisher, A.S.5    Reschke, C.6
  • 11
    • 84873361594 scopus 로고    scopus 로고
    • Predicting cognitive decline in subjects at risk for Alzheimer disease by using combined cerebrospinal fluid, MR Imaging, and PET biomarkers
    • 23232293 10.1148/radiol.12120010
    • Shaffer JL, Petrella JR, Sheldon FC, Choudhury KR, Calhoun VD, Coleman RE, et al. Predicting cognitive decline in subjects at risk for Alzheimer disease by using combined cerebrospinal fluid, MR Imaging, and PET biomarkers. Radiology. 2013;266:583-91
    • (2013) Radiology , vol.266 , pp. 583-591
    • Shaffer, J.L.1    Petrella, J.R.2    Sheldon, F.C.3    Choudhury, K.R.4    Calhoun, V.D.5    Coleman, R.E.6
  • 12
    • 84859406520 scopus 로고    scopus 로고
    • Summary metrics to assess Alzheimer disease-related hypometabolic pattern with 18F-FDG PET: Head-to-head comparison
    • 22343502 10.2967/jnumed.111.094946 1:CAS:528:DC%2BC38XmvFejs70%3D
    • Caroli A, Prestia A, Chen K, Ayutyanont N, Landau SM, Madison CM, et al. Summary metrics to assess Alzheimer disease-related hypometabolic pattern with 18F-FDG PET: head-to-head comparison. J Nucl Med. 2012;53:592-600
    • (2012) J Nucl Med , vol.53 , pp. 592-600
    • Caroli, A.1    Prestia, A.2    Chen, K.3    Ayutyanont, N.4    Landau, S.M.5    Madison, C.M.6
  • 13
    • 80051703593 scopus 로고    scopus 로고
    • Evaluation of a calibrated 18F-FDG PET score as a biomarker for progression in Alzheimer Disease and mild cognitive impairment
    • 21764801 10.2967/jnumed.111.090902
    • Herholz K, Westwood S, Haense C, Dunn G. Evaluation of a calibrated 18F-FDG PET score as a biomarker for progression in Alzheimer Disease and mild cognitive impairment. J Nucl Med. 2011;52:1218-26.
    • (2011) J Nucl Med , vol.52 , pp. 1218-1226
    • Herholz, K.1    Westwood, S.2    Haense, C.3    Dunn, G.4
  • 15
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • 6610841 10.1212/WNL.34.7.939 1:STN:280:DyaL2c3ks1altQ%3D%3D
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939-44.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 16
    • 4544335597 scopus 로고    scopus 로고
    • Mild cognitive impairment as a diagnostic entity
    • 15324362 10.1111/j.1365-2796.2004.01388.x 1:STN:280: DC%2BD2cvhvFCkug%3D%3D
    • Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004;256:183-94.
    • (2004) J Intern Med , vol.256 , pp. 183-194
    • Petersen, R.C.1
  • 17
    • 0034986196 scopus 로고    scopus 로고
    • A new rating scale for age-related white matter changes applicable to MRI and CT
    • 11387493 10.1161/01.STR.32.6.1318 1:STN:280:DC%2BD3MzhsVerug%3D%3D
    • Wahlund L, Barkhof F, Fazekas F, Bronge L, Augustin M, Sjögren M, et al. A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke. 2001;32:1318-22.
    • (2001) Stroke , vol.32 , pp. 1318-1322
    • Wahlund, L.1    Barkhof, F.2    Fazekas, F.3    Bronge, L.4    Augustin, M.5    Sjögren, M.6
  • 18
    • 78650417030 scopus 로고    scopus 로고
    • Brain glucose metabolism in vascular white matter disease with dementia: Differentiation from Alzheimer disease
    • 21051671 10.1161/STROKEAHA.110.591552
    • Pascual B, Prieto E, Arbizu J, Marti-Climent J, Olier J, Masdeu JC. Brain glucose metabolism in vascular white matter disease with dementia: differentiation from Alzheimer disease. Stroke. 2010;41:2889-93.
    • (2010) Stroke , vol.41 , pp. 2889-2893
    • Pascual, B.1    Prieto, E.2    Arbizu, J.3    Marti-Climent, J.4    Olier, J.5    Masdeu, J.C.6
  • 20
    • 0036322886 scopus 로고    scopus 로고
    • Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain
    • 11771995 10.1006/nimg.2001.0978 1:STN:280:DC%2BD38%2FltFCntw%3D%3D
    • Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage. 2002;15:273-89.
    • (2002) Neuroimage , vol.15 , pp. 273-289
    • Tzourio-Mazoyer, N.1    Landeau, B.2    Papathanassiou, D.3    Crivello, F.4    Etard, O.5    Delcroix, N.6
  • 23
    • 70350061949 scopus 로고    scopus 로고
    • Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
    • 19829371 10.1038/nature08538 1:CAS:528:DC%2BD1MXht1KntLvO
    • Perrin RJ, Fagan AM, Holtzman DM. Multimodal techniques for diagnosis and prognosis of Alzheimer's disease. Nature. 2009;461:916-22.
    • (2009) Nature , vol.461 , pp. 916-922
    • Perrin, R.J.1    Fagan, A.M.2    Holtzman, D.M.3
  • 24
    • 84856414697 scopus 로고    scopus 로고
    • The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception
    • 22047634 10.1016/j.jalz.2011.09.172
    • Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, et al. The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement. 2012;8:S1-68.
    • (2012) Alzheimers Dement , vol.8
    • Weiner, M.W.1    Veitch, D.P.2    Aisen, P.S.3    Beckett, L.A.4    Cairns, N.J.5    Green, R.C.6
  • 25
    • 67549147148 scopus 로고    scopus 로고
    • Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease
    • 19339712 10.1212/WNL.0b013e3181a2e8d0 1:CAS:528:DC%2BD1MXkslOjs74%3D
    • Drzezga A, Grimmer T, Henriksen G, Mühlau M, Perneczky R, Miederer I, et al. Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease. Neurology. 2009;72:1487-94.
    • (2009) Neurology , vol.72 , pp. 1487-1494
    • Drzezga, A.1    Grimmer, T.2    Henriksen, G.3    Mühlau, M.4    Perneczky, R.5    Miederer, I.6
  • 26
    • 79952072253 scopus 로고    scopus 로고
    • APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease
    • 21224004 10.1016/j.neuroimage.2010.12.081 1:CAS:528:DC%2BC3MXjs12jsL8%3D
    • Pievani M, Galluzzi S, Thompson PM, Rasser PE, Bonetti M, Frisoni GB. APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease. Neuroimage. 2011;55:909-19.
    • (2011) Neuroimage , vol.55 , pp. 909-919
    • Pievani, M.1    Galluzzi, S.2    Thompson, P.M.3    Rasser, P.E.4    Bonetti, M.5    Frisoni, G.B.6
  • 27
    • 84862820930 scopus 로고    scopus 로고
    • Correlations between FDG PET glucose uptake-MRI gray matter volume scores and apolipoprotein e ε4 gene dose in cognitively normal adults: A cross-validation study using voxel-based multi-modal partial least squares
    • 22348880 10.1016/j.neuroimage.2012.02.005 1:CAS:528:DC%2BC38XltVyrtL0%3D
    • Chen K, Ayutyanont N, Langbaum JB, Langbaum J, Fleisher AS, Reschke C, et al. Correlations between FDG PET glucose uptake-MRI gray matter volume scores and apolipoprotein E ε4 gene dose in cognitively normal adults: a cross-validation study using voxel-based multi-modal partial least squares. Neuroimage 2012;60:2316-22
    • (2012) Neuroimage , vol.60 , pp. 2316-2322
    • Chen, K.1    Ayutyanont, N.2    Langbaum, J.B.3    Langbaum, J.4    Fleisher, A.S.5    Reschke, C.6
  • 28
    • 15444344926 scopus 로고    scopus 로고
    • Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease
    • 9708558 10.1002/ana.410440226 1:STN:280:DyaK1cznt1alsQ%3D%3D
    • Reiman EM, Uecker A, Caselli RJ, Lewis S, Bandy D, De Leon MJ, et al. Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease. Ann Neurol. 1998;44:288-91.
    • (1998) Ann Neurol , vol.44 , pp. 288-291
    • Reiman, E.M.1    Uecker, A.2    Caselli, R.J.3    Lewis, S.4    Bandy, D.5    De Leon, M.J.6
  • 29
    • 33644697324 scopus 로고    scopus 로고
    • Prediction of individual clinical outcome in MCI by means of genetic assessment and 18F-FDG PET
    • 16204712 1:CAS:528:DC%2BD28XitVGltrc%3D
    • Drzezga A, Grimmer T, Riemenschneider M, Lautenschlager N, Siebner H, Alexopoulus P, et al. Prediction of individual clinical outcome in MCI by means of genetic assessment and 18F-FDG PET. J Nucl Med. 2005;46:1625-32.
    • (2005) J Nucl Med , vol.46 , pp. 1625-1632
    • Drzezga, A.1    Grimmer, T.2    Riemenschneider, M.3    Lautenschlager, N.4    Siebner, H.5    Alexopoulus, P.6
  • 30
    • 19944406770 scopus 로고    scopus 로고
    • MCI conversion to dementia and the APOE genotype: A prediction study with FDG-PET
    • 15623696 10.1212/01.WNL.0000147469.18313.3B 1:STN:280: DC%2BD2cnkslWitw%3D%3D
    • Mosconi L, Perani D, Sorbi S, Herholz K, Nacmias B, Holthoff V, et al. MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET. Neurology. 2004;63:2332-40.
    • (2004) Neurology , vol.63 , pp. 2332-2340
    • Mosconi, L.1    Perani, D.2    Sorbi, S.3    Herholz, K.4    Nacmias, B.5    Holthoff, V.6
  • 31
    • 65249101314 scopus 로고    scopus 로고
    • MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers
    • 19251758 10.1093/brain/awp007 1:STN:280:DC%2BD1M3ns1Klug%3D%3D
    • Schuff N, Woerner N, Boreta L, Kornfield T, Shaw L, Trojanowski J, et al. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain. 2009;132:1067-77.
    • (2009) Brain , vol.132 , pp. 1067-1077
    • Schuff, N.1    Woerner, N.2    Boreta, L.3    Kornfield, T.4    Shaw, L.5    Trojanowski, J.6
  • 32
    • 77954181615 scopus 로고    scopus 로고
    • New research criteria for the diagnosis of Alzheimer's disease applied in a memory clinic population
    • 20606438 10.1159/000315542 1:STN:280:DC%2BC3cfgtVyqsg%3D%3D
    • Bouwman FH, Verwey NA, Klein M, Kok A, Blankenstein M, Sluimer J, et al. New research criteria for the diagnosis of Alzheimer's disease applied in a memory clinic population. Dement Geriatr Cogn Disord. 2010;30:1-7.
    • (2010) Dement Geriatr Cogn Disord , vol.30 , pp. 1-7
    • Bouwman, F.H.1    Verwey, N.A.2    Klein, M.3    Kok, A.4    Blankenstein, M.5    Sluimer, J.6
  • 34
    • 0030874251 scopus 로고    scopus 로고
    • Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
    • 9225689 10.1002/ana.410420114 1:STN:280:DyaK2szmvFajsw%3D%3D
    • Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol. 1997;42:85-94.
    • (1997) Ann Neurol , vol.42 , pp. 85-94
    • Minoshima, S.1    Giordani, B.2    Berent, S.3    Frey, K.A.4    Foster, N.L.5    Kuhl, D.E.6
  • 35
    • 17844364259 scopus 로고    scopus 로고
    • Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD
    • 15747152 10.1007/s00259-005-1762-7 1:CAS:528:DC%2BD2MXjtV2hs7o%3D
    • Mosconi L. Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD. Eur J Nucl Med Mol Imaging. 2005;32:486-510.
    • (2005) Eur J Nucl Med Mol Imaging , vol.32 , pp. 486-510
    • Mosconi, L.1
  • 36
    • 72049130805 scopus 로고    scopus 로고
    • Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
    • 20083042 10.1016/S1474-4422(09)70299-6 1:CAS:528:DC%2BC3cXhtFeru74%3D
    • Jack Jr CR, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, et al. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 2010;9:119-28.
    • (2010) Lancet Neurol , vol.9 , pp. 119-128
    • Jack, Jr.C.R.1    Knopman, D.S.2    Jagust, W.J.3    Shaw, L.M.4    Aisen, P.S.5    Weiner, M.W.6
  • 37
    • 77953963850 scopus 로고    scopus 로고
    • MCI patients declining and not-declining at mid-term follow-up: FDG-PET findings
    • 19939228 10.2174/156720510791162368 1:CAS:528:DC%2BC3cXmvFaisr4%3D
    • Pagani M, Dessi B, Morbelli S, Brugnolo A, Salmaso D, Piccini A, et al. MCI patients declining and not-declining at mid-term follow-up: FDG-PET findings. Curr Alzheimer Res. 2010;7:287-94.
    • (2010) Curr Alzheimer Res , vol.7 , pp. 287-294
    • Pagani, M.1    Dessi, B.2    Morbelli, S.3    Brugnolo, A.4    Salmaso, D.5    Piccini, A.6
  • 38
    • 0042736668 scopus 로고    scopus 로고
    • Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: A PET follow-up study
    • 12764551 10.1007/s00259-003-1194-1
    • Drzezga A, Lautenschlager N, Siebner H, Riemenschneider M, Willoch F, Minoshima S, et al. Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study. Eur J Nucl Med Mol Imaging. 2003;30:1104-13.
    • (2003) Eur J Nucl Med Mol Imaging , vol.30 , pp. 1104-1113
    • Drzezga, A.1    Lautenschlager, N.2    Siebner, H.3    Riemenschneider, M.4    Willoch, F.5    Minoshima, S.6
  • 39
    • 84856208685 scopus 로고    scopus 로고
    • Functional implications of hippocampal degeneration in early Alzheimer's disease: A combined DTI and PET study
    • 21792570 10.1007/s00259-011-1882-1
    • Yakushev I, Schreckenberger M, Müller MJ, Schermuly I, Cumming P, Stoeter P, et al. Functional implications of hippocampal degeneration in early Alzheimer's disease: a combined DTI and PET study. Eur J Nucl Med Mol Imaging. 2011;38:2219-27.
    • (2011) Eur J Nucl Med Mol Imaging , vol.38 , pp. 2219-2227
    • Yakushev, I.1    Schreckenberger, M.2    Müller, M.J.3    Schermuly, I.4    Cumming, P.5    Stoeter, P.6
  • 40
    • 84865597882 scopus 로고    scopus 로고
    • Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project
    • 22365486 10.1016/j.neurobiolaging.2012.01.005
    • Morbelli S, Drzezga A, Perneczky R, Frisoni GB, Caroli A, van Berckel BN, et al. Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project. Neurobiol Aging. 2012;33:2533-50
    • (2012) Neurobiol Aging , vol.33 , pp. 2533-2550
    • Morbelli, S.1    Drzezga, A.2    Perneczky, R.3    Frisoni, G.B.4    Caroli, A.5    Van Berckel, B.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.