The use of surface immobilization of P-selectin glycoprotein ligand-1 on mesenchymal stem cells to facilitate selectin mediated cell tethering and rolling

Biomaterials

Volumn 34, Issue 33, 2013, Pages 8213-8222

  Lo, Chi Y ^a   Antonopoulos, Aristotelis ^b   Dell, Anne ^b   Haslam, Stuart M ^b   Lee, Techung ^c   Neelamegham, Sriram ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Adhesion molecule; Blood flow; Cell adhesion; Endothelial cell; Mesenchymal stem cells; Recombinant protein

Indexed keywords

ADHESION MOLECULES; BLOOD FLOW; CELL-BASED THERAPY; FUCOSYLTRANSFERASES; HYDRODYNAMIC SHEAR; MESENCHYMAL STEM CELL; P-SELECTIN GLYCOPROTEIN LIGAND-1; SURFACE IMMOBILIZATION;

AMINO ACIDS; BLOOD VESSELS; CELL ADHESION; ENDOTHELIAL CELLS; FLOWCHARTING; GLYCOPROTEINS; LIGANDS; MOLECULES; POLYSACCHARIDES; PROTEINS; RECOMBINANT PROTEINS;

CELL IMMOBILIZATION;

ALPHA 1,3 FUCOSYLTRANSFERASE; AMINO ACID; GLYCAN DERIVATIVE; IMMUNOGLOBULIN G1; P SELECTIN GLYCOPROTEIN LIGAND 1; SELECTIN; SIALYL LEWIS X ANTIGEN;

ARTICLE; CELL ACTIVITY; CELL ADHESION; CELL FUNCTION; CELL ROLLING; CELL SURFACE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIUM CELL; HYDRODYNAMICS; IMMOBILIZED CELL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SHEAR STRESS; SIGNAL TRANSDUCTION; TETHERING CELL; THROMBOCYTE;

19FC AND 19FC[FUT7(+)]; ADHESION MOLECULE; BLOOD FLOW; CELL ADHESION; ENDOTHELIAL CELL; FUSION PROTEIN OF PSGL-1 N-TERMINAL PEPTIDE FUSED TO HUMAN IGG1 FC EXPRESSED IN EITHER WILD-TYPE HEK293T (HEK) OR HEK OVEREXPRESSING Α(1,3)FUCOSYLTRANSFERASE, FUT7; MESENCHYMAL STEM CELLS; PALMITATED-PROTEIN G CONJUGATE; PPG; RECOMBINANT PROTEIN;

ALKALINE PHOSPHATASE; CELL ADHESION; CELL LINE; CELL SURVIVAL; E-SELECTIN; HUMANS; MEMBRANE GLYCOPROTEINS; MESENCHYMAL STROMAL CELLS; MICROSCOPY, CONFOCAL; P-SELECTIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84881664296     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.07.033     Document Type: Article

References (43)

1. Ren G., Chen X., Dong F., Li W., Ren X., Zhang Y., et al. Concise review: mesenchymal stem cells and translational medicine: emerging issues. Stem Cells Transl Med 2012, 1:51-58.
2. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
3. Uccelli A., Moretta L., Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008, 8:726-736.
4. Phinney D.G., Prockop D.J. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells 2007, 25:2896-2902.
5. Steingen C., Brenig F., Baumgartner L., Schmidt J., Schmidt A., Bloch W. Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells. JMol Cell Cardiol 2008, 44:1072-1084.
6. Karp J.M., Leng Teo G.S. Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell. 2009, 4:206-216.
7. Ruster B., Gottig S., Ludwig R.J., Bistrian R., Muller S., Seifried E., et al. Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells. Blood 2006, 108:3938-3944.
8. Thankamony S.P., Sackstein R. Enforced hematopoietic cell E- and L-selectin ligand (HCELL) expression primes transendothelial migration of human mesenchymal stem cells. Proc Natl Acad Sci USA 2011, 108:2258-2263.
9. Barbash I.M., Chouraqui P., Baron J., Feinberg M.S., Etzion S., Tessone A., et al. Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation 2003, 108:863-868.
10. Devine S.M., Cobbs C., Jennings M., Bartholomew A., Hoffman R. Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. Blood 2003, 101:2999-3001.
11. Macmillan M.L., Blazar B.R., DeFor T.E., Wagner J.E. Transplantation of ex-vivo culture-expanded parental haploidentical mesenchymal stem cells to promote engraftment in pediatric recipients of unrelated donor umbilical cord blood: results of a phase I-II clinical trial. Bone Marrow Transplant 2009, 43:447-454.
12. Le Blanc K., Frassoni F., Ball L., Locatelli F., Roelofs H., Lewis I., et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008, 371:1579-1586.
13. Freyman T., Polin G., Osman H., Crary J., Lu M., Cheng L., et al. Aquantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction. Eur Heart J 2006, 27:1114-1122.
14. Leiker M., Suzuki G., Iyer V.S., Canty J.M., Lee T. Assessment of a nuclear affinity labeling method for tracking implanted mesenchymal stem cells. Cell Transplant 2008, 17:911-922.
15. Millard S.M., Fisk N.M. Mesenchymal stem cells for systemic therapy: shotgun approach or magic bullets?. Bioassays 2013, 35:173-182.
16. Cheng Z., Ou L., Zhou X., Li F., Jia X., Zhang Y., et al. Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance. Mol Ther 2008, 16:571-579.
17. Sackstein R., Merzaban J.S., Cain D.W., Dagia N.M., Spencer J.A., Lin C.P., et al. Exvivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. Nat Med 2008, 14:181-187.
18. Sarkar D., Vemula P.K., Zhao W., Gupta A., Karnik R., Karp J.M. Engineered mesenchymal stem cells with self-assembled vesicles for systemic cell targeting. Biomaterials 2010, 31:5266-5274.
19. Sarkar D., Spencer J.A., Phillips J.A., Zhao W., Schafer S., Spelke D.P., et al. Engineered cell homing. Blood 2011, 118:e184-e191.
20. Cheng H., Byrska-Bishop M., Zhang C.T., Kastrup C.J., Hwang N.S., Tai A.K., et al. Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics. Biomaterials 2012, 33:5004-5012.
21. Ko I.K., Kean T.J., Dennis J.E. Targeting mesenchymal stem cells to activated endothelial cells. Biomaterials 2009, 30:3702-3710.
22. Ko I.K., Kim B.G., Awadallah A., Mikulan J., Lin P., Letterio J.J., et al. Targeting improves MSC treatment of inflammatory bowel disease. Mol Ther 2010, 18:1365-1372.
23. Guan M., Yao W., Liu R., Lam K.S., Nolta J., Jia J., et al. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nat Med 2012, 18:456-462.
24. Beauharnois M.E., Lindquist K.C., Marathe D., Vanderslice P., Xia J., Matta K.L., et al. Affinity and kinetics of sialyl Lewis-X and core-2 based oligosaccharides binding to L- and P-selectin. Biochemistry 2005, 44:9507-9519.
25. Lo C.Y., Antonopoulos A., Gupta R., Qu J., Dell A., Haslam S.M., et al. Competition between core-2 GlcNAc-transferase and ST6GalNAc-transferase regulates the synthesis of the leukocyte selectin ligand on human P-selectin glycoprotein ligand-1. JBiol Chem 2013, 288:13974-13987.
26. Goetz D.J., Greif D.M., Ding H., Camphausen R.T., Howes S., Comess K.M., et al. Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin. JCell Biol 1997, 137:509-519.
27. Jones D.A., Smith C.W., McIntire L.V. Leucocyte adhesion under flow conditions: principles important in tissue engineering. Biomaterials 1996, 17:337-347.
28. Kim S.A., Peacock J.S. The use of palmitate-conjugated protein A for coating cells with artificial receptors which facilitate intercellular interactions. JImmunol Methods 1993, 158:57-65.
29. Marathe D.D., Buffone A., Chandrasekaran E.V., Xue J., Locke R.D., Nasirikenari M., et al. Fluorinated per-acetylated GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins. Blood 2010, 115:1303-1312.
30. Buffone A., Mondal N., Gupta R., McHugh K.P., Lau J.T., Neelamegham S. Silencing alpha1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion. JBiol Chem 2013, 288:1620-1633.
31. Jang-Lee J., North S.J., Sutton-Smith M., Goldberg D., Panico M., Morris H., et al. Glycomic profiling of cells and tissues by mass spectrometry: fingerprinting and sequencing methodologies. Methods Enzymol 2006, 415:59-86.
32. Ceroni A., Maass K., Geyer H., Geyer R., Dell A., Haslam S.M. GlycoWorkbench: a tool for the computer-assisted annotation of mass spectra of glycans. JProteome Res 2008, 7:1650-1659.
33. Xiao Z.H., Goldsmith H.L., McIntosh F.A., Shankaran H., Neelamegham S. Biomechanics of P-selectin PSGL-1 bonds: shear threshold and integrin-independent cell adhesion. Biophys J 2006, 90:2221-2234.
34. Vestweber D., Blanks J.E. Mechanisms that regulate the function of the selectins and their ligands. Physiol Rev 1999, 79:181-213. [Review].
35. Babu P., North S.J., Jang-Lee J., Chalabi S., Mackerness K., Stowell S.R., et al. Structural characterisation of neutrophil glycans by ultra sensitive mass spectrometric glycomics methodology. Glycoconj J 2009, 26:975-986.
36. Huhn C., Selman M.H., Ruhaak L.R., Deelder A.M., Wuhrer M. IgG glycosylation analysis. Proteomics 2009, 9:882-913.
37. Raju T.S., Briggs J.B., Borge S.M., Jones A.J. Species-specific variation in glycosylation of IgG: evidence for the species-specific sialylation and branch-specific galactosylation and importance for engineering recombinant glycoprotein therapeutics. Glycobiology 2000, 10:477-486.
38. Baumann H., Doyle D. Turnover of plasma membrane glycoproteins and glycolipids of hepatoma tissue culture cells. JBiol Chem 1978, 253:4408-4418.
39. Zhang Y., Neelamegham S. Estimating the efficiency of cell capture and arrest in flow chambers: study of neutrophil binding via E-selectin and ICAM-1. Biophys J 2002, 83:1934-1952.
40. Komarova S., Roth J., Alvarez R., Curiel D.T., Pereboeva L. Targeting of mesenchymal stem cells to ovarian tumors via an artificial receptor. JOvarian Res 2010, 3:12.
41. Somers W.S., Tang J., Shaw G.D., Camphausen R.T. Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell 2000, 103:467-479.
42. Teo G.S., Ankrum J.A., Martinelli R., Boetto S.E., Simms K., Sciuto T.E., et al. Mesenchymal stem cells transmigrate between and directly through tumor necrosis factor-alpha-activated endothelial cells via both leukocyte-like and novel mechanisms. Stem Cells 2012, 30:2472-2486.
43. Chamberlain G., Smith H., Rainger G.E., Middleton J. Mesenchymal stem cells exhibit firm adhesion, crawling, spreading and transmigration across aortic endothelial cells: effects of chemokines and shear. PLoS One 2011, 6:e25663.