CYP450 enzyme inhibition of berberine in pooled human liver microsomes by cocktail probe drugs

Zhongguo Zhongyao Zazhi

Volumn 38, Issue 12, 2013, Pages 2009-2014

  Chen, Jian Long ^a,b   Zhang, Yu Ling ^a,b   Dong, Yu ^b   Gong, Ji Yu ^a   Cui, Han Ming ^b  

^a CHANGCHUN UNIVERSITY   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

Berberine; Cocktail; CYP450 enzyme inhibition; Pooled human liver microsomes; Probe drugs

Indexed keywords

BERBERINE; CHLORZOXAZONE; COCKTAIL PROBE DRUG; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; DIPHENHYDRAMINE; DRUG; MIDAZOLAM; PHENACETIN; TOLBUTAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY;

BERBERINE; CHLORZOXAZONE; CYTOCHROME P-450 ENZYME SYSTEM; DEXTROMETHORPHAN; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICROSOMES, LIVER; MIDAZOLAM; PHENACETIN; TOLBUTAMIDE;

EID: 84881655903     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20131233     Document Type: Article

References (14)

1. Wienkers L C, Heath T G. Predicting in vivo drug interactions from in vitro drug discovery data[J]. Nat Rev Drug Discov, 2005, 4: 825.
2. 2013, 38(4): 618.
3. 2007, 41(2): 105.
4. Hua W, Ding L, Chen Y, et al. Determination of berberine in human plasma by liquid chromatography-electrospray ionization-mass spectrometry[J]. J Pharm Biomed Anal, 2007, 44: 931.
5. 2012, 37(7): 985.
6. Yi Li, Gang Ren, Yan-Xiang Wang, et al. Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes[J]. J Transl Med, 2011, 9: 62.
7. Ying Guo, Feng Li, Xiaochao Ma, et al. CYP2D plays a major role in berberine metabolism in liver of mice and humans[J]. Xenobiotica, 2011, 41(11): 996.
8. Food and drug Administration. Guidance for industry drug interaction studies[S]. U.S. Department of Health and Human Services, 2006.
9. Kobayashi K, Kajiwara E, Ishikawa M, et al. Identification of CYP isozymes involved in benzbromarone metabolism in human liver microsomes[J]. Biopharm Drug Dispos, 2012, 33(8): 466.
10. Jiang R, Yamaori S, Takeda S, et al. Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes[J]. Life Sci, 2011, 89(5/6): 165.
11. Goldberg R M, Mabee J, Chan L, et al. Drug-drug and drug-disease interactions in the ED analysis of a high-risk population[J]. Am J Emerg Med, 1996, 14(5): 447.
12. 1997, 13(1): 57.
13. Beriz R J, Granneman G R. Use of in vitro and in vivo data to estimate the likelihood of metabolie phannacokinetic interactions[J]. Clin Pharmacokinet, 1997, 32(3): 210.
14. 2012, 37(14): 2164.