Safety and immunological outcomes following human inoculation with nontypeable haemophilus influenzae

Journal of Infectious Diseases

Volumn 208, Issue 5, 2013, Pages 728-738

  Winokur, Patricia L ^a,c   Chaloner, Kathryn ^a   Doern, Gary V ^a   Ferreira, Jennifer ^d   Apicella, Michael A ^b  

^a Department of Internal Medicine ^*  (United States)

^b UNIVERSITY OF IOWA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d EMMES CORPORATION   (United States)

Author keywords

adaptive design; Bayesian analysis; Haemophilus influenzae; nasopharyngeal colonization; respiratory pathogens; upper respiratory tract

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADULT; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BIOSAFETY; COLONY FORMING UNIT; FEMALE; HAEMOPHILUS INFLUENZAE; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNODETECTION; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOLOGICAL TOLERANCE; MALE; NONHUMAN; NONTYPEABLE HAEMOPHILUS INFLUENZAE; NORMAL HUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SIALYLATION;

ADAPTIVE DESIGN; BAYESIAN ANALYSIS; HAEMOPHILUS INFLUENZAE; NASOPHARYNGEAL COLONIZATION; RESPIRATORY PATHOGENS; UPPER RESPIRATORY TRACT;

ADOLESCENT; ADULT; CARRIER STATE; FEMALE; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMAN EXPERIMENTATION; HUMANS; MALE; MODELS, THEORETICAL; YOUNG ADULT;

EID: 84881649420     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit238     Document Type: Article

References (42)

1. Mukundan D, Ecevit Z, Patel M, Marrs CF, Gilsdorf JR. Pharyngeal colonization dynamics of Haemophilus influenzae and Haemophilus haemolyticus in healthy adult carriers. J Clin Micro 2007; 45:3207-17.
2. Murphy TF, Apicella MA. Nontypable Haemophilus influenzae: a review of clinical aspects, surface antigens, and the human immune response to infection. Rev Infect Dis 1987; 9:1-15.
3. Faden H, Duffy L, Williams A, Krystofik DA, Wolf J. Epidemiology of nasopharyngeal colonization with nontypeable Haemophilus influenzae in the first 2 years of life. J Infect Dis 1995; 172:132-5.
4. Raymond J, Armand-Lefevre L, Moulin F, et al. Nasopharyngeal colonization by Haemophilus influenzae in children living in an orphanage. Pediactr Infect Dis J 2001; 20:779-84.
5. Samuelson A, Freijd A, Jonasson J, Lindberg AA. Turnover of nonencapsulated Haemophilus influenzae in the nasopharynges of otitisprone children. J Clin Micro 1995; 33:2027-31.
6. van Wessel K, Rodenburg GD, Veenhoven RH, Spanjaard L, van der Ende A, Sanders EA. Nontypeable Haemophilus influenzae invasive disease in The Netherlands: a retrospective surveillance study 2001-2008. Clin Infect Dis 2011; 53:e1-7.
7. Ingvarsson L, Tungren K, Olofsson B. Epidemiology of otitis media in children. In: Tim DJ, ed. Recent advances in otitis media with effusion. Toronto: Decker, 1984:22-5.
8. Casey JR, Pichichero ME. Changes in frequency and pathogens causing acute otitis media in 1995-2003. Pediatr Infect Dis J 2004; 23:824-8.
9. Pichichero ME, Casey JR, Hoberman A, Schwartz R. Pathogens causing recurrent and difficult-to-treat acute otitis media, 2003-2006. Clin Pediatr (Phila) 2008; 47:901-6.
10. Talbot GH, Kennedy DW, Scheld WM, Granito K. Rigid nasal endoscopy versus sinus puncture and aspiration for microbiologic documentation of acute bacterial maxillary sinusitis. Clin Infect Dis 2001; 33: 1668-75.
11. Sethi S, Murphy TF. Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review. Clin Micro Rev 2001; 14:336-63.
12. Ruuskanen O, Arola M, Putto-Laurila A, et al. Acute otitis media and respiratory virus infections. Pediatr Infect Dis J 1989; 8:94-9.
13. Heikkinen T, Chonmaitree T. Importance of respiratory viruses in acute otitis media. Clin Micro Rev 2003; 16:230-41.
14. Prymula R, Peeters P, Chrobok V, et al. Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study. Lancet 2006; 367:740-8.
15. Poolman JT, Bakaletz L, Cripps A, et al. Developing a nontypeable Haemophilus influenzae (NTHi) vaccine. Vaccine 2000;19(Suppl 1): S108-15.
16. Gu XX, Rudy SF, Chu C, et al. Phase I study of a lipooligosaccharidebased conjugate vaccine against nontypeable Haemophilus influenzae. Vaccine 2003; 21:2107-14.
17. Lim DJ, Bluestone CD, Casselbradnt ML, eds. Recent advances in otitis media: report of the Ninth Research Conference, 2010:94-119. http://otitissymposium.org/pdfs/9th-IOMS-FINAL-Res-Conf-Report.pdf.
18. Foxwell AR, Kyd JM, Cripps AW. Nontypeable Haemophilus influenzae: pathogenesis and prevention. MicrobiolMol Biol Rev 1998; 62:294-308.
19. Bong CT, Throm RE, Fortney KR, et al. DsrA-deficient mutant of Haemophilus ducreyi is impaired in its ability to infect human volunteers. Infect Immun 2001; 69:1488-91.
20. Young RS, Fortney KR, Gelfanova V, et al. Expression of cytolethal distending toxin and hemolysin is not required for pustule formation by Haemophilus ducreyi in human volunteers. Infect Immun 2001; 69: 1938-42.
21. Schneider H, Cross AS, Kuschner RA, et al. Experimental human gonococcal urethritis: 250 Neisseria gonorrhoeae MS11mkC are infective. J Infect Dis 1995; 172:180-5.
22. Schneider H, Schmidt KA, Skillman DR, et al. Sialylation lessens the infectivity of Neisseria gonorrhoeae MS11mkC. J Infect Dis 1996; 173:1422-7.
23. McCool TL, Cate TR, Moy G, Weiser JN. The immune response to pneumococcal proteins during experimental human carriage. J Exp Med 2002; 195:359-65.
24. McCool TL, Cate TR, Tuomanen EI, Adrian P, Mitchell TJ, Weiser JN. Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization. Infect Immun 2003; 71:5724-32.
25. Leach AJ, Boswell JB, Asche V, Nienhuys TG, Mathews JD. Bacterial colonization of the nasopharynx predicts very early onset and persistence of otitis media in Australian aboriginal infants. Pediatr Infect Dis J 1994; 13:983-9.
26. Jurcisek J, Greiner L, Watanabe H, Zaleski A, Apicella MA, Bakaletz LO. Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear. Infect Immun 2005; 73:3210-8.
27. Pang B, Winn D, Johnson R, et al. Lipooligosaccharides containing phosphorylcholine delay pulmonary clearance of nontypeable Haemophilus influenzae. Infect Immun 2008; 76:2037-43.
28. Schachern PA, Tsuprun V, Wang B, et al. Effect of lipooligosaccharide mutations of Haemophilus influenzae on the middle and inner ears. Int J Pediatr Otorhinolaryngol 2009; 73:1757-60.
29. Swords WE, Buscher BA, Ver Steeg Ii K, et al. Non-typeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptor. Mol Microbiol 2000; 37:13-27.
30. Swords WE, Ketterer MR, Shao J, Campbell CA,Weiser JN, Apicella MA. Binding of the non-typeable Haemophilus influenzae lipooligosaccharide to the PAF receptor initiates host cell signalling. Cell Microbiol 2001; 3: 525-36.
31. Jones PA, Samuels NM, Phillips NJ, et al. Haemophilus influenzae type b strain A2 has multiple sialyltransferases involved in lipooligosaccharide sialylation. J Biol Chem 2002; 277:14598-611.
32. Johnston JW, Shamsulddin H, Miller AF, Apicella MA. Sialic acid transport and catabolism are cooperatively regulated by SiaR and CRP in nontypeable Haemophilus influenzae. BMC Microbiol 2010; 10:240.
33. Gilja OH, Halstensen A, Digranes A, Mylvaganam H, Aksnes A, Hoiby EA. Use of single-dose ofloxacin to eradicate tonsillopharyngeal carriage of Neisseria meningitidis. Antimicrob Agents Chemother 1993; 37:2024-6.
34. Pugsley MP, Dworzack DL, Horowitz EA, Cuevas TA, Sanders WE Jr, Sanders CC. Efficacy of ciprofloxacin in the treatment of nasopharyngeal carriers of Neisseria meningitidis. J Infect Dis 1987; 156:211-3.
35. Baron EJ, Bailey WR, Finegold SM. Bailey and Scott's diagnostic microbiology. 8th ed. St. Louis: Mosby, 1990.
36. Abdillahi H, Poolman JT. Whole-cell ELISA for typing Neisseria meningitidis with monoclonal antibodies. FEMS Microbiol Lett 1987; 48:367-71.
37. Babb JS, Rogatko A. Bayesian methods for cancer phase I clinical trials. In: Geller NL, ed. Advances in clinical trial biostatistics. New York: Marcel Dekker, 2004:1-39.
38. Gastonis C, Greenhouse JB. Bayesian methods for phase I clinical trials. Stat Med 1992; 11:1377-89.
39. Spiegelhalter D, Thomas A, Best N. WinBUGS user manual. Medical Research Council, 2003.
40. Sethi S, Evans N, Grant BJ, Murphy TF. New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med 2002; 347:465-71.
41. Sethi S, Wrona C, Grant BJ, Murphy TF. Strain-specific immune response to Haemophilus influenzae in chronic obstructive pulmonary disease. Am J Resp Crit Care Med 2004; 169:448-53.
42. Pichichero ME, Kaur R, Casey JR, Sabirov A, Khan MN, Almudevar A. Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children. Vaccine 2010; 28:7184-92.