Antifibrotic therapy in pancreatic diseases

Gut

Volumn 62, Issue 9, 2013, Pages 1244-1245

  Erkan, Mert ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBROTIC AGENT; BEVACIZUMAB; CHAPERONE; COLLAGEN; GEMCITABINE; HEAT SHOCK PROTEIN 47; LIPOSOME; PLACEBO; PROTEIN GP46; RETINOL; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; CELL ACTIVATION; CELL TRANSDIFFERENTIATION; CHRONIC PANCREATITIS; CYSTIC FIBROSIS; DRUG EFFICACY; HUMAN; LIVER CIRRHOSIS; NONHUMAN; NOTE; PANCREAS CANCER; PANCREAS DISEASE; PANCREAS INJURY; PANCREATIC STELLATE CELL; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN LOCALIZATION; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ANGIOGENESIS; CELL MATRIX INTERACTION; CIRRHOSIS; PANCREATIC CANCER; PANCREATIC FIBROSIS;

ANIMALS; COLLAGEN; FIBROSIS; HSP47 HEAT-SHOCK PROTEINS; HUMANS; MALE; PANCREAS; PANCREATITIS, CHRONIC; RNA, SMALL INTERFERING;

EID: 84881546336     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-303937     Document Type: Note

References (11)

1. Ishiwatari. H, Sato Y, Murase K, et al Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitaminA-coupled liposome. Gut 2013;62:1328-39.
2. Sato Y, Murase K, Kato J, et al. Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat Biotechnol 2008;26:431-42. (Pubitemid 351501817)
3. Erkan M, Adler G, Apte MV, et al. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut 2012;61: 172-8.
4. Erkan M, Reiser-Erkan C, Michalski CW, et al. The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance. Curr Mol Med 2012;12:288-303.
5. Pinzani M. Pancreatic stellate cells: new kids become mature. Gut 2006;55:12-14. (Pubitemid 41820628)
6. Dafforn TR, Della M, Miller AD. The molecular interactions of heat shock protein 47 (Hsp47) and their implications for collagen biosynthesis. J Biol Chem 2001;276:49310-19.
7. Masamune A, Watanabe T, Kikuta K, et al. Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis. Clin Gastroenterol Hepatol 2009;7: S48-54.
8. Masamune A, Kikuta K, Watanabe T, et al. Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol 2008;295: G709-17.
9. Kindler HL, Niedzwiecki D, Hollis D, et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol 2010;28:3617-22.
10. Jacobetz MA, Chan DS, Neesse A, et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut 2012;62:112-20.
11. Olive KP, Jacobetz MA, Davidson CJ, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009;324:1457-61.