Distinct Gene Expression Signatures in Lynch Syndrome and Familial Colorectal Cancer Type X

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Dominguez Valentin, Mev ^a   Therkildsen, Christina ^b   Veerla, Srinivas ^a   Jönsson, Mats ^a   Bernstein, Inge ^b   Borg, Åke ^a   Nilbert, Mef ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b Mental Health Center Glostrup   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; G PROTEIN COUPLED RECEPTOR;

ADULT; AGED; ARTICLE; AXIN2 GENE; CARCINOGENESIS; CELL CYCLE; CONTROLLED STUDY; DISEASE CLASSIFICATION; DNA2 GENE; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE TARGETING; GENETIC COUNSELING; H2AFZ GENE; HEREDITARY COLORECTAL CANCER; HEREDITARY COLORECTAL CANCER TYPE X; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; LIGATION; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MISMATCH REPAIR; MITOSIS; NDUFA9 GENE; ONCOGENE MYC; OXIDATIVE PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOMATOUS POLYPOSIS COLI; CLUSTER ANALYSIS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 84881540394     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071755     Document Type: Article

References (45)

1. Mecklin JP, Järvinen HJ (2005) Surveillance in Lynch syndrome. Fam Cancer 4: 267-271. Review.
2. Balmaña J, Castells A, Cervantes A, (2010) ESMO Guidelines Working Group (2010) Familial colorectal cancer risk: ESMO Clinical Practice Guidelines. Ann Oncol 5: v78-81.
3. Vasen HF, Mecklin JP, Khan PM, Lynch HT, (1991) The international collaborative group on hereditary non-polyposis colorectal cancer (ICG-HNPCC). Dis Colon Rectum 34: 424-425.
4. Vasen HF, Watson P, Mecklin JP, Lynch HT, (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 116: 1453-1456.
5. Lynch HT, Lynch PM, (2005) Molecular screening for the Lynch syndrome-better than family history? N Engl J Med 352: 1920-1922.
6. Jass JR (2006) Colorectal cancer: a multipathway disease. Crit Rev Oncog 12: 273-287. Review.
7. Vasen HF, Möslein G, Alonso A, Bernstein I, Bertario L, et al. (2007) Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). J Med Genet 44: 353-362.
8. Lindor NM, Rabe K, Petersen GM, Haile R, Casey G, et al. (2005) Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. JAMA. 293: 1979-1985.
9. Abdel-Rahman WM, Ollikainen M, Kariola R, Järvinen HJ, Mecklin J, et al. (2005) Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations. Oncogene 24: 1542-1551.
10. Llor X, Pons E, Xicola RM, Castells A, Alenda C, et al. (2005) Differential features of colorectal cancers fulfilling Amsterdam criteria without involvement of the mutator pathway. Clin Cancer Res 11: 7304-7310.
11. Klarskov L, Holck S, Bernstein I, Nilbert M, (2012) Hereditary colorectal cancer diagnostics: morphological features of familial colorectal cancer type X versus Lynch syndrome. J Clin Pathol 65: 352-356.
12. Middeldorp A, Van Eijk R, Oosting J, Forte GI, van Puijenbroek M, et al. (2012) Increased frequency of 20q gain and copy-neutral loss of heterozygosity in mismatch repair proficient familial colorectal carcinomas. Int J Cancer 130: 837-846.
13. Therkildsen C, Jönsson G, Dominguez-Valentin M, Nissen A, Rambech E, et al. (2012) Gain of chromosomal region 20q and loss of 18 discriminates between Lynch syndrome and familial colorectal cancer. Eur J Cancer. Dec 11. doi:pii: S0959-8049(12)00896-9.10.1016/j.ejca.2012.11.011.
14. Lee WS, Seo G, Shin HJ, Yun SH, Yun H, et al. (2008) Identification of differentially expressed genes in microsatellite stable HNPCC and sporadic colon cancer. J Surg Res 144: 29-35.
15. Sánchez-de-Abajo A, de la Hoya M, van Puijenbroek M, Tosar A, López-Asenjo JA, et al. (2007) Molecular analysis of colorectal cancer tumors from patients with mismatch repair proficient hereditary nonpolyposis colorectal cancer suggests novel carcinogenic pathways. Clin Cancer Res 13: 5729-5735.
16. Kim H, Nam SW, Rhee H, Shan Li L, Ju Kang H, et al. (2004) Different gene expression profiles between microsatellite instability-high and microsatellite stable colorectal carcinomas. Oncogene 23: 6218-6225.
17. Banerjea A, Ahmed S, Hands RE, Huang F, Han X, et al. (2004) Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity. Mol Cancer 3: 21.
18. Bertucci F, Salas S, Eysteries S, Nasser V, Finetti P, et al. (2004) Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters. Oncogene 23: 1377-1391.
19. Fan JB, Yeakley JM, Bibikova M, Chudin E, Wickham E, et al. (2004) A versatile assay for high-throughput gene expression profiling on universal array matrices. Genome Res 14: 878-885.
20. Kuhn K, Baker SC, Chudin E, Lieu MH, Oeser S, et al. (2004) A novel, high-performance random array platform for quantitative gene expression profiling. Genome Res 14: 2347-2356.
21. Workman C, Jensen LJ, Jarmer H, Berka R, Gautier L, et al. (2002) A new non-linear normalization method for reducing variability in DNA microarray experiments. Genome Biol 30 3(9): research0048.
22. Saeed AI, Sharov V, White J, Li J, Liang W, et al. (2003) TM4: a free, open-source system for microarray data management and analysis. Biotechniques 34: 374-378.
23. Tusher VG, Tibshirani R, Chu G, (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 24: 5116-5121. Erratum in: Proc Natl Acad Sci USA 28: 10515.
24. Benjamini Y, Drai D, Elmer G, Kafkafi N, Golani I, (2001) Controlling the false discovery rate in behavior genetics research. Behav Brain Res 125: 279-284.
25. Huang da W, Sherman BT, Lempicki RA, (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.
26. Cancer Genome Atlas Network, (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487: 330-337.
27. Watanabe T, Kobunai T, Toda E, Yamamoto Y, Kanazawa T, et al. (2006) Distal colorectal cancers with microsatellite instability (MSI) display distinct gene expression profiles that are different from proximal MSI cancers. Cancer Res 66: 9804-988.
28. Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314: 268-274.
29. Wilson CH, McIntyre RE, Arends MJ, Adams DJ, (2010) The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways. Oncogene 29: 4567-4575.
30. Hu Y, Fang C, Xu Y, (2005) The effect of isoforms of the cell polarity protein, human ASIP, on the cell cycle and Fas/FasL-mediated apoptosis in human hepatoma cells. Cell Mol Life Sci 62: 1974-1983.
31. Jin YT, Ying XX, Hu YH, Zou Q, Wang HY, et al. (2008) aPKC inhibitors might be the sensitizer of chemotherapy and adoptive immunotherapy in the treatment of hASIPa-overexpressed breast cancer. Oncol Res 17: 59-68.
32. Watanabe K, Kawamori T, Nakatsugi S, Ohta T, Ohuchida S, et al. (1999) Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Cancer Res 59: 5093-5096.
33. Kim SH, Park YY, Kim SW, Lee JS, Wang D, et al. (2011) ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression. Cancer Res 71: 7010-7020.
34. Greenhough A, Smartt HJ, Moore AE, Roberts HR, Williams AC, et al. (2009) The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis 30: 377-386. Review.
35. Yuan Z, Sotsky KT, Weber TK, (2003) Differential expression of DOC-1 in microsatellite-unstable human colorectal cancer. Oncogene 22: 6304-6310.
36. Dunican DS, McWilliam P, Tighe O, Parle-McDermott A, Croke DT (2002) Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density hybridization. Oncogene 21,3253-3257.
37. Sinicrope FA, Roddey G, Lemoine M, Ruan S, Stephens LC, et al. (1998) Loss of p21WAF1/Cip1 protein expression accompanies progression of sporadic colorectal neoplasms but not hereditary nonpolyposis colorectal cancers. Clin Cancer Res 4: 1251-1261.
38. Duldulao MP, Lee W, Le M, Chen Z, Li W, et al. (2012) Gene expression variations in microsatellite stable and unstable colon cancer cells. J Surg Res 174: 1-6.
39. Jardim MJ, Wang Q, Furumai R, Wakeman T, Goodman BK, Wang XF, (2009b) Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells. Mol Biol Cell 20: 3801-3809.
40. Pires IM, Ward TH, Dive C, (2010) Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors. Br J Pharmacol 159: 1326-1338.
41. Benatti P, Roncucci L, Ganazzi D, Percesepe A, Di GC, et al. (2001) Clinical and biologic heterogeneity of hereditary nonpolyposis colorectal cancer. Int J Cancer 95: 323-328.
42. Belt EJ, Brosens RP, Delis-van Diemen PM, Bril H, Tijssen M, et al. (2012) Cell Cycle Proteins Predict Recurrence in Stage II and III Colon Cancer. Ann Surg Oncol 3: S682-692.
43. Ogino S, Nosho K, Irahara N, Meyerhardt JA, Baba Y, et al. (2009) Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpGisland and methylator phenotype. Clin Cancer Res 15: 6412-6420.
44. Yang M, Zhong WW, Srivastava N, Slavin A, Yang J, et al. (2005) G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway. Proc Natl Acad Sci USA 102: 6027-6032.
45. Malbon CC (2005). Beta-catenin, cancer, and G proteins: not just for frizzleds anymore. Sci STKE 292: pe35. Review.