Low serum levels of 25-hydroxyvitamin D predict hip fracture in the elderly: A NOREPOS study

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 8, 2013, Pages 3341-3350

  Holvik, Kristin ^a,b   Ahmed, Luai A ^c   Forsmo, Siri ^d   Gjesdal, Clara G ^a,e   Grimnes, Guri ^c   Samuelsen, Sven Ove ^b,f   Schei, Berit ^d   Blomhoff, Rune ^f   Tell, Grethe S ^a,b   Meyer, Haakon E ^b,f  

^a UNIVERSITY OF BERGEN   (Norway)

^b NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^c UNIVERSITY OF TROMSØ   (Norway)

^d NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^e HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^f UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D;

AGE; AGED; ARTICLE; BODY MASS; COHORT ANALYSIS; COMMUNITY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GENDER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; NORWAY; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; REGISTER; VITAMIN BLOOD LEVEL;

EID: 84881533662     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-1468     Document Type: Article

References (40)

1. Cheng SY, Levy AR, Lefaivre KA, Guy P, Kuramoto L, Sobolev B. Geographic trends in incidence of hip fractures: a comprehensive literature review. Osteoporos Int. 2011;22:2575-2586.
2. Maggi S, Kelsey JL, Litvak J, Heyse SP. Incidence of hip fractures in the elderly: a cross-national analysis. Osteoporos Int. 1991;1:232-241.
3. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001;22:477-501.
4. Malavolta N, Pratelli L, Frigato M, Mulè R, Mascia ML, Gnudi S. The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women. Osteoporos Int. 2005;16:1691-1697.
5. Saquib N, von Mühlen D, Garland CF, Barrett-Connor E. Serum 25-hydroxy vitamin D, parathyroid hormone, and bone mineral density in men: the Rancho Bernardo study. Osteoporos Int. 2006;17: 1734-1741.
6. von Mühlen DG, Greendale GA, Garland CF, Wan L, Barrett-Connor E. Vitamin D , parathyroid hormone levels and bone mineral density in community-dwelling older women: the Rancho Bernardo Study. Osteoporos Int. 2005;16:1721-1726.
7. Garnero P, Munoz F, Sornay-Rendu E, Delmas PD. Associations of vitamin D status with bone mineral density, bone turnover, bone loss and fracture risk in healthy postmenopausal women. The OFELY study. Bone. 2007;40:716-722.
8. Sigurdsson G, Franzson L, Steingrimsdottir L, Sigvaldason H. The association between parathyroid hormone, vitamin D and bone mineral density in 70-year-old Icelandic women. Osteoporos Int. 2000; 11:1031-1035.
9. Murad MH, Elamin KB, Abu Elnour NO, et al. Clinical review: the effect of vitamin D on falls: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011;96:2997-3006.
10. Cauley JA, Danielson ME, Boudreau R, et al. Serum 25-hydroxy vitamin D and clinical fracture risk in a multiethnic cohort of women: the Women's Health Initiative (WHI). J Bone Miner Res. 2011;26: 2378-2388.
11. Gerdhem P, Ringsberg KA, Obrant KJ, Åkesson K. Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women. Osteoporos Int. 2005;16:1425-1431.
12. Roddam AW, Neale R, Appleby P, Allen NE, Tipper S, Key TJ. Association between plasma 25-hydroxy vitamin D levels and fracture risk: the EPIC-Oxford study.AmJ Epidemiol. 2007;166:1327-1336.
13. van Schoor NM, Visser M, Pluijm SMF, Kuchuk N, Smit JH, Lips P. Vitamin D deficiency as a risk factor for osteoporotic fractures. Bone. 2008;42:260-266.
14. Melhus H, Snellman G, Gedeborg R, et al. Plasma 25-hydroxy vitamin D levels and fracture risk in a community-based cohort of elderly men in Sweden. J Clin Endocrinol Metab. 2010;95:2637-2645.
15. Looker AC, Mussolino ME. Serum 25-hydroxy vitamin D and hip fracture risk in older US white adults. J Bone Miner Res. 2008;23: 143-150.
16. Cauley JA, Parimi N, Ensrud KE, et al. Serum 25-hydroxy vitamin D and the risk of hip and nonspine fractures in older men. J Bone Miner Res. 2010;25:545-553.
17. Cauley JA, Lacroix AZ, Horwitz M, et al. Serum 25-hydroxy vitamin D concentrations and risk for hip fractures. Ann Intern Med. 2008; 149:242-250.
18. Avenell A, Gillespie WJ, Gillespie LD, O'Connell D. Vitamin D and Vitamin D Analogues for Preventing Fractures Associated With Involutional and Post-Menopausal Osteoporosis (Review). The Cochrane Library: John Wiley & Sons, Hoboken, NJ; 2009:1-120.
19. Abrahamsen B, Masud T, Avenell A, et al. Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. The DIPART (Vitamin D Individual Patient Analysis of Randomized Trials) Group. BMJ. 2010;340:b5463.
20. Lai JK, Lucas RM, Clements MS, Roddam AW, Banks E. Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxy vitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies.BMCPublic Health. 2010;10:331.
21. Bischoff-Ferrari HA, Willett WC, Orav EJ, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012;367:40-49.
22. Borgan O, Langholz B, Samuelsen SO, Goldstein L, Pogoda J. Exposure stratified case-cohort designs. Lifetime Data Anal. 2000;6: 39-58.
23. Cologne J, Preston DL, Imai K, et al. Conventional case-cohort design and analysis for studies of interaction. Int J Epidemiol. 2012; 41:1174-1186.
24. Næss O, Søgaard AJ, Arnesen E, et al. Cohort profile: cohort of Norway (CONOR). Int J Epidemiol. 2008;37:481-485.
25. Ahmed LA, Emaus N, Berntsen GK, et al. Bone loss and the risk of non-vertebral fractures in women and men: the Tromsø study. Osteoporos Int. 2010;21:1503-1511.
26. Grønskag AB, Forsmo S, Romundstad P, Langhammer A, Schei B. Incidence and seasonal variation in hip fracture incidence among elderly women in Norway. The HUNT Study. Bone. 2010;46: 1294-1298.
27. Gjesdal CG, Vollset SE, Ueland PM, Refsum H, Meyer HE, Tell GS. Plasma homocysteine, folate, and vitamin B 12 and the risk of hip fracture: the Hordaland homocysteine study. J Bone Miner Res. 2007;22:747-756.
28. Tsugawa N, Suhara Y, Kamao M, Okano T. Determination of 25-hydroxy vitamin D in human plasma using high-performance liquid chromatography-tandem mass spectrometry. Anal Chem. 2005; 77:3001-3007.
29. R Core Team. The R Project for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria, 2013. http:// www.R-project.org. Accessed February 22, 2013.
30. Breslow N. "cch: fits proportional hazards regression model to casecohort data." Function in Therneau T: "Package 'survival': survival analysis, including penalised likelihood." 2012. http://cran.rproject. org/web/packages/survival/survival.pdf. Accessed February 22, 2013.
31. Therneau T, Grambsch PM. Modeling Survival Data. Extending the Cox Model. 1st ed. Springer Science, Berlin, Germany; 2000.
32. Wang Y, Jacobs EJ, McCullough ML, et al. Comparing methods for accounting for seasonal variability in a biomarker when only a single sample is available: insights from simulations based on serum 25-hydroxy vitamin D. Am J Epidemiol. 2009;170:88-94.
33. Cummings SR, Browner WS, Bauer D, et al. Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group. N Engl J Med. 1998;339:733-738.
34. Snellman G, Melhus H, Gedeborg R, et al. Determining vitamin D status: a comparison between commercially available assays. PLoS One. 2010;5:e11555.
35. Farrell CJ, Martin S, McWhinney B, Straub I, Williams P, Herrmann M. State-of-the-art vitamin D assays: a comparison of automated immunoassays with liquid chromatography-tandem mass spectrometry methods. Clin Chem. 2012;58:531-542.
36. Ensrud KE, Ewing SK, Fredman L, et al. Circulating 25-hydroxy vitamin D levels and frailty status in older women. J Clin Endocrinol Metab. 2010;95:5266-5273.
37. Lips P. Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol. 2007;103:620-625.
38. Jorde R, Sneve M, Hutchinson M, Emaus N, Figenschau Y, Grimnes G. Tracking of serum 25-hydroxy vitamin D levels during 14 years in a population-based study and during 12 months in an intervention study. Am J Epidemiol. 2010;171:903-908.
39. Carter GD. 25-Hydroxy vitamin D: a difficult analyte. Clin Chem. 2012;58:486-488.
40. Rothman KJ, Greenland S, Lash TL. Modern Epidemiology. 3rd ed. Philadelphia: Lippincott Williams and Wilkins; 2008.