The significance of pretransplant donor-specific antibodies reactive with intact or denatured human leucocyte antigen in kidney transplantation

Clinical and Experimental Immunology

Volumn 173, Issue 3, 2013, Pages 536-543

  Otten, H G ^a   Verhaar, M C ^a   Borst, H P E ^a   van Eck, M ^a   van Ginkel, W G J ^a   Hene R J ^a,b   van Zuilen, A D ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b Dianet Foundation   (Netherlands)

Author keywords

Denatured HLA; Donor specific antibodies; Kidney transplantation; Single antigen bead array

Indexed keywords

HLA A1 ANTIGEN; HLA A11 ANTIGEN; HLA A23 ANTIGEN; HLA A24 ANTIGEN; HLA A25 ANTIGEN; HLA A29 ANTIGEN; HLA A3 ANTIGEN; HLA A30 ANTIGEN; HLA A31 ANTIGEN; HLA A32 ANTIGEN; HLA A33 ANTIGEN; HLA A34 ANTIGEN; HLA ANTIBODY; HLA ANTIGEN; HLA B13 ANTIGEN; HLA B18 ANTIGEN; HLA B27 ANTIGEN; HLA B35 ANTIGEN; HLA B49 ANTIGEN; HLA B50 ANTIGEN; HLA B51 ANTIGEN; HLA B52 ANTIGEN; HLA B55 ANTIGEN; HLA B57 ANTIGEN; HLA B58 ANTIGEN; HLA B62 ANTIGEN; HLA B63 ANTIGEN; HLA B7 ANTIGEN; HLA B8 ANTIGEN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; DENATURATION; DOUBLE BLIND PROCEDURE; FEMALE; GRAFT FAILURE; GRAFT SURVIVAL; HUMAN; HUMAN TISSUE; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SENSITIZATION;

DENATURED HLA; DONOR SPECIFIC ANTIBODIES; KIDNEY TRANSPLANTATION; SINGLE-ANTIGEN BEAD ARRAY;

ADULT; ANTIBODY SPECIFICITY; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HLA ANTIGENS; HUMANS; ISOANTIBODIES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PROTEIN BINDING; PROTEIN DENATURATION; TISSUE DONORS;

EID: 84881517987     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12127     Document Type: Article

References (20)

1. El-Awar N, Lee J, Terasaki PI. HLA antibody identification with single antigen beads compared to conventional methods. Hum Immunol 2005; 66:989-997.
2. Bielmann D, Hönger G, Lutz D, Mihatsch MJ, Steiger J, Schaub S. Pretransplant risk assessment in renal allograft recipients using virtual crossmatching. Am J Transplant 2007; 7:626-632.
3. Cecka JM, Kucheryavaya AY, Reinsmoen NL, Leffell MS. Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive crossmatches. Am J Transplant 2011; 11:719-724.
4. Morales-Buenrostro LE, Terasaki PI, Marino-Vázquez LA, Lee JH, El-Awar N, Alberú J. 'Natural' human leukocyte antigen antibodies found in nonalloimmunized healthy males. Transplantation 2008; 86:1111-1115.
5. Jacob EK, De Goey SR, Gandhi MJ. Positive virtual crossmatch with negative flow crossmatch results in two cases. Transpl Immunol 2011; 25:77-81.
6. Tait BD, Süsal C, Gebel HM etal. Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation. Transplantation 2013; 95:19-49.
7. Cai J, Terasaki PI, Anderson N, Lachmann N, Schönemann C. Intact HLA not beta2m-free heavy chain-specific HLA class I antibodies are predictive of graft failure. Transplantation 2009; 88:226-230.
8. El-Awar N, Terasaki PI, Nguyen A etal. Epitopes of human leukocyte antigen class I antibodies found in sera of normal healthy males and cord blood. Hum Immunol 2009; 70:844-853.
9. Poli F, Benazzi E, Innocente A etal. Heart transplantation with donor-specific antibodies directed toward denatured HLA-A*02:01: a case report. Hum Immunol 2011; 72:1045-1048.
10. Pereira S, Perkins S, Lee JH etal. Donor-specific antibody against denatured HLA-A1: clinically nonsignificant? Hum Immunol 2011; 72:492-498.
11. Matko J, Bushkin Y, Wei T, Edidin M. Clustering of class I HLA molecules on the surfaces of activated and transformed human cells. J Immunol 1994; 152:3353-3360.
12. El-Awar NR, Terasaki PI, Hajeer A etal. A novel HLA class I single antigen bead preparation eliminates false positive reactions attributed to natural antibodies in the sera of normal males and pre-transplant patients. Hum Immunol 2010; 71 (Suppl. 1):S26.
13. Rodey GE, Neylan JF, Whelchel JD, Revels KW, Bray RA. Epitope specificity of HLA class I alloantibodies. I. Frequency analysis of antibodies to private versus public specificities in potential transplant recipients. Hum Immunol 1994; 39:272-280.
14. Barnstable CJ, Bodmer WF, Brown G etal. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens - new tools for genetic analysis. Cell 1978; 14:9-20.
15. Bijen CB, Bantema-Joppe EJ, de Jong RA etal. The prognostic role of classical and nonclassical MHC class I expression in endometrial cancer. Int J Cancer 2010; 126:1417-1427.
16. Pasquinelli G, Pistillo MP, Ricci F etal. The 'in situ' expression of human leukocyte antigen class I antigens is not altered by cryopreservation in human arterial allografts. Cell Tissue Bank 2007; 8:195-203.
17. Jin YP, Singh RP, Du ZY, Rajasekaran AK, Rozengurt E, Reed EF. Ligation of HLA class I molecules on endothelial cells induces phosphorylation of Src, paxillin, and focal adhesion kinase in an actin-dependent manner. J Immunol 2002; 168:5415-5423.
18. Perosa F, Luccarelli G, Prete M, Favoino E, Ferrone S, Dammacco F. Beta 2-microglobulin-free HLA class I heavy chain epitope mimicry by monoclonal antibody HC-10-specific peptide. J Immunol 2003; 171:1918-1926.
19. Sacks SH, Zhou W. The role of complement in the early immune response to transplantation. Nat Rev Immunol 2012; 12:431-442.
20. Duquesnoy RJ, Takemoto S, de Lange P etal. HLA matchmaker: a molecularly based algorithm for histocompatibility determination. III. Effect of matching at the HLA-A, B amino acid triplet level on kidney transplant survival. Transplantation 2003; 75:884-889.