메뉴 건너뛰기




Volumn 8, Issue 8, 2013, Pages

Clinical Relevance of Gain-Of-Function Mutations of p53 in High-Grade Serous Ovarian Carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PLATINUM COMPLEX; PROTEIN P53;

EID: 84881510929     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072609     Document Type: Article
Times cited : (66)

References (32)
  • 1
    • 84871830221 scopus 로고    scopus 로고
    • p53 mutations in cancer
    • doi:10.1038/ncb2641
    • Muller PA, Vousden KH, (2013) p53 mutations in cancer. Nat Cell Biol 15: 2-8. doi:10.1038/ncb2641. PubMed: 23263379.
    • (2013) Nat Cell Biol , vol.15 , pp. 2-8
    • Muller, P.A.1    Vousden, K.H.2
  • 2
    • 77955363995 scopus 로고    scopus 로고
    • TP53 mutations in human cancers: origins, consequences, and clinical use
    • doi:10.1101/cshperspect.a001008
    • Olivier M, Hollstein M, Hainaut P, (2010) TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol 2: a001008. doi:10.1101/cshperspect.a001008. PubMed: 20182602.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Olivier, M.1    Hollstein, M.2    Hainaut, P.3
  • 3
    • 80053039210 scopus 로고    scopus 로고
    • Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis
    • doi:10.1177/1947601911408889
    • Rivlin N, Brosh R, Oren M, Rotter V, (2011) Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis. Genes Cancer 2: 466-474. doi:10.1177/1947601911408889. PubMed: 21779514.
    • (2011) Genes Cancer , vol.2 , pp. 466-474
    • Rivlin, N.1    Brosh, R.2    Oren, M.3    Rotter, V.4
  • 4
    • 77950521214 scopus 로고    scopus 로고
    • Mutant p53 gain-of-function in cancer
    • doi:10.1101/cshperspect.a001107
    • Oren M, Rotter V, (2010) Mutant p53 gain-of-function in cancer. Cold Spring Harb Perspect Biol 2: a001107. doi:10.1101/cshperspect.a001107. PubMed: 20182618.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Oren, M.1    Rotter, V.2
  • 5
    • 40349087171 scopus 로고    scopus 로고
    • Mutant p53(R270H) gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis
    • Heinlein C, Krepulat F, Löhler J, Speidel D, Deppert W, et al. (2008) Mutant p53(R270H) gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis. Int J Cancer 122: 1701-1709. PubMed: 18092324.
    • (2008) Int J Cancer , vol.122 , pp. 1701-1709
    • Heinlein, C.1    Krepulat, F.2    Löhler, J.3    Speidel, D.4    Deppert, W.5
  • 6
    • 13644260907 scopus 로고    scopus 로고
    • Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
    • doi:10.1016/j.cell.2004.11.006
    • Lang GA, Iwakuma T, Suh YA, Liu G, Rao VA, et al. (2004) Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 119: 861-872. doi:10.1016/j.cell.2004.11.006. PubMed: 15607981.
    • (2004) Cell , vol.119 , pp. 861-872
    • Lang, G.A.1    Iwakuma, T.2    Suh, Y.A.3    Liu, G.4    Rao, V.A.5
  • 7
    • 77957958732 scopus 로고    scopus 로고
    • p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma
    • doi:10.1002/path.2748
    • Doyle B, Morton JP, Delaney DW, Ridgway RA, Wilkins JA, et al. (2010) p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma. J Pathol 222: 129-137. doi:10.1002/path.2748. PubMed: 20662002.
    • (2010) J Pathol , vol.222 , pp. 129-137
    • Doyle, B.1    Morton, J.P.2    Delaney, D.W.3    Ridgway, R.A.4    Wilkins, J.A.5
  • 8
    • 0034636094 scopus 로고    scopus 로고
    • High metastatic potential in mice inheriting a targeted p53 missense mutation
    • doi:10.1073/pnas.97.8.4174
    • Liu G, McDonnell TJ, Montes de Oca Luna R, Kapoor M, Mims B, et al. (2000) High metastatic potential in mice inheriting a targeted p53 missense mutation. Proc Natl Acad Sci U S A 97: 4174-4179. doi:10.1073/pnas.97.8.4174. PubMed: 10760284.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 4174-4179
    • Liu, G.1    McDonnell, T.J.2    Montes de Oca Luna, R.3    Kapoor, M.4    Mims, B.5
  • 9
    • 76249108357 scopus 로고    scopus 로고
    • Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
    • doi:10.1073/pnas.0908428107
    • Morton JP, Timpson P, Karim SA, Ridgway RA, Athineos D, et al. (2010) Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A 107: 246-251. doi:10.1073/pnas.0908428107. PubMed: 20018721.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 246-251
    • Morton, J.P.1    Timpson, P.2    Karim, S.A.3    Ridgway, R.A.4    Athineos, D.5
  • 10
    • 78951475020 scopus 로고    scopus 로고
    • p53 and its mutants in tumor cell migration and invasion
    • doi:10.1083/jcb.201009059
    • Muller PA, Vousden KH, Norman JC, (2011) p53 and its mutants in tumor cell migration and invasion. J Cell Biol 192: 209-218. doi:10.1083/jcb.201009059. PubMed: 21263025.
    • (2011) J Cell Biol , vol.192 , pp. 209-218
    • Muller, P.A.1    Vousden, K.H.2    Norman, J.C.3
  • 11
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations
    • doi:10.1126/science.8023157
    • Cho Y, Gorina S, Jeffrey PD, Pavletich NP, (1994) Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 265: 346-355. doi:10.1126/science.8023157. PubMed: 8023157.
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 12
    • 77950965840 scopus 로고    scopus 로고
    • Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary
    • doi:10.1002/path.2696
    • Ahmed AA, Etemadmoghadam D, Temple J, Lynch AG, Riad M, et al. (2010) Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary. J Pathol 221: 49-56. doi:10.1002/path.2696. PubMed: 20229506.
    • (2010) J Pathol , vol.221 , pp. 49-56
    • Ahmed, A.A.1    Etemadmoghadam, D.2    Temple, J.3    Lynch, A.G.4    Riad, M.5
  • 13
    • 84866682056 scopus 로고    scopus 로고
    • The genomic landscape of TP53 and p53 annotated high grade ovarian serous carcinomas from a defined founder population associated with patient outcome
    • doi:10.1371/journal.pone.0045484
    • Wojnarowicz PM, Oros KK, Quinn MC, Arcand SL, Gambaro K, et al. (2012) The genomic landscape of TP53 and p53 annotated high grade ovarian serous carcinomas from a defined founder population associated with patient outcome. PLOS ONE 7: e45484. doi:10.1371/journal.pone.0045484. PubMed: 23029043.
    • (2012) PLOS ONE , vol.7
    • Wojnarowicz, P.M.1    Oros, K.K.2    Quinn, M.C.3    Arcand, S.L.4    Gambaro, K.5
  • 14
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • The Cancer Genome Atlas Research Network
    • The Cancer Genome Atlas Research Network (2011) Integrated genomic analyses of ovarian carcinoma. Nature 474: 609-615.
    • (2011) Nature , vol.474 , pp. 609-615
  • 15
    • 77956290079 scopus 로고    scopus 로고
    • Cutaneous papillomavirus E6 proteins must interact with p300 and block p53-mediated apoptosis for cellular immortalization and tumorigenesis
    • doi:10.1158/0008-5472.CAN-10-1307
    • Muench P, Probst S, Schuetz J, Leiprecht N, Busch M, et al. (2010) Cutaneous papillomavirus E6 proteins must interact with p300 and block p53-mediated apoptosis for cellular immortalization and tumorigenesis. Cancer Res 70: 6913-6924. doi:10.1158/0008-5472.CAN-10-1307. PubMed: 20663910.
    • (2010) Cancer Res , vol.70 , pp. 6913-6924
    • Muench, P.1    Probst, S.2    Schuetz, J.3    Leiprecht, N.4    Busch, M.5
  • 16
    • 33750456480 scopus 로고    scopus 로고
    • Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells
    • doi:10.1158/1535-7163.MCT-06-0334
    • Tibes R, Qiu Y, Lu Y, Hennessy B, Andreeff M, et al. (2006) Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells. Mol Cancer Ther 5: 2512-2521. doi:10.1158/1535-7163.MCT-06-0334. PubMed: 17041095.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2512-2521
    • Tibes, R.1    Qiu, Y.2    Lu, Y.3    Hennessy, B.4    Andreeff, M.5
  • 17
    • 84862758076 scopus 로고    scopus 로고
    • Somatic hypermutation and outcomes of platinum based chemotherapy in patients with high grade serous ovarian cancer
    • doi:10.1016/j.ygyno.2012.03.050
    • Sohn I, Jung WY, Sung CO, (2012) Somatic hypermutation and outcomes of platinum based chemotherapy in patients with high grade serous ovarian cancer. Gynecol Oncol 126: 103-108. doi:10.1016/j.ygyno.2012.03.050. PubMed: 22484402.
    • (2012) Gynecol Oncol , vol.126 , pp. 103-108
    • Sohn, I.1    Jung, W.Y.2    Sung, C.O.3
  • 18
    • 84872225199 scopus 로고    scopus 로고
    • Predictive modeling using a somatic mutational profile in ovarian high grade serous carcinoma
    • doi:10.1371/journal.pone.0054089
    • Sohn I, Sung CO, (2013) Predictive modeling using a somatic mutational profile in ovarian high grade serous carcinoma. PLOS ONE 8: e54089. doi:10.1371/journal.pone.0054089. PubMed: 23326577.
    • (2013) PLOS ONE , vol.8
    • Sohn, I.1    Sung, C.O.2
  • 19
    • 68149169706 scopus 로고    scopus 로고
    • Investigation and prediction of the severity of p53 mutants using parameters from structural calculations
    • doi:10.1111/j.1742-4658.2009.07124.x
    • Carlsson J, Soussi T, Persson B, (2009) Investigation and prediction of the severity of p53 mutants using parameters from structural calculations. FEBS J 276: 4142-4155. doi:10.1111/j.1742-4658.2009.07124.x. PubMed: 19558493.
    • (2009) FEBS J , vol.276 , pp. 4142-4155
    • Carlsson, J.1    Soussi, T.2    Persson, B.3
  • 20
    • 34248379012 scopus 로고    scopus 로고
    • Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database
    • doi:10.1002/humu.20495
    • Petitjean A, Mathe E, Kato S, Ishioka C, Tavtigian SV, et al. (2007) Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum Mutat 28: 622-629. doi:10.1002/humu.20495. PubMed: 17311302.
    • (2007) Hum Mutat , vol.28 , pp. 622-629
    • Petitjean, A.1    Mathe, E.2    Kato, S.3    Ishioka, C.4    Tavtigian, S.V.5
  • 21
    • 34447560961 scopus 로고    scopus 로고
    • Analysis of gene expression data using BRB-ArrayTools
    • Simon R, Lam A, Li MC, Ngan M, Menenzes S, et al. (2007) Analysis of gene expression data using BRB-ArrayTools. Cancer INFORM 3: 11-17. PubMed: 19455231.
    • (2007) Cancer INFORM , vol.3 , pp. 11-17
    • Simon, R.1    Lam, A.2    Li, M.C.3    Ngan, M.4    Menenzes, S.5
  • 22
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • doi:10.1073/pnas.091062498
    • Tusher VG, Tibshirani R, Chu G, (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 98: 5116-5121. doi:10.1073/pnas.091062498. PubMed: 11309499.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 23
    • 0033552948 scopus 로고    scopus 로고
    • Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy
    • doi:10.1038/sj.onc.1202314
    • Blandino G, Levine AJ, Oren M, (1999) Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene 18: 477-485. doi:10.1038/sj.onc.1202314. PubMed: 9927204.
    • (1999) Oncogene , vol.18 , pp. 477-485
    • Blandino, G.1    Levine, A.J.2    Oren, M.3
  • 24
    • 63049136592 scopus 로고    scopus 로고
    • A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
    • doi:10.1016/j.cell.2009.01.039
    • Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, et al. (2009) A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell 137: 87-98. doi:10.1016/j.cell.2009.01.039. PubMed: 19345189.
    • (2009) Cell , vol.137 , pp. 87-98
    • Adorno, M.1    Cordenonsi, M.2    Montagner, M.3    Dupont, S.4    Wong, C.5
  • 25
    • 78651289008 scopus 로고    scopus 로고
    • Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells
    • doi:10.1038/cdd.2010.94
    • Kogan-Sakin I, Tabach Y, Buganim Y, Molchadsky A, Solomon H, et al. (2011) Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells. Cell Death Differ 18: 271-281. doi:10.1038/cdd.2010.94. PubMed: 20689556.
    • (2011) Cell Death Differ , vol.18 , pp. 271-281
    • Kogan-Sakin, I.1    Tabach, Y.2    Buganim, Y.3    Molchadsky, A.4    Solomon, H.5
  • 26
    • 67349166210 scopus 로고    scopus 로고
    • p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug
    • doi:10.1038/ncb1875
    • Wang SP, Wang WL, Chang YL, Wu CT, Chao YC, et al. (2009) p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug. Nat Cell Biol 11: 694-704. doi:10.1038/ncb1875. PubMed: 19448627.
    • (2009) Nat Cell Biol , vol.11 , pp. 694-704
    • Wang, S.P.1    Wang, W.L.2    Chang, Y.L.3    Wu, C.T.4    Chao, Y.C.5
  • 27
    • 40949097860 scopus 로고    scopus 로고
    • PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations
    • Li Y, Guessous F, Kwon S, Kumar M, Ibidapo O, et al (2008) PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations. Cancer Res 15: 1723-1731.
    • (2008) Cancer Res , vol.15 , pp. 1723-1731
    • Li, Y.1    Guessous, F.2    Kwon, S.3    Kumar, M.4    Ibidapo, O.5
  • 28
    • 0035844886 scopus 로고    scopus 로고
    • Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation
    • doi:10.1083/jcb.153.6.1161
    • Persad S, Troussard AA, McPhee TR, Mulholland DJ, Dedhar S, (2001) Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J Cell Biol 153: 1161-1174. doi:10.1083/jcb.153.6.1161. PubMed: 11402061.
    • (2001) J Cell Biol , vol.153 , pp. 1161-1174
    • Persad, S.1    Troussard, A.A.2    McPhee, T.R.3    Mulholland, D.J.4    Dedhar, S.5
  • 29
    • 77958484951 scopus 로고    scopus 로고
    • The genesis and evolution of high-grade serous ovarian cancer
    • doi:10.1038/nrc2946
    • Bowtell DD, (2010) The genesis and evolution of high-grade serous ovarian cancer. Nat Rev Cancer 10: 803-808. doi:10.1038/nrc2946. PubMed: 20944665.
    • (2010) Nat Rev Cancer , vol.10 , pp. 803-808
    • Bowtell, D.D.1
  • 30
    • 71749087775 scopus 로고    scopus 로고
    • Gene expression profiling and prediction of clinical outcome in ovarian cancer
    • doi:10.1016/j.critrevonc.2009.01.007
    • Sabatier R, Finetti P, Cervera N, Birnbaum D, Bertucci F, (2009) Gene expression profiling and prediction of clinical outcome in ovarian cancer. Crit Rev Oncol/Hematol 72: 98-109. doi:10.1016/j.critrevonc.2009.01.007. PubMed: 19249225.
    • (2009) Crit Rev Oncol/Hematol , vol.72 , pp. 98-109
    • Sabatier, R.1    Finetti, P.2    Cervera, N.3    Birnbaum, D.4    Bertucci, F.5
  • 31
    • 1242289884 scopus 로고    scopus 로고
    • Developmental chemotherapy and management of recurrent ovarian cancer
    • doi:10.1200/JCO.2003.02.553
    • Bookman MA, (2003) Developmental chemotherapy and management of recurrent ovarian cancer. J Clin Oncol 21: 149s-167s. doi:10.1200/JCO.2003.02.553. PubMed: 17633784.
    • (2003) J Clin Oncol , vol.21
    • Bookman, M.A.1
  • 32
    • 66849114911 scopus 로고    scopus 로고
    • Phase II evaluation of pemetrexed in the treatment of recurrent or persistent platinum-resistant ovarian or primary peritoneal carcinoma: a study of the Gynecologic Oncology Group
    • doi:10.1200/JCO.2008.19.2963
    • Miller DS, Blessing JA, Krasner CN, Mannel RS, Hanjani P, et al. (2009) Phase II evaluation of pemetrexed in the treatment of recurrent or persistent platinum-resistant ovarian or primary peritoneal carcinoma: a study of the Gynecologic Oncology Group. J Clin Oncol 27: 2686-2691. doi:10.1200/JCO.2008.19.2963. PubMed: 19332726.
    • (2009) J Clin Oncol , vol.27 , pp. 2686-2691
    • Miller, D.S.1    Blessing, J.A.2    Krasner, C.N.3    Mannel, R.S.4    Hanjani, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.