Microarray-Based Genotyping and Clinical Outcomes of Staphylococcus aureus Bloodstream Infection: An Exploratory Study

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Rieg, Siegbert ^a   Jonas, Daniel ^a   Kaasch, Achim J ^b   Porzelius, Christine ^a,c   Peyerl Hoffmann, Gabriele ^a   Theilacker, Christian ^a   Küpper, Marc Fabian ^a   Schneider, Christian ^a   Seifert, Harald ^b   Kern, Winfried V ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; AGED; ARTICLE; BACTERIAL GENE; BLA GENE; BLOOD CULTURE; CAUSE OF DEATH; CLASSIFICATION; CLINICAL FEATURE; COMMUNITY; COMORBIDITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; DNA MICROARRAY; ENDOCARDITIS; EXPLORATORY RESEARCH; FEMALE; GENE CLUSTER; GENOTYPE; HOST; HUMAN; INFECTIOUS ARTHRITIS; MAJOR CLINICAL STUDY; MALE; MCCABE CLASSIFICATION; MECA GENE; MOLECULAR CLONING; NONHUMAN; OSTEOARTICULAR INFECTION; PENICILLIN RESISTANCE; PHENOTYPE; PROGNOSIS; SED GENE; SEJ GENE; SEPTIC SHOCK; SER GENE; SPA GENE; STAPHYLOCOCCAL BACTEREMIA;

AGED; BACTEREMIA; BLOOD VESSELS; BONE DISEASES, INFECTIOUS; COHORT STUDIES; ENDOCARDITIS, BACTERIAL; FEMALE; GENOTYPING TECHNIQUES; HUMANS; JOINT DISEASES; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; PROSPECTIVE STUDIES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TROPISM;

EID: 84881497636     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071259     Document Type: Article

References (30)

1. Kern WV, (2010) Management of Staphylococcus aureus bacteremia and endocarditis: progresses and challenges. Curr Opin Infect Dis 23: 346-358.
2. Chambers HF, DeLeo FR, (2009) Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol 7: 629-641.
3. Priest NK, Rudkin JK, Feil EJ, van den Elsen JM, Cheung A, et al. (2012) From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence? Nat Rev Microbiol 10: 791-797.
4. Feil EJ, Cooper JE, Grundmann H, Robinson DA, Enright MC, et al. (2003) How clonal is Staphylococcus aureus? J Bacteriol 185: 3307-3316.
5. Gill SR, McIntyre LM, Nelson CL, Remortel B, Rude T, et al. (2011) Potential associations between severity of infection and the presence of virulence-associated genes in clinical strains of Staphylococcus aureus. PLoS One 6: e18673.
6. Holtfreter S, Grumann D, Schmudde M, Nguyen HT, Eichler P, et al. (2007) Clonal distribution of superantigen genes in clinical Staphylococcus aureus isolates. J Clin Microbiol 45: 2669-2680.
7. Lindsay JA, Moore CE, Day NP, Peacock SJ, Witney AA, et al. (2006) Microarrays reveal that each of the ten dominant lineages of Staphylococcus aureus has a unique combination of surface-associated and regulatory genes. J Bacteriol 188: 669-676.
8. Luedicke C, Slickers P, Ehricht R, Monecke S, (2010) Molecular fingerprinting of Staphylococcus aureus from bone and joint infections. Eur J Clin Microbiol Infect Dis 29: 457-463.
9. Wehrhahn MC, Robinson JO, Pascoe EM, Coombs GW, Pearson JC, et al. (2012) Illness severity in community-onset invasive Staphylococcus aureus infection and the presence of virulence genes. J Infect Dis 205: 1840-1848.
10. Wertheim HF, van Leeuwen WB, Snijders S, Vos MC, Voss A, et al. (2005) Associations between Staphylococcus aureus Genotype, Infection, and In-Hospital Mortality: A Nested Case-Control Study. J Infect Dis 192: 1196-1200.
11. Desachy A, Lina G, Vignon P, Hashemzadeh A, Denis F, et al. (2007) Role of superantigenic strains in the prognosis of community-acquired methicillin-susceptible Staphylococcus aureus bacteraemia. Clin Microbiol Infect 13: 1131-1133 CLM1810 [pii];10.1111/j.1469-0691.2007.01810.x [doi].
12. Xiong YQ, Fowler VG, Yeaman MR, Perdreau-Remington F, Kreiswirth BN, et al. (2009) Phenotypic and genotypic characteristics of persistent methicillin-resistant Staphylococcus aureus bacteremia in vitro and in an experimental endocarditis model. J Infect Dis 199: 201-208.
13. Peacock SJ, Moore CE, Justice A, Kantzanou M, Story L, et al. (2002) Virulent combinations of adhesin and toxin genes in natural populations of Staphylococcus aureus. Infect Immun 70: 4987-4996.
14. Chi CY, Wang SM, Lin CC, Liu CC, (2010) Microbiological characteristics of community-associated Staphylococcus aureus causing uncomplicated bacteremia and infective endocarditis. J Clin Microbiol 48: 292-294.
15. Monecke S, Slickers P, Ehricht R, (2008) Assignment of Staphylococcus aureus isolates to clonal complexes based on microarray analysis and pattern recognition. FEMS Immunol Med Microbiol 53: 237-251.
16. Rieg S, Peyerl-Hoffmann G, de With K, Theilacker C, Wagner D, et al. (2009) Mortality of S. aureus bacteremia and infectious diseases specialist consultation-a study of 521 patients in Germany. J Infect 59: 232-239.
17. Monecke S, Jatzwauk L, Weber S, Slickers P, Ehricht R, (2008) DNA microarray-based genotyping of methicillin-resistant Staphylococcus aureus strains from Eastern Saxony. Clin Microbiol Infect 14: 534-545.
18. Monecke S, Luedicke C, Slickers P, Ehricht R, (2009) Molecular epidemiology of Staphylococcus aureus in asymptomatic carriers. Eur J Clin Microbiol Infect Dis 28: 1159-1165.
19. Ferry T, Thomas D, Genestier AL, Bes M, Lina G, et al. (2005) Comparative prevalence of superantigen genes in Staphylococcus aureus isolates causing sepsis with and without septic shock. Clin Infect Dis 41: 771-777.
20. Kaasch AJ, Rieg S, Neumann S, Seifert H, Kern WV, (2011) Measuring mortality in Staphylococcus aureus bloodstream infections: are 3 months of follow-up enough? Infection 39: 281-282 10.1007/s15010-011-0104-x [doi].
21. van Hal SJ, Jensen SO, Vaska VL, Espedido BA, Paterson DL, et al. (2012) Predictors of mortality in Staphylococcus aureus Bacteremia. Clin Microbiol Rev 25: 362-386.
22. Fowler VG Jr, Nelson CL, McIntyre LM, Kreiswirth BN, Monk A, et al. (2007) Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection. J Infect Dis 196: 738-747.
23. Melles DC, Gorkink RF, Boelens HA, Snijders SV, Peeters JK, et al. (2004) Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus. J Clin Invest 114: 1732-1740.
24. Nienaber JJ, Sharma Kuinkel BK, Clarke-Pearson M, Lamlertthon S, Park L, et al. (2011) Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins. J Infect Dis 204: 704-713.
25. Kechrid A, Perez-Vazquez M, Smaoui H, Hariga D, Rodriguez-Banos M, et al. (2011) Molecular analysis of community-acquired methicillin-susceptible and resistant Staphylococcus aureus isolates recovered from bacteraemic and osteomyelitis infections in children from Tunisia. Clin Microbiol Infect 17: 1020-1026.
26. Fowler VG Jr, Justice A, Moore C, Benjamin DK Jr, Woods CW, et al. (2005) Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia. Clin Infect Dis 40: 695-703.
27. Fowler VG Jr, Olsen MK, Corey GR, Woods CW, Cabell CH, et al. (2003) Clinical identifiers of complicated Staphylococcus aureus bacteremia. Arch Intern Med 163: 2066-2072.
28. Kaech C, Elzi L, Sendi P, Frei R, Laifer G, et al. (2006) Course and outcome of Staphylococcus aureus bacteraemia: a retrospective analysis of 308 episodes in a Swiss tertiary-care centre. Clin Microbiol Infect 12: 345-352.
29. Ziebandt AK, Kusch H, Degner M, Jaglitz S, Sibbald MJ, et al. (2010) Proteomics uncovers extreme heterogeneity in the Staphylococcus aureus exoproteome due to genomic plasticity and variant gene regulation. Proteomics 10: 1634-1644.
30. Grundmann H, Aanensen DM, van den Wijngaard CC, Spratt BG, Harmsen D, et al. (2010) Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: a molecular-epidemiological analysis. PLoS Med 7: e1000215.