FMR1-dependent variability of ovarian aging patterns is already apparent in young oocyte donors

Reproductive Biology and Endocrinology

Volumn 11, Issue 1, 2013, Pages

  Gleicher, Norbert ^a,b   Kim, Ann ^a   Barad, David H ^a,b   Shohat Tal, Aya ^a   Lazzaroni, Emanuela ^a   Michaeli, Tamar ^a   Lee, Ho Joon ^a   Kushnir, Vitaly A ^a   Weghofer, Andrea ^a,c  

^a CENTER FOR HUMAN REPRODUCTION   (United States)

^b Foundation for Reproductive Medicine   (United States)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Anti m llerian hormone (AMH); FMR1 gene; Fragile X gene; Oocyte donor; Ovarian reserve

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; MUELLERIAN INHIBITING FACTOR; FMR1 PROTEIN, HUMAN;

ADULT; AGE; ALLELE; ARTICLE; ASIAN; CAUCASIAN; DONOR; FEMALE; HUMAN; MENARCHE; OOCYTE; OVARIAN RESERVE; TRINUCLEOTIDE REPEAT; AGING; ASIAN CONTINENTAL ANCESTRY GROUP; BLACK PERSON; BLOOD; COHORT ANALYSIS; ETHNIC GROUP; GENETICS; GENOTYPE; GROWTH, DEVELOPMENT AND AGING; OOCYTE DONATION; OVARY; PHYSIOLOGY; YOUNG ADULT;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGING; ANTI-MULLERIAN HORMONE; ASIAN CONTINENTAL ANCESTRY GROUP; COHORT STUDIES; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FRAGILE X MENTAL RETARDATION PROTEIN; GENOTYPE; HUMANS; OOCYTE DONATION; OVARY; YOUNG ADULT;

EID: 84881485602     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-11-80     Document Type: Article

References (13)

1. Lledo B, Guerrero J, Ortiz JA, Morales R, Ten J, Llacer J, Gimenez J, Bernabeu R. Intermediate and normal sized CGG repeats on the FMR1 gene does not negatively affect donor ovarian response. Hum Reprod 2012, 27:609-614. 10.1093/humrep/der415, 22157911.
2. Gleicher N, Weghofer A, Barad DH. Ovarian reserve determinations suggest new function of FMR1 (fragile X gene) in regulating ovarian ageing. Reprod Biomed Online 2010, 20:768-755. 10.1016/j.rbmo.2010.02.020, 20378415.
3. Gleicher N, Weghofer A, Lee IH, Barad DH. FMR1 genotype with autoimmune-associated polycystic ovary-like phenotype and decreased pregnancy chances. PLoS One 2010, 5:315303.
4. Gleicher N, Weghofer A, Barad DH. Intermediate and normal sized CGG repeats on the FMR1 gene does not negatively affect donor ovarian response. Hum Reprod 2012, 27(7):2241-2241. author reply 2242-2243.
5. Weghofer A, Tea M-K, Barad DH, Kim A, Singer CF, Wagner K, Gleicher N. RCA1/2 mutations appear embryo lethal in humans, unless rescued by low (GCCn < 26) FMR1 sub-genotypes. PLoS One 2012, in press.
6. Hoffman G, Le WW, Entezam A, Otsuka N, Tong Z-B, Nelson L, Flaws JA, McDonald JH, Jafar S, Usdin K. Ovarian abnormalities in a mouse model of Fragile X Primary Insufficiency. J Histochem Cytochem 2012, 60:439. 10.1369/0022155412441002, 3393073, 22470123.
7. Gleicher N, Kim A, Weghofer A, Barad DH. Differences in ovarian aging patterns between races are likely related to ovarian genotypes and sub-genotypes of the FMR1 gene. Reprod Biol Endocrinol 2012, 10:77. 10.1186/1477-7827-10-77, 3495196, 22963248.
8. Gleicher N, Weghofer A, Lee IH, Barad DH. Association of FMR1 genotypes with in vitro fertilization (IVF) outcomes based on ethnicity/race. PLoS One 2011, 6:e18781. 10.1371/journal.pone.0018781, 3078144, 21526209.
9. Wittenberger MD, Hagerman RJ, Sherman SL, McConkie-Rosell A, Welt CK, Rebar RW, Corrigan EC, Simpson JL, Nelson LM. The FMR1 premutation and reproduction. Fertil Steril 2007, 87:456-465. 10.1016/j.fertnstert.2006.09.004, 17074338.
10. Fu YJ, Kuhl DP, Pizzuti A, Pieretti M, Sutcliffe JS, Richards S, Verkerk AJ, Holden JJ, Fenwick RG, Warren ST, et al. Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Cell 1991, 20(67):1074-1058.
11. Gleicher N, Weghofer A, Oktay K, Barad DH. Effects of race/ethnicity on triple CGG counts on the FMR1 (fragile X) gene in infertile women. Reprod Biomed Online 2010, 20:485-491. 10.1016/j.rbmo.2009.12.017, 20149747.
12. Gleicher N, Weghofer A, Kim A, Barad DH. The impact in older women of ovarian FMR1 genotypes and sub-genotypes on ovarian reserve. PLoS One 2012, 7:e33638. 10.1371/journal.pone.0033638, 3306274, 22438971.
13. Weghofer A, Kim A, Barad DH, Gleicher N. Age at menarche: a predictor of diminished ovarian function?. Fertil Steril 2013, [Epub ahead of print].