The ability of lumbar Spine DXA and phalanx QUS to detect previous fractures in young thalassemic patients with hypogonadism, hypothyroidism, diabetes, and hepatitis-B: A 2-year subgroup analysis from the taranto area of Apulia Region

Journal of Pediatric Hematology/Oncology

Volumn 35, Issue 6, 2013, Pages

  Argentiero, Alberto ^a,b   Neglia, Cosimo ^a,c   Peluso, Angelo ^d   Di Rosa, Salvatore ^d   Ferrarese, Antonio ^d   Di Tanna, Gianluca ^e   Caiaffa, Vincenzo ^d   Benvenuto, Marco ^a   Cozma, Alexandru ^a   Chitano, Giovanna ^a   Agnello, Nadia ^a   Paladini, Daniele ^a   Baldi, Nicola ^d   Distante, Alessandro ^a,b   Piscitelli, Prisco ^a,e,f  

^a C/o ISBEM Research Centre ^*  (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF SALENTO   (Italy)

^d Statistics and Epidemiology Unit   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f UNIVERSITY OF FLORENCE   (Italy)

Author keywords

fractures; hypogonadism; osteoporosis; thalassemia; ultrasound (QUS)

Indexed keywords

ADULT; ARTICLE; BETA THALASSEMIA; BODY HEIGHT; BODY WEIGHT; BONE DEMINERALIZATION; BONE DENSITOMETER; CONTROLLED STUDY; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; ECHOGRAPHY; FEMALE; FRACTURE; FRAGILITY FRACTURE; HEPATITIS B; HUMAN; HYPOGONADISM; HYPOGONADOTROPIC HYPOGONADISM; HYPOTHYROIDISM; IRON CHELATION; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; OSTEOPENIA; OSTEOPOROSIS; PHALANX; PREVALENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEX DIFFERENCE; THALASSEMIA INTERMEDIA; THALASSEMIA MAJOR;

ABSORPTIOMETRY, PHOTON; ADULT; AGED; BETA-THALASSEMIA; DIABETES MELLITUS; FEMALE; FINGER PHALANGES; FRACTURES, BONE; HEPATITIS B; HUMANS; HYPOGONADISM; HYPOTHYROIDISM; ITALY; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; OSTEOPOROSIS; PREVALENCE; ULTRASONOGRAPHY; YOUNG ADULT;

EID: 84881481427     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e31828e6cab     Document Type: Article

References (35)

1. Borgna-Pignatti C, Rugolotto S, De Stefano P, et al. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematology. 2004; 89:1187-1193.
2. Weatherall DJ, Clegg JB. The Thalassaemia Syndromes. 4th ed. Oxford: Blackwell Science Ltd; 2001.
3. World Bank. Report of a Joint WHO-March of Dimes Meetings on Management of Birth Defects and Haemoglobin Disorders. Geneva, Switzerland: WHO; 2006. ISBN: 92 4 159492 6.
4. Wonke B. Bone disease in b-thalassaemia major. Br J Haematol. 1998;103:897-901.
5. Voskaridou E, Terpos E. New insights into the pathophysiology and management of osteoporosis in patients with thalassaemia. Br J Haematol. 2004;127:127-189.
6. Carmina E, Di Fede G, Napoli N, et al. Hypogonadism and hormone replacement therapy on bone mass of adult women with thalassemia major. Calcif Tissue Int. 2004;74:68-71.
7. WillingMC, Torner JC, Burns TL, et al. Percentile distribution of bone measurements in Iowa children: the Iowa Bone Development Study. J Clin Densitom. 2005;8:39-47.
8. Heaney RP, Kam JA. The interpretation and utility of ultrasound measurement of bone. Bone. 1996;18:491-492.
9. Gluer CC. Quantitative ultrasound techniques for the assessment of osteoporosis. Expert agreement on current status. J Bone Miner Res. 1997;12:1280-1288.
10. Baroncelli GI, Federico G, Vignolo M, et al. Cross-sectional reference data for phalangeal quantitative ultrasound from early childhood to young-adulthood according to gender, age, skeletal growth and pubertal development. Bone. 2006;39:159-173.
11. Njehc F, Boivinc M, Langtonc M. The role of ultrasound in the assessment of osteoporosis: a review. Osteoporos Int. 1997;7:7-22.
12. Flöter M, Bittar CK, Zabeu JL, et al. Review of comparative studies between bone densitometry and quantitative ultrasound of the calcaneus in osteoporosis. Acta Reumatol Port. 2011;36:327-335.
13. Kanis JA, Melton LJ, Christiansen C, et al. The diagnosis of osteoporosis. J Bone Miner Res. 1994;9:1137-1141.
14. Wü ster C, Albanese C, De Aloysio D, et al. Phalangeal osteosonogrammetry study: age-related changes, diagnostic sensitivity, and discrimination power. J Bone Miner Res. 2000; 15:1603-1614.
15. Mylona M, Leotsinides M, Alexandrides T, et al. Comparison of DXA, QCT and trabecular structure in beta-thalassaemia. Eur J Haematol. 2005;74:430-437.
16. Wonke B, Jensen C, Hanslip JJ, et al. Genetic and acquired predisposing factors and treatment of osteoporosis in thalassaemia major. J Pediatr Endocrinol Metab. 1998;11:795-801.
17. Bilezician J, Morishima A, Bell J, et al. Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. N Engl J Med. 2005;339:599-603.
18. Angelopoulos NG, Goula A, Rombopoulos G, et al. Hypoparathyroidism in transfusion-dependent patients with betathalassaemia. J Bone Miner Metab. 2006;24:138-145.
19. Leung TF, Hung ECW, Lam CWK, et al. Bone mineral density in children with thalassemia major: Determining factors and effects of bone marrow transplantation. Bone Marrow Transplant. 2005;36:331-336.
20. Jensen CE, Tuck SM, Agnew JE, et al. High prevalence of low bone mass in thalassaemia major. Br J Haematol. 1998;103:911-915.
21. Angastiniotis M, Pavlides N, Aristidou K, et al. Bone pain in thalassaemia: assessment of DXA and MRI findings. J Pediatr Endocrinol Metab. 1998;11:779-784.
22. Fung EB, Vichinsky PE, Kwiatkowski LJ, et al. Characterization of low bone mass in young patients with thalassemia by DXA, pQCT and markers of bone turnover. Bone. 2011;48: 1305-1312.
23. Lala R, Chiabotto P, Di Stefano M, et al. Bone density and metabolism in thalassaemia. J Pediatr Endocrinol Metab. 1998;11:785-790.
24. Perrotta S, Cappellini MD, Bertoldo F, et al. Osteoporosis in beta-thalassaemia major patients: analysis of the genetic background. Br J Haematol. 2000;111:461-466.
25. Kalef-Ezra J, Zibis A, Chaliassos N, et al. Body composition in homozygous beta-thalassemia. Ann N Y Acad Sci. 2000;904: 621-624.
26. Akpek S, Canatan D, Arac M, et al. Evaluation of osteoporosis in thalassemia by quantitative computed tomography: is it reliable? Pediatr Hematol Oncol. 2001;18: 111-116.
27. Cummings SR, Nevitt MC, Browner WS, et al. Risk factors for hip fracture in white women. N Engl J Med. 1995;332: 767-773.
28. Glüer CC, Wu CY, Jergas M, et al. Three quantitative ultrasound parameters reflect bone structure. Calcif Tissue Int. 1994;55:46-52.
29. Njeh CF, Boivin CM, Langton CM. The role of ultrasound in the assessment of osteoporosis: a review. Osteoporos Int. 1997;7:7-22.
30. Bagni B, Palazzi G, Bagni I, et al. pQCT (quantitative peripheral tomography) and data evaluation of phosphocalcic metabolism in thalassaemic patients. J Pediatr Endocrinol Metab. 1998;11:791-794.
31. Njeh CF, Hans D, Li J, et al. Comparison of six calcaneal quantitative ultrasound devices: precision and hip fracture discrimination. Osteoporos Int. 2000;11:1051-1062.
32. Hartl F, Tyndall A, Kraenzlin M, et al. Discriminatory ability of quantitative ultrasound parameters and bone mineral density in a population based sample of postmenopausal women with vertebral fractures: results of the Basel Osteoporosis Study. J Bone Miner Res. 2002;17:321-330.
33. Huopio J, Kroger H, Honkanen R, et al. Calcaneal ultrasound predicts early postmenopausal fractures as well as axial BMD A prospective study of 422 women. Osteoporos Int. 2004;15: 190-195.
34. Hartl F, Tyndall A, Kraenzlin M, et al. Discriminatory ability of quantitative ultrasound parameters and bone mineral density in a population-based sample of postmenopausal women with vertebral fractures; results of the Basel Osteoporosis Study. J Bone Miner Res. 2002;17:321-330.
35. Gluer CC, Eastell R, Reid DM, et al. Association of five quantitative ultrasound devices, and bone densitometry with osteoporotic vertebral fractures in a population-based sample: the OPUS study. J Bone Miner Res. 2004;19:782-793.